Details for: TRIB2

Gene ID: 28951

Symbol: TRIB2

Ensembl ID: ENSG00000071575

Description: tribbles pseudokinase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 128.9979
    Cell Significance Index: -20.0700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 82.2020
    Cell Significance Index: -20.8500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 50.0792
    Cell Significance Index: -20.6300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 45.2423
    Cell Significance Index: -18.3800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.0997
    Cell Significance Index: -19.1900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.6673
    Cell Significance Index: -20.5500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.9955
    Cell Significance Index: -18.7400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.2914
    Cell Significance Index: -20.8800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.8088
    Cell Significance Index: -14.7700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.2394
    Cell Significance Index: 17.8800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.7456
    Cell Significance Index: 37.3100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.4314
    Cell Significance Index: 74.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.2723
    Cell Significance Index: 80.1900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.1754
    Cell Significance Index: 9.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1708
    Cell Significance Index: 60.8200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.0911
    Cell Significance Index: 28.6900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0712
    Cell Significance Index: 212.5900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.0623
    Cell Significance Index: 23.2600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.8741
    Cell Significance Index: 10.4200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6216
    Cell Significance Index: 118.2900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.4733
    Cell Significance Index: 5.8700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.4707
    Cell Significance Index: 6.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3720
    Cell Significance Index: 51.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3635
    Cell Significance Index: 20.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3467
    Cell Significance Index: 9.6900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3359
    Cell Significance Index: 183.4200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.3230
    Cell Significance Index: 4.6500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2950
    Cell Significance Index: 10.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2816
    Cell Significance Index: 101.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2537
    Cell Significance Index: 13.3200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2215
    Cell Significance Index: 200.0300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2038
    Cell Significance Index: 20.1700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1984
    Cell Significance Index: 23.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1781
    Cell Significance Index: 11.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1623
    Cell Significance Index: 7.6300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1569
    Cell Significance Index: 4.2100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1403
    Cell Significance Index: 8.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1319
    Cell Significance Index: 26.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1299
    Cell Significance Index: 23.4200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1169
    Cell Significance Index: 12.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1141
    Cell Significance Index: 18.5600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1090
    Cell Significance Index: 3.2000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0955
    Cell Significance Index: 2.0700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0893
    Cell Significance Index: 1.8700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0883
    Cell Significance Index: 5.4300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0834
    Cell Significance Index: 14.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0739
    Cell Significance Index: 9.0900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0735
    Cell Significance Index: 50.8100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0620
    Cell Significance Index: 1.5500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0301
    Cell Significance Index: 3.8600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0251
    Cell Significance Index: 0.4200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0233
    Cell Significance Index: 0.6700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0105
    Cell Significance Index: 0.3700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0097
    Cell Significance Index: 18.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0053
    Cell Significance Index: 0.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0051
    Cell Significance Index: 0.4000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0012
    Cell Significance Index: -0.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0035
    Cell Significance Index: -6.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0072
    Cell Significance Index: -11.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0096
    Cell Significance Index: -7.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0110
    Cell Significance Index: -6.8700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0111
    Cell Significance Index: -1.4300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0129
    Cell Significance Index: -9.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0134
    Cell Significance Index: -5.9300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0161
    Cell Significance Index: -21.9400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0166
    Cell Significance Index: -12.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0189
    Cell Significance Index: -10.6800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0256
    Cell Significance Index: -16.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0365
    Cell Significance Index: -16.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0558
    Cell Significance Index: -16.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0660
    Cell Significance Index: -2.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0675
    Cell Significance Index: -14.2200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0704
    Cell Significance Index: -8.2000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1060
    Cell Significance Index: -10.8300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1101
    Cell Significance Index: -16.0000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1193
    Cell Significance Index: -13.6200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1222
    Cell Significance Index: -0.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1412
    Cell Significance Index: -16.1800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1468
    Cell Significance Index: -2.6000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1536
    Cell Significance Index: -4.9200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1623
    Cell Significance Index: -11.4800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1655
    Cell Significance Index: -10.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1740
    Cell Significance Index: -12.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1782
    Cell Significance Index: -18.5600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1840
    Cell Significance Index: -2.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1951
    Cell Significance Index: -4.1600
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.2264
    Cell Significance Index: -1.3300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2287
    Cell Significance Index: -4.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2388
    Cell Significance Index: -18.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2588
    Cell Significance Index: -17.4000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2787
    Cell Significance Index: -8.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2805
    Cell Significance Index: -7.2100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3081
    Cell Significance Index: -7.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3457
    Cell Significance Index: -9.4100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3467
    Cell Significance Index: -4.7300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4264
    Cell Significance Index: -13.9600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4316
    Cell Significance Index: -10.3500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4462
    Cell Significance Index: -11.1300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.4471
    Cell Significance Index: -3.8000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4535
    Cell Significance Index: -20.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRIB2 is a pseudokinase that lacks the catalytic activity of its homologs, TRIB1 and TRIB3. Despite this, it exhibits a high degree of structural similarity to these proteins, with a conserved Tribbles domain that mediates protein-protein interactions. TRIB2 has been shown to bind to a wide range of proteins, including kinases, phosphatases, and transcription factors, and has been implicated in the regulation of various signaling pathways. The protein is highly expressed in cells involved in immune responses, including peripheral nervous system neurons, vascular leptomeningeal cells, and inhibitory motor neurons. **Pathways and Functions:** TRIB2 has been shown to interact with and regulate various signaling pathways, including: 1. **MAPK pathway:** TRIB2 has been implicated in the regulation of the MAPK pathway, which plays a critical role in cell growth, differentiation, and survival. 2. **Negative regulation of fat cell differentiation:** TRIB2 has been shown to inhibit the differentiation of adipocytes, suggesting a role in the regulation of lipid metabolism. 3. **Negative regulation of interleukin-10 production:** TRIB2 has been implicated in the regulation of interleukin-10 (IL-10) production, a cytokine involved in anti-inflammatory responses. 4. **Negative regulation of protein kinase activity:** TRIB2 has been shown to inhibit the activity of various protein kinases, including those involved in cell growth and differentiation. 5. **Positive regulation of proteasomal ubiquitin-dependent protein catabolic process:** TRIB2 has been implicated in the regulation of protein degradation, suggesting a role in the clearance of damaged or aberrant proteins. **Clinical Significance:** The dysregulation of TRIB2 has been implicated in various diseases, including: 1. **Autoimmune disorders:** TRIB2 has been shown to play a role in the regulation of immune responses, and its dysregulation has been implicated in autoimmune disorders such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer:** TRIB2 has been implicated in the regulation of cell growth and differentiation, and its dysregulation has been associated with various types of cancer, including breast and lung cancer. 3. **Neurological disorders:** TRIB2 has been shown to play a role in the regulation of neural development and function, and its dysregulation has been implicated in neurological disorders such as Alzheimer's disease and Parkinson's disease. In conclusion, TRIB2 is a multifunctional protein that plays a critical role in regulating various cellular processes, including cell signaling, differentiation, and survival. Its dysregulation has been implicated in various diseases, and further research is needed to fully understand the role of TRIB2 in human health and disease.

Genular Protein ID: 2062838278

Symbol: TRIB2_HUMAN

Name: Tribbles homolog 2

UniProtKB Accession Codes:

Q92519 B2R851 D6W510

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15299019

Title: Human tribbles, a protein family controlling mitogen-activated protein kinase cascades.

PubMed ID: 15299019

DOI: 10.1074/jbc.m407732200

PubMed ID: 15950723

Title: Identification of tribbles homolog 2 as an autoantigen in autoimmune uveitis by phage display.

PubMed ID: 15950723

DOI: 10.1016/j.molimm.2004.11.020

PubMed ID: 27041596

Title: Structural basis for substrate selectivity of the E3 ligase COP1.

PubMed ID: 27041596

DOI: 10.1016/j.str.2016.03.002

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 343
  • Mass: 38801
  • Checksum: BF8B7366DACB84FA
  • Sequence:
    • MNIHRSTPIT IARYGRSRNK TQDFEELSSI RSAEPSQSFS PNLGSPSPPE TPNLSHCVSC 
IGKYLLLEPL EGDHVFRAVH LHSGEELVCK VFDISCYQES LAPCFCLSAH SNINQITEII 
LGETKAYVFF ERSYGDMHSF VRTCKKLREE EAARLFYQIA SAVAHCHDGG LVLRDLKLRK 
FIFKDEERTR VKLESLEDAY ILRGDDDSLS DKHGCPAYVS PEILNTSGSY SGKAADVWSL 
GVMLYTMLVG RYPFHDIEPS SLFSKIRRGQ FNIPETLSPK AKCLIRSILR REPSERLTSQ 
EILDHPWFST DFSVSNSAYG AKEVSDQLVP DVNMEENLDP FFN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.