Details for: SNX24

Gene ID: 28966

Symbol: SNX24

Ensembl ID: ENSG00000064652

Description: sorting nexin 24

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 238.6444
    Cell Significance Index: -37.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 147.5694
    Cell Significance Index: -37.4300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 79.1532
    Cell Significance Index: -37.3700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 70.4919
    Cell Significance Index: -36.2600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.3093
    Cell Significance Index: -37.3700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.7447
    Cell Significance Index: -36.8200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.2610
    Cell Significance Index: -34.5900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.4892
    Cell Significance Index: -37.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.2530
    Cell Significance Index: 86.8600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.3510
    Cell Significance Index: 676.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5706
    Cell Significance Index: 315.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0390
    Cell Significance Index: 206.1900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8825
    Cell Significance Index: 102.8400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8136
    Cell Significance Index: 11.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8004
    Cell Significance Index: 61.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7638
    Cell Significance Index: 273.9500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.7571
    Cell Significance Index: 28.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7521
    Cell Significance Index: 21.0200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7396
    Cell Significance Index: 41.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6244
    Cell Significance Index: 27.6200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5609
    Cell Significance Index: 506.4100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5582
    Cell Significance Index: 386.0800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.5506
    Cell Significance Index: 4.4900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.5408
    Cell Significance Index: 11.5600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4889
    Cell Significance Index: 13.1000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4649
    Cell Significance Index: 10.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3910
    Cell Significance Index: 8.4700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3870
    Cell Significance Index: 7.5500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3553
    Cell Significance Index: 38.6500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3529
    Cell Significance Index: 9.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3519
    Cell Significance Index: 192.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3255
    Cell Significance Index: 21.8900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3190
    Cell Significance Index: 51.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3121
    Cell Significance Index: 19.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2878
    Cell Significance Index: 17.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1826
    Cell Significance Index: 22.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1485
    Cell Significance Index: 6.7300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1456
    Cell Significance Index: 26.2400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1038
    Cell Significance Index: 7.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0865
    Cell Significance Index: 133.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0830
    Cell Significance Index: 153.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0820
    Cell Significance Index: 52.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0720
    Cell Significance Index: 135.6500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0716
    Cell Significance Index: 3.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0635
    Cell Significance Index: 86.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0596
    Cell Significance Index: 26.3500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0424
    Cell Significance Index: 4.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0326
    Cell Significance Index: 1.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0047
    Cell Significance Index: 2.1300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0003
    Cell Significance Index: 0.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0034
    Cell Significance Index: -0.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0103
    Cell Significance Index: -1.4100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0143
    Cell Significance Index: -0.7200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0188
    Cell Significance Index: -0.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0276
    Cell Significance Index: -20.8700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0290
    Cell Significance Index: -21.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0417
    Cell Significance Index: -30.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0608
    Cell Significance Index: -34.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0653
    Cell Significance Index: -6.6800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0656
    Cell Significance Index: -40.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0683
    Cell Significance Index: -11.6700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0743
    Cell Significance Index: -2.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0898
    Cell Significance Index: -11.5100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1287
    Cell Significance Index: -1.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1322
    Cell Significance Index: -19.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1607
    Cell Significance Index: -18.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1916
    Cell Significance Index: -40.3500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2010
    Cell Significance Index: -4.8200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2203
    Cell Significance Index: -28.4600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.2231
    Cell Significance Index: -3.0100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2676
    Cell Significance Index: -6.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2854
    Cell Significance Index: -29.7200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2883
    Cell Significance Index: -21.4900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2955
    Cell Significance Index: -34.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3021
    Cell Significance Index: -18.5200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3053
    Cell Significance Index: -14.3500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3887
    Cell Significance Index: -27.4900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3980
    Cell Significance Index: -31.5200
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.4083
    Cell Significance Index: -2.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4254
    Cell Significance Index: -13.6300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4290
    Cell Significance Index: -27.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4748
    Cell Significance Index: -12.9200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5041
    Cell Significance Index: -10.7400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5781
    Cell Significance Index: -30.3500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6324
    Cell Significance Index: -20.1400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.6380
    Cell Significance Index: -5.8800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6511
    Cell Significance Index: -13.8200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6573
    Cell Significance Index: -22.8400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6829
    Cell Significance Index: -8.1400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.6902
    Cell Significance Index: -16.8400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.6961
    Cell Significance Index: -11.7300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7043
    Cell Significance Index: -23.0600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.7103
    Cell Significance Index: -10.2000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.7175
    Cell Significance Index: -10.2800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.7380
    Cell Significance Index: -7.6400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7884
    Cell Significance Index: -27.6200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7945
    Cell Significance Index: -15.9500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.7947
    Cell Significance Index: -11.7300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8131
    Cell Significance Index: -29.8500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.8252
    Cell Significance Index: -13.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNX24 exhibits a unique set of characteristics that distinguish it from other sorting nexins. Its ability to bind to phosphatidylinositol-3-phosphate (PI3P), phosphatidylinositol-4-phosphate (PI4P), phosphatidylinositol-5-phosphate (PI5P), and phosphatidylinositol phosphate (PIP) suggests a role in regulating membrane dynamics and vesicle transport. Additionally, SNX24's interaction with proteins is a critical aspect of its function, as it may participate in protein sorting, targeting, and degradation. **Pathways and Functions:** SNX24's involvement in various cellular processes can be attributed to its participation in several key pathways: 1. **Cytoplasmic Vesicle Membrane:** SNX24 regulates the formation and fusion of cytoplasmic vesicles, which are essential for cellular transport and trafficking. 2. **Phosphatidylinositol-3-phosphate binding:** PI3P binding is crucial for SNX24's role in regulating membrane dynamics and vesicle transport. 3. **Protein binding:** SNX24 interacts with various proteins, including those involved in protein sorting, targeting, and degradation. 4. **Protein transport:** SNX24 plays a critical role in regulating the transport of proteins within the cell, which is essential for maintaining cellular homeostasis. **Clinical Significance:** The identification of SNX24 as a significantly expressed gene in various cell types highlights its potential role in various diseases. Dysregulation of SNX24's function may contribute to the development of conditions such as: 1. **Neurological disorders:** SNX24's involvement in neuronal function and synaptic transmission suggests that its dysregulation may contribute to neurological disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Renal diseases:** SNX24's expression in renal alpha-intercalated cells suggests that its dysregulation may contribute to renal diseases, such as kidney damage and fibrosis. 3. **Cancer:** SNX24's role in protein transport and binding may also contribute to cancer progression, as altered protein expression and trafficking can promote tumor growth and metastasis. In conclusion, SNX24 is a multifunctional protein that plays a critical role in regulating membrane trafficking and vesicle transport. Its involvement in various cellular processes and its expression in significant cell types highlight the importance of further research into the function and dysregulation of SNX24 in various diseases.

Genular Protein ID: 2984205050

Symbol: SNX24_HUMAN

Name: Sorting nexin-24

UniProtKB Accession Codes:

Q9Y343 Q6UY33

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 169
  • Mass: 19818
  • Checksum: 651B3964493AFE5D
  • Sequence:
    • MEVYIPSFRY EESDLERGYT VFKIEVLMNG RKHFVEKRYS EFHALHKKLK KCIKTPEIPS 
KHVRNWVPKV LEQRRQGLET YLQAVILENE ELPKLFLDFL NVRHLPSLPK AESCGSFDET 
ESEESSKLSH QPVLLFLRDP YVLPAASDFP NVVIEGVLHG IFYPHLQPR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.