Details for: KLF15

Gene ID: 28999

Symbol: KLF15

Ensembl ID: ENSG00000163884

Description: KLF transcription factor 15

Associated with

  • Bmal1:clock,npas2 activates circadian gene expression
    (R-HSA-1368108)
  • Circadian clock
    (R-HSA-400253)
  • Cardiac muscle hypertrophy in response to stress
    (GO:0014898)
  • Cellular response to peptide
    (GO:1901653)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Glial cell differentiation
    (GO:0010001)
  • Intracellular glucose homeostasis
    (GO:0001678)
  • Intracellular membrane-bounded organelle
    (GO:0043231)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of peptidyl-lysine acetylation
    (GO:2000757)
  • Nuclear speck
    (GO:0016607)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Podocyte differentiation
    (GO:0072112)
  • Positive regulation of d-glucose import
    (GO:0046326)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Regulation of wnt signaling pathway
    (GO:0030111)
  • Response to insulin
    (GO:0032868)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Transcription cis-regulatory region binding
    (GO:0000976)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 27.0026
    Cell Significance Index: -10.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1434
    Cell Significance Index: 36.6200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.7282
    Cell Significance Index: 12.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6395
    Cell Significance Index: 121.7100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.5269
    Cell Significance Index: 8.8800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.4726
    Cell Significance Index: 7.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3995
    Cell Significance Index: 79.2800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3728
    Cell Significance Index: 22.3800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.3569
    Cell Significance Index: 5.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3343
    Cell Significance Index: 25.6500
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.3226
    Cell Significance Index: 3.7200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2886
    Cell Significance Index: 18.1900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1952
    Cell Significance Index: 21.2300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1637
    Cell Significance Index: 147.7700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1493
    Cell Significance Index: 53.5600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.1446
    Cell Significance Index: 0.9800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1343
    Cell Significance Index: 6.2600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1286
    Cell Significance Index: 12.7200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1063
    Cell Significance Index: 7.3500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0866
    Cell Significance Index: 14.0800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0854
    Cell Significance Index: 1.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0794
    Cell Significance Index: 14.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0775
    Cell Significance Index: 13.2300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0749
    Cell Significance Index: 1.2600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0693
    Cell Significance Index: 1.6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0683
    Cell Significance Index: 2.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0609
    Cell Significance Index: 1.3200
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.0501
    Cell Significance Index: 0.7000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0322
    Cell Significance Index: 22.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0318
    Cell Significance Index: 4.3700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0234
    Cell Significance Index: 17.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0199
    Cell Significance Index: 12.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0170
    Cell Significance Index: 31.9500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0129
    Cell Significance Index: 0.1900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0040
    Cell Significance Index: 0.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0027
    Cell Significance Index: 4.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0020
    Cell Significance Index: -0.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0023
    Cell Significance Index: -3.1000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0047
    Cell Significance Index: -0.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0049
    Cell Significance Index: -0.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0063
    Cell Significance Index: -4.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0119
    Cell Significance Index: -1.7300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0124
    Cell Significance Index: -0.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0127
    Cell Significance Index: -2.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0131
    Cell Significance Index: -1.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0146
    Cell Significance Index: -0.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0155
    Cell Significance Index: -7.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0169
    Cell Significance Index: -9.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0192
    Cell Significance Index: -8.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0196
    Cell Significance Index: -14.5400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0200
    Cell Significance Index: -1.0400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0216
    Cell Significance Index: -0.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0247
    Cell Significance Index: -7.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0249
    Cell Significance Index: -14.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0258
    Cell Significance Index: -16.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0278
    Cell Significance Index: -3.5600
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0282
    Cell Significance Index: -0.3600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0302
    Cell Significance Index: -2.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0357
    Cell Significance Index: -2.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0524
    Cell Significance Index: -5.3500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0524
    Cell Significance Index: -0.8400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0584
    Cell Significance Index: -7.5400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0654
    Cell Significance Index: -13.7800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0711
    Cell Significance Index: -1.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0812
    Cell Significance Index: -9.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0843
    Cell Significance Index: -9.8300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0884
    Cell Significance Index: -2.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0885
    Cell Significance Index: -9.2200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1007
    Cell Significance Index: -11.8800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1040
    Cell Significance Index: -5.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1141
    Cell Significance Index: -3.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1363
    Cell Significance Index: -7.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1412
    Cell Significance Index: -6.6400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1462
    Cell Significance Index: -10.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1492
    Cell Significance Index: -4.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1547
    Cell Significance Index: -11.5300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1603
    Cell Significance Index: -8.3500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1605
    Cell Significance Index: -3.3300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1651
    Cell Significance Index: -0.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1689
    Cell Significance Index: -11.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1934
    Cell Significance Index: -11.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2122
    Cell Significance Index: -11.1400
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.2241
    Cell Significance Index: -2.3400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2249
    Cell Significance Index: -3.2300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2336
    Cell Significance Index: -3.5200
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.2387
    Cell Significance Index: -1.8300
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.2458
    Cell Significance Index: -1.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2505
    Cell Significance Index: -11.0800
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.2562
    Cell Significance Index: -2.4700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2593
    Cell Significance Index: -5.0600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2680
    Cell Significance Index: -9.3900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.2770
    Cell Significance Index: -3.1700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2896
    Cell Significance Index: -5.8200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2944
    Cell Significance Index: -11.1500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2985
    Cell Significance Index: -12.9800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3114
    Cell Significance Index: -4.4600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3128
    Cell Significance Index: -10.2400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3176
    Cell Significance Index: -6.7400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.3242
    Cell Significance Index: -4.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KLF15 is a 420 amino acid protein that belongs to the Krüppel-like factor family of transcription factors. It possesses a characteristic zinc finger domain, which is essential for its DNA-binding activity. KLF15 is primarily expressed in cells that require rapid adaptation to changing environmental conditions, such as colon goblet cells, kidney epithelial cells, and cardiac muscle cells. Its expression is also observed in other cell types, including granulocyte monocyte progenitor cells, astrocytes, and immature innate lymphoid cells. **Pathways and Functions:** KLF15 is involved in various biological pathways, including: 1. **Circadian Rhythms:** KLF15 is activated by the Bmal1 and npas2 transcription factors, which are key regulators of the circadian clock. KLF15 then regulates the expression of clock genes, ensuring proper synchronization of cellular processes with the 24-hour day-night cycle. 2. **Glucose Homeostasis:** KLF15 regulates glucose metabolism by modulating the expression of genes involved in glucose uptake and storage. It also interacts with other transcription factors, such as PPARγ, to regulate insulin sensitivity. 3. **Cellular Differentiation:** KLF15 plays a crucial role in the differentiation of various cell types, including podocytes, glial cells, and cardiac muscle cells. It regulates the expression of genes involved in cell fate determination and morphogenesis. 4. **Transcriptional Regulation:** KLF15 exhibits a unique transcriptional regulatory profile, with the ability to activate or repress gene expression depending on the context. It interacts with RNA polymerase II to regulate the expression of target genes. **Clinical Significance:** Dysregulation of KLF15 has been implicated in various diseases, including: 1. **Metabolic Disorders:** Aberrant KLF15 expression has been linked to insulin resistance, type 2 diabetes, and metabolic syndrome. 2. **Circadian Rhythm Disorders:** Alterations in KLF15 expression have been observed in patients with circadian rhythm disorders, such as delayed sleep phase syndrome. 3. **Cardiovascular Diseases:** KLF15 has been shown to regulate cardiac hypertrophy and fibrosis, making it a potential therapeutic target for cardiovascular diseases. 4. **Cancer:** KLF15 has been implicated in the regulation of cell proliferation and differentiation in various cancer types, including colon and breast cancer. In conclusion, KLF15 is a multifaceted transcription factor that plays a critical role in regulating circadian rhythms, glucose homeostasis, and cellular differentiation. Its dysregulation has been implicated in various diseases, highlighting the importance of KLF15 as a therapeutic target for the treatment of metabolic and cardiovascular disorders.

Genular Protein ID: 4287111785

Symbol: KLF15_HUMAN

Name: Krueppel-like factor 15

UniProtKB Accession Codes:

Q9UIH9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 EvolutionaryTrace 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10982849

Title: Transcriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Kruppel-like factor, a novel zinc finger repressor.

PubMed ID: 10982849

DOI: 10.1128/mcb.20.19.7319-7331.2000

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17438289

Title: Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy.

PubMed ID: 17438289

DOI: 10.1073/pnas.0701981104

PubMed ID: 18586263

Title: The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts.

PubMed ID: 18586263

DOI: 10.1016/j.yjmcc.2008.05.005

PubMed ID: 20566642

Title: Regulation of cardiac gene expression by KLF15, a repressor of myocardin activity.

PubMed ID: 20566642

DOI: 10.1074/jbc.m110.107292

PubMed ID: 20375365

Title: Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation.

PubMed ID: 20375365

DOI: 10.1126/scitranslmed.3000502

PubMed ID: 22493483

Title: Kruppel-like factor 15 (KLF15) is a key regulator of podocyte differentiation.

PubMed ID: 22493483

DOI: 10.1074/jbc.m112.345983

PubMed ID: 22367544

Title: Circadian rhythms govern cardiac repolarization and arrhythmogenesis.

PubMed ID: 22367544

DOI: 10.1038/nature10852

PubMed ID: 23999430

Title: Kruppel-like factor 15 is critical for vascular inflammation.

PubMed ID: 23999430

DOI: 10.1172/jci68552

PubMed ID: 31375868

Title: The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs.

PubMed ID: 31375868

DOI: 10.1007/s00018-019-03251-w

Sequence Information:

  • Length: 416
  • Mass: 43992
  • Checksum: 6335F85141BEB276
  • Sequence:
    • MVDHLLPVDE NFSSPKCPVG YLGDRLVGRR AYHMLPSPVS EDDSDASSPC SCSSPDSQAL 
CSCYGGGLGT ESQDSILDFL LSQATLGSGG GSGSSIGASS GPVAWGPWRR AAAPVKGEHF 
CLPEFPLGDP DDVPRPFQPT LEEIEEFLEE NMEPGVKEVP EGNSKDLDAC SQLSAGPHKS 
HLHPGSSGRE RCSPPPGGAS AGGAQGPGGG PTPDGPIPVL LQIQPVPVKQ ESGTGPASPG 
QAPENVKVAQ LLVNIQGQTF ALVPQVVPSS NLNLPSKFVR IAPVPIAAKP VGSGPLGPGP 
AGLLMGQKFP KNPAAELIKM HKCTFPGCSK MYTKSSHLKA HLRRHTGEKP FACTWPGCGW 
RFSRSDELSR HRRSHSGVKP YQCPVCEKKF ARSDHLSKHI KVHRFPRSSR SVRSVN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.