Details for: ANPEP

Gene ID: 290

Symbol: ANPEP

Ensembl ID: ENSG00000166825

Description: alanyl aminopeptidase, membrane

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 133.6589
    Cell Significance Index: -20.7900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 73.3707
    Cell Significance Index: -18.6100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 42.4779
    Cell Significance Index: -21.8500
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 35.9211
    Cell Significance Index: 18.0400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.4817
    Cell Significance Index: -18.6000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.8619
    Cell Significance Index: -20.7900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.9362
    Cell Significance Index: -21.2600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.2635
    Cell Significance Index: -20.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 4.9389
    Cell Significance Index: 142.3000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 3.1074
    Cell Significance Index: 52.2700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.0796
    Cell Significance Index: -6.7400
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 2.7270
    Cell Significance Index: 27.5100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.5640
    Cell Significance Index: 47.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.4789
    Cell Significance Index: 423.2900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.2854
    Cell Significance Index: 137.2000
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 2.0418
    Cell Significance Index: 7.6900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.9710
    Cell Significance Index: 194.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.8763
    Cell Significance Index: 1694.1800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6674
    Cell Significance Index: 181.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3971
    Cell Significance Index: 277.2600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.8433
    Cell Significance Index: 27.0100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5475
    Cell Significance Index: 13.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5151
    Cell Significance Index: 24.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4839
    Cell Significance Index: 21.9400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.4809
    Cell Significance Index: 54.9000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4403
    Cell Significance Index: 56.8900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.4355
    Cell Significance Index: 8.5000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.4227
    Cell Significance Index: 7.1200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3671
    Cell Significance Index: 18.5500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3446
    Cell Significance Index: 65.5800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2368
    Cell Significance Index: 38.5200
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.1735
    Cell Significance Index: 2.9800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1335
    Cell Significance Index: 2.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1255
    Cell Significance Index: 4.4100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0596
    Cell Significance Index: 0.8800
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.0337
    Cell Significance Index: 0.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0314
    Cell Significance Index: 2.1700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0244
    Cell Significance Index: 0.7000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0078
    Cell Significance Index: 0.1200
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0039
    Cell Significance Index: -0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0099
    Cell Significance Index: -18.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0100
    Cell Significance Index: -7.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0100
    Cell Significance Index: -1.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0111
    Cell Significance Index: -6.9200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0136
    Cell Significance Index: -9.4100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0152
    Cell Significance Index: -27.9600
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0161
    Cell Significance Index: -0.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0176
    Cell Significance Index: -27.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0213
    Cell Significance Index: -28.9700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0222
    Cell Significance Index: -16.8300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0229
    Cell Significance Index: -16.8100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0256
    Cell Significance Index: -0.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0273
    Cell Significance Index: -15.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0310
    Cell Significance Index: -19.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0380
    Cell Significance Index: -4.3500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0399
    Cell Significance Index: -21.8100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0420
    Cell Significance Index: -0.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0455
    Cell Significance Index: -5.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0508
    Cell Significance Index: -18.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0519
    Cell Significance Index: -23.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0559
    Cell Significance Index: -16.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0570
    Cell Significance Index: -12.0000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0668
    Cell Significance Index: -6.8200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0686
    Cell Significance Index: -13.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0756
    Cell Significance Index: -13.6300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0989
    Cell Significance Index: -1.4900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1103
    Cell Significance Index: -2.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1273
    Cell Significance Index: -18.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1315
    Cell Significance Index: -16.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1476
    Cell Significance Index: -11.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1531
    Cell Significance Index: -7.1400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1603
    Cell Significance Index: -9.8300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1727
    Cell Significance Index: -2.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1737
    Cell Significance Index: -13.7600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1822
    Cell Significance Index: -2.8900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1955
    Cell Significance Index: -5.2200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2026
    Cell Significance Index: -21.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2093
    Cell Significance Index: -5.8500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.2314
    Cell Significance Index: -2.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2384
    Cell Significance Index: -4.9900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2467
    Cell Significance Index: -6.6000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2551
    Cell Significance Index: -4.2700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2752
    Cell Significance Index: -11.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2849
    Cell Significance Index: -18.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2936
    Cell Significance Index: -19.7400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2983
    Cell Significance Index: -12.9700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3096
    Cell Significance Index: -19.5100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3152
    Cell Significance Index: -24.1900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3293
    Cell Significance Index: -2.6900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3490
    Cell Significance Index: -18.1800
  • Cell Name: precursor cell (CL0011115)
    Fold Change: -0.3706
    Cell Significance Index: -2.8100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.3737
    Cell Significance Index: -5.3100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3788
    Cell Significance Index: -23.2800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3793
    Cell Significance Index: -9.7500
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.3963
    Cell Significance Index: -2.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4387
    Cell Significance Index: -24.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4442
    Cell Significance Index: -19.6500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4509
    Cell Significance Index: -11.5200
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.4984
    Cell Significance Index: -3.0800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5001
    Cell Significance Index: -25.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure and Function:** ANPEP is a membrane-bound enzyme that belongs to the metalloaminopeptidase family. It possesses a zinc ion-binding site, which is essential for its catalytic activity. ANPEP is involved in the degradation of peptides and proteins, including angiotensinogen to angiotensins, and plays a role in various signaling pathways, including angiogenesis, cell differentiation, and immune system regulation. 2. **Expression Patterns:** ANPEP is significantly expressed in various cell types, including tracheal goblet cells, enterocytes, and epithelial cells of the proximal tubule, colon, and ileum. This widespread expression suggests that ANPEP plays a crucial role in maintaining tissue homeostasis and regulating cellular metabolism. 3. **Catalytic Activity:** ANPEP has a broad substrate specificity, degrading a wide range of peptides and proteins, including angiotensinogen, peptides, and proteins. This activity is essential for regulating various cellular processes, including metabolism, signaling, and immune response. **Pathways and Functions:** 1. **Angiogenesis:** ANPEP plays a role in angiogenesis, the process of new blood vessel formation, by degrading angiogenic peptides, such as vascular endothelial growth factor (VEGF). 2. **Cell Differentiation:** ANPEP is involved in cell differentiation, regulating the expression of genes involved in cell development and differentiation. 3. **Immune System Regulation:** ANPEP modulates the immune response by degrading peptides and proteins involved in immune signaling, such as angiotensinogen and angiotensin II. 4. **Metabolism of Angiotensinogen to Angiotensins:** ANPEP is essential for the degradation of angiotensinogen to angiotensins, which are key players in blood pressure regulation and electrolyte balance. 5. **Proteolysis and Peptide Catabolism:** ANPEP is involved in the degradation of peptides and proteins, regulating various cellular processes, including metabolism, signaling, and immune response. **Clinical Significance:** 1. **Diseases Associated with ANPEP Dysfunction:** Dysregulation of ANPEP has been implicated in various diseases, including hypertension, cardiovascular disease, and cancer. ANPEP dysfunction can lead to abnormal protein degradation, resulting in the accumulation of peptides and proteins that can contribute to disease pathology. 2. **Therapeutic Targeting of ANPEP:** ANPEP has been identified as a potential therapeutic target for the treatment of various diseases, including hypertension, cardiovascular disease, and cancer. Inhibitors of ANPEP have been developed, which can modulate its activity and regulate protein degradation. 3. **Implications for Immune Regulation:** ANPEP plays a crucial role in regulating the immune response, and dysregulation of ANPEP can lead to immune-related diseases, such as autoimmune disorders and cancer. In conclusion, ANPEP is a multifunctional enzyme that plays a critical role in immune regulation, cellular metabolism, and signaling pathways. Its dysregulation has been implicated in various diseases, and therapeutic targeting of ANPEP has shown promise in treating these conditions. Further research is needed to fully understand the role of ANPEP in human health and disease.

Genular Protein ID: 2417888377

Symbol: AMPN_HUMAN

Name: Alanyl aminopeptidase

UniProtKB Accession Codes:

P15144 Q16728 Q6GT90 Q8IUK3 Q8IVH3 Q9UCE0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EC 1 EMBL 13 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2901990

Title: Complete amino acid sequence of human intestinal aminopeptidase N as deduced from cloned cDNA.

PubMed ID: 2901990

DOI: 10.1016/0014-5793(88)80502-7

PubMed ID: 2564851

Title: Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase N.

PubMed ID: 2564851

DOI: 10.1172/jci114015

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1675638

Title: Separate promoters control transcription of the human aminopeptidase N gene in myeloid and intestinal epithelial cells.

PubMed ID: 1675638

DOI: 10.1016/s0021-9258(18)99056-3

PubMed ID: 7576235

Title: Identification of an alanine aminopeptidase in human maternal serum as a membrane-bound aminopeptidase N.

PubMed ID: 7576235

DOI: 10.1515/bchm3.1995.376.7.397

PubMed ID: 8102610

Title: Cholesterol crystallization-promoting activity of aminopeptidase-N isolated from the vesicular carrier of biliary lipids.

PubMed ID: 8102610

DOI: 10.1016/0014-5793(93)80199-5

PubMed ID: 6149934

Title: Purification and characterization of aminopeptidase N from human plasma.

PubMed ID: 6149934

DOI: 10.1159/000469453

PubMed ID: 1705556

Title: Variable O-glycosylation of CD13 (aminopeptidase N).

PubMed ID: 1705556

DOI: 10.1016/s0021-9258(20)64364-2

PubMed ID: 1350662

Title: Human aminopeptidase N is a receptor for human coronavirus 229E.

PubMed ID: 1350662

DOI: 10.1038/357420a0

PubMed ID: 7902291

Title: CD13 (GP150; aminopeptidase-N): predominant functional activity in blood is localized to plasma and is not cell-surface associated.

PubMed ID: 7902291

PubMed ID: 8105105

Title: CD13 (human aminopeptidase N) mediates human cytomegalovirus infection.

PubMed ID: 8105105

DOI: 10.1128/jvi.67.11.6576-6585.1993

PubMed ID: 8887485

Title: Characterization of functional domains in the human coronavirus HCV 229E receptor.

PubMed ID: 8887485

DOI: 10.1099/0022-1317-77-10-2515

PubMed ID: 9056417

Title: Defectively N-glycosylated and non-O-glycosylated aminopeptidase N (CD13) is normally expressed at the cell surface and has full enzymatic activity.

PubMed ID: 9056417

DOI: 10.1006/excr.1996.3455

PubMed ID: 9367365

Title: Identification of residues critical for the human coronavirus 229E receptor function of human aminopeptidase N.

PubMed ID: 9367365

DOI: 10.1099/0022-1317-78-11-2795

PubMed ID: 10605003

Title: Modification of the amino terminus of a class II epitope confers resistance to degradation by CD13 on dendritic cells and enhances presentation to T cells.

PubMed ID: 10605003

DOI: 10.4049/jimmunol.164.1.129

PubMed ID: 10676659

Title: Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis.

PubMed ID: 10676659

PubMed ID: 11384645

Title: Expression of aminopeptidase N in human endometrium and regulation of its activity by estrogen.

PubMed ID: 11384645

DOI: 10.1016/s0015-0282(01)01779-4

PubMed ID: 11559807

Title: Molecular determinants of species specificity in the coronavirus receptor aminopeptidase N (CD13): influence of N-linked glycosylation.

PubMed ID: 11559807

DOI: 10.1128/jvi.75.20.9741-9752.2001

PubMed ID: 12473585

Title: Soluble aminopeptidase N/CD13 in malignant and nonmalignant effusions and intratumoral fluid.

PubMed ID: 12473585

PubMed ID: 12551991

Title: Identification of a receptor-binding domain of the spike glycoprotein of human coronavirus HCoV-229E.

PubMed ID: 12551991

DOI: 10.1128/jvi.77.4.2530-2538.2003

PubMed ID: 15084671

Title: A proteomic analysis of human bile.

PubMed ID: 15084671

DOI: 10.1074/mcp.m400015-mcp200

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 22932899

Title: The X-ray crystal structure of human aminopeptidase N reveals a novel dimer and the basis for peptide processing.

PubMed ID: 22932899

DOI: 10.1074/jbc.m112.398842

PubMed ID: 9452074

Title: Identification of point mutations in the aminopeptidase N gene by SSCP analysis and sequencing.

PubMed ID: 9452074

DOI: 10.1002/humu.1380110153

Sequence Information:

  • Length: 967
  • Mass: 109540
  • Checksum: 37B6BC1BF0D6B1F2
  • Sequence:
    • MAKGFYISKS LGILGILLGV AAVCTIIALS VVYSQEKNKN ANSSPVASTT PSASATTNPA 
SATTLDQSKA WNRYRLPNTL KPDSYRVTLR PYLTPNDRGL YVFKGSSTVR FTCKEATDVI 
IIHSKKLNYT LSQGHRVVLR GVGGSQPPDI DKTELVEPTE YLVVHLKGSL VKDSQYEMDS 
EFEGELADDL AGFYRSEYME GNVRKVVATT QMQAADARKS FPCFDEPAMK AEFNITLIHP 
KDLTALSNML PKGPSTPLPE DPNWNVTEFH TTPKMSTYLL AFIVSEFDYV EKQASNGVLI 
RIWARPSAIA AGHGDYALNV TGPILNFFAG HYDTPYPLPK SDQIGLPDFN AGAMENWGLV 
TYRENSLLFD PLSSSSSNKE RVVTVIAHEL AHQWFGNLVT IEWWNDLWLN EGFASYVEYL 
GADYAEPTWN LKDLMVLNDV YRVMAVDALA SSHPLSTPAS EINTPAQISE LFDAISYSKG 
ASVLRMLSSF LSEDVFKQGL ASYLHTFAYQ NTIYLNLWDH LQEAVNNRSI QLPTTVRDIM 
NRWTLQMGFP VITVDTSTGT LSQEHFLLDP DSNVTRPSEF NYVWIVPITS IRDGRQQQDY 
WLIDVRAQND LFSTSGNEWV LLNLNVTGYY RVNYDEENWR KIQTQLQRDH SAIPVINRAQ 
IINDAFNLAS AHKVPVTLAL NNTLFLIEER QYMPWEAALS SLSYFKLMFD RSEVYGPMKN 
YLKKQVTPLF IHFRNNTNNW REIPENLMDQ YSEVNAISTA CSNGVPECEE MVSGLFKQWM 
ENPNNNPIHP NLRSTVYCNA IAQGGEEEWD FAWEQFRNAT LVNEADKLRA ALACSKELWI 
LNRYLSYTLN PDLIRKQDAT STIISITNNV IGQGLVWDFV QSNWKKLFND YGGGSFSFSN 
LIQAVTRRFS TEYELQQLEQ FKKDNEETGF GSGTRALEQA LEKTKANIKW VKENKEVVLQ 
WFTENSK

Genular Protein ID: 2975395160

Symbol: Q59E93_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59E93

Database IDs:

ARBA 15 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 4 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 4 InterPro 8 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 3 PRINTS 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 2

Sequence Information:

  • Length: 977
  • Mass: 110593
  • Checksum: 92DDAF01C7BBAAC3
  • Sequence:
    • GSLSRLPTIT MAKGFYISKS LGILGILLGV AAVCTIIALS VVYSQEKNKN ANSSPVASTT 
PSASATTNPA SATTLDQSKA WNRYRLPNTL KPDSYRVTLR PYLTPNDRGL YVFKGSSTVR 
FTCKEATDVI IIHSKKLNYT LSQGHRVVLR GVGGSQPPDI DKTELVEPTE YLVVHLKGSL 
VKDSQYEMDS EFEGELADDL AGFYRSEYME GNVRKVVATT QMQAADARKS FPCFDEPAMK 
AEFNITLIHP KDLTALSNML PKGPSTPLPE DPNWNVTEFH TTPKMSTYLL AFIVSEFDYV 
EKQASNGVLI RIWARPSAIA AGHGDYALNV TGPILNFFAG HYDTPYPLPK SDQIGLPDFN 
AGAMENWGLV TYRENSLLFD PLSSSSSNKE RVVTVIAHEL AHQWFGNLVT IEWWNDLWLN 
EGFASYVEYL GADYAEPTWN LKDLMVLNDV YRVMAVDALA SSHPLSTPAS EINTPAQISE 
LFDAISYSKG ASVLRMLSSF LSEDVFKQGL ASYLHTFAYQ NTIYLNLWDH LQEAVNNRSI 
QLPTTVRDIM NRWTLQMGFP VITVDTSTGT LSQEHFLLDP DSNVTRPSEF NYVWIVPITS 
IRDGRQQQDY WLIDVRAQND LFSTSGNEWV LLNLNVTGYY RVNYDEENWR KIQTQLQRDH 
SAIPVINRAQ IINDAFNLAS AHKVPVTLAL NNTLFLIEER QYMPWEAALS SLSYFKLMFD 
RSEVYGPMKN YLKKQVTPLF IHFRNNTNNW REIPENLMDQ YNEVNAISTA CSNGVPECEE 
MVSGLFKQWM ENPNNNPIHP NLRSTVYCNA IAQGGEEEWD FAWEQFRNAT LVNEADKLRA 
ALACSKELWI LNRYLSYTLN PDLIRKQDAT STIISITNNV IGQGLVWDFV QSNWKKLFND 
YGGGSFSFSN LIQAVTRRFS TEYELQQLEQ FKKDNEETGF GSGTRALEQA LEKTKANIKW 
VKENKEVVLQ WFTENSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.