Details for: GRIN1

Gene ID: 2902

Symbol: GRIN1

Ensembl ID: ENSG00000176884

Description: glutamate ionotropic receptor NMDA type subunit 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.7
    Marker Score: 53,628
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.67
    Marker Score: 4,478
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.66
    Marker Score: 39,801
  • Cell Name: neuron (CL0000540)
    Fold Change: 2.63
    Marker Score: 10,695
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.6
    Marker Score: 19,920
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.58
    Marker Score: 2,597
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.51
    Marker Score: 95,372
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.27
    Marker Score: 83,877
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.25
    Marker Score: 8,694
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.22
    Marker Score: 9,213
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.1
    Marker Score: 19,739
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.04
    Marker Score: 125,325
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.04
    Marker Score: 9,419
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.01
    Marker Score: 20,763
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.99
    Marker Score: 5,688
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.9
    Marker Score: 18,007
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.84
    Marker Score: 15,778
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.8
    Marker Score: 1,182
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.71
    Marker Score: 717
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.63
    Marker Score: 3,312
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.63
    Marker Score: 2,511
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.61
    Marker Score: 1,608
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.36
    Marker Score: 754
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.3
    Marker Score: 5,402
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.27
    Marker Score: 346
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 856
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.2
    Marker Score: 435
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.18
    Marker Score: 2,230
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 488
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,813
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 504
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.04
    Marker Score: 1,198
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.03
    Marker Score: 2,138
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.03
    Marker Score: 397
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,822
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,046
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1
    Marker Score: 942
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,352
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.92
    Marker Score: 1,108
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.92
    Marker Score: 547
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.91
    Marker Score: 30,740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,289
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.87
    Marker Score: 18,595
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.86
    Marker Score: 497
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 326
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.79
    Marker Score: 782
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,264
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.77
    Marker Score: 12,027
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.76
    Marker Score: 1,555
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.74
    Marker Score: 7,509
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 463
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.7
    Marker Score: 3,770
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.62
    Marker Score: 329
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.62
    Marker Score: 327
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 481
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.57
    Marker Score: 181
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.54
    Marker Score: 325
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.54
    Marker Score: 1,241
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.52
    Marker Score: 645
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.51
    Marker Score: 208
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.49
    Marker Score: 3,725
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.49
    Marker Score: 577
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.48
    Marker Score: 524
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.44
    Marker Score: 212
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.42
    Marker Score: 134
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.4
    Marker Score: 191
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.4
    Marker Score: 550
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.38
    Marker Score: 1,259
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.34
    Marker Score: 166
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.33
    Marker Score: 137
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.32
    Marker Score: 280
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.32
    Marker Score: 399
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.31
    Marker Score: 173
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.3
    Marker Score: 168
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.29
    Marker Score: 209
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.29
    Marker Score: 672
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.26
    Marker Score: 151
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.26
    Marker Score: 93
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.24
    Marker Score: 1,276
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.24
    Marker Score: 107
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.24
    Marker Score: 71
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.24
    Marker Score: 73
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.24
    Marker Score: 185
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.24
    Marker Score: 139
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.23
    Marker Score: 64
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.22
    Marker Score: 532
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.21
    Marker Score: 69
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.21
    Marker Score: 384
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.2
    Marker Score: 70

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **NMDA Receptor Subunit**: GRIN1 is a subunit of the NMDA receptor, which is composed of three subunits (NR1, NR2A-D, and NR3A). 2. **Glutamate Binding**: GRIN1 binds to glutamate, the primary excitatory neurotransmitter in the central nervous system. 3. **Ion Channel Activity**: The NMDA receptor, including GRIN1, forms a channel that allows the influx of calcium ions into the neuron, leading to excitatory postsynaptic potentials (EPSPs). 4. **Regulation of Synaptic Plasticity**: GRIN1 plays a crucial role in regulating synaptic plasticity, which is the ability of neurons to reorganize their connections in response to experience. **Pathways and Functions:** The GRIN1 gene is involved in various signaling pathways, including: 1. **Calcium-Mediated Signaling**: GRIN1 regulates calcium ion influx into the neuron, leading to the activation of downstream signaling pathways. 2. **MAPK1/Mapk3 Signaling**: GRIN1 activates the MAPK1/Mapk3 signaling cascade, which regulates cell survival, differentiation, and synaptic plasticity. 3. **Ras Activation**: GRIN1 activates Ras, a small GTPase that regulates cell signaling pathways, including those involved in synaptic plasticity. 4. **Neurotransmitter Receptor Signaling**: GRIN1 is involved in the regulation of neurotransmitter receptor signaling, including glutamate-gated calcium ion channel activity and excitatory postsynaptic potential. **Clinical Significance:** Dysregulation of the GRIN1 gene has been implicated in various neurological disorders, including: 1. **Alzheimer's Disease**: GRIN1 has been shown to be downregulated in Alzheimer's disease, leading to impaired synaptic plasticity and memory formation. 2. **Schizophrenia**: GRIN1 has been implicated in the pathophysiology of schizophrenia, with altered expression and function in schizophrenia patients. 3. **Neurodegenerative Diseases**: GRIN1 has been shown to be downregulated in various neurodegenerative diseases, including Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis (ALS). In conclusion, the GRIN1 gene plays a critical role in regulating synaptic plasticity, learning, and memory formation through its involvement in NMDA receptor signaling. Dysregulation of the GRIN1 gene has been implicated in various neurological disorders, highlighting the importance of this gene in maintaining normal brain function.

Genular Protein ID: 1749005387

Symbol: NMDZ1_HUMAN

Name: Glutamate receptor ionotropic, NMDA 1

UniProtKB Accession Codes:

Q05586 A6NLK7 A6NLR1 C9K0X1 P35437 Q12867 Q12868 Q5VSF3 Q5VSF4 Q5VSF5 Q5VSF6 Q5VSF7 Q5VSF8 Q9UPF8 Q9UPF9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 2 CORUM 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 ComplexPortal 5 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 31 DrugCentral 1 EMBL 14 EMDB 24 EPD 1 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 49 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 53 PDBsum 36 PIR 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 7 RNAct 1 Reactome 9 RefSeq 7 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8406025

Title: Cloning and sequence analysis of cDNAs encoding human hippocampus N-methyl-D-aspartate receptor subunits: evidence for alternative RNA splicing.

PubMed ID: 8406025

DOI: 10.1016/0378-1119(93)90309-q

PubMed ID: 7679115

Title: Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor.

PubMed ID: 7679115

DOI: 10.1016/s0021-9258(18)53754-6

PubMed ID: 7685113

Title: Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain.

PubMed ID: 7685113

DOI: 10.1073/pnas.90.11.5057

PubMed ID: 7622053

Title: Cloning and structure of the gene encoding the human N-methyl-D-aspartate receptor (NMDAR1).

PubMed ID: 7622053

DOI: 10.1016/0378-1119(95)00044-7

PubMed ID: 9231706

Title: Cloning and localization of exon 5-containing isoforms of the NMDAR1 subunit in human and rat brains.

PubMed ID: 9231706

DOI: 10.1046/j.1471-4159.1997.69020485.x

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 7926821

Title: Cloning and sequence analysis of additional splice variants encoding human N-methyl-D-aspartate receptor (hNR1) subunits.

PubMed ID: 7926821

DOI: 10.1016/0378-1119(94)90089-2

PubMed ID: 7681588

Title: Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line.

PubMed ID: 7681588

DOI: 10.1073/pnas.90.6.2174

PubMed ID: 8316301

Title: Regulation of NMDA receptor phosphorylation by alternative splicing of the C-terminal domain.

PubMed ID: 8316301

DOI: 10.1038/364070a0

PubMed ID: 18849881

Title: GRINL1A colocalizes with N-methyl D-aspartate receptor NR1 subunit and reduces N-methyl D-aspartate toxicity.

PubMed ID: 18849881

DOI: 10.1097/wnr.0b013e328317f05f

PubMed ID: 27458189

Title: Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity.

PubMed ID: 27458189

DOI: 10.15252/embj.201593070

PubMed ID: 28126851

Title: Functional evaluation of a de novo GRIN2A mutation identified in a patient with profound global developmental delay and refractory epilepsy.

PubMed ID: 28126851

DOI: 10.1124/mol.116.106781

PubMed ID: 10201407

Title: Structures of the M2 channel-lining segments from nicotinic acetylcholine and NMDA receptors by NMR spectroscopy.

PubMed ID: 10201407

DOI: 10.1038/7610

PubMed ID: 26919761

Title: Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.

PubMed ID: 26919761

DOI: 10.1021/acs.jmedchem.5b02010

PubMed ID: 26875626

Title: Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.

PubMed ID: 26875626

DOI: 10.1016/j.neuron.2016.01.016

PubMed ID: 28105280

Title: GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile.

PubMed ID: 28105280

DOI: 10.1021/acsmedchemlett.6b00388

PubMed ID: 21376300

Title: Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability.

PubMed ID: 21376300

DOI: 10.1016/j.ajhg.2011.02.001

PubMed ID: 22833210

Title: Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia.

PubMed ID: 22833210

DOI: 10.1038/tp.2011.52

PubMed ID: 25167861

Title: Efficient strategy for the molecular diagnosis of intellectual disability using targeted high-throughput sequencing.

PubMed ID: 25167861

DOI: 10.1136/jmedgenet-2014-102554

PubMed ID: 25864721

Title: GRIN1 mutations cause encephalopathy with infantile-onset epilepsy, and hyperkinetic and stereotyped movement disorders.

PubMed ID: 25864721

DOI: 10.1111/epi.12987

PubMed ID: 27164704

Title: Delineating the GRIN1 phenotypic spectrum: A distinct genetic NMDA receptor encephalopathy.

PubMed ID: 27164704

DOI: 10.1212/wnl.0000000000002740

PubMed ID: 28051072

Title: Novel homozygous missense variant of GRIN1 in two sibs with intellectual disability and autistic features without epilepsy.

PubMed ID: 28051072

DOI: 10.1038/ejhg.2016.163

PubMed ID: 28389307

Title: De novo GRIN1 mutations: An emerging cause of severe early infantile encephalopathy.

PubMed ID: 28389307

DOI: 10.1016/j.ejmg.2017.04.001

PubMed ID: 28228639

Title: GRIN1 mutation associated with intellectual disability alters NMDA receptor trafficking and function.

PubMed ID: 28228639

DOI: 10.1038/jhg.2017.19

PubMed ID: 28095420

Title: Molecular mechanism of disease-associated mutations in the pre-M1 helix of NMDA receptors and potential rescue pharmacology.

PubMed ID: 28095420

DOI: 10.1371/journal.pgen.1006536

PubMed ID: 34611970

Title: A homozygous GRIN1 null variant causes a more severe phenotype of early infantile epileptic encephalopathy.

PubMed ID: 34611970

DOI: 10.1002/ajmg.a.62528

Sequence Information:

  • Length: 938
  • Mass: 105373
  • Checksum: CDF5402769E530AB
  • Sequence:
    • MSTMRLLTLA LLFSCSVARA ACDPKIVNIG AVLSTRKHEQ MFREAVNQAN KRHGSWKIQL 
NATSVTHKPN AIQMALSVCE DLISSQVYAI LVSHPPTPND HFTPTPVSYT AGFYRIPVLG 
LTTRMSIYSD KSIHLSFLRT VPPYSHQSSV WFEMMRVYSW NHIILLVSDD HEGRAAQKRL 
ETLLEERESK AEKVLQFDPG TKNVTALLME AKELEARVII LSASEDDAAT VYRAAAMLNM 
TGSGYVWLVG EREISGNALR YAPDGILGLQ LINGKNESAH ISDAVGVVAQ AVHELLEKEN 
ITDPPRGCVG NTNIWKTGPL FKRVLMSSKY ADGVTGRVEF NEDGDRKFAN YSIMNLQNRK 
LVQVGIYNGT HVIPNDRKII WPGGETEKPR GYQMSTRLKI VTIHQEPFVY VKPTLSDGTC 
KEEFTVNGDP VKKVICTGPN DTSPGSPRHT VPQCCYGFCI DLLIKLARTM NFTYEVHLVA 
DGKFGTQERV NNSNKKEWNG MMGELLSGQA DMIVAPLTIN NERAQYIEFS KPFKYQGLTI 
LVKKEIPRST LDSFMQPFQS TLWLLVGLSV HVVAVMLYLL DRFSPFGRFK VNSEEEEEDA 
LTLSSAMWFS WGVLLNSGIG EGAPRSFSAR ILGMVWAGFA MIIVASYTAN LAAFLVLDRP 
EERITGINDP RLRNPSDKFI YATVKQSSVD IYFRRQVELS TMYRHMEKHN YESAAEAIQA 
VRDNKLHAFI WDSAVLEFEA SQKCDLVTTG ELFFRSGFGI GMRKDSPWKQ NVSLSILKSH 
ENGFMEDLDK TWVRYQECDS RSNAPATLTF ENMAGVFMLV AGGIVAGIFL IFIEIAYKRH 
KDARRKQMQL AFAAVNVWRK NLQDRKSGRA EPDPKKKATF RAITSTLASS FKRRRSSKDT 
STGGGRGALQ NQKDTVLPRR AIEREEGQLQ LCSRHRES

Genular Protein ID: 1130175979

Symbol: Q5VSF9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5VSF9 A6NED8 A6NGR6

Database IDs:

ARBA 18 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 7 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 2 Pfam 4 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SMART 4 SMR 1 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

Sequence Information:

  • Length: 922
  • Mass: 103745
  • Checksum: B198F7F5A4A638EC
  • Sequence:
    • MSTMRLLTLA LLFSCSVARA ACDPKIVNIG AVLSTRKHEQ MFREAVNQAN KRHGSWKIQL 
NATSVTHKPN AIQMALSVCE DLISSQVYAI LVSHPPTPND HFTPTPVSYT AGFYRIPVLG 
LTTRMSIYSD KSIHLSFLRT VPPYSHQSSV WFEMMRVYSW NHIILLVSDD HEGRAAQKRL 
ETLLEERESK SKKRNYENLD QLSYDNKRGP KAEKVLQFDP GTKNVTALLM EAKELEARVI 
ILSASEDDAA TVYRAAAMLN MTGSGYVWLV GEREISGNAL RYAPDGILGL QLINGKNESA 
HISDAVGVVA QAVHELLEKE NITDPPRGCV GNTNIWKTGP LFKRVLMSSK YADGVTGRVE 
FNEDGDRKFA NYSIMNLQNR KLVQVGIYNG THVIPNDRKI IWPGGETEKP RGYQMSTRLK 
IVTIHQEPFV YVKPTLSDGT CKEEFTVNGD PVKKVICTGP NDTSPGSPRH TVPQCCYGFC 
IDLLIKLART MNFTYEVHLV ADGKFGTQER VNNSNKKEWN GMMGELLSGQ ADMIVAPLTI 
NNERAQYIEF SKPFKYQGLT ILVKKEIPRS TLDSFMQPFQ STLWLLVGLS VHVVAVMLYL 
LDRFSPFGRF KVNSEEEEED ALTLSSAMWF SWGVLLNSGI GEGAPRSFSA RILGMVWAGF 
AMIIVASYTA NLAAFLVLDR PEERITGIND PRLRNPSDKF IYATVKQSSV DIYFRRQVEL 
STMYRHMEKH NYESAAEAIQ AVRDNKLHAF IWDSAVLEFE ASQKCDLVTT GELFFRSGFG 
IGMRKDSPWK QNVSLSILKS HENGFMEDLD KTWVRYQECD SRSNAPATLT FENMAGVFML 
VAGGIVAGIF LIFIEIAYKR HKDARRKQMQ LAFAAVNVWR KNLQSTGGGR GALQNQKDTV 
LPRRAIEREE GQLQLCSRHR ES

Genular Protein ID: 2005595063

Symbol: Q59GW0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59GW0

Database IDs:

ARBA 18 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 4 Gene3D 3 Genevisible 1 GenomeRNAi 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 4 RefSeq 2 RuleBase 1 SMART 4 SUPFAM 3

Sequence Information:

  • Length: 663
  • Mass: 73976
  • Checksum: 84A2BB8BD5C87CB6
  • Sequence:
    • RAPGTCGWSA SARSRGTPCA TPRTLINGKN ESAHISDAVG VVAQAVHELL EKENITDPPR 
GCVGNTNIWK TGPLFKRVLM SSKYADGVTG RVEFNEDGDR KFANYSIMNL QNRKLVQVGI 
YNGTHVIPND RKIIWPGGET EKPRGYQMST RLKIVTIHQE PFVYVKPTLS DGTCKEEFTV 
NGDPVKKVIC TGPNDTSPGS PRHTVPQCCY GFCIDLLIKL ARTMNFTYEV HLVADGKFGT 
QERVNNSNKK EWNGMMGELL SGQADMIVAP LTINNERAQY IKFSKPFKYQ GLTILVKKEI 
PRSTLDSFMQ PFQSTLWLLV GLSVHVVAVM LYLLDRFSPF GRFKVNSEEE EEDALTLSSA 
MWFSWGVLLN SGIGEGAPRS FSARILGMVW AGFAMIIVAS YTANLAAFLV LDRPEERITG 
INDPRLRNPS DKFIYATVKQ SSVDIYFRRQ VELSTMYRHM EKHNYESAAE AIQAVRDNKL 
HAFIWDSAVL EFEASQKCDL VTTGELFFRS GFGIGMRKDS PWKQNVSLSI LKSHENGFME 
DLDKTWVRYQ ECDSRSNAPA TLTFENMAGV FMLVAGGIVA GIFLIFIEIA YKRHKDARRK 
QMQLAFAAVN VWRKNLQVGQ ATLRGLVPRA RPGHGPPPSP KAVALALALV GRTGARSHGQ 
GQW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.