Details for: GRIN1
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.7
Marker Score: 53,628 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: 2.67
Marker Score: 4,478 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.66
Marker Score: 39,801 - Cell Name: neuron (CL0000540)
Fold Change: 2.63
Marker Score: 10,695 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.6
Marker Score: 19,920 - Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 2.58
Marker Score: 2,597 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.51
Marker Score: 95,372 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 2.27
Marker Score: 83,877 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.25
Marker Score: 8,694 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 2.22
Marker Score: 9,213 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 2.1
Marker Score: 19,739 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.04
Marker Score: 125,325 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 2.04
Marker Score: 9,419 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 2.01
Marker Score: 20,763 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 1.99
Marker Score: 5,688 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.9
Marker Score: 18,007 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.84
Marker Score: 15,778 - Cell Name: mature astrocyte (CL0002627)
Fold Change: 1.8
Marker Score: 1,182 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.71
Marker Score: 717 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.63
Marker Score: 3,312 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.63
Marker Score: 2,511 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.61
Marker Score: 1,608 - Cell Name: erythrocyte (CL0000232)
Fold Change: 1.36
Marker Score: 754 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: 1.3
Marker Score: 5,402 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.27
Marker Score: 346 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.26
Marker Score: 856 - Cell Name: mature microglial cell (CL0002629)
Fold Change: 1.2
Marker Score: 435 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.18
Marker Score: 2,230 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.18
Marker Score: 488 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4,813 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.1
Marker Score: 504 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.04
Marker Score: 1,198 - Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 1.03
Marker Score: 2,138 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.03
Marker Score: 397 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,822 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,046 - Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 1
Marker Score: 942 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 510 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,407 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 463 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,413 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5,352 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.92
Marker Score: 1,108 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.92
Marker Score: 547 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2,742 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.91
Marker Score: 30,740 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 326 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,289 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.87
Marker Score: 18,595 - Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 0.86
Marker Score: 497 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.81
Marker Score: 326 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.79
Marker Score: 782 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,264 - Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 709 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.77
Marker Score: 12,027 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 397 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.76
Marker Score: 1,555 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.74
Marker Score: 7,509 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 463 - Cell Name: stellate neuron (CL0000122)
Fold Change: 0.7
Marker Score: 3,770 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.62
Marker Score: 329 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.62
Marker Score: 327 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.6
Marker Score: 481 - Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 0.57
Marker Score: 181 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 174 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.54
Marker Score: 325 - Cell Name: macroglial cell (CL0000126)
Fold Change: 0.54
Marker Score: 1,241 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.52
Marker Score: 645 - Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.51
Marker Score: 208 - Cell Name: granule cell (CL0000120)
Fold Change: 0.49
Marker Score: 3,725 - Cell Name: stromal cell (CL0000499)
Fold Change: 0.49
Marker Score: 577 - Cell Name: glial cell (CL0000125)
Fold Change: 0.48
Marker Score: 524 - Cell Name: CNS interneuron (CL0000402)
Fold Change: 0.44
Marker Score: 212 - Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.42
Marker Score: 134 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.4
Marker Score: 191 - Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.4
Marker Score: 550 - Cell Name: neuronal brush cell (CL0000555)
Fold Change: 0.38
Marker Score: 1,259 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.34
Marker Score: 166 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.33
Marker Score: 137 - Cell Name: astrocyte (CL0000127)
Fold Change: 0.32
Marker Score: 280 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.32
Marker Score: 399 - Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.31
Marker Score: 173 - Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.3
Marker Score: 168 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.29
Marker Score: 209 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.29
Marker Score: 672 - Cell Name: pericyte (CL0000669)
Fold Change: 0.26
Marker Score: 151 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.26
Marker Score: 93 - Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 0.24
Marker Score: 1,276 - Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.24
Marker Score: 107 - Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.24
Marker Score: 71 - Cell Name: ganglion interneuron (CL0000397)
Fold Change: 0.24
Marker Score: 73 - Cell Name: renal principal cell (CL0005009)
Fold Change: 0.24
Marker Score: 185 - Cell Name: mast cell (CL0000097)
Fold Change: 0.24
Marker Score: 139 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.23
Marker Score: 65 - Cell Name: meningeal macrophage (CL0000879)
Fold Change: 0.23
Marker Score: 64 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.22
Marker Score: 532 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 74 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.21
Marker Score: 69 - Cell Name: microglial cell (CL0000129)
Fold Change: 0.21
Marker Score: 384 - Cell Name: ependymal cell (CL0000065)
Fold Change: 0.2
Marker Score: 70
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1749005387
Symbol: NMDZ1_HUMAN
Name: Glutamate receptor ionotropic, NMDA 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8406025
Title: Cloning and sequence analysis of cDNAs encoding human hippocampus N-methyl-D-aspartate receptor subunits: evidence for alternative RNA splicing.
PubMed ID: 8406025
PubMed ID: 7679115
Title: Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor.
PubMed ID: 7679115
PubMed ID: 7685113
Title: Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain.
PubMed ID: 7685113
PubMed ID: 7622053
Title: Cloning and structure of the gene encoding the human N-methyl-D-aspartate receptor (NMDAR1).
PubMed ID: 7622053
PubMed ID: 9231706
Title: Cloning and localization of exon 5-containing isoforms of the NMDAR1 subunit in human and rat brains.
PubMed ID: 9231706
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 7926821
Title: Cloning and sequence analysis of additional splice variants encoding human N-methyl-D-aspartate receptor (hNR1) subunits.
PubMed ID: 7926821
PubMed ID: 7681588
Title: Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line.
PubMed ID: 7681588
PubMed ID: 8316301
Title: Regulation of NMDA receptor phosphorylation by alternative splicing of the C-terminal domain.
PubMed ID: 8316301
DOI: 10.1038/364070a0
PubMed ID: 18849881
Title: GRINL1A colocalizes with N-methyl D-aspartate receptor NR1 subunit and reduces N-methyl D-aspartate toxicity.
PubMed ID: 18849881
PubMed ID: 27458189
Title: Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity.
PubMed ID: 27458189
PubMed ID: 28126851
Title: Functional evaluation of a de novo GRIN2A mutation identified in a patient with profound global developmental delay and refractory epilepsy.
PubMed ID: 28126851
PubMed ID: 10201407
Title: Structures of the M2 channel-lining segments from nicotinic acetylcholine and NMDA receptors by NMR spectroscopy.
PubMed ID: 10201407
DOI: 10.1038/7610
PubMed ID: 26919761
Title: Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.
PubMed ID: 26919761
PubMed ID: 26875626
Title: Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.
PubMed ID: 26875626
PubMed ID: 28105280
Title: GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile.
PubMed ID: 28105280
PubMed ID: 21376300
Title: Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability.
PubMed ID: 21376300
PubMed ID: 22833210
Title: Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia.
PubMed ID: 22833210
DOI: 10.1038/tp.2011.52
PubMed ID: 25167861
Title: Efficient strategy for the molecular diagnosis of intellectual disability using targeted high-throughput sequencing.
PubMed ID: 25167861
PubMed ID: 25864721
Title: GRIN1 mutations cause encephalopathy with infantile-onset epilepsy, and hyperkinetic and stereotyped movement disorders.
PubMed ID: 25864721
DOI: 10.1111/epi.12987
PubMed ID: 27164704
Title: Delineating the GRIN1 phenotypic spectrum: A distinct genetic NMDA receptor encephalopathy.
PubMed ID: 27164704
PubMed ID: 28051072
Title: Novel homozygous missense variant of GRIN1 in two sibs with intellectual disability and autistic features without epilepsy.
PubMed ID: 28051072
PubMed ID: 28389307
Title: De novo GRIN1 mutations: An emerging cause of severe early infantile encephalopathy.
PubMed ID: 28389307
PubMed ID: 28228639
Title: GRIN1 mutation associated with intellectual disability alters NMDA receptor trafficking and function.
PubMed ID: 28228639
DOI: 10.1038/jhg.2017.19
PubMed ID: 28095420
Title: Molecular mechanism of disease-associated mutations in the pre-M1 helix of NMDA receptors and potential rescue pharmacology.
PubMed ID: 28095420
PubMed ID: 34611970
Title: A homozygous GRIN1 null variant causes a more severe phenotype of early infantile epileptic encephalopathy.
PubMed ID: 34611970
DOI: 10.1002/ajmg.a.62528
Sequence Information:
- Length: 938
- Mass: 105373
- Checksum: CDF5402769E530AB
- Sequence:
MSTMRLLTLA LLFSCSVARA ACDPKIVNIG AVLSTRKHEQ MFREAVNQAN KRHGSWKIQL NATSVTHKPN AIQMALSVCE DLISSQVYAI LVSHPPTPND HFTPTPVSYT AGFYRIPVLG LTTRMSIYSD KSIHLSFLRT VPPYSHQSSV WFEMMRVYSW NHIILLVSDD HEGRAAQKRL ETLLEERESK AEKVLQFDPG TKNVTALLME AKELEARVII LSASEDDAAT VYRAAAMLNM TGSGYVWLVG EREISGNALR YAPDGILGLQ LINGKNESAH ISDAVGVVAQ AVHELLEKEN ITDPPRGCVG NTNIWKTGPL FKRVLMSSKY ADGVTGRVEF NEDGDRKFAN YSIMNLQNRK LVQVGIYNGT HVIPNDRKII WPGGETEKPR GYQMSTRLKI VTIHQEPFVY VKPTLSDGTC KEEFTVNGDP VKKVICTGPN DTSPGSPRHT VPQCCYGFCI DLLIKLARTM NFTYEVHLVA DGKFGTQERV NNSNKKEWNG MMGELLSGQA DMIVAPLTIN NERAQYIEFS KPFKYQGLTI LVKKEIPRST LDSFMQPFQS TLWLLVGLSV HVVAVMLYLL DRFSPFGRFK VNSEEEEEDA LTLSSAMWFS WGVLLNSGIG EGAPRSFSAR ILGMVWAGFA MIIVASYTAN LAAFLVLDRP EERITGINDP RLRNPSDKFI YATVKQSSVD IYFRRQVELS TMYRHMEKHN YESAAEAIQA VRDNKLHAFI WDSAVLEFEA SQKCDLVTTG ELFFRSGFGI GMRKDSPWKQ NVSLSILKSH ENGFMEDLDK TWVRYQECDS RSNAPATLTF ENMAGVFMLV AGGIVAGIFL IFIEIAYKRH KDARRKQMQL AFAAVNVWRK NLQDRKSGRA EPDPKKKATF RAITSTLASS FKRRRSSKDT STGGGRGALQ NQKDTVLPRR AIEREEGQLQ LCSRHRES
Genular Protein ID: 1130175979
Symbol: Q5VSF9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
Sequence Information:
- Length: 922
- Mass: 103745
- Checksum: B198F7F5A4A638EC
- Sequence:
MSTMRLLTLA LLFSCSVARA ACDPKIVNIG AVLSTRKHEQ MFREAVNQAN KRHGSWKIQL NATSVTHKPN AIQMALSVCE DLISSQVYAI LVSHPPTPND HFTPTPVSYT AGFYRIPVLG LTTRMSIYSD KSIHLSFLRT VPPYSHQSSV WFEMMRVYSW NHIILLVSDD HEGRAAQKRL ETLLEERESK SKKRNYENLD QLSYDNKRGP KAEKVLQFDP GTKNVTALLM EAKELEARVI ILSASEDDAA TVYRAAAMLN MTGSGYVWLV GEREISGNAL RYAPDGILGL QLINGKNESA HISDAVGVVA QAVHELLEKE NITDPPRGCV GNTNIWKTGP LFKRVLMSSK YADGVTGRVE FNEDGDRKFA NYSIMNLQNR KLVQVGIYNG THVIPNDRKI IWPGGETEKP RGYQMSTRLK IVTIHQEPFV YVKPTLSDGT CKEEFTVNGD PVKKVICTGP NDTSPGSPRH TVPQCCYGFC IDLLIKLART MNFTYEVHLV ADGKFGTQER VNNSNKKEWN GMMGELLSGQ ADMIVAPLTI NNERAQYIEF SKPFKYQGLT ILVKKEIPRS TLDSFMQPFQ STLWLLVGLS VHVVAVMLYL LDRFSPFGRF KVNSEEEEED ALTLSSAMWF SWGVLLNSGI GEGAPRSFSA RILGMVWAGF AMIIVASYTA NLAAFLVLDR PEERITGIND PRLRNPSDKF IYATVKQSSV DIYFRRQVEL STMYRHMEKH NYESAAEAIQ AVRDNKLHAF IWDSAVLEFE ASQKCDLVTT GELFFRSGFG IGMRKDSPWK QNVSLSILKS HENGFMEDLD KTWVRYQECD SRSNAPATLT FENMAGVFML VAGGIVAGIF LIFIEIAYKR HKDARRKQMQ LAFAAVNVWR KNLQSTGGGR GALQNQKDTV LPRRAIEREE GQLQLCSRHR ES
Genular Protein ID: 2005595063
Symbol: Q59GW0_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 663
- Mass: 73976
- Checksum: 84A2BB8BD5C87CB6
- Sequence:
RAPGTCGWSA SARSRGTPCA TPRTLINGKN ESAHISDAVG VVAQAVHELL EKENITDPPR GCVGNTNIWK TGPLFKRVLM SSKYADGVTG RVEFNEDGDR KFANYSIMNL QNRKLVQVGI YNGTHVIPND RKIIWPGGET EKPRGYQMST RLKIVTIHQE PFVYVKPTLS DGTCKEEFTV NGDPVKKVIC TGPNDTSPGS PRHTVPQCCY GFCIDLLIKL ARTMNFTYEV HLVADGKFGT QERVNNSNKK EWNGMMGELL SGQADMIVAP LTINNERAQY IKFSKPFKYQ GLTILVKKEI PRSTLDSFMQ PFQSTLWLLV GLSVHVVAVM LYLLDRFSPF GRFKVNSEEE EEDALTLSSA MWFSWGVLLN SGIGEGAPRS FSARILGMVW AGFAMIIVAS YTANLAAFLV LDRPEERITG INDPRLRNPS DKFIYATVKQ SSVDIYFRRQ VELSTMYRHM EKHNYESAAE AIQAVRDNKL HAFIWDSAVL EFEASQKCDL VTTGELFFRS GFGIGMRKDS PWKQNVSLSI LKSHENGFME DLDKTWVRYQ ECDSRSNAPA TLTFENMAGV FMLVAGGIVA GIFLIFIEIA YKRHKDARRK QMQLAFAAVN VWRKNLQVGQ ATLRGLVPRA RPGHGPPPSP KAVALALALV GRTGARSHGQ GQW
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.