Details for: GRIN2C

Gene ID: 2905

Symbol: GRIN2C

Ensembl ID: ENSG00000161509

Description: glutamate ionotropic receptor NMDA type subunit 2C

Associated with

  • Activation of nmda receptors and postsynaptic events
    (R-HSA-442755)
  • Assembly and cell surface presentation of nmda receptors
    (R-HSA-9609736)
  • Long-term potentiation
    (R-HSA-9620244)
  • Negative regulation of nmda receptor-mediated neuronal transmission
    (R-HSA-9617324)
  • Neurexins and neuroligins
    (R-HSA-6794361)
  • Neuronal system
    (R-HSA-112316)
  • Neurotransmitter receptors and postsynaptic signal transmission
    (R-HSA-112314)
  • Post nmda receptor activation events
    (R-HSA-438064)
  • Protein-protein interactions at synapses
    (R-HSA-6794362)
  • Synaptic adhesion-like molecules
    (R-HSA-8849932)
  • Transmission across chemical synapses
    (R-HSA-112315)
  • Unblocking of nmda receptors, glutamate binding and activation
    (R-HSA-438066)
  • Brain development
    (GO:0007420)
  • Calcium-mediated signaling
    (GO:0019722)
  • Calcium ion transmembrane import into cytosol
    (GO:0097553)
  • Directional locomotion
    (GO:0033058)
  • Endoplasmic reticulum membrane
    (GO:0005789)
  • Excitatory chemical synaptic transmission
    (GO:0098976)
  • Excitatory postsynaptic potential
    (GO:0060079)
  • Glutamate-gated calcium ion channel activity
    (GO:0022849)
  • Glutamate receptor signaling pathway
    (GO:0007215)
  • Glutamatergic synapse
    (GO:0098978)
  • Ionotropic glutamate receptor signaling pathway
    (GO:0035235)
  • Long-term synaptic potentiation
    (GO:0060291)
  • Monoatomic cation transmembrane transport
    (GO:0098655)
  • Negative regulation of protein catabolic process
    (GO:0042177)
  • Neuromuscular process controlling balance
    (GO:0050885)
  • Nmda glutamate receptor activity
    (GO:0004972)
  • Nmda selective glutamate receptor complex
    (GO:0017146)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of excitatory postsynaptic potential
    (GO:2000463)
  • Positive regulation of synaptic transmission, glutamatergic
    (GO:0051968)
  • Postsynaptic density membrane
    (GO:0098839)
  • Postsynaptic membrane
    (GO:0045211)
  • Protein binding
    (GO:0005515)
  • Protein localization to postsynaptic membrane
    (GO:1903539)
  • Regulation of monoatomic cation transmembrane transport
    (GO:1904062)
  • Regulation of neuronal synaptic plasticity
    (GO:0048168)
  • Regulation of synaptic plasticity
    (GO:0048167)
  • Response to wounding
    (GO:0009611)
  • Synaptic transmission, glutamatergic
    (GO:0035249)
  • Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
    (GO:1904315)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 28.1912
    Cell Significance Index: -4.3900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 17.1106
    Cell Significance Index: -4.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.8449
    Cell Significance Index: 129.8200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.5687
    Cell Significance Index: -4.4000
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 2.7554
    Cell Significance Index: 38.5300
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.1222
    Cell Significance Index: 12.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8839
    Cell Significance Index: 19.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.8144
    Cell Significance Index: 49.9300
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.7725
    Cell Significance Index: 8.8000
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 0.6613
    Cell Significance Index: 5.3400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.6096
    Cell Significance Index: 10.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5526
    Cell Significance Index: 17.7000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.3642
    Cell Significance Index: 3.8700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3624
    Cell Significance Index: 6.2100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3128
    Cell Significance Index: 59.5200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1770
    Cell Significance Index: 2.2000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1659
    Cell Significance Index: 16.4100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1499
    Cell Significance Index: 9.0000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1369
    Cell Significance Index: 2.9200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.1361
    Cell Significance Index: 1.1100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.1357
    Cell Significance Index: 1.1400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1312
    Cell Significance Index: 118.4800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1231
    Cell Significance Index: 85.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1161
    Cell Significance Index: 12.6300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1056
    Cell Significance Index: 194.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0956
    Cell Significance Index: 34.2900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0813
    Cell Significance Index: 13.2200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.0738
    Cell Significance Index: 0.9200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0607
    Cell Significance Index: 1.2600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0535
    Cell Significance Index: 1.5400
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.0470
    Cell Significance Index: 0.9800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.0428
    Cell Significance Index: 0.6000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0392
    Cell Significance Index: 2.7100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.0339
    Cell Significance Index: 0.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0261
    Cell Significance Index: 1.1900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0241
    Cell Significance Index: 45.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0238
    Cell Significance Index: 4.7800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0197
    Cell Significance Index: 30.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0096
    Cell Significance Index: 0.2400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.0063
    Cell Significance Index: 0.0800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0060
    Cell Significance Index: 0.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0039
    Cell Significance Index: 0.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0027
    Cell Significance Index: 0.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0015
    Cell Significance Index: 2.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0002
    Cell Significance Index: 0.1600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0007
    Cell Significance Index: -0.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0021
    Cell Significance Index: -0.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0041
    Cell Significance Index: -2.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0057
    Cell Significance Index: -4.2100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0062
    Cell Significance Index: -4.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0067
    Cell Significance Index: -5.0400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0071
    Cell Significance Index: -0.4500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0078
    Cell Significance Index: -4.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0079
    Cell Significance Index: -3.5800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0091
    Cell Significance Index: -0.1900
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0096
    Cell Significance Index: -0.1100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0108
    Cell Significance Index: -0.1600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0109
    Cell Significance Index: -0.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0117
    Cell Significance Index: -3.3700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0157
    Cell Significance Index: -0.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0169
    Cell Significance Index: -2.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0184
    Cell Significance Index: -2.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0198
    Cell Significance Index: -2.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0204
    Cell Significance Index: -1.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0205
    Cell Significance Index: -3.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0218
    Cell Significance Index: -4.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0240
    Cell Significance Index: -3.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0291
    Cell Significance Index: -2.0600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0292
    Cell Significance Index: -1.2700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0293
    Cell Significance Index: -0.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0313
    Cell Significance Index: -3.5900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0321
    Cell Significance Index: -0.4600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0329
    Cell Significance Index: -3.8800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0341
    Cell Significance Index: -4.4100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0345
    Cell Significance Index: -1.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0376
    Cell Significance Index: -3.9100
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0376
    Cell Significance Index: -0.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0387
    Cell Significance Index: -2.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0398
    Cell Significance Index: -3.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0408
    Cell Significance Index: -4.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0444
    Cell Significance Index: -2.4900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0479
    Cell Significance Index: -1.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0486
    Cell Significance Index: -2.9900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0493
    Cell Significance Index: -1.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0586
    Cell Significance Index: -3.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0593
    Cell Significance Index: -4.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0689
    Cell Significance Index: -1.7700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0715
    Cell Significance Index: -1.0800
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.0725
    Cell Significance Index: -0.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0729
    Cell Significance Index: -3.4300
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0766
    Cell Significance Index: -0.8200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0868
    Cell Significance Index: -3.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0879
    Cell Significance Index: -3.8900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0966
    Cell Significance Index: -2.0500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0994
    Cell Significance Index: -2.0800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1007
    Cell Significance Index: -2.6900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1011
    Cell Significance Index: -3.3100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1020
    Cell Significance Index: -3.2500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1065
    Cell Significance Index: -3.9100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1075
    Cell Significance Index: -1.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** The GRIN2C subunit is a pentameric receptor composed of two NMDA-type glutamate receptors, each consisting of a single glutamate-binding site, two voltage-gated calcium channels, and a pore-forming alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit. 2. **Expression:** GRIN2C is highly expressed in the cerebral cortex, where it plays a critical role in regulating synaptic plasticity and learning. 3. **Function:** The GRIN2C subunit is involved in regulating excitatory postsynaptic potential, synaptic transmission, and neuronal synaptic plasticity. 4. **Regulation:** The GRIN2C subunit is subject to various regulatory mechanisms, including negative regulation by NMDA receptor antagonists and positive regulation by neuroligins and neurexins. **Pathways and Functions:** 1. **Excitatory Postsynaptic Potential (EPSP):** GRIN2C regulates EPSP by modulating the activity of NMDA receptors, which are critical for synaptic plasticity and learning. 2. **Synaptic Transmission:** GRIN2C plays a crucial role in regulating synaptic transmission by modulating the activity of NMDA receptors and AMPA receptors. 3. **Neuronal Synaptic Plasticity:** GRIN2C is involved in regulating neuronal synaptic plasticity by modulating the activity of NMDA receptors and AMPA receptors. 4. **Calcium-Mediated Signaling:** GRIN2C regulates calcium-mediated signaling by modulating the activity of NMDA receptors and voltage-gated calcium channels. **Clinical Significance:** 1. **Epilepsy:** Alterations in GRIN2C expression have been implicated in the pathogenesis of epilepsy, a neurological disorder characterized by recurrent seizures. 2. **Schizophrenia:** GRIN2C has been linked to schizophrenia, a psychiatric disorder characterized by cognitive impairments and hallucinations. 3. **Alzheimer's Disease:** Dysregulation of GRIN2C has been implicated in Alzheimer's disease, a neurodegenerative disorder characterized by cognitive decline and memory loss. 4. **Neurodevelopmental Disorders:** GRIN2C has been implicated in various neurodevelopmental disorders, including autism spectrum disorder and attention-deficit/hyperactivity disorder. In conclusion, the GRIN2C gene plays a critical role in regulating synaptic plasticity, learning, and memory, and its dysregulation has been implicated in various neurological disorders. Further research is needed to fully understand the mechanisms by which GRIN2C regulates neural function and to develop effective therapeutic strategies for the treatment of GRIN2C-related disorders.

Genular Protein ID: 2299920343

Symbol: NMDE3_HUMAN

Name: Glutamate receptor ionotropic, NMDA 2C

UniProtKB Accession Codes:

Q14957 B2RTT1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 5 ChEMBL 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 25 DrugCentral 1 EMBL 3 EMDB 7 Ensembl 1 ExpressionAtlas 1 GO 28 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 6 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9037519

Title: Cloning of the cDNA for the human NMDA receptor NR2C subunit and its expression in the central nervous system and periphery.

PubMed ID: 9037519

DOI: 10.1016/s0169-328x(96)00146-5

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21300787

Title: Deficiency of sorting nexin 27 (SNX27) leads to growth retardation and elevated levels of N-methyl-D-aspartate receptor 2C (NR2C).

PubMed ID: 21300787

DOI: 10.1128/mcb.01044-10

PubMed ID: 26875626

Title: Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.

PubMed ID: 26875626

DOI: 10.1016/j.neuron.2016.01.016

PubMed ID: 28095420

Title: Molecular mechanism of disease-associated mutations in the pre-M1 helix of NMDA receptors and potential rescue pharmacology.

PubMed ID: 28095420

DOI: 10.1371/journal.pgen.1006536

PubMed ID: 22833210

Title: Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia.

PubMed ID: 22833210

DOI: 10.1038/tp.2011.52

Sequence Information:

  • Length: 1233
  • Mass: 134209
  • Checksum: 7B1F2F7995C0D689
  • Sequence:
    • MGGALGPALL LTSLFGAWAG LGPGQGEQGM TVAVVFSSSG PPQAQFRARL TPQSFLDLPL 
EIQPLTVGVN TTNPSSLLTQ ICGLLGAAHV HGIVFEDNVD TEAVAQILDF ISSQTHVPIL 
SISGGSAVVL TPKEPGSAFL QLGVSLEQQL QVLFKVLEEY DWSAFAVITS LHPGHALFLE 
GVRAVADASH VSWRLLDVVT LELGPGGPRA RTQRLLRQLD APVFVAYCSR EEAEVLFAEA 
AQAGLVGPGH VWLVPNLALG STDAPPATFP VGLISVVTES WRLSLRQKVR DGVAILALGA 
HSYWRQHGTL PAPAGDCRVH PGPVSPAREA FYRHLLNVTW EGRDFSFSPG GYLVQPTMVV 
IALNRHRLWE MVGRWEHGVL YMKYPVWPRY SASLQPVVDS RHLTVATLEE RPFVIVESPD 
PGTGGCVPNT VPCRRQSNHT FSSGDVAPYT KLCCKGFCID ILKKLARVVK FSYDLYLVTN 
GKHGKRVRGV WNGMIGEVYY KRADMAIGSL TINEERSEIV DFSVPFVETG ISVMVARSNG 
TVSPSAFLEP YSPAVWVMMF VMCLTVVAIT VFMFEYFSPV SYNQNLTRGK KSGGPAFTIG 
KSVWLLWALV FNNSVPIENP RGTTSKIMVL VWAFFAVIFL ASYTANLAAF MIQEQYIDTV 
SGLSDKKFQR PQDQYPPFRF GTVPNGSTER NIRSNYRDMH THMVKFNQRS VEDALTSLKM 
GKLDAFIYDA AVLNYMAGKD EGCKLVTIGS GKVFATTGYG IAMQKDSHWK RAIDLALLQF 
LGDGETQKLE TVWLSGICQN EKNEVMSSKL DIDNMAGVFY MLLVAMGLAL LVFAWEHLVY 
WKLRHSVPNS SQLDFLLAFS RGIYSCFSGV QSLASPPRQA SPDLTASSAQ ASVLKMLQAA 
RDMVTTAGVS SSLDRATRTI ENWGGGRRAP PPSPCPTPRS GPSPCLPTPD PPPEPSPTGW 
GPPDGGRAAL VRRAPQPPGR PPTPGPPLSD VSRVSRRPAW EARWPVRTGH CGRHLSASER 
PLSPARCHYS SFPRADRSGR PFLPLFPELE DLPLLGPEQL ARREALLHAA WARGSRPRHA 
SLPSSVAEAF ARPSSLPAGC TGPACARPDG HSACRRLAQA QSMCLPIYRE ACQEGEQAGA 
PAWQHRQHVC LHAHAHLPFC WGAVCPHLPP CASHGSWLSG AWGPLGHRGR TLGLGTGYRD 
SGGLDEISRV ARGTQGFPGP CTWRRISSLE SEV

Genular Protein ID: 3419460486

Symbol: H0Y2V8_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0Y2V8

Database IDs:

ARBA 12 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 4 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 3 Proteomes 2 RefSeq 1 RuleBase 1 SMART 4 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 873
  • Mass: 95967
  • Checksum: F6C7E20496FBC894
  • Sequence:
    • MGGALGPALL LTSLFGAWAG LGPGQGEQGM TVAVVFSSSG PPQAQFRARL TPQSFLDLPL 
EIQPLTVGVN TTNPSSLLTQ ICGLLGAAHV HGIVFEDNVD TEAVAQILDF ISSQTHVPIL 
SISGGSAVVL TPKEPGSAFL QLGVSLEQQL QVLFKVLEEY DWSAFAVITS LHPGHALFLE 
GVRAVADASH VSWRLLDVVT LELGPGGPRA RTQRLLRQLD APVFVAYCSR EEAEVLFAEA 
AQAGLVGPGH VWLVPNLALG STDAPPATFP VGLISVVTES WRLSLRQKVR DGVAILALGA 
HSYWRQHGTL PAPAGDCRVH PGPVSPAREA FYRHLLNVTW EGRDFSFSPG GYLVQPTMVV 
IALNRHRLWE MVGRWEHGVL YMKYPVWPRY SASLQPVVDS RHLTVATLEE RPFVIVESPD 
PGTGGCVPNT VPCRRQSNHT FSSGDVAPYT KLCCKGFCID ILKKLARVVK FSYDLYLVTN 
GKHGKRVRGV WNGMIGEVYY KRADMAIGSL TINEERSEIV DFSVPFVETG ISVMVARSNG 
TVSPSAFLEP YSPAVWVMMF VMCLTVVAIT VFMFEYFSPV SYNQNLTRGK KSGGPAFTIG 
KSVWLLWALV FNNSVPIENP RGTTSKIMVL VWAFFAVIFL ASYTANLAAF MIQEQYIDTV 
SGLSDKKFQR PQDQYPPFRF GTVPNGSTER NIRSNYRDMH THMVKFNQRS VEDALTSLKM 
GKLDAFIYDA AVLNYMAGKD EGCKLVTIGS GKVFATTGYG IAMQKDSHWK RAIDLALLQF 
LGDGETQKLE TVWLSGICQN EKNEVMSSKL DIDNMAGVFY MLLVAMGLAL LVFAWEHLVY 
WKLRHSVPNS SQLDFLLAFS RVGAHPSPHR PKF

Genular Protein ID: 571896093

Symbol: Q8IW23_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8IW23

Database IDs:

ARBA 12 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 2 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 3 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 4 SUPFAM 2

Sequence Information:

  • Length: 907
  • Mass: 99584
  • Checksum: FA999083EAACBA31
  • Sequence:
    • RGQGGDTRSK GTRQPEPPGA SRDPARSCWD PPVDMGGALG PALLLTSLFG AWAGLGPGQG 
EQGMTVAVVF SSSGPPQAQF RARLTPQSFL DLPLEIQPLT VGVNTTNPSS LLTQICGLLG 
AAHVHGIVFE DNVDTEAVAQ ILDFISSQTH VPILSISGGS AVVLTPKEPG SAFLQLGVSL 
EQQLQVLFKV LEEYDWSAFA VITSLHPGHA LFLEGVRAVA DASHVSWRLL DVVTLELGPG 
GPRARTQRLL RQLDAPVFVA YCSREEAEVL FAEAAQAGLV GPGHVWLVPN LALGSTDAPP 
ATFPVGLISV VTESWRLSLR QKVRDGVAIL ALGAHSYWRQ HGTLPAPAGD CRVHPGPVSP 
AREAFYRHLL NVTWEGRDFS FSPGGYLVQP TMVVIALNRH RLWEMVGRWE HGVLYMKYPV 
WPRYSASLQP VVDSRHLTVA TLEERPFVIV ESPDPGTGGC VPNTVPCRRQ SNHTFSSGDV 
APYTKLCCKG FCIDILKKLA RVVKFSYDLY LVTNGKHGKR VRGVWNGMIG EVYYKRADMA 
IGSLTINEER SEIVDFSVPF VETGISVMVA RSNGTVSPSA FLEPYSPAVW VMMFVMCLTV 
VAITVFMFEY FSPVSYNQNL TRGKKSGGPA FTIGKSVWLL WALVFNNSVP IENPRGTTSK 
IMVLVWAFFA VIFLASYTAN LAAFMIQEQY IDTVSGLSDK KFQRPQDQYP PFRFGTVPNG 
STERNIRSNY RDMHTHMVKF NQRSVEDALT SLKMGKLDAF IYDAAVLNYM AGKDEGCKLV 
TIGSGKVFAT TGYGIAMQKD SHWKRAIDLA LLQFLGDGET QKLETVWLSG ICQNEKNEVM 
SSKLDIDNMA GVFYMLLVAM GLALLVFAWE HLVYWKLRHS VPNSSQLDFL LAFSRVGAHP 
SPHRPKF

Genular Protein ID: 2411535821

Symbol: O15398_HUMAN

Name: N/A

UniProtKB Accession Codes:

O15398

Database IDs:

ARBA 14 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 2 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 4 SMR 1 SUPFAM 2

Sequence Information:

  • Length: 1236
  • Mass: 134463
  • Checksum: E57D38B26290A0F1
  • Sequence:
    • MGGALGPALL LTSLFGAWAG LGPGQGEQGM TVAVVFSSSG PPQAQFRARL TPQSFLDLPL 
EIQPLTVGVN TTNPSSLLTQ ICGLLGAAHV HGIVFEDNVD TEAVAQILDF ISSQTHVPIL 
SISGGSAVVL TPKEPGSAFL QLGVSLEQQL QVLFKVLEEY DWSAFAVITS LHPGHALFLE 
GVRAVADASH VSWRLLDVVT LELGPGGPRA RTQRLLRQLD APVFVAYCSR EEAEVLFAEA 
AQAGLVGPGH VWLVPNLALG STDAPPATFP VGLISVVTES WRLSLRQKVR DGVAILALGA 
HSYWRQHGTL PAPAGDCRVH PGPVSPAREA FYRHLLNVTW EGRDFSFSPG GYLVQPTMVV 
IALNRHRLWE MVGRWEHGVL YMKYPVWPRY SASLQPVVDS RHLTVATLEE RPFVIVESPD 
PGTGGCVPNT VPCRRQSNHT FSSGDVAPYT KLCCKGFCID ILKKLARVVK FSYDLYLVTN 
GKHGKRVRGV WNGMIGEVYY KRADMAIGSL TINEERSEIV DFSVPFVETG ISVMVARSNG 
TVSPSAFLEP YSPAVWVMMF VMCLTVVAIT VFMFEYFSPV SYNQNLTRGK KSGGPAFTIG 
KSVWLLWALV FNNSVPIENP RGTTSKIMVL VWAFFAVIFL ASYTANLAAF MIQEQYIDTV 
SGLSDKKFQR PQDQYPPFRF GTVPNGSTER NIRSNYRDMH THMVKFNQRS VEDALTSLKM 
GKLDAFIYDA AVLNYMAGKD EGCKLVTIGS GKVFATTGYG IAMQKDSHWK RAIDLALLQF 
LGDGETQKLE TVWLSGICQN EKNEVMSSKL DIDNMAGVFY MLLVAMGLAL LVFAWEHLVY 
WKLRHSVPNS SQLDFLLAFS RGIYSCFSGV QSLASPPRQA SPDLTASSAQ ASVLKMLQAA 
RDMVTTAGVS SSLDRATRTI ENWGGGRRAP PPSPCPTPRS GPSPCLPTPD PPPEPSPTGW 
GPPDGGRAAL VRRAPQPPGR PPTPGPPLSD VSRVSRRPAW EARWPVRTGH CGRHLSASER 
PLSPARCHYS SFPRADRSGR PFLPLFPEPP ELEDLPLLGP EQLARREALL HAAWARGSRP 
RHASLPSSVA EAFARPSSLP AGCTGPACAR PDGHSACRRL AQAQSMCLPI YREACQEGEQ 
AGAPAWQHRQ HVCLHAHAHL PFCWGAVCPH LPPCASHGSW LSGAWGPLGH RGRTLGLGTG 
YRDSGGLDEI SSVARGTQGF PGPCTWRRIS SLESEV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.