Details for: GRIN2C

Gene ID: 2905

Symbol: GRIN2C

Ensembl ID: ENSG00000161509

Description: glutamate ionotropic receptor NMDA type subunit 2C

Associated with

  • Activation of nmda receptors and postsynaptic events
    (R-HSA-442755)
  • Assembly and cell surface presentation of nmda receptors
    (R-HSA-9609736)
  • Long-term potentiation
    (R-HSA-9620244)
  • Negative regulation of nmda receptor-mediated neuronal transmission
    (R-HSA-9617324)
  • Neurexins and neuroligins
    (R-HSA-6794361)
  • Neuronal system
    (R-HSA-112316)
  • Neurotransmitter receptors and postsynaptic signal transmission
    (R-HSA-112314)
  • Post nmda receptor activation events
    (R-HSA-438064)
  • Protein-protein interactions at synapses
    (R-HSA-6794362)
  • Synaptic adhesion-like molecules
    (R-HSA-8849932)
  • Transmission across chemical synapses
    (R-HSA-112315)
  • Unblocking of nmda receptors, glutamate binding and activation
    (R-HSA-438066)
  • Brain development
    (GO:0007420)
  • Calcium-mediated signaling
    (GO:0019722)
  • Calcium ion transmembrane import into cytosol
    (GO:0097553)
  • Directional locomotion
    (GO:0033058)
  • Endoplasmic reticulum membrane
    (GO:0005789)
  • Excitatory chemical synaptic transmission
    (GO:0098976)
  • Excitatory postsynaptic potential
    (GO:0060079)
  • Glutamate-gated calcium ion channel activity
    (GO:0022849)
  • Glutamate receptor signaling pathway
    (GO:0007215)
  • Glutamatergic synapse
    (GO:0098978)
  • Ionotropic glutamate receptor signaling pathway
    (GO:0035235)
  • Long-term synaptic potentiation
    (GO:0060291)
  • Monoatomic cation transmembrane transport
    (GO:0098655)
  • Negative regulation of protein catabolic process
    (GO:0042177)
  • Neuromuscular process controlling balance
    (GO:0050885)
  • Nmda glutamate receptor activity
    (GO:0004972)
  • Nmda selective glutamate receptor complex
    (GO:0017146)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of excitatory postsynaptic potential
    (GO:2000463)
  • Positive regulation of synaptic transmission, glutamatergic
    (GO:0051968)
  • Postsynaptic density membrane
    (GO:0098839)
  • Postsynaptic membrane
    (GO:0045211)
  • Protein binding
    (GO:0005515)
  • Protein localization to postsynaptic membrane
    (GO:1903539)
  • Regulation of monoatomic cation transmembrane transport
    (GO:1904062)
  • Regulation of neuronal synaptic plasticity
    (GO:0048168)
  • Regulation of synaptic plasticity
    (GO:0048167)
  • Response to wounding
    (GO:0009611)
  • Synaptic transmission, glutamatergic
    (GO:0035249)
  • Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
    (GO:1904315)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.08
    Marker Score: 44435
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.62
    Marker Score: 1068
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1171
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.35
    Marker Score: 1817.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.34
    Marker Score: 2777.5
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.17
    Marker Score: 20766
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4819
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 503
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.05
    Marker Score: 4353
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71832
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48056
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.96
    Marker Score: 399.5
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.96
    Marker Score: 649
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5349
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.85
    Marker Score: 356
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.78
    Marker Score: 678
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.78
    Marker Score: 1590
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.67
    Marker Score: 184
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.65
    Marker Score: 1227
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.6
    Marker Score: 4518.5
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6
    Marker Score: 383
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.59
    Marker Score: 9253
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 455
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.55
    Marker Score: 1266
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.53
    Marker Score: 353
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.49
    Marker Score: 272
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.47
    Marker Score: 1099
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.45
    Marker Score: 213
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.43
    Marker Score: 228
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.42
    Marker Score: 133
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.42
    Marker Score: 185
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.41
    Marker Score: 935
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.39
    Marker Score: 1377
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.38
    Marker Score: 1576.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.36
    Marker Score: 214
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.35
    Marker Score: 123
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.35
    Marker Score: 2059
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.34
    Marker Score: 110
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.31
    Marker Score: 301
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.29
    Marker Score: 357
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.29
    Marker Score: 78
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.29
    Marker Score: 132
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.29
    Marker Score: 164
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.29
    Marker Score: 225
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.28
    Marker Score: 175
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.25
    Marker Score: 77
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.24
    Marker Score: 919
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.23
    Marker Score: 159
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.22
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.22
    Marker Score: 99
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.21
    Marker Score: 83.5
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.21
    Marker Score: 104
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.2
    Marker Score: 71
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.2
    Marker Score: 95
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.18
    Marker Score: 982
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.18
    Marker Score: 47
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.18
    Marker Score: 193
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.17
    Marker Score: 119
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.17
    Marker Score: 96
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.15
    Marker Score: 918
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.14
    Marker Score: 751
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.14
    Marker Score: 84.5
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.14
    Marker Score: 160
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.13
    Marker Score: 132
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.13
    Marker Score: 377
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.13
    Marker Score: 117
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.13
    Marker Score: 209
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.13
    Marker Score: 128
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.13
    Marker Score: 46
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.13
    Marker Score: 839
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.12
    Marker Score: 95
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.12
    Marker Score: 157
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.12
    Marker Score: 208
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.12
    Marker Score: 87
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.12
    Marker Score: 48
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.12
    Marker Score: 146
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.12
    Marker Score: 162
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.12
    Marker Score: 40
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.12
    Marker Score: 79
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.11
    Marker Score: 48
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.11
    Marker Score: 161
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.11
    Marker Score: 226

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Other Information

**Key characteristics:** * NMDA receptors are a family of ionotropic glutamate receptors that are found in the central nervous system. * They are known as NMDA receptors because they exhibit NMDA-like properties in cell-based assays. * NMDA receptors are composed of a single polypeptide chain that is encoded by the GRIN2C gene. * They are transmembrane proteins that are expressed on the surface of neurons and astrocytes. * NMDA receptors are responsible for the excitatory postsynaptic potential (EPSP) that is elicited by glutamate in the central nervous system. **Pathways and functions:** * NMDA receptors are activated by glutamate, a neurotransmitter that is released by presynaptic neurons. * Upon activation, NMDA receptors undergo a conformational change that exposes a glutamate-binding site on the receptor. * This binding of glutamate triggers the opening of NMDA channels, which allow sodium ions to flow into the cell. * This influx of sodium ions depolarizes the cell, which can lead to a variety of cellular responses, including synaptic plasticity, learning and memory. **Clinical significance:** * Mutations in the GRIN2C gene have been linked to a number of neurological disorders, including schizophrenia, autism, and epilepsy. * NMDA receptor antagonists are a class of drugs that are used to treat these disorders. * By blocking NMDA receptors, these drugs can prevent the opening of NMDA channels and reduce synaptic plasticity, learning, and memory. **Additional information:** * The GRIN2C gene is located on chromosome 15q21.1. * NMDA receptors are a highly conserved family of proteins. * They are expressed in a wide variety of cell types, including neurons, astrocytes, and oligodendrocytes.

Genular Protein ID: 2299920343

Symbol: NMDE3_HUMAN

Name: Glutamate receptor ionotropic, NMDA 2C

UniProtKB Accession Codes:

Q14957 B2RTT1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 5 ChEMBL 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 25 DrugCentral 1 EMBL 3 EMDB 7 Ensembl 1 ExpressionAtlas 1 GO 28 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 6 RefSeq 1 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9037519

Title: Cloning of the cDNA for the human NMDA receptor NR2C subunit and its expression in the central nervous system and periphery.

PubMed ID: 9037519

DOI: 10.1016/s0169-328x(96)00146-5

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21300787

Title: Deficiency of sorting nexin 27 (SNX27) leads to growth retardation and elevated levels of N-methyl-D-aspartate receptor 2C (NR2C).

PubMed ID: 21300787

DOI: 10.1128/mcb.01044-10

PubMed ID: 26875626

Title: Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.

PubMed ID: 26875626

DOI: 10.1016/j.neuron.2016.01.016

PubMed ID: 28095420

Title: Molecular mechanism of disease-associated mutations in the pre-M1 helix of NMDA receptors and potential rescue pharmacology.

PubMed ID: 28095420

DOI: 10.1371/journal.pgen.1006536

PubMed ID: 22833210

Title: Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia.

PubMed ID: 22833210

DOI: 10.1038/tp.2011.52

Sequence Information:

  • Length: 1233
  • Mass: 134209
  • Checksum: 7B1F2F7995C0D689
  • Sequence:
    • MGGALGPALL LTSLFGAWAG LGPGQGEQGM TVAVVFSSSG PPQAQFRARL TPQSFLDLPL 
EIQPLTVGVN TTNPSSLLTQ ICGLLGAAHV HGIVFEDNVD TEAVAQILDF ISSQTHVPIL 
SISGGSAVVL TPKEPGSAFL QLGVSLEQQL QVLFKVLEEY DWSAFAVITS LHPGHALFLE 
GVRAVADASH VSWRLLDVVT LELGPGGPRA RTQRLLRQLD APVFVAYCSR EEAEVLFAEA 
AQAGLVGPGH VWLVPNLALG STDAPPATFP VGLISVVTES WRLSLRQKVR DGVAILALGA 
HSYWRQHGTL PAPAGDCRVH PGPVSPAREA FYRHLLNVTW EGRDFSFSPG GYLVQPTMVV 
IALNRHRLWE MVGRWEHGVL YMKYPVWPRY SASLQPVVDS RHLTVATLEE RPFVIVESPD 
PGTGGCVPNT VPCRRQSNHT FSSGDVAPYT KLCCKGFCID ILKKLARVVK FSYDLYLVTN 
GKHGKRVRGV WNGMIGEVYY KRADMAIGSL TINEERSEIV DFSVPFVETG ISVMVARSNG 
TVSPSAFLEP YSPAVWVMMF VMCLTVVAIT VFMFEYFSPV SYNQNLTRGK KSGGPAFTIG 
KSVWLLWALV FNNSVPIENP RGTTSKIMVL VWAFFAVIFL ASYTANLAAF MIQEQYIDTV 
SGLSDKKFQR PQDQYPPFRF GTVPNGSTER NIRSNYRDMH THMVKFNQRS VEDALTSLKM 
GKLDAFIYDA AVLNYMAGKD EGCKLVTIGS GKVFATTGYG IAMQKDSHWK RAIDLALLQF 
LGDGETQKLE TVWLSGICQN EKNEVMSSKL DIDNMAGVFY MLLVAMGLAL LVFAWEHLVY 
WKLRHSVPNS SQLDFLLAFS RGIYSCFSGV QSLASPPRQA SPDLTASSAQ ASVLKMLQAA 
RDMVTTAGVS SSLDRATRTI ENWGGGRRAP PPSPCPTPRS GPSPCLPTPD PPPEPSPTGW 
GPPDGGRAAL VRRAPQPPGR PPTPGPPLSD VSRVSRRPAW EARWPVRTGH CGRHLSASER 
PLSPARCHYS SFPRADRSGR PFLPLFPELE DLPLLGPEQL ARREALLHAA WARGSRPRHA 
SLPSSVAEAF ARPSSLPAGC TGPACARPDG HSACRRLAQA QSMCLPIYRE ACQEGEQAGA 
PAWQHRQHVC LHAHAHLPFC WGAVCPHLPP CASHGSWLSG AWGPLGHRGR TLGLGTGYRD 
SGGLDEISRV ARGTQGFPGP CTWRRISSLE SEV

Genular Protein ID: 3419460486

Symbol: H0Y2V8_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0Y2V8

Database IDs:

ARBA 14 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 4 Ensembl 2 GO 2 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 7 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 4 Proteomes 2 RefSeq 1 RuleBase 1 SMART 4 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 873
  • Mass: 95967
  • Checksum: F6C7E20496FBC894
  • Sequence:
    • MGGALGPALL LTSLFGAWAG LGPGQGEQGM TVAVVFSSSG PPQAQFRARL TPQSFLDLPL 
EIQPLTVGVN TTNPSSLLTQ ICGLLGAAHV HGIVFEDNVD TEAVAQILDF ISSQTHVPIL 
SISGGSAVVL TPKEPGSAFL QLGVSLEQQL QVLFKVLEEY DWSAFAVITS LHPGHALFLE 
GVRAVADASH VSWRLLDVVT LELGPGGPRA RTQRLLRQLD APVFVAYCSR EEAEVLFAEA 
AQAGLVGPGH VWLVPNLALG STDAPPATFP VGLISVVTES WRLSLRQKVR DGVAILALGA 
HSYWRQHGTL PAPAGDCRVH PGPVSPAREA FYRHLLNVTW EGRDFSFSPG GYLVQPTMVV 
IALNRHRLWE MVGRWEHGVL YMKYPVWPRY SASLQPVVDS RHLTVATLEE RPFVIVESPD 
PGTGGCVPNT VPCRRQSNHT FSSGDVAPYT KLCCKGFCID ILKKLARVVK FSYDLYLVTN 
GKHGKRVRGV WNGMIGEVYY KRADMAIGSL TINEERSEIV DFSVPFVETG ISVMVARSNG 
TVSPSAFLEP YSPAVWVMMF VMCLTVVAIT VFMFEYFSPV SYNQNLTRGK KSGGPAFTIG 
KSVWLLWALV FNNSVPIENP RGTTSKIMVL VWAFFAVIFL ASYTANLAAF MIQEQYIDTV 
SGLSDKKFQR PQDQYPPFRF GTVPNGSTER NIRSNYRDMH THMVKFNQRS VEDALTSLKM 
GKLDAFIYDA AVLNYMAGKD EGCKLVTIGS GKVFATTGYG IAMQKDSHWK RAIDLALLQF 
LGDGETQKLE TVWLSGICQN EKNEVMSSKL DIDNMAGVFY MLLVAMGLAL LVFAWEHLVY 
WKLRHSVPNS SQLDFLLAFS RVGAHPSPHR PKF

Genular Protein ID: 2411535821

Symbol: O15398_HUMAN

Name: N/A

UniProtKB Accession Codes:

O15398

Database IDs:

ARBA 16 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 8 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 4 SMR 1 SUPFAM 2

Sequence Information:

  • Length: 1236
  • Mass: 134463
  • Checksum: E57D38B26290A0F1
  • Sequence:
    • MGGALGPALL LTSLFGAWAG LGPGQGEQGM TVAVVFSSSG PPQAQFRARL TPQSFLDLPL 
EIQPLTVGVN TTNPSSLLTQ ICGLLGAAHV HGIVFEDNVD TEAVAQILDF ISSQTHVPIL 
SISGGSAVVL TPKEPGSAFL QLGVSLEQQL QVLFKVLEEY DWSAFAVITS LHPGHALFLE 
GVRAVADASH VSWRLLDVVT LELGPGGPRA RTQRLLRQLD APVFVAYCSR EEAEVLFAEA 
AQAGLVGPGH VWLVPNLALG STDAPPATFP VGLISVVTES WRLSLRQKVR DGVAILALGA 
HSYWRQHGTL PAPAGDCRVH PGPVSPAREA FYRHLLNVTW EGRDFSFSPG GYLVQPTMVV 
IALNRHRLWE MVGRWEHGVL YMKYPVWPRY SASLQPVVDS RHLTVATLEE RPFVIVESPD 
PGTGGCVPNT VPCRRQSNHT FSSGDVAPYT KLCCKGFCID ILKKLARVVK FSYDLYLVTN 
GKHGKRVRGV WNGMIGEVYY KRADMAIGSL TINEERSEIV DFSVPFVETG ISVMVARSNG 
TVSPSAFLEP YSPAVWVMMF VMCLTVVAIT VFMFEYFSPV SYNQNLTRGK KSGGPAFTIG 
KSVWLLWALV FNNSVPIENP RGTTSKIMVL VWAFFAVIFL ASYTANLAAF MIQEQYIDTV 
SGLSDKKFQR PQDQYPPFRF GTVPNGSTER NIRSNYRDMH THMVKFNQRS VEDALTSLKM 
GKLDAFIYDA AVLNYMAGKD EGCKLVTIGS GKVFATTGYG IAMQKDSHWK RAIDLALLQF 
LGDGETQKLE TVWLSGICQN EKNEVMSSKL DIDNMAGVFY MLLVAMGLAL LVFAWEHLVY 
WKLRHSVPNS SQLDFLLAFS RGIYSCFSGV QSLASPPRQA SPDLTASSAQ ASVLKMLQAA 
RDMVTTAGVS SSLDRATRTI ENWGGGRRAP PPSPCPTPRS GPSPCLPTPD PPPEPSPTGW 
GPPDGGRAAL VRRAPQPPGR PPTPGPPLSD VSRVSRRPAW EARWPVRTGH CGRHLSASER 
PLSPARCHYS SFPRADRSGR PFLPLFPEPP ELEDLPLLGP EQLARREALL HAAWARGSRP 
RHASLPSSVA EAFARPSSLP AGCTGPACAR PDGHSACRRL AQAQSMCLPI YREACQEGEQ 
AGAPAWQHRQ HVCLHAHAHL PFCWGAVCPH LPPCASHGSW LSGAWGPLGH RGRTLGLGTG 
YRDSGGLDEI SSVARGTQGF PGPCTWRRIS SLESEV

Genular Protein ID: 571896093

Symbol: Q8IW23_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8IW23

Database IDs:

ARBA 14 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 2 GenomeRNAi 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 4 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 4 SUPFAM 2

Sequence Information:

  • Length: 907
  • Mass: 99584
  • Checksum: FA999083EAACBA31
  • Sequence:
    • RGQGGDTRSK GTRQPEPPGA SRDPARSCWD PPVDMGGALG PALLLTSLFG AWAGLGPGQG 
EQGMTVAVVF SSSGPPQAQF RARLTPQSFL DLPLEIQPLT VGVNTTNPSS LLTQICGLLG 
AAHVHGIVFE DNVDTEAVAQ ILDFISSQTH VPILSISGGS AVVLTPKEPG SAFLQLGVSL 
EQQLQVLFKV LEEYDWSAFA VITSLHPGHA LFLEGVRAVA DASHVSWRLL DVVTLELGPG 
GPRARTQRLL RQLDAPVFVA YCSREEAEVL FAEAAQAGLV GPGHVWLVPN LALGSTDAPP 
ATFPVGLISV VTESWRLSLR QKVRDGVAIL ALGAHSYWRQ HGTLPAPAGD CRVHPGPVSP 
AREAFYRHLL NVTWEGRDFS FSPGGYLVQP TMVVIALNRH RLWEMVGRWE HGVLYMKYPV 
WPRYSASLQP VVDSRHLTVA TLEERPFVIV ESPDPGTGGC VPNTVPCRRQ SNHTFSSGDV 
APYTKLCCKG FCIDILKKLA RVVKFSYDLY LVTNGKHGKR VRGVWNGMIG EVYYKRADMA 
IGSLTINEER SEIVDFSVPF VETGISVMVA RSNGTVSPSA FLEPYSPAVW VMMFVMCLTV 
VAITVFMFEY FSPVSYNQNL TRGKKSGGPA FTIGKSVWLL WALVFNNSVP IENPRGTTSK 
IMVLVWAFFA VIFLASYTAN LAAFMIQEQY IDTVSGLSDK KFQRPQDQYP PFRFGTVPNG 
STERNIRSNY RDMHTHMVKF NQRSVEDALT SLKMGKLDAF IYDAAVLNYM AGKDEGCKLV 
TIGSGKVFAT TGYGIAMQKD SHWKRAIDLA LLQFLGDGET QKLETVWLSG ICQNEKNEVM 
SSKLDIDNMA GVFYMLLVAM GLALLVFAWE HLVYWKLRHS VPNSSQLDFL LAFSRVGAHP 
SPHRPKF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.