Details for: GRIN2D
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 42.6583
Cell Significance Index: -10.8200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.0225
Cell Significance Index: 32.7500 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.7819
Cell Significance Index: 17.1200 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.6402
Cell Significance Index: 39.3500 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 0.6169
Cell Significance Index: 8.0000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.6024
Cell Significance Index: 216.0900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.4870
Cell Significance Index: 29.8600 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.4610
Cell Significance Index: 7.9000 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.4236
Cell Significance Index: 10.1600 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.3461
Cell Significance Index: 5.0300 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.3380
Cell Significance Index: 233.7600 - Cell Name: suprabasal keratinocyte (CL4033013)
Fold Change: 0.3035
Cell Significance Index: 4.8800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2297
Cell Significance Index: 43.7100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2090
Cell Significance Index: 9.4800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2062
Cell Significance Index: 40.9300 - Cell Name: chandelier cell (CL4023083)
Fold Change: 0.2043
Cell Significance Index: 1.6500 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.1320
Cell Significance Index: 8.3200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0905
Cell Significance Index: 18.1600 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0604
Cell Significance Index: 54.5000 - Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.0569
Cell Significance Index: 0.3700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0430
Cell Significance Index: 1.2400 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.0428
Cell Significance Index: 2.5700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0418
Cell Significance Index: 1.4700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0355
Cell Significance Index: 0.7700 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.0262
Cell Significance Index: 2.8600 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: 0.0249
Cell Significance Index: 0.5000 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.0170
Cell Significance Index: 0.3600 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0144
Cell Significance Index: 2.3500 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0089
Cell Significance Index: 0.8900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0026
Cell Significance Index: 4.9800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0023
Cell Significance Index: 0.4200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0010
Cell Significance Index: 1.6100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0006
Cell Significance Index: -1.1500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0040
Cell Significance Index: -5.4400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0095
Cell Significance Index: -4.2100 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0096
Cell Significance Index: -0.2400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0121
Cell Significance Index: -7.7100 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0129
Cell Significance Index: -0.1900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0147
Cell Significance Index: -0.4100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0150
Cell Significance Index: -11.0200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0156
Cell Significance Index: -11.5600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0157
Cell Significance Index: -11.8900 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0175
Cell Significance Index: -9.5700 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0186
Cell Significance Index: -0.3700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0191
Cell Significance Index: -8.6800 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0192
Cell Significance Index: -11.9600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0215
Cell Significance Index: -12.1000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0220
Cell Significance Index: -3.2000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0278
Cell Significance Index: -8.0100 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.0292
Cell Significance Index: -0.6100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0333
Cell Significance Index: -0.8900 - Cell Name: photoreceptor cell (CL0000210)
Fold Change: -0.0384
Cell Significance Index: -0.5400 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0429
Cell Significance Index: -2.9700 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0443
Cell Significance Index: -5.1600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0464
Cell Significance Index: -7.9300 - Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: -0.0567
Cell Significance Index: -0.6300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0582
Cell Significance Index: -12.2500 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0639
Cell Significance Index: -1.3800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0643
Cell Significance Index: -7.9100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0745
Cell Significance Index: -10.2300 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0747
Cell Significance Index: -1.5500 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0868
Cell Significance Index: -11.2200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0888
Cell Significance Index: -6.2800 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -0.0987
Cell Significance Index: -1.1800 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1014
Cell Significance Index: -7.7800 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1029
Cell Significance Index: -10.7100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1040
Cell Significance Index: -10.6200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1063
Cell Significance Index: -12.1800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1128
Cell Significance Index: -6.3300 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.1141
Cell Significance Index: -1.4400 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1166
Cell Significance Index: -7.8400 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.1181
Cell Significance Index: -1.7800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1345
Cell Significance Index: -6.2700 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1451
Cell Significance Index: -6.4200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1516
Cell Significance Index: -11.3000 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1553
Cell Significance Index: -5.8800 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.1692
Cell Significance Index: -3.3300 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1718
Cell Significance Index: -4.4200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1766
Cell Significance Index: -9.2700 - Cell Name: neuron (CL0000540)
Fold Change: -0.1793
Cell Significance Index: -1.7000 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: -0.1827
Cell Significance Index: -1.8400 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1841
Cell Significance Index: -9.5900 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.1853
Cell Significance Index: -4.6200 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1877
Cell Significance Index: -12.1100 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1910
Cell Significance Index: -6.6900 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.1922
Cell Significance Index: -4.8000 - Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.1928
Cell Significance Index: -2.8100 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.2052
Cell Significance Index: -1.3900 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2077
Cell Significance Index: -10.7900 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.2085
Cell Significance Index: -4.0700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.2195
Cell Significance Index: -10.3200 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2246
Cell Significance Index: -4.7800 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2315
Cell Significance Index: -7.5800 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2342
Cell Significance Index: -7.4600 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.2505
Cell Significance Index: -3.1100 - Cell Name: neural cell (CL0002319)
Fold Change: -0.2563
Cell Significance Index: -2.9900 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.2631
Cell Significance Index: -4.0700 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.2808
Cell Significance Index: -5.6000 - Cell Name: perivascular cell (CL4033054)
Fold Change: -0.2881
Cell Significance Index: -1.3300 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.3052
Cell Significance Index: -13.2700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1418369922
Symbol: NMDE4_HUMAN
Name: Glutamate receptor ionotropic, NMDA 2D
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9489750
Title: Functional characterization of human N-methyl-D-aspartate subtype 1A/2D receptors.
PubMed ID: 9489750
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 27616483
Title: GRIN2D recurrent de novo dominant mutation causes a severe epileptic encephalopathy treatable with NMDA receptor channel blockers.
PubMed ID: 27616483
PubMed ID: 26875626
Title: Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.
PubMed ID: 26875626
PubMed ID: 28126851
Title: Functional evaluation of a de novo GRIN2A mutation identified in a patient with profound global developmental delay and refractory epilepsy.
PubMed ID: 28126851
PubMed ID: 28095420
Title: Molecular mechanism of disease-associated mutations in the pre-M1 helix of NMDA receptors and potential rescue pharmacology.
PubMed ID: 28095420
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
PubMed ID: 22833210
Title: Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia.
PubMed ID: 22833210
DOI: 10.1038/tp.2011.52
Sequence Information:
- Length: 1336
- Mass: 143752
- Checksum: 0DB7559056AE4593
- Sequence:
MRGAGGPRGP RGPAKMLLLL ALACASPFPE EAPGPGGAGG PGGGLGGARP LNVALVFSGP AYAAEAARLG PAVAAAVRSP GLDVRPVALV LNGSDPRSLV LQLCDLLSGL RVHGVVFEDD SRAPAVAPIL DFLSAQTSLP IVAVHGGAAL VLTPKEKGST FLQLGSSTEQ QLQVIFEVLE EYDWTSFVAV TTRAPGHRAF LSYIEVLTDG SLVGWEHRGA LTLDPGAGEA VLSAQLRSVS AQIRLLFCAR EEAEPVFRAA EEAGLTGSGY VWFMVGPQLA GGGGSGAPGE PPLLPGGAPL PAGLFAVRSA GWRDDLARRV AAGVAVVARG AQALLRDYGF LPELGHDCRA QNRTHRGESL HRYFMNITWD NRDYSFNEDG FLVNPSLVVI SLTRDRTWEV VGSWEQQTLR LKYPLWSRYG RFLQPVDDTQ HLTVATLEER PFVIVEPADP ISGTCIRDSV PCRSQLNRTH SPPPDAPRPE KRCCKGFCID ILKRLAHTIG FSYDLYLVTN GKHGKKIDGV WNGMIGEVFY QRADMAIGSL TINEERSEIV DFSVPFVETG ISVMVARSNG TVSPSAFLEP YSPAVWVMMF VMCLTVVAVT VFIFEYLSPV GYNRSLATGK RPGGSTFTIG KSIWLLWALV FNNSVPVENP RGTTSKIMVL VWAFFAVIFL ASYTANLAAF MIQEEYVDTV SGLSDRKFQR PQEQYPPLKF GTVPNGSTEK NIRSNYPDMH SYMVRYNQPR VEEALTQLKA GKLDAFIYDA AVLNYMARKD EGCKLVTIGS GKVFATTGYG IALHKGSRWK RPIDLALLQF LGDDEIEMLE RLWLSGICHN DKIEVMSSKL DIDNMAGVFY MLLVAMGLSL LVFAWEHLVY WRLRHCLGPT HRMDFLLAFS RGMYSCCSAE AAPPPAKPPP PPQPLPSPAY PAPRPAPGPA PFVPRERASV DRWRRTKGAG PPGGAGLADG FHRYYGPIEP QGLGLGLGEA RAAPRGAAGR PLSPPAAQPP QKPPPSYFAI VRDKEPAEPP AGAFPGFPSP PAPPAAAATA VGPPLCRLAF EDESPPAPAR WPRSDPESQP LLGPGAGGAG GTGGAGGGAP AAPPPCRAAP PPCPYLDLEP SPSDSEDSES LGGASLGGLE PWWFADFPYP YAERLGPPPG RYWSVDKLGG WRAGSWDYLP PRSGPAAWHC RHCASLELLP PPRHLSCSHD GLDGGWWAPP PPPWAAGPLP RRRARCGCPR SHPHRPRASH RTPAAAAPHH HRHRRAAGGW DLPPPAPTSR SLEDLSSCPR AAPARRLTGP SRHARRCPHA AHWGPPLPTA SHRRHRGGDL GTRRGSAHFS SLESEV
Genular Protein ID: 2602389934
Symbol: Q59G17_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 610
- Mass: 65087
- Checksum: 669643F00A33D23A
- Sequence:
SLGPCPTAPR RRTSAATIPT CTATWKLDAF IYDAAVLNYM ARKDEGCKLV TIGSGKVFAT TGYGIALHKG SRWKRPIDLA LLQFLGDDEI EMLERLWLSG ICHNDKIEVM SSKLDIDNMA GVFYMLLVAM GLSLLVFAWE HLVYWRLRHC LGPTHRMDFL LAFSRGMYSC CSAEAAPPPA KPPPPPQPLP SPAYPAPRPA PGPAPFVPRE RASVDRWRRT KGAGPPGGAG LADGFHRYYG PIEPQGLGLG LGEARAAPRG AAGRPLSPPA AQPPQKPPPS YFAIVRDKEP AEPPAGAFPG FPSPPAPPAA AATAVGPPLC RLAFEDESPP APARWPRSDP ESQPLLGPGA GGAGGTGGAG GGAPAAPPPC RAAPPPCPYL DLEPSPSDSE DSESLGGASL GGLEPWWFAD FPYPYAERLG PPPGRYWSVD KLGGWRAGSW DYLPPRSGPA AWHCRHCASL ELLPPPRHLS CSHDGLDGGW WAPPPPPWAA GPLPRRRARC GCPRSHPHRP RASHRTPAAA APHHHRHRRA AGGWDLPPPA PTSRSLEDLS SCPRAAPARR LTGPSRHARR CPHAAHWGPP LPTASHRRHR GGDLGTRRGS AHFSSLESEV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.