Details for: GRIN2D

Gene ID: 2906

Symbol: GRIN2D

Ensembl ID: ENSG00000105464

Description: glutamate ionotropic receptor NMDA type subunit 2D

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: interneuron (CL0000099)
    Fold Change: 3.04
    Marker Score: 1388
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.48
    Marker Score: 7130
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.01
    Marker Score: 902
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.84
    Marker Score: 7610
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.77
    Marker Score: 67060
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.72
    Marker Score: 63559.5
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.68
    Marker Score: 12847
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.63
    Marker Score: 3082
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1170
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.5
    Marker Score: 15441
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169071
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.46
    Marker Score: 1459
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.45
    Marker Score: 21636
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.37
    Marker Score: 27196
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.34
    Marker Score: 6202
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.27
    Marker Score: 2583
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 854
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 487
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1
    Marker Score: 4265
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 503
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 796
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71821
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48045
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5338
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.92
    Marker Score: 14362
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.87
    Marker Score: 4590
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.82
    Marker Score: 495
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.82
    Marker Score: 264
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.78
    Marker Score: 3263
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 304
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 501
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.73
    Marker Score: 1520
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 462
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7
    Marker Score: 269
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.59
    Marker Score: 5553
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.58
    Marker Score: 275
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.52
    Marker Score: 2767
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.49
    Marker Score: 2012
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.49
    Marker Score: 140
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.48
    Marker Score: 2878
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.44
    Marker Score: 248
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.43
    Marker Score: 136
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.43
    Marker Score: 528
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.42
    Marker Score: 3202
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.42
    Marker Score: 1768
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.41
    Marker Score: 13969
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.38
    Marker Score: 883
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.37
    Marker Score: 117
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.37
    Marker Score: 162
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.35
    Marker Score: 542
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.34
    Marker Score: 378
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.34
    Marker Score: 86
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.32
    Marker Score: 241
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.32
    Marker Score: 200
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.31
    Marker Score: 81
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.3
    Marker Score: 94
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.28
    Marker Score: 338
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.27
    Marker Score: 71
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.26
    Marker Score: 153
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.26
    Marker Score: 104
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.25
    Marker Score: 431
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.24
    Marker Score: 72
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.23
    Marker Score: 14334
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.23
    Marker Score: 81
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.23
    Marker Score: 199
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.23
    Marker Score: 135
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.22
    Marker Score: 81
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.22
    Marker Score: 758
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.22
    Marker Score: 92
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.21
    Marker Score: 86
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.2
    Marker Score: 177
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.2
    Marker Score: 609
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.19
    Marker Score: 127
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.19
    Marker Score: 192
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.19
    Marker Score: 52
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.19
    Marker Score: 70
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.18
    Marker Score: 176
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.18
    Marker Score: 178
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.17
    Marker Score: 63
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.17
    Marker Score: 167
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.17
    Marker Score: 98
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.17
    Marker Score: 61
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.16
    Marker Score: 384

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Other Information

**Key characteristics:** * NMDE4 is a transmembrane protein with a molecular weight of approximately 140 kDa. * It is a member of the NMDA receptor family of ionotropic glutamate receptors. * NMDE4 is expressed in a variety of brain regions, including the cerebral cortex, hippocampus, and cerebellum. * It is a key regulator of synaptic plasticity and learning and memory. **Pathways and functions:** * NMDE4 is a key component of the NMDA receptor signaling pathway. * It is activated by glutamate, a neurotransmitter released by presynaptic neurons. * Activation of NMDE4 triggers a cascade of intracellular events that lead to the phosphorylation of the transcription factor CREB1. * Phosphorylated CREB1 translocates to the nucleus and activates the expression of genes involved in synaptic plasticity. * NMDE4 also plays a role in the regulation of long-term potentiation, a process that allows for the strengthening of synaptic connections over time. **Clinical significance:** * Mutations in the GRIN2D gene have been linked to a number of neurological disorders, including schizophrenia, autism, and epilepsy. * NMDE4 is a potential therapeutic target for these disorders. * The development of NMDA receptor antagonists, such as memantine, has shown promise in treating these disorders.

Genular Protein ID: 1418369922

Symbol: NMDE4_HUMAN

Name: Glutamate receptor ionotropic, NMDA 2D

UniProtKB Accession Codes:

O15399

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 DrugBank 26 DrugCentral 1 EMBL 3 EMDB 6 EPD 1 Ensembl 1 GO 31 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 6 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 8 RefSeq 2 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9489750

Title: Functional characterization of human N-methyl-D-aspartate subtype 1A/2D receptors.

PubMed ID: 9489750

DOI: 10.1046/j.1471-4159.1998.70031269.x

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 27616483

Title: GRIN2D recurrent de novo dominant mutation causes a severe epileptic encephalopathy treatable with NMDA receptor channel blockers.

PubMed ID: 27616483

DOI: 10.1016/j.ajhg.2016.07.013

PubMed ID: 26875626

Title: Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.

PubMed ID: 26875626

DOI: 10.1016/j.neuron.2016.01.016

PubMed ID: 28126851

Title: Functional evaluation of a de novo GRIN2A mutation identified in a patient with profound global developmental delay and refractory epilepsy.

PubMed ID: 28126851

DOI: 10.1124/mol.116.106781

PubMed ID: 28095420

Title: Molecular mechanism of disease-associated mutations in the pre-M1 helix of NMDA receptors and potential rescue pharmacology.

PubMed ID: 28095420

DOI: 10.1371/journal.pgen.1006536

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 22833210

Title: Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia.

PubMed ID: 22833210

DOI: 10.1038/tp.2011.52

Sequence Information:

  • Length: 1336
  • Mass: 143752
  • Checksum: 0DB7559056AE4593
  • Sequence:
    • MRGAGGPRGP RGPAKMLLLL ALACASPFPE EAPGPGGAGG PGGGLGGARP LNVALVFSGP 
AYAAEAARLG PAVAAAVRSP GLDVRPVALV LNGSDPRSLV LQLCDLLSGL RVHGVVFEDD 
SRAPAVAPIL DFLSAQTSLP IVAVHGGAAL VLTPKEKGST FLQLGSSTEQ QLQVIFEVLE 
EYDWTSFVAV TTRAPGHRAF LSYIEVLTDG SLVGWEHRGA LTLDPGAGEA VLSAQLRSVS 
AQIRLLFCAR EEAEPVFRAA EEAGLTGSGY VWFMVGPQLA GGGGSGAPGE PPLLPGGAPL 
PAGLFAVRSA GWRDDLARRV AAGVAVVARG AQALLRDYGF LPELGHDCRA QNRTHRGESL 
HRYFMNITWD NRDYSFNEDG FLVNPSLVVI SLTRDRTWEV VGSWEQQTLR LKYPLWSRYG 
RFLQPVDDTQ HLTVATLEER PFVIVEPADP ISGTCIRDSV PCRSQLNRTH SPPPDAPRPE 
KRCCKGFCID ILKRLAHTIG FSYDLYLVTN GKHGKKIDGV WNGMIGEVFY QRADMAIGSL 
TINEERSEIV DFSVPFVETG ISVMVARSNG TVSPSAFLEP YSPAVWVMMF VMCLTVVAVT 
VFIFEYLSPV GYNRSLATGK RPGGSTFTIG KSIWLLWALV FNNSVPVENP RGTTSKIMVL 
VWAFFAVIFL ASYTANLAAF MIQEEYVDTV SGLSDRKFQR PQEQYPPLKF GTVPNGSTEK 
NIRSNYPDMH SYMVRYNQPR VEEALTQLKA GKLDAFIYDA AVLNYMARKD EGCKLVTIGS 
GKVFATTGYG IALHKGSRWK RPIDLALLQF LGDDEIEMLE RLWLSGICHN DKIEVMSSKL 
DIDNMAGVFY MLLVAMGLSL LVFAWEHLVY WRLRHCLGPT HRMDFLLAFS RGMYSCCSAE 
AAPPPAKPPP PPQPLPSPAY PAPRPAPGPA PFVPRERASV DRWRRTKGAG PPGGAGLADG 
FHRYYGPIEP QGLGLGLGEA RAAPRGAAGR PLSPPAAQPP QKPPPSYFAI VRDKEPAEPP 
AGAFPGFPSP PAPPAAAATA VGPPLCRLAF EDESPPAPAR WPRSDPESQP LLGPGAGGAG 
GTGGAGGGAP AAPPPCRAAP PPCPYLDLEP SPSDSEDSES LGGASLGGLE PWWFADFPYP 
YAERLGPPPG RYWSVDKLGG WRAGSWDYLP PRSGPAAWHC RHCASLELLP PPRHLSCSHD 
GLDGGWWAPP PPPWAAGPLP RRRARCGCPR SHPHRPRASH RTPAAAAPHH HRHRRAAGGW 
DLPPPAPTSR SLEDLSSCPR AAPARRLTGP SRHARRCPHA AHWGPPLPTA SHRRHRGGDL 
GTRRGSAHFS SLESEV

Genular Protein ID: 2602389934

Symbol: Q59G17_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59G17

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 PharmGKB 1 RefSeq 1 SAM 2 SUPFAM 1

Sequence Information:

  • Length: 610
  • Mass: 65087
  • Checksum: 669643F00A33D23A
  • Sequence:
    • SLGPCPTAPR RRTSAATIPT CTATWKLDAF IYDAAVLNYM ARKDEGCKLV TIGSGKVFAT 
TGYGIALHKG SRWKRPIDLA LLQFLGDDEI EMLERLWLSG ICHNDKIEVM SSKLDIDNMA 
GVFYMLLVAM GLSLLVFAWE HLVYWRLRHC LGPTHRMDFL LAFSRGMYSC CSAEAAPPPA 
KPPPPPQPLP SPAYPAPRPA PGPAPFVPRE RASVDRWRRT KGAGPPGGAG LADGFHRYYG 
PIEPQGLGLG LGEARAAPRG AAGRPLSPPA AQPPQKPPPS YFAIVRDKEP AEPPAGAFPG 
FPSPPAPPAA AATAVGPPLC RLAFEDESPP APARWPRSDP ESQPLLGPGA GGAGGTGGAG 
GGAPAAPPPC RAAPPPCPYL DLEPSPSDSE DSESLGGASL GGLEPWWFAD FPYPYAERLG 
PPPGRYWSVD KLGGWRAGSW DYLPPRSGPA AWHCRHCASL ELLPPPRHLS CSHDGLDGGW 
WAPPPPPWAA GPLPRRRARC GCPRSHPHRP RASHRTPAAA APHHHRHRRA AGGWDLPPPA 
PTSRSLEDLS SCPRAAPARR LTGPSRHARR CPHAAHWGPP LPTASHRRHR GGDLGTRRGS 
AHFSSLESEV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.