Details for: ZBTB44

Gene ID: 29068

Symbol: ZBTB44

Ensembl ID: ENSG00000196323

Description: zinc finger and BTB domain containing 44

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 269.0536
    Cell Significance Index: -41.8500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 151.6696
    Cell Significance Index: -38.4700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 97.8347
    Cell Significance Index: -46.1900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 95.2476
    Cell Significance Index: -38.7000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 85.7334
    Cell Significance Index: -44.1000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 68.8651
    Cell Significance Index: -46.2100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 40.6287
    Cell Significance Index: -38.7900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.4652
    Cell Significance Index: -44.9600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.4324
    Cell Significance Index: -44.0200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.7171
    Cell Significance Index: -39.0600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.6015
    Cell Significance Index: -45.7800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.4118
    Cell Significance Index: -18.4100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.7214
    Cell Significance Index: 37.1300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.4726
    Cell Significance Index: 288.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.0806
    Cell Significance Index: 116.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6551
    Cell Significance Index: 332.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.5131
    Cell Significance Index: 1366.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4676
    Cell Significance Index: 180.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.4468
    Cell Significance Index: 260.8100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.4173
    Cell Significance Index: 36.4300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2574
    Cell Significance Index: 75.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0904
    Cell Significance Index: 216.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9998
    Cell Significance Index: 358.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9986
    Cell Significance Index: 27.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8745
    Cell Significance Index: 24.4400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8459
    Cell Significance Index: 58.5000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6723
    Cell Significance Index: 51.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5973
    Cell Significance Index: 82.0200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5854
    Cell Significance Index: 30.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5774
    Cell Significance Index: 315.3400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5748
    Cell Significance Index: 37.0800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5701
    Cell Significance Index: 394.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5229
    Cell Significance Index: 231.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4435
    Cell Significance Index: 72.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4222
    Cell Significance Index: 80.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4165
    Cell Significance Index: 19.4200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3998
    Cell Significance Index: 25.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3795
    Cell Significance Index: 17.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3277
    Cell Significance Index: 20.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3165
    Cell Significance Index: 14.0000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3023
    Cell Significance Index: 8.7100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2959
    Cell Significance Index: 19.9000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2931
    Cell Significance Index: 6.3500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2906
    Cell Significance Index: 20.5500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2800
    Cell Significance Index: 33.0200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2517
    Cell Significance Index: 9.5300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1788
    Cell Significance Index: 4.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1017
    Cell Significance Index: 4.7800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0862
    Cell Significance Index: 2.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0840
    Cell Significance Index: 129.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0767
    Cell Significance Index: 141.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0683
    Cell Significance Index: 8.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0657
    Cell Significance Index: 2.3100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0571
    Cell Significance Index: 77.6800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0567
    Cell Significance Index: 9.6800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0536
    Cell Significance Index: 5.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0525
    Cell Significance Index: 98.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0403
    Cell Significance Index: 18.2900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0403
    Cell Significance Index: 0.6900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0329
    Cell Significance Index: 24.1300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0208
    Cell Significance Index: 13.1800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0046
    Cell Significance Index: 0.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0045
    Cell Significance Index: -0.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0161
    Cell Significance Index: -10.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0277
    Cell Significance Index: -20.5200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0277
    Cell Significance Index: -0.7400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0370
    Cell Significance Index: -27.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0534
    Cell Significance Index: -30.1200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0925
    Cell Significance Index: -1.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0936
    Cell Significance Index: -9.5600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1024
    Cell Significance Index: -13.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1263
    Cell Significance Index: -26.6000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1271
    Cell Significance Index: -9.4700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1282
    Cell Significance Index: -3.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1305
    Cell Significance Index: -37.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1587
    Cell Significance Index: -23.0700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1643
    Cell Significance Index: -4.0100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1876
    Cell Significance Index: -20.4000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1879
    Cell Significance Index: -4.9400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2220
    Cell Significance Index: -5.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2454
    Cell Significance Index: -28.1200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2705
    Cell Significance Index: -9.4000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2821
    Cell Significance Index: -14.8100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2903
    Cell Significance Index: -8.2900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3075
    Cell Significance Index: -4.5400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3197
    Cell Significance Index: -5.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3439
    Cell Significance Index: -11.0200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3594
    Cell Significance Index: -41.0300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3749
    Cell Significance Index: -8.9900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3755
    Cell Significance Index: -19.5600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3948
    Cell Significance Index: -41.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3994
    Cell Significance Index: -31.6300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4888
    Cell Significance Index: -10.1400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6040
    Cell Significance Index: -15.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6453
    Cell Significance Index: -39.5600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.7335
    Cell Significance Index: -4.9700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7548
    Cell Significance Index: -24.7100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7617
    Cell Significance Index: -9.0800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7731
    Cell Significance Index: -16.5300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.8287
    Cell Significance Index: -11.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc Finger and BTB Domain Structure:** ZBTB44 possesses a characteristic zinc finger and BTB domain, which are essential for its DNA-binding and transcriptional regulatory functions. 2. **Tissue-Specific Expression:** ZBTB44 is expressed in a variety of cell types, including epithelial cells of the kidney loop of Henle, neurons, and skeletal muscle satellite stem cells, suggesting its involvement in tissue-specific processes. 3. **Metal Ion Binding:** The presence of metal ion-binding sites in ZBTB44 suggests its potential role in regulating metal ion homeostasis and influencing gene expression. **Pathways and Functions:** 1. **DNA Binding and Transcriptional Regulation:** ZBTB44's zinc finger and BTB domains enable it to bind to specific DNA sequences, regulating the expression of target genes involved in tissue development and maintenance. 2. **Metal Ion Homeostasis:** ZBTB44's metal ion-binding capabilities may contribute to its role in regulating metal ion homeostasis, which is essential for maintaining cellular function and preventing oxidative stress. 3. **Cell Signaling and Proliferation:** ZBTB44 may also participate in cell signaling pathways, influencing cell proliferation, differentiation, and survival in various tissues. **Clinical Significance:** 1. **Kidney Disease:** ZBTB44's expression in kidney epithelial cells and its potential role in regulating metal ion homeostasis make it an interesting candidate for studying kidney disease, particularly in the context of metal ion toxicity. 2. **Neurological Disorders:** ZBTB44's expression in neurons and its involvement in cell signaling pathways suggest its potential role in neurological disorders, such as neurodegenerative diseases and developmental brain disorders. 3. **Muscle Disorders:** ZBTB44's expression in skeletal muscle satellite stem cells and its potential role in regulating cell proliferation and differentiation make it an interesting candidate for studying muscle disorders, such as muscular dystrophy. In conclusion, ZBTB44 is a multifunctional protein with a complex expression pattern and potential involvement in various tissue-specific processes. Further research is necessary to elucidate the molecular mechanisms underlying its functions and to explore its clinical significance in different diseases.

Genular Protein ID: 3599665358

Symbol: ZBT44_HUMAN

Name: Zinc finger and BTB domain-containing protein 44

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 570
  • Mass: 63848
  • Checksum: 9C0E64DB7D0343DF
  • Sequence:
  • MGVKTFTHSS SSHSQEMLGK LNMLRNDGHF CDITIRVQDK IFRAHKVVLA ACSDFFRTKL 
    VGQAEDENKN VLDLHHVTVT GFIPLLEYAY TATLSINTEN IIDVLAAASY MQMFSVASTC 
    SEFMKSSILW NTPNSQPEKG LDAGQENNSN CNFTSRDGSI SPVSSECSVV ERTIPVCRES 
    RRKRKSYIVM SPESPVKCGT QTSSPQVLNS SASYSENRNQ PVDSSLAFPW TFPFGIDRRI 
    QPEKVKQAEN TRTLELPGPS ETGRRMADYV TCESTKTTLP LGTEEDVRVK VERLSDEEVH 
    EEVSQPVSAS QSSLSDQQTV PGSEQVQEDL LISPQSSSIG SVDEGVSEGL PTLQSTSSTN 
    APPDDDDRLE NVQYPYQLYI APSTSSTERP SPNGPDRPFQ CPTCGVRFTR IQNLKQHMLI 
    HSGIKPFQCD RCGKKFTRAY SLKMHRLKHE GKRCFRCQIC SATFTSFGEY KHHMRVSRHI 
    IRKPRIYECK TCGAMLTNSG NLIVHLRSLN HEASELANYF QSSDFLVPDY LNQEQEETLV 
    QYDLGEHGFE SNSSVQMPVI SQYHSKGKEP

Genular Protein ID: 2054497415

Symbol: H7BY22_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 570
  • Mass: 63882
  • Checksum: 9C0E6C71DF0BE97D
  • Sequence:
  • MGVKTFTHSS SSHSQEMLGK LNMLRNDGHF CDITIRVQDK IFRAHKVVLA ACSDFFRTKL 
    VGQAEDENKN VLDLHHVTVT GFIPLLEYAY TATLSINTEN IIDVLAAASY MQMFSVASTC 
    SEFMKSSILW NTPNSQPEKG LDAGQENNSN CNFTSRDGSI SPVSSECSVV ERTIPVCRES 
    RRKRKSYIVM SPESPVKCGT QTSSPQVLNS SASYSENRNQ PVDSSLAFPW TFPFGIDRRI 
    QPEKVKQAEN TRTLELPGPS ETGRRMADYV TCESTKTTLP LGTEEDVRVK VERLSDEEVH 
    EEVSQPVSAS QSSLSDQQTV PGSEQVQEDL LISPQSSSIG SVDEGVSEGL PTLQSTSSTN 
    APPDDDDRLE NVQYPYQLYI APSTSSTERP SPNGPDRPFQ CPTCGVRFTR IQNLKQHMLI 
    HSGIKPFQCD RCGKKFTRAY SLKMHRLKHE GKRCFRCQIC SATFTSFGEY KHHMRVSRHI 
    IRKPRIYECK TCGAMFTNSG NLIVHLRSLN HEASELANYF QSSDFLVPDY LNQEQEETLV 
    QYDLGEHGFE SNSSVQMPVI SQYHSKGKEP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.