Details for: STXBP6

Gene ID: 29091

Symbol: STXBP6

Ensembl ID: ENSG00000168952

Description: syntaxin binding protein 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 355.2664
    Cell Significance Index: -55.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 218.1015
    Cell Significance Index: -55.3200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 116.4533
    Cell Significance Index: -47.3100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 85.8765
    Cell Significance Index: -57.6300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 49.5840
    Cell Significance Index: -47.3400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 44.8272
    Cell Significance Index: -55.2700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 21.8414
    Cell Significance Index: -58.5100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.3824
    Cell Significance Index: -27.1000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 3.8456
    Cell Significance Index: 258.5800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.6653
    Cell Significance Index: 253.4800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.9252
    Cell Significance Index: 19.8200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.6026
    Cell Significance Index: 199.7200
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.9558
    Cell Significance Index: 12.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.9418
    Cell Significance Index: 1060.4600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.8578
    Cell Significance Index: 111.5300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.5973
    Cell Significance Index: 186.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4529
    Cell Significance Index: 288.3400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.4351
    Cell Significance Index: 74.7500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0552
    Cell Significance Index: 378.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.0441
    Cell Significance Index: 22.6200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9984
    Cell Significance Index: 690.5300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9901
    Cell Significance Index: 26.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7696
    Cell Significance Index: 34.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6911
    Cell Significance Index: 138.6300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6076
    Cell Significance Index: 8.2900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5600
    Cell Significance Index: 10.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4607
    Cell Significance Index: 78.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4064
    Cell Significance Index: 15.3900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.3818
    Cell Significance Index: 8.1600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2366
    Cell Significance Index: 11.9600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1506
    Cell Significance Index: 0.9100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1399
    Cell Significance Index: 4.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1301
    Cell Significance Index: 24.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1156
    Cell Significance Index: 5.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0817
    Cell Significance Index: 36.1200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0734
    Cell Significance Index: 1.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0538
    Cell Significance Index: 5.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0497
    Cell Significance Index: 93.5300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0270
    Cell Significance Index: 49.8300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0120
    Cell Significance Index: 18.4900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0177
    Cell Significance Index: -0.4100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0259
    Cell Significance Index: -23.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0435
    Cell Significance Index: -19.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0443
    Cell Significance Index: -60.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0657
    Cell Significance Index: -48.6900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0735
    Cell Significance Index: -46.7000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0736
    Cell Significance Index: -53.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0775
    Cell Significance Index: -1.6500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0797
    Cell Significance Index: -60.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1014
    Cell Significance Index: -57.1600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1016
    Cell Significance Index: -63.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1644
    Cell Significance Index: -47.3100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1840
    Cell Significance Index: -2.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1986
    Cell Significance Index: -35.8100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2336
    Cell Significance Index: -16.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2921
    Cell Significance Index: -37.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3022
    Cell Significance Index: -30.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3038
    Cell Significance Index: -64.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3195
    Cell Significance Index: -36.6000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3206
    Cell Significance Index: -8.9600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.3217
    Cell Significance Index: -44.1800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3302
    Cell Significance Index: -6.5300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3414
    Cell Significance Index: -5.0400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.3493
    Cell Significance Index: -42.9500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3611
    Cell Significance Index: -42.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3632
    Cell Significance Index: -10.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3888
    Cell Significance Index: -56.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4040
    Cell Significance Index: -52.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4102
    Cell Significance Index: -42.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5926
    Cell Significance Index: -18.9800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.6804
    Cell Significance Index: -9.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6833
    Cell Significance Index: -54.1200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.7724
    Cell Significance Index: -57.5700
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.8404
    Cell Significance Index: -4.0200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.8566
    Cell Significance Index: -12.3200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.8773
    Cell Significance Index: -56.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.9197
    Cell Significance Index: -51.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9354
    Cell Significance Index: -57.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.9443
    Cell Significance Index: -44.0300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.9447
    Cell Significance Index: -20.0500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.9514
    Cell Significance Index: -12.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.9547
    Cell Significance Index: -58.6800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9750
    Cell Significance Index: -61.4500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.9997
    Cell Significance Index: -24.9900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -1.0080
    Cell Significance Index: -43.8300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.0171
    Cell Significance Index: -53.4000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.0224
    Cell Significance Index: -53.1100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.0253
    Cell Significance Index: -35.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.1094
    Cell Significance Index: -52.1400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -1.1276
    Cell Significance Index: -28.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.1333
    Cell Significance Index: -29.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.2258
    Cell Significance Index: -31.5100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.2429
    Cell Significance Index: -43.5400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.2568
    Cell Significance Index: -31.3500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -1.2602
    Cell Significance Index: -18.9900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.2688
    Cell Significance Index: -26.3200
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -1.2817
    Cell Significance Index: -12.9300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.2841
    Cell Significance Index: -26.8000
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -1.2948
    Cell Significance Index: -12.3200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -1.3015
    Cell Significance Index: -31.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** STXBP6 is a small protein (approximately 54 kDa) that belongs to the syntaxin-binding protein family. It is characterized by its ability to bind syntaxin, a key component of the SNARE complex, and regulate its assembly and function. STXBP6 is also involved in the negative regulation of exocytosis, a process critical for maintaining cellular homeostasis and preventing excessive release of neurotransmitters or other cellular contents. Its expression is widespread, with significant presence in various cell types, including neurons, endothelial cells, and fibroblasts. **Pathways and Functions:** STXBP6 plays a critical role in several cellular pathways, including: 1. **Adherens Junction and Cell-Cell Adhesion:** STXBP6 interacts with cadherins, a class of cell adhesion molecules, to regulate cell-cell adhesion and maintain tissue integrity. 2. **Negative Regulation of Exocytosis:** STXBP6 inhibits the assembly of the SNARE complex, thereby regulating the release of neurotransmitters and other cellular contents. 3. **Snare Complex Assembly:** STXBP6 facilitates the assembly of the SNARE complex, a critical component of membrane fusion required for neurotransmitter release and exocytosis. 4. **Cytoplasm and Membrane:** STXBP6 is localized to the cytoplasm and membrane, where it interacts with syntaxin and other SNARE proteins to regulate their function. **Clinical Significance:** Dysregulation of STXBP6 has been implicated in various human diseases, including: 1. **Neurodegenerative Disorders:** Mutations in STXBP6 have been associated with neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). 2. **Cardiac Disease:** STXBP6 dysregulation has been linked to cardiac disease, including heart failure and arrhythmias. 3. **Cancer:** STXBP6 has been implicated in cancer, including ovarian and breast cancer, where its dysregulation can contribute to tumorigenesis and metastasis. 4. **Neurodevelopmental Disorders:** STXBP6 dysregulation has been associated with neurodevelopmental disorders, including autism spectrum disorder (ASD) and schizophrenia. In conclusion, STXBP6 is a critical gene that plays a pivotal role in various cellular processes, including cell-cell adhesion, negative regulation of exocytosis, and snare complex assembly. Its dysregulation has been implicated in various human diseases, highlighting the importance of further research into its function and clinical significance.

Genular Protein ID: 3253204239

Symbol: STXB6_HUMAN

Name: Syntaxin-binding protein 6

UniProtKB Accession Codes:

Q8NFX7 D3DS78 Q8N3H1 Q8N8D5 Q96GF3 Q9P008

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 6 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 15 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12145319

Title: Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly.

PubMed ID: 12145319

DOI: 10.1074/jbc.m204929200

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 210
  • Mass: 23554
  • Checksum: 7C046A90D4C4B2D8
  • Sequence:
    • MSAKSAISKE IFAPLDERML GAVQVKRRTK KKIPFLATGG QGEYLTYICL SVTNKKPTQA 
SITKVKQFEG STSFVRRSQW MLEQLRQVNG IDPNGDSAEF DLLFENAFDQ WVASTASEKC 
TFFQILHHTC QRYLTDRKPE FINCQSKIMG GNSILHSAAD SVTSAVQKAS QALNERGERL 
GRAEEKTEDL KNSAQQFAET AHKLAMKHKC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.