Details for: UHRF1

Gene ID: 29128

Symbol: UHRF1

Ensembl ID: ENSG00000276043

Description: ubiquitin like with PHD and ring finger domains 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 18.2643
    Cell Significance Index: -7.4200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 7.8267
    Cell Significance Index: -7.4700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 4.2182
    Cell Significance Index: 107.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.8000
    Cell Significance Index: 180.6500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.8245
    Cell Significance Index: 63.4000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.7882
    Cell Significance Index: 19.4400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.5327
    Cell Significance Index: 41.0000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 1.3022
    Cell Significance Index: 13.4800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0918
    Cell Significance Index: 108.0000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.9550
    Cell Significance Index: -2.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9441
    Cell Significance Index: 111.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.8307
    Cell Significance Index: 46.6200
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.7580
    Cell Significance Index: 4.7600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6611
    Cell Significance Index: 39.6900
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.6602
    Cell Significance Index: 4.3800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5754
    Cell Significance Index: 62.5900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5683
    Cell Significance Index: 92.4300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5045
    Cell Significance Index: 10.5600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5040
    Cell Significance Index: 100.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4945
    Cell Significance Index: 94.1000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.4830
    Cell Significance Index: 10.0200
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.3751
    Cell Significance Index: 5.2100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3590
    Cell Significance Index: 10.0300
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.3243
    Cell Significance Index: 2.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2650
    Cell Significance Index: 7.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2433
    Cell Significance Index: 11.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1761
    Cell Significance Index: 5.6400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1560
    Cell Significance Index: 11.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1075
    Cell Significance Index: 12.5300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1021
    Cell Significance Index: 55.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0941
    Cell Significance Index: 6.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0628
    Cell Significance Index: 56.7400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0621
    Cell Significance Index: 27.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0521
    Cell Significance Index: 1.1100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0448
    Cell Significance Index: 0.9800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0380
    Cell Significance Index: 0.9500
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: 0.0275
    Cell Significance Index: 0.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0249
    Cell Significance Index: 0.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0049
    Cell Significance Index: 1.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0018
    Cell Significance Index: 0.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0006
    Cell Significance Index: -0.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0013
    Cell Significance Index: -0.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0013
    Cell Significance Index: -2.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0032
    Cell Significance Index: -5.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0033
    Cell Significance Index: -5.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0038
    Cell Significance Index: -0.3900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0056
    Cell Significance Index: -7.5800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0074
    Cell Significance Index: -5.6200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0091
    Cell Significance Index: -0.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0103
    Cell Significance Index: -6.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0109
    Cell Significance Index: -8.0800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0111
    Cell Significance Index: -8.1700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0117
    Cell Significance Index: -0.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0158
    Cell Significance Index: -7.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0166
    Cell Significance Index: -9.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0179
    Cell Significance Index: -0.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0220
    Cell Significance Index: -3.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0227
    Cell Significance Index: -3.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0244
    Cell Significance Index: -2.8000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0250
    Cell Significance Index: -0.2000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0300
    Cell Significance Index: -8.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0304
    Cell Significance Index: -6.4000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0325
    Cell Significance Index: -4.1700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0343
    Cell Significance Index: -1.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0367
    Cell Significance Index: -5.3400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0388
    Cell Significance Index: -0.6000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0437
    Cell Significance Index: -0.5600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0441
    Cell Significance Index: -5.7000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0457
    Cell Significance Index: -1.8700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0642
    Cell Significance Index: -0.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0645
    Cell Significance Index: -3.3500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0697
    Cell Significance Index: -1.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0746
    Cell Significance Index: -7.7700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0800
    Cell Significance Index: -5.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0884
    Cell Significance Index: -4.1600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0934
    Cell Significance Index: -2.3300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0944
    Cell Significance Index: -0.5600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0974
    Cell Significance Index: -2.5600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1037
    Cell Significance Index: -7.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1071
    Cell Significance Index: -6.5900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1079
    Cell Significance Index: -2.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1101
    Cell Significance Index: -7.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1158
    Cell Significance Index: -5.4000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1184
    Cell Significance Index: -7.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1225
    Cell Significance Index: -6.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1230
    Cell Significance Index: -7.5400
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.1389
    Cell Significance Index: -1.7300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1440
    Cell Significance Index: -2.0900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1646
    Cell Significance Index: -2.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1687
    Cell Significance Index: -8.8600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1924
    Cell Significance Index: -8.5100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1939
    Cell Significance Index: -2.7200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1955
    Cell Significance Index: -6.8500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1955
    Cell Significance Index: -2.9300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1965
    Cell Significance Index: -5.0500
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.2076
    Cell Significance Index: -2.3500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2177
    Cell Significance Index: -6.8900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2295
    Cell Significance Index: -8.6900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2303
    Cell Significance Index: -7.5400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2380
    Cell Significance Index: -7.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** UHRF1 is a ubiquitin-like protein that possesses distinct domains, including PHD and ring finger motifs. These domains enable UHRF1 to interact with various proteins, modulate chromatin structure, and regulate gene expression. The protein's ability to bind to histones, specifically H3K9me3 and H3me2, underscores its role in epigenetic regulation. UHRF1's expression is characterized by its high levels in early pro-B cells, thymocytes, and lymphoid progenitors, suggesting a critical involvement in immune cell development. **Pathways and Functions** UHRF1's involvement in multiple pathways underscores its multifaceted role in cellular regulation. Notably, its participation in: 1. **Chromatin regulation**: UHRF1 modulates chromatin structure by interacting with histones, influencing gene expression and DNA methylation. 2. **DNA damage response**: UHRF1 acts as a DNA damage sensor, facilitating the repair of double-strand breaks via homologous recombination. 3. **Transcriptional control**: UHRF1 regulates gene expression by binding to specific DNA sequences, influencing transcriptional initiation and termination. 4. **Epigenetic regulation**: UHRF1 participates in the regulation of DNA methylation, particularly in CpG islands, impacting gene expression and cellular differentiation. **Clinical Significance** UHRF1's involvement in immune cell development and function has significant implications for various clinical disorders: 1. **Immune system dysregulation**: Alterations in UHRF1 expression have been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: UHRF1's role in DNA damage response and chromatin regulation suggests its potential involvement in cancer development and progression. 3. **Neurological disorders**: UHRF1's expression in neural crest cells and its involvement in transcriptional control suggest a potential link to neurological disorders, such as autism and schizophrenia. In conclusion, UHRF1 is a vital protein that plays a multifaceted role in cellular regulation, particularly in the immune system. Its involvement in chromatin regulation, DNA damage response, and transcriptional control highlights its clinical significance in various disorders. Further research into UHRF1's functions and dysregulation will provide valuable insights into the development of novel therapeutic strategies for immune-related diseases.

Genular Protein ID: 495915256

Symbol: UHRF1_HUMAN

Name: E3 ubiquitin-protein ligase UHRF1

UniProtKB Accession Codes:

Q96T88 A0JBR2 A8K024 B2RBA9 Q2HIX7 Q8J022 Q9H6S6 Q9P115 Q9P1U7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 5 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EC 1 EMBL 14 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 36 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 14 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 36 PDBsum 36 PRO 1 PROSITE 6 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 5 SASBDB 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10646863

Title: ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIa expression.

PubMed ID: 10646863

PubMed ID: 17067204

Title: Isolation and characterization of a novel human radiosusceptibility gene, NP95.

PubMed ID: 17067204

DOI: 10.1667/rr0459.1

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12838312

Title: ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells.

PubMed ID: 12838312

DOI: 10.1038/sj.bjc.6601068

PubMed ID: 15178447

Title: Phosphorylation of ICBP90 by protein kinase A enhances topoisomerase IIalpha expression.

PubMed ID: 15178447

DOI: 10.1016/j.bbrc.2004.05.028

PubMed ID: 15009091

Title: Down-regulation of nuclear protein ICBP90 by p53/p21Cip1/WAF1-dependent DNA-damage checkpoint signals contributes to cell cycle arrest at G1/S transition.

PubMed ID: 15009091

DOI: 10.1111/j.1356-9597.2004.00710.x

PubMed ID: 15361834

Title: ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain.

PubMed ID: 15361834

DOI: 10.1038/sj.onc.1208053

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17673620

Title: UHRF1 plays a role in maintaining DNA methylation in mammalian cells.

PubMed ID: 17673620

DOI: 10.1126/science.1147939

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 17967883

Title: ICBP90, a novel methyl K9 H3 binding protein linking protein ubiquitination with heterochromatin formation.

PubMed ID: 17967883

DOI: 10.1128/mcb.01598-07

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19491893

Title: UHRF1 is a novel molecular marker for diagnosis and the prognosis of bladder cancer.

PubMed ID: 19491893

DOI: 10.1038/sj.bjc.6605123

PubMed ID: 19056828

Title: UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells.

PubMed ID: 19056828

DOI: 10.1093/nar/gkn961

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20026581

Title: The multi-domain protein Np95 connects DNA methylation and histone modification.

PubMed ID: 20026581

DOI: 10.1093/nar/gkp1152

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21745816

Title: The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1.

PubMed ID: 21745816

DOI: 10.1093/nar/gkr528

PubMed ID: 21731699

Title: Recognition of 5-hydroxymethylcytosine by the Uhrf1 SRA domain.

PubMed ID: 21731699

DOI: 10.1371/journal.pone.0021306

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 22945642

Title: The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia protein.

PubMed ID: 22945642

DOI: 10.1038/onc.2012.406

PubMed ID: 22286757

Title: UHRF1 coordinates peroxisome proliferator activated receptor gamma (PPARG) epigenetic silencing and mediates colorectal cancer progression.

PubMed ID: 22286757

DOI: 10.1038/onc.2012.3

PubMed ID: 22330138

Title: The SRA protein UHRF1 promotes epigenetic crosstalks and is involved in prostate cancer progression.

PubMed ID: 22330138

DOI: 10.1038/onc.2011.641

PubMed ID: 22411829

Title: M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability.

PubMed ID: 22411829

DOI: 10.1073/pnas.1116349109

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30335751

Title: Identification of UHRF2 as a novel DNA interstrand crosslink sensor protein.

PubMed ID: 30335751

DOI: 10.1371/journal.pgen.1007643

PubMed ID: 32051553

Title: The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.

PubMed ID: 32051553

DOI: 10.1038/s41388-020-1206-7

PubMed ID: 37728657

Title: UHRF1 promotes spindle assembly and chromosome congression by catalyzing EG5 polyubiquitination.

PubMed ID: 37728657

DOI: 10.1083/jcb.202210093

PubMed ID: 18931436

Title: Expression, purification, crystallization and preliminary crystallographic study of the SRA domain of the human UHRF1 protein.

PubMed ID: 18931436

DOI: 10.1107/s1744309108027462

PubMed ID: 18945682

Title: Structure and hemimethylated CpG binding of the SRA domain from human UHRF1.

PubMed ID: 18945682

DOI: 10.1074/jbc.c800169200

PubMed ID: 18772889

Title: Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1.

PubMed ID: 18772889

DOI: 10.1038/nature07273

PubMed ID: 21808300

Title: Crystal structure of PHD domain of UHRF1 and insights into recognition of unmodified histone H3 arginine residue 2.

PubMed ID: 21808300

DOI: 10.1038/cr.2011.124

PubMed ID: 21808299

Title: Structural basis for site-specific reading of unmodified R2 of histone H3 tail by UHRF1 PHD finger.

PubMed ID: 21808299

DOI: 10.1038/cr.2011.123

PubMed ID: 21489993

Title: Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein.

PubMed ID: 21489993

DOI: 10.1074/jbc.m111.234104

PubMed ID: 21777816

Title: PHD finger recognition of unmodified histone H3R2 links UHRF1 to regulation of euchromatic gene expression.

PubMed ID: 21777816

DOI: 10.1016/j.molcel.2011.07.006

PubMed ID: 22096602

Title: The PHD finger of human UHRF1 reveals a new subgroup of unmethylated histone H3 tail readers.

PubMed ID: 22096602

DOI: 10.1371/journal.pone.0027599

PubMed ID: 22100450

Title: UHRF1 double tudor domain and the adjacent PHD finger act together to recognize K9me3-containing histone H3 tail.

PubMed ID: 22100450

DOI: 10.1016/j.jmb.2011.11.012

PubMed ID: 22837395

Title: Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1.

PubMed ID: 22837395

DOI: 10.1073/pnas.1203701109

Sequence Information:

  • Length: 793
  • Mass: 89814
  • Checksum: E65B15657525C89F
  • Sequence:
    • MWIQVRTMDG RQTHTVDSLS RLTKVEELRR KIQELFHVEP GLQRLFYRGK QMEDGHTLFD 
YEVRLNDTIQ LLVRQSLVLP HSTKERDSEL SDTDSGCCLG QSESDKSSTH GEAAAETDSR 
PADEDMWDET ELGLYKVNEY VDARDTNMGA WFEAQVVRVT RKAPSRDEPC SSTSRPALEE 
DVIYHVKYDD YPENGVVQMN SRDVRARART IIKWQDLEVG QVVMLNYNPD NPKERGFWYD 
AEISRKRETR TARELYANVV LGDDSLNDCR IIFVDEVFKI ERPGEGSPMV DNPMRRKSGP 
SCKHCKDDVN RLCRVCACHL CGGRQDPDKQ LMCDECDMAF HIYCLDPPLS SVPSEDEWYC 
PECRNDASEV VLAGERLRES KKKAKMASAT SSSQRDWGKG MACVGRTKEC TIVPSNHYGP 
IPGIPVGTMW RFRVQVSESG VHRPHVAGIH GRSNDGAYSL VLAGGYEDDV DHGNFFTYTG 
SGGRDLSGNK RTAEQSCDQK LTNTNRALAL NCFAPINDQE GAEAKDWRSG KPVRVVRNVK 
GGKNSKYAPA EGNRYDGIYK VVKYWPEKGK SGFLVWRYLL RRDDDEPGPW TKEGKDRIKK 
LGLTMQYPEG YLEALANRER EKENSKREEE EQQEGGFASP RTGKGKWKRK SAGGGPSRAG 
SPRRTSKKTK VEPYSLTAQQ SSLIREDKSN AKLWNEVLAS LKDRPASGSP FQLFLSKVEE 
TFQCICCQEL VFRPITTVCQ HNVCKDCLDR SFRAQVFSCP ACRYDLGRSY AMQVNQPLQT 
VLNQLFPGYG NGR

Genular Protein ID: 4173263698

Symbol: A0A087WVR3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WVR3

Database IDs:

ARBA 14 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 5 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 5 Ensembl 2 GO 6 Gene3D 4 GeneTree 1 HGNC 1 InterPro 14 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 9 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 4 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 4 SUPFAM 4 UCSC 1 UniPathway 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 806
  • Mass: 91100
  • Checksum: 4D471EAC9249653D
  • Sequence:
    • MGVFAVPPLS ADTMWIQVRT MDGRQTHTVD SLSRLTKVEE LRRKIQELFH VEPGLQRLFY 
RGKQMEDGHT LFDYEVRLND TIQLLVRQSL VLPHSTKERD SELSDTDSGC CLGQSESDKS 
STHGEAAAET DSRPADEDMW DETELGLYKV NEYVDARDTN MGAWFEAQVV RVTRKAPSRD 
EPCSSTSRPA LEEDVIYHVK YDDYPENGVV QMNSRDVRAR ARTIIKWQDL EVGQVVMLNY 
NPDNPKERGF WYDAEISRKR ETRTARELYA NVVLGDDSLN DCRIIFVDEV FKIERPGEGS 
PMVDNPMRRK SGPSCKHCKD DVNRLCRVCA CHLCGGRQDP DKQLMCDECD MAFHIYCLDP 
PLSSVPSEDE WYCPECRNDA SEVVLAGERL RESKKKAKMA SATSSSQRDW GKGMACVGRT 
KECTIVPSNH YGPIPGIPVG TMWRFRVQVS ESGVHRPHVA GIHGRSNDGA YSLVLAGGYE 
DDVDHGNFFT YTGSGGRDLS GNKRTAEQSC DQKLTNTNRA LALNCFAPIN DQEGAEAKDW 
RSGKPVRVVR NVKGGKNSKY APAEGNRYDG IYKVVKYWPE KGKSGFLVWR YLLRRDDDEP 
GPWTKEGKDR IKKLGLTMQY PEGYLEALAN REREKENSKR EEEEQQEGGF ASPRTGKGKW 
KRKSAGGGPS RAGSPRRTSK KTKVEPYSLT AQQSSLIRED KSNAKLWNEV LASLKDRPAS 
GSPFQLFLSK VEETFQCICC QELVFRPITT VCQHNVCKDC LDRSFRAQVF SCPACRYDLG 
RSYAMQVNQP LQTVLNQLFP GYGNGR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.