Details for: BRF1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 150.0850
Cell Significance Index: -23.3500 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 88.7466
Cell Significance Index: -22.5100 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 52.2851
Cell Significance Index: -24.6900 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 47.6299
Cell Significance Index: -19.3500 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 20.3458
Cell Significance Index: -19.4300 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 19.4573
Cell Significance Index: -23.9900 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 8.5036
Cell Significance Index: -22.7800 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 6.1200
Cell Significance Index: -24.1500 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 6.0883
Cell Significance Index: -18.7000 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 4.5052
Cell Significance Index: -9.8600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.6193
Cell Significance Index: 308.1600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.0871
Cell Significance Index: 218.0800 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.9779
Cell Significance Index: 28.1800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.8610
Cell Significance Index: 777.3800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.7270
Cell Significance Index: 144.2700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.7250
Cell Significance Index: 32.8600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.6921
Cell Significance Index: 248.2600 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6072
Cell Significance Index: 98.7600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.5304
Cell Significance Index: 11.4900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.4388
Cell Significance Index: 51.1400 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.4258
Cell Significance Index: 11.9000 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3856
Cell Significance Index: 23.1500 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.3576
Cell Significance Index: 7.8300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3286
Cell Significance Index: 17.0700 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.3186
Cell Significance Index: 8.1900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.3047
Cell Significance Index: 17.1000 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2981
Cell Significance Index: 206.1700 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.2931
Cell Significance Index: 15.2700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.2869
Cell Significance Index: 22.0200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.2808
Cell Significance Index: 12.4200 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.2506
Cell Significance Index: 9.4900 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.2472
Cell Significance Index: 6.1800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2439
Cell Significance Index: 43.9800 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2392
Cell Significance Index: 16.5500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.2048
Cell Significance Index: 7.2000 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.1676
Cell Significance Index: 10.8200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1624
Cell Significance Index: 19.9700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1224
Cell Significance Index: 16.8100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1137
Cell Significance Index: 62.1200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0956
Cell Significance Index: 42.2700 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.0727
Cell Significance Index: 4.8900 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0720
Cell Significance Index: 7.1200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0613
Cell Significance Index: 3.8700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0586
Cell Significance Index: 2.7300 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.0514
Cell Significance Index: 0.7700 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0432
Cell Significance Index: 0.7400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0429
Cell Significance Index: 80.8400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0303
Cell Significance Index: 46.6900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0277
Cell Significance Index: 17.6000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0244
Cell Significance Index: 44.9400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0129
Cell Significance Index: 17.5900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0079
Cell Significance Index: 3.5700 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0047
Cell Significance Index: 0.1000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0005
Cell Significance Index: -0.0900 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0074
Cell Significance Index: -0.9500 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0157
Cell Significance Index: -0.4200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0210
Cell Significance Index: -15.3700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0272
Cell Significance Index: -20.6000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0273
Cell Significance Index: -20.2200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0278
Cell Significance Index: -4.0400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0402
Cell Significance Index: -22.6500 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0429
Cell Significance Index: -26.7700 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0448
Cell Significance Index: -0.7500 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0676
Cell Significance Index: -19.4500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0807
Cell Significance Index: -8.2400 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0829
Cell Significance Index: -10.7100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0985
Cell Significance Index: -11.2900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1031
Cell Significance Index: -12.1600 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1056
Cell Significance Index: -2.1900 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1072
Cell Significance Index: -5.6300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1101
Cell Significance Index: -5.1800 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1246
Cell Significance Index: -26.2500 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1323
Cell Significance Index: -1.9000 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.1463
Cell Significance Index: -4.1800 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1746
Cell Significance Index: -12.3500 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1770
Cell Significance Index: -13.1900 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1844
Cell Significance Index: -5.0200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1897
Cell Significance Index: -19.7500 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2075
Cell Significance Index: -7.2100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2120
Cell Significance Index: -6.7900 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.2269
Cell Significance Index: -6.0800 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2625
Cell Significance Index: -20.7900 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.2812
Cell Significance Index: -5.4900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3200
Cell Significance Index: -19.6200 - Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: -0.3262
Cell Significance Index: -1.4200 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.3285
Cell Significance Index: -5.2700 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.3385
Cell Significance Index: -8.9000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3400
Cell Significance Index: -20.9000 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.3733
Cell Significance Index: -4.4500 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.3863
Cell Significance Index: -5.2700 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.4273
Cell Significance Index: -12.2500 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.4281
Cell Significance Index: -9.1500 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.4528
Cell Significance Index: -14.4200 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.4577
Cell Significance Index: -4.2200 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.4715
Cell Significance Index: -9.8700 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.4731
Cell Significance Index: -15.4900 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.4760
Cell Significance Index: -12.1600 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.5110
Cell Significance Index: -7.7000 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.5195
Cell Significance Index: -7.6700 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.5324
Cell Significance Index: -15.6800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3702656121
Symbol: TF3B_HUMAN
Name: Transcription factor IIIB 90 kDa subunit
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7624363
Title: Structure and function of a human transcription factor TFIIIB subunit that is evolutionarily conserved and contains both TFIIB- and high-mobility-group protein 2-related domains.
PubMed ID: 7624363
PubMed ID: 8943358
Title: RNA polymerase III transcription from the human U6 and adenovirus type 2 VAI promoters has different requirements for human BRF, a subunit of human TFIIIB.
PubMed ID: 8943358
PubMed ID: 10921893
Title: Alternatively spliced hBRF variants function at different RNA polymerase III promoters.
PubMed ID: 10921893
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12508121
Title: The DNA sequence and analysis of human chromosome 14.
PubMed ID: 12508121
DOI: 10.1038/nature01348
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14592981
Title: TFIIIB is phosphorylated, disrupted and selectively released from tRNA promoters during mitosis in vivo.
PubMed ID: 14592981
DOI: 10.1093/emboj/cdg544
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 18377933
Title: Regulation of RNA polymerase III transcription by Maf1 in mammalian cells.
PubMed ID: 18377933
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25561519
Title: BRF1 mutations alter RNA polymerase III-dependent transcription and cause neurodevelopmental anomalies.
PubMed ID: 25561519
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
Sequence Information:
- Length: 677
- Mass: 73840
- Checksum: 5866304B879EC1DE
- Sequence:
MTGRVCRGCG GTDIELDAAR GDAVCTACGS VLEDNIIVSE VQFVESSGGG SSAVGQFVSL DGAGKTPTLG GGFHVNLGKE SRAQTLQNGR RHIHHLGNQL QLNQHCLDTA FNFFKMAVSR HLTRGRKMAH VIAACLYLVC RTEGTPHMLL DLSDLLQVNV YVLGKTFLLL ARELCINAPA IDPCLYIPRF AHLLEFGEKN HEVSMTALRL LQRMKRDWMH TGRRPSGLCG AALLVAARMH DFRRTVKEVI SVVKVCESTL RKRLTEFEDT PTSQLTIDEF MKIDLEEECD PPSYTAGQRK LRMKQLEQVL SKKLEEVEGE ISSYQDAIEI ELENSRPKAK GGLASLAKDG STEDTASSLC GEEDTEDEEL EAAASHLNKD LYRELLGGAP GSSEAAGSPE WGGRPPALGS LLDPLPTAAS LGISDSIREC ISSQSSDPKD ASGDGELDLS GIDDLEIDRY ILNESEARVK AELWMRENAE YLREQREKEA RIAKEKELGI YKEHKPKKSC KRREPIQAST AREAIEKMLE QKKISSKINY SVLRGLSSAG GGSPHREDAQ PEHSASARKL SRRRTPASRS GADPVTSVGK RLRPLVSTQP AKKVATGEAL LPSSPTLGAE PARPQAVLVE SGPVSYHADE EADEEEPDEE DGEPCVSALQ MMGSNDYGCD GDEDDGY
Genular Protein ID: 889167371
Symbol: V9HVY2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 208
- Mass: 22309
- Checksum: 8761AE32A65FFE89
- Sequence:
MTGRVCRGCG GTDIELDAAR GDAVCTACGS VLEDNIIVSE VQFVESSGGG SSAVGQFVSL DGAGKTPTLG GGFHVNLGKE SRAQTLQNGR RHIHHLGNQL QLNQHCLDTA FNFFKMAVSR HLTRGRKMAH VIAACLYLVC RTEGTPHMLL DLSDLLQVDS LRPASFPTWG CDLGVVTRVV TGVYPRCLHA SQWPVCAACP VRKFWSVG
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.