Details for: BRF1

Gene ID: 2972

Symbol: BRF1

Ensembl ID: ENSG00000185024

Description: BRF1 RNA polymerase III transcription initiation factor subunit

Associated with

  • Gene expression (transcription)
    (R-HSA-74160)
  • Rna polymerase iii abortive and retractive initiation
    (R-HSA-749476)
  • Rna polymerase iii transcription
    (R-HSA-74158)
  • Rna polymerase iii transcription initiation
    (R-HSA-76046)
  • Rna polymerase iii transcription initiation from type 1 promoter
    (R-HSA-76061)
  • Rna polymerase iii transcription initiation from type 2 promoter
    (R-HSA-76066)
  • Dna-templated transcription initiation
    (GO:0006352)
  • Metal ion binding
    (GO:0046872)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase iii
    (GO:0045945)
  • Protein binding
    (GO:0005515)
  • Rna polymerase iii general transcription initiation factor activity
    (GO:0000995)
  • Rna polymerase iii type 3 promoter sequence-specific dna binding
    (GO:0001006)
  • Rrna transcription
    (GO:0009303)
  • Tbp-class protein binding
    (GO:0017025)
  • Transcription by rna polymerase iii
    (GO:0006383)
  • Transcription factor tfiiib complex
    (GO:0000126)
  • Transcription initiation at rna polymerase iii promoter
    (GO:0006384)
  • Transcription preinitiation complex
    (GO:0097550)
  • Transcription preinitiation complex assembly
    (GO:0070897)
  • Trna transcription
    (GO:0009304)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.47
    Marker Score: 3471
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.41
    Marker Score: 2870
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.33
    Marker Score: 5416
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.33
    Marker Score: 50459
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.31
    Marker Score: 12347
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.31
    Marker Score: 12400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3
    Marker Score: 79791
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.28
    Marker Score: 4965
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.28
    Marker Score: 401
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.27
    Marker Score: 10949
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.27
    Marker Score: 19898
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.26
    Marker Score: 12977
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.23
    Marker Score: 18343
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.22
    Marker Score: 45056
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.21
    Marker Score: 9308
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.19
    Marker Score: 383
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.19
    Marker Score: 1831
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.17
    Marker Score: 23347
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.12
    Marker Score: 672
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.06
    Marker Score: 1844
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.05
    Marker Score: 4363
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71742
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47966
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.97
    Marker Score: 1070
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 483
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2717
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.88
    Marker Score: 5290
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4946
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.85
    Marker Score: 18151
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.84
    Marker Score: 382
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.81
    Marker Score: 973
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.78
    Marker Score: 326
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.77
    Marker Score: 453
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 580
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.76
    Marker Score: 361
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.74
    Marker Score: 1774
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 290.5
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.72
    Marker Score: 265
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.7
    Marker Score: 342
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.7
    Marker Score: 222
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2927.5
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.7
    Marker Score: 2921
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.7
    Marker Score: 537
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.68
    Marker Score: 395
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.68
    Marker Score: 198
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.68
    Marker Score: 817.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 615
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.67
    Marker Score: 3107
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.65
    Marker Score: 169
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.65
    Marker Score: 748
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.65
    Marker Score: 1425
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.64
    Marker Score: 634
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.62
    Marker Score: 345
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.61
    Marker Score: 168
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.61
    Marker Score: 1032
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.61
    Marker Score: 654
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.6
    Marker Score: 2072
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.6
    Marker Score: 807
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.59
    Marker Score: 186
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.58
    Marker Score: 1111
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.57
    Marker Score: 1406
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.57
    Marker Score: 493
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.57
    Marker Score: 318
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.56
    Marker Score: 216
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.56
    Marker Score: 247
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.55
    Marker Score: 18629
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.55
    Marker Score: 2029
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.54
    Marker Score: 765
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.54
    Marker Score: 356
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.54
    Marker Score: 198
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 427
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.53
    Marker Score: 686
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.53
    Marker Score: 4587
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.53
    Marker Score: 358
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.52
    Marker Score: 345
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.52
    Marker Score: 354
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.51
    Marker Score: 578
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.51
    Marker Score: 147
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.51
    Marker Score: 575
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.51
    Marker Score: 133
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.5
    Marker Score: 539
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.5
    Marker Score: 458.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.49
    Marker Score: 295
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.49
    Marker Score: 156
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.49
    Marker Score: 4296
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.49
    Marker Score: 198
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.48
    Marker Score: 341
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.48
    Marker Score: 7730
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.48
    Marker Score: 690
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.47
    Marker Score: 233
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.47
    Marker Score: 191
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.47
    Marker Score: 450

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Other Information

**Key characteristics:** * BRF1 is a protein of the BRF1 family of transcription factors. * It is a highly conserved protein with significant sequence homology to BRF2 and BRF3. * BRF1 is expressed in a variety of cell types, including epithelial cells, neurons, and immune cells. * It is a key regulator of gene expression in these cells. **Pathways and functions:** * BRF1 is involved in a variety of cellular processes, including: * Transcription initiation * Gene expression * Cell cycle regulation * Apoptosis * It is a key regulator of the expression of genes involved in cell cycle regulation, including the G1/S transition. * BRF1 is also involved in the regulation of apoptosis. * It is a key regulator of the development of the kidney and the nervous system. **Clinical significance:** * Mutations in BRF1 have been linked to a number of human diseases, including: * Kidney cancer * Neuroblastoma * Rett syndrome * Autism **BRF1 is a critical protein for the regulation of gene expression and cell growth and survival. Its mutations can lead to a variety of diseases, highlighting its importance in human health.**

Genular Protein ID: 3702656121

Symbol: TF3B_HUMAN

Name: Transcription factor IIIB 90 kDa subunit

UniProtKB Accession Codes:

Q92994 B3KU36 B4DIG5 B7Z2N3 F5H5Z7 F8WA46 Q13223 Q3SYD9 Q5PR24 Q6IQ02 Q96KX3 Q9HCW6 Q9HCW7 Q9HCW8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 7 CDD 2 CORUM 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 EPD 1 Ensembl 7 ExpressionAtlas 1 GO 15 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 Pumba 1 RNAct 1 Reactome 3 RefSeq 8 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7624363

Title: Structure and function of a human transcription factor TFIIIB subunit that is evolutionarily conserved and contains both TFIIB- and high-mobility-group protein 2-related domains.

PubMed ID: 7624363

DOI: 10.1073/pnas.92.15.7026

PubMed ID: 8943358

Title: RNA polymerase III transcription from the human U6 and adenovirus type 2 VAI promoters has different requirements for human BRF, a subunit of human TFIIIB.

PubMed ID: 8943358

DOI: 10.1128/mcb.16.12.7031

PubMed ID: 10921893

Title: Alternatively spliced hBRF variants function at different RNA polymerase III promoters.

PubMed ID: 10921893

DOI: 10.1093/emboj/19.15.4134

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14592981

Title: TFIIIB is phosphorylated, disrupted and selectively released from tRNA promoters during mitosis in vivo.

PubMed ID: 14592981

DOI: 10.1093/emboj/cdg544

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18377933

Title: Regulation of RNA polymerase III transcription by Maf1 in mammalian cells.

PubMed ID: 18377933

DOI: 10.1016/j.jmb.2008.02.060

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25561519

Title: BRF1 mutations alter RNA polymerase III-dependent transcription and cause neurodevelopmental anomalies.

PubMed ID: 25561519

DOI: 10.1101/gr.176925.114

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 677
  • Mass: 73840
  • Checksum: 5866304B879EC1DE
  • Sequence:
    • MTGRVCRGCG GTDIELDAAR GDAVCTACGS VLEDNIIVSE VQFVESSGGG SSAVGQFVSL 
DGAGKTPTLG GGFHVNLGKE SRAQTLQNGR RHIHHLGNQL QLNQHCLDTA FNFFKMAVSR 
HLTRGRKMAH VIAACLYLVC RTEGTPHMLL DLSDLLQVNV YVLGKTFLLL ARELCINAPA 
IDPCLYIPRF AHLLEFGEKN HEVSMTALRL LQRMKRDWMH TGRRPSGLCG AALLVAARMH 
DFRRTVKEVI SVVKVCESTL RKRLTEFEDT PTSQLTIDEF MKIDLEEECD PPSYTAGQRK 
LRMKQLEQVL SKKLEEVEGE ISSYQDAIEI ELENSRPKAK GGLASLAKDG STEDTASSLC 
GEEDTEDEEL EAAASHLNKD LYRELLGGAP GSSEAAGSPE WGGRPPALGS LLDPLPTAAS 
LGISDSIREC ISSQSSDPKD ASGDGELDLS GIDDLEIDRY ILNESEARVK AELWMRENAE 
YLREQREKEA RIAKEKELGI YKEHKPKKSC KRREPIQAST AREAIEKMLE QKKISSKINY 
SVLRGLSSAG GGSPHREDAQ PEHSASARKL SRRRTPASRS GADPVTSVGK RLRPLVSTQP 
AKKVATGEAL LPSSPTLGAE PARPQAVLVE SGPVSYHADE EADEEEPDEE DGEPCVSALQ 
MMGSNDYGCD GDEDDGY

Genular Protein ID: 889167371

Symbol: V9HVY2_HUMAN

Name: N/A

UniProtKB Accession Codes:

V9HVY2

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 3 Gene3D 2 GenomeRNAi 1 HOGENOM 1 InterPro 5 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PROSITE-ProRule 1 Pfam 2 RefSeq 1 SMART 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Sequence Information:

  • Length: 208
  • Mass: 22309
  • Checksum: 8761AE32A65FFE89
  • Sequence:
    • MTGRVCRGCG GTDIELDAAR GDAVCTACGS VLEDNIIVSE VQFVESSGGG SSAVGQFVSL 
DGAGKTPTLG GGFHVNLGKE SRAQTLQNGR RHIHHLGNQL QLNQHCLDTA FNFFKMAVSR 
HLTRGRKMAH VIAACLYLVC RTEGTPHMLL DLSDLLQVDS LRPASFPTWG CDLGVVTRVV 
TGVYPRCLHA SQWPVCAACP VRKFWSVG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.