Details for: GUCA1B

Gene ID: 2979

Symbol: GUCA1B

Ensembl ID: ENSG00000112599

Description: guanylate cyclase activator 1B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.78
    Marker Score: 827
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.15
    Marker Score: 6128
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1171
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 856
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.07
    Marker Score: 676
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71830
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48054
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5343
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.93
    Marker Score: 387.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 612.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 294
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 463
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2975
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.64
    Marker Score: 711
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 446
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 233
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.48
    Marker Score: 740
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.43
    Marker Score: 9104
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.39
    Marker Score: 258
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.37
    Marker Score: 5842
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.37
    Marker Score: 3466
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.36
    Marker Score: 3394
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.35
    Marker Score: 3004
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.34
    Marker Score: 982
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.34
    Marker Score: 20959
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.33
    Marker Score: 692.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.33
    Marker Score: 2004
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.33
    Marker Score: 12160
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.3
    Marker Score: 136
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3
    Marker Score: 1161
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.29
    Marker Score: 78
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.29
    Marker Score: 250
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.29
    Marker Score: 290
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.28
    Marker Score: 146
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.28
    Marker Score: 4174
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.28
    Marker Score: 522
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.28
    Marker Score: 10451
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.28
    Marker Score: 87
  • Cell Name: S cone cell (CL0003050)
    Fold Change: 0.27
    Marker Score: 82
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.27
    Marker Score: 1129
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.27
    Marker Score: 111
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.27
    Marker Score: 129
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.27
    Marker Score: 85
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.26
    Marker Score: 1998
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.26
    Marker Score: 109
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.25
    Marker Score: 115
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.23
    Marker Score: 4634
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.23
    Marker Score: 67
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.23
    Marker Score: 151
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.23
    Marker Score: 92
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.22
    Marker Score: 231
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.21
    Marker Score: 74
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.21
    Marker Score: 74
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.21
    Marker Score: 106
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2
    Marker Score: 502
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.19
    Marker Score: 53
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.19
    Marker Score: 112
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.19
    Marker Score: 108.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.19
    Marker Score: 773
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.19
    Marker Score: 381
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.19
    Marker Score: 65.5
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.18
    Marker Score: 764.5
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.18
    Marker Score: 218
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.17
    Marker Score: 154
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.17
    Marker Score: 407
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.17
    Marker Score: 372
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.16
    Marker Score: 98
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.16
    Marker Score: 73
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.15
    Marker Score: 37
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.15
    Marker Score: 171
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.14
    Marker Score: 175
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.14
    Marker Score: 98
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.14
    Marker Score: 178
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.14
    Marker Score: 43
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.13
    Marker Score: 39
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.13
    Marker Score: 79
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.13
    Marker Score: 462
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.13
    Marker Score: 50
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.13
    Marker Score: 171
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.13
    Marker Score: 83
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.13
    Marker Score: 133
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.12
    Marker Score: 1268
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.12
    Marker Score: 169
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.12
    Marker Score: 67
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.12
    Marker Score: 68
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.11
    Marker Score: 110
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.11
    Marker Score: 286

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Other Information

**Key characteristics:** - It is a transmembrane protein that is localized to the plasma membrane. - It is a guanylate cyclase activator, which is an enzyme that activates the guanylate cyclase enzyme, which is responsible for the production of cyclic GMP in the cell. - It is a key regulator of the phototransduction cascade, which is the process by which light energy is converted into electrical signals in the visual cells of the eye. **Pathways and functions:** - GUCA1B is involved in the regulation of the phototransduction cascade by activating the guanylate cyclase enzyme. - The guanylate cyclase enzyme converts cyclic GMP to cyclic AMP (cAMP), which is a second messenger that regulates the activity of a variety of cellular proteins. - cAMP also regulates the expression of genes involved in the phototransduction cascade. **Clinical significance:** - Mutations in the GUCA1B gene have been linked to a number of eye diseases, including retinitis pigmentosa, which is an degenerative eye disease that is characterized by the loss of vision. - In one study, mutations in the GUCA1B gene were found to be responsible for the progressive retinal atrophy that occurs in retinitis pigmentosa. - Understanding the role of GUCA1B in the phototransduction cascade could lead to the development of new treatments for eye diseases that are caused by mutations in this gene.

Genular Protein ID: 366487989

Symbol: GUC1B_HUMAN

Name: Guanylyl cyclase-activating protein 2

UniProtKB Accession Codes:

Q9UMX6 Q9NU15

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 15 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 10 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9119368

Title: The human GCAP1 and GCAP2 genes are arranged in a tail-to-tail array on the short arm of chromosome 6 (p21.1).

PubMed ID: 9119368

DOI: 10.1006/geno.1996.4513

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 9620085

Title: The localization of guanylyl cyclase-activating proteins in the mammalian retina.

PubMed ID: 9620085

PubMed ID: 10507726

Title: Genetic analysis of the guanylate cyclase activator 1B (GUCA1B) gene in patients with autosomal dominant retinal dystrophies.

PubMed ID: 10507726

PubMed ID: 15452722

Title: Mutations in the gene coding for guanylate cyclase-activating protein 2 (GUCA1B gene) in patients with autosomal dominant retinal dystrophies.

PubMed ID: 15452722

DOI: 10.1007/s00417-004-1015-7

Sequence Information:

  • Length: 200
  • Mass: 23420
  • Checksum: 79B898868BA35768
  • Sequence:
    • MGQEFSWEEA EAAGEIDVAE LQEWYKKFVM ECPSGTLFMH EFKRFFKVTD DEEASQYVEG 
MFRAFDKNGD NTIDFLEYVA ALNLVLRGTL EHKLKWTFKI YDKDGNGCID RLELLNIVEG 
IYQLKKACRR ELQTEQGQLL TPEEVVDRIF LLVDENGDGQ LSLNEFVEGA RRDKWVMKML 
QMDMNPSSWL AQQRRKSAMF

Genular Protein ID: 4140771767

Symbol: Q7Z3V9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7Z3V9

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 200
  • Mass: 23318
  • Checksum: 7DA8DD918CD32729
  • Sequence:
    • MGQEFSWEEA EAAGEIDVAE LQEWYKKFVM ECPSGTLFMH EFKRFFKVTD DEEASQYVEG 
MFRAFDKNGD NTIDFLEYVA ALNLVLRGTL EHKLKRTFKI YDKDGNGCID RLELLNIVEG 
IYQLKKACRR ELQTEQGQLL TPEEVVDRIF LLVDENGDGQ LSLNGFVEGA RRDKWVMKML 
QMDMNPSSWL AQQRRKSAMF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.