Details for: GUCA1B

Gene ID: 2979

Symbol: GUCA1B

Ensembl ID: ENSG00000112599

Description: guanylate cyclase activator 1B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 50.3391
    Cell Significance Index: -7.8300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 31.0081
    Cell Significance Index: -7.8700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 10.8692
    Cell Significance Index: 685.0500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.1675
    Cell Significance Index: 16.6200
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.5980
    Cell Significance Index: 7.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3991
    Cell Significance Index: 5.4500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2342
    Cell Significance Index: 6.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2149
    Cell Significance Index: 43.1000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1351
    Cell Significance Index: 1.6100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1152
    Cell Significance Index: 21.9300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1137
    Cell Significance Index: 40.7800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0776
    Cell Significance Index: 1.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0610
    Cell Significance Index: 17.5600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0553
    Cell Significance Index: 3.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0527
    Cell Significance Index: 7.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0462
    Cell Significance Index: 2.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0458
    Cell Significance Index: 1.3200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0425
    Cell Significance Index: 1.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0400
    Cell Significance Index: 7.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0335
    Cell Significance Index: 2.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0275
    Cell Significance Index: 3.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0249
    Cell Significance Index: 4.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0229
    Cell Significance Index: 1.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0127
    Cell Significance Index: 11.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0080
    Cell Significance Index: 0.2800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0078
    Cell Significance Index: 0.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0066
    Cell Significance Index: 12.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0066
    Cell Significance Index: 10.1400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0053
    Cell Significance Index: 0.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0029
    Cell Significance Index: 5.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0016
    Cell Significance Index: 1.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0013
    Cell Significance Index: 1.7400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0029
    Cell Significance Index: -0.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0032
    Cell Significance Index: -1.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0080
    Cell Significance Index: -1.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0082
    Cell Significance Index: -6.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0087
    Cell Significance Index: -3.8400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0089
    Cell Significance Index: -0.8900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0095
    Cell Significance Index: -7.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0099
    Cell Significance Index: -0.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0101
    Cell Significance Index: -7.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0112
    Cell Significance Index: -6.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0119
    Cell Significance Index: -6.4900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0209
    Cell Significance Index: -0.7900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0216
    Cell Significance Index: -1.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0223
    Cell Significance Index: -1.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0224
    Cell Significance Index: -2.7600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0228
    Cell Significance Index: -3.8900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0264
    Cell Significance Index: -0.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0314
    Cell Significance Index: -6.6200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0330
    Cell Significance Index: -2.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0416
    Cell Significance Index: -5.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0425
    Cell Significance Index: -2.2100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0429
    Cell Significance Index: -5.0000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0437
    Cell Significance Index: -3.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0447
    Cell Significance Index: -2.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0454
    Cell Significance Index: -5.2100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0555
    Cell Significance Index: -1.5500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0573
    Cell Significance Index: -7.4000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0610
    Cell Significance Index: -1.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0639
    Cell Significance Index: -1.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0647
    Cell Significance Index: -7.6300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0668
    Cell Significance Index: -6.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0683
    Cell Significance Index: -7.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0719
    Cell Significance Index: -3.3500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0750
    Cell Significance Index: -3.7900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0771
    Cell Significance Index: -1.6000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0806
    Cell Significance Index: -2.5800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0840
    Cell Significance Index: -1.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0885
    Cell Significance Index: -7.0100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0939
    Cell Significance Index: -7.0000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0941
    Cell Significance Index: -4.0900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0973
    Cell Significance Index: -1.3500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0989
    Cell Significance Index: -1.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1062
    Cell Significance Index: -4.9900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1135
    Cell Significance Index: -1.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1153
    Cell Significance Index: -7.4400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1203
    Cell Significance Index: -2.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1225
    Cell Significance Index: -6.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1227
    Cell Significance Index: -6.3900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1350
    Cell Significance Index: -4.3000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1357
    Cell Significance Index: -2.8800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1445
    Cell Significance Index: -4.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1453
    Cell Significance Index: -3.8800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1459
    Cell Significance Index: -5.1100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1470
    Cell Significance Index: -2.1700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1689
    Cell Significance Index: -4.8200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1703
    Cell Significance Index: -1.3100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1708
    Cell Significance Index: -3.6900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1728
    Cell Significance Index: -3.4700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1736
    Cell Significance Index: -4.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1906
    Cell Significance Index: -4.0600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1907
    Cell Significance Index: -3.9800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1926
    Cell Significance Index: -2.7600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1997
    Cell Significance Index: -4.1800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2035
    Cell Significance Index: -4.8800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2051
    Cell Significance Index: -5.8800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2076
    Cell Significance Index: -3.0700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2089
    Cell Significance Index: -7.2600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2096
    Cell Significance Index: -3.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression in Specific Cells:** GUC1B is predominantly expressed in photoreceptor cells of the retina, as well as in other cell types such as colon goblet cells, intestinal crypt stem cells, and cerebral cortex GABAergic interneurons. 2. **Function as a Guanylate Cyclase Activator:** GUC1B acts as a guanylate cyclase activator, increasing the activity of guanylate cyclase enzymes, which are essential for the production of cyclic guanosine monophosphate (cGMP). 3. **Role in Visual Perception:** GUC1B plays a critical role in the phototransduction cascade, facilitating the conversion of light into electrical signals in photoreceptor cells. 4. **Calcium Ion Binding:** GUC1B exhibits calcium ion binding capabilities, suggesting a potential role in regulating calcium-dependent signaling pathways. **Pathways and Functions:** 1. **Photoreceptor Outer Segment Signaling:** GUC1B is involved in the regulation of guanylate cyclase activity in photoreceptor outer segments, enabling the conversion of light into electrical signals. 2. **Cell-Cell Signaling:** GUC1B participates in cell-cell signaling pathways, potentially influencing the communication between photoreceptor cells and other retinal cells. 3. **Calcium Ion Binding:** GUC1B's ability to bind calcium ions suggests a role in regulating calcium-dependent signaling pathways, which are essential for various cellular processes, including muscle contraction and neuronal excitability. 4. **Regulation of Guanylate Cyclase Activity:** GUC1B acts as a guanylate cyclase activator, increasing the activity of guanylate cyclase enzymes, which are involved in various cellular processes, including signal transduction and gene expression. **Clinical Significance:** 1. **Visual Impairment:** Mutations in the GUCA1B gene have been associated with visual impairment and retinal degeneration, highlighting the gene's critical role in visual perception. 2. **Retinal Diseases:** GUC1B's involvement in the phototransduction cascade makes it a potential target for the development of novel therapies for retinal diseases, such as retinitis pigmentosa. 3. **Other Diseases:** The gene's expression in other cell types, including colon goblet cells and intestinal crypt stem cells, suggests a potential role in the pathogenesis of other diseases, such as inflammatory bowel disease and cancer. 4. **Cancer Research:** The identification of GUC1B as a tumor suppressor gene in certain contexts highlights the gene's potential as a biomarker for cancer diagnosis and treatment. In conclusion, the GUCA1B gene is a vital component of the phototransduction cascade, and its discovery has far-reaching implications for our understanding of human physiology and disease. Further research into GUC1B's functions and clinical significance is essential for the development of novel therapies and the diagnosis of diseases associated with this gene.

Genular Protein ID: 366487989

Symbol: GUC1B_HUMAN

Name: Guanylyl cyclase-activating protein 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9119368

Title: The human GCAP1 and GCAP2 genes are arranged in a tail-to-tail array on the short arm of chromosome 6 (p21.1).

PubMed ID: 9119368

DOI: 10.1006/geno.1996.4513

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 9620085

Title: The localization of guanylyl cyclase-activating proteins in the mammalian retina.

PubMed ID: 9620085

PubMed ID: 10507726

Title: Genetic analysis of the guanylate cyclase activator 1B (GUCA1B) gene in patients with autosomal dominant retinal dystrophies.

PubMed ID: 10507726

PubMed ID: 15452722

Title: Mutations in the gene coding for guanylate cyclase-activating protein 2 (GUCA1B gene) in patients with autosomal dominant retinal dystrophies.

PubMed ID: 15452722

DOI: 10.1007/s00417-004-1015-7

Sequence Information:

  • Length: 200
  • Mass: 23420
  • Checksum: 79B898868BA35768
  • Sequence:
  • MGQEFSWEEA EAAGEIDVAE LQEWYKKFVM ECPSGTLFMH EFKRFFKVTD DEEASQYVEG 
    MFRAFDKNGD NTIDFLEYVA ALNLVLRGTL EHKLKWTFKI YDKDGNGCID RLELLNIVEG 
    IYQLKKACRR ELQTEQGQLL TPEEVVDRIF LLVDENGDGQ LSLNEFVEGA RRDKWVMKML 
    QMDMNPSSWL AQQRRKSAMF

Genular Protein ID: 4140771767

Symbol: Q7Z3V9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 200
  • Mass: 23318
  • Checksum: 7DA8DD918CD32729
  • Sequence:
  • MGQEFSWEEA EAAGEIDVAE LQEWYKKFVM ECPSGTLFMH EFKRFFKVTD DEEASQYVEG 
    MFRAFDKNGD NTIDFLEYVA ALNLVLRGTL EHKLKRTFKI YDKDGNGCID RLELLNIVEG 
    IYQLKKACRR ELQTEQGQLL TPEEVVDRIF LLVDENGDGQ LSLNGFVEGA RRDKWVMKML 
    QMDMNPSSWL AQQRRKSAMF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.