Details for: RHOD

Gene ID: 29984

Symbol: RHOD

Ensembl ID: ENSG00000173156

Description: ras homolog family member D

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 69.0734
    Cell Significance Index: -17.5200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 31.2610
    Cell Significance Index: -12.7000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.1895
    Cell Significance Index: -17.5000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.2915
    Cell Significance Index: -12.6900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 8.3545
    Cell Significance Index: 71.7900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.4132
    Cell Significance Index: -17.1800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.4297
    Cell Significance Index: -17.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.4450
    Cell Significance Index: 284.9400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.3006
    Cell Significance Index: 32.7500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3895
    Cell Significance Index: 37.8200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.3486
    Cell Significance Index: 36.1400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.2942
    Cell Significance Index: 7.9700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.0069
    Cell Significance Index: 71.2100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8202
    Cell Significance Index: 447.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7881
    Cell Significance Index: 58.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7049
    Cell Significance Index: 36.6200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6903
    Cell Significance Index: 14.4500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6840
    Cell Significance Index: 41.0600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.6100
    Cell Significance Index: 3.7900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.6060
    Cell Significance Index: 9.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6039
    Cell Significance Index: 17.4000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5954
    Cell Significance Index: 263.2300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.5901
    Cell Significance Index: 9.9300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4849
    Cell Significance Index: 437.7900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4605
    Cell Significance Index: 50.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4152
    Cell Significance Index: 19.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4129
    Cell Significance Index: 50.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3693
    Cell Significance Index: 47.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3414
    Cell Significance Index: 43.7700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3348
    Cell Significance Index: 15.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3335
    Cell Significance Index: 9.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3077
    Cell Significance Index: 30.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3069
    Cell Significance Index: 60.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3043
    Cell Significance Index: 49.4900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2769
    Cell Significance Index: 49.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2609
    Cell Significance Index: 18.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2292
    Cell Significance Index: 31.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2198
    Cell Significance Index: 5.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2104
    Cell Significance Index: 9.5400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2026
    Cell Significance Index: 38.5600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1724
    Cell Significance Index: 1.7900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1466
    Cell Significance Index: 5.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0809
    Cell Significance Index: 6.2100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0690
    Cell Significance Index: 0.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0591
    Cell Significance Index: 10.1000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0290
    Cell Significance Index: 0.2700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0230
    Cell Significance Index: 15.9200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0083
    Cell Significance Index: 6.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0015
    Cell Significance Index: -1.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0025
    Cell Significance Index: -1.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0036
    Cell Significance Index: -6.7400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0071
    Cell Significance Index: -13.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0088
    Cell Significance Index: -13.5600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0143
    Cell Significance Index: -19.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0222
    Cell Significance Index: -16.4300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0281
    Cell Significance Index: -12.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0284
    Cell Significance Index: -16.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0287
    Cell Significance Index: -3.2900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0352
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0353
    Cell Significance Index: -22.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0408
    Cell Significance Index: -14.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0457
    Cell Significance Index: -13.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0466
    Cell Significance Index: -4.7600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0512
    Cell Significance Index: -1.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0541
    Cell Significance Index: -10.8600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0574
    Cell Significance Index: -2.9000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0657
    Cell Significance Index: -1.1000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0770
    Cell Significance Index: -1.6400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0796
    Cell Significance Index: -11.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0872
    Cell Significance Index: -18.3600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0894
    Cell Significance Index: -2.2400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0901
    Cell Significance Index: -5.5300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0923
    Cell Significance Index: -4.8100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0950
    Cell Significance Index: -1.6000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0998
    Cell Significance Index: -2.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1112
    Cell Significance Index: -3.5600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1324
    Cell Significance Index: -5.4200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1325
    Cell Significance Index: -1.5100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1416
    Cell Significance Index: -3.4300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1444
    Cell Significance Index: -11.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1449
    Cell Significance Index: -17.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1658
    Cell Significance Index: -17.2600
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.1819
    Cell Significance Index: -0.6900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1998
    Cell Significance Index: -2.9500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2094
    Cell Significance Index: -3.0900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2275
    Cell Significance Index: -3.6100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2494
    Cell Significance Index: -16.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2609
    Cell Significance Index: -6.8600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2629
    Cell Significance Index: -16.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2824
    Cell Significance Index: -17.3600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2933
    Cell Significance Index: -4.0700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3050
    Cell Significance Index: -7.8400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3066
    Cell Significance Index: -8.7900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3067
    Cell Significance Index: -7.6600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3147
    Cell Significance Index: -9.2700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3402
    Cell Significance Index: -12.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3407
    Cell Significance Index: -19.1200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.3432
    Cell Significance Index: -4.4200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3460
    Cell Significance Index: -15.0400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3545
    Cell Significance Index: -4.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **RHOD protein structure:** The RHOD protein belongs to the Rho family of GTPases, which are characterized by their small size, high GTP-binding affinity, and ability to regulate actin cytoskeleton organization. 2. **Expression patterns:** RHOD is expressed in various cell types, including epithelial cells, retinal cone cells, and cardiac muscle myoblasts, suggesting its involvement in tissue-specific functions. 3. **Interactions with other proteins:** RHOD interacts with other proteins, such as formins, to regulate actin filament assembly and disassembly. 4. **GTPase cycle:** RHOD is involved in the Rho GTPase cycle, which regulates its activity and interactions with other proteins. **Pathways and Functions:** 1. **Actin filament organization:** RHOD regulates actin filament assembly and disassembly, which is essential for cell migration, shape changes, and cytokinesis. 2. **Cell migration:** RHOD is involved in the regulation of cell migration, which is critical for tissue development, wound healing, and immune responses. 3. **Signaling by Rho GTPases:** RHOD interacts with other Rho GTPases to regulate signaling pathways, including those involved in cell adhesion, cell migration, and cytoskeleton organization. 4. **Regulation of small GTPase-mediated signal transduction:** RHOD regulates the activity of small GTPases, such as Miro and Rhobtb3, which are involved in various signaling pathways. **Clinical Significance:** 1. **Cancer:** Dysregulation of RHOD has been implicated in various cancers, including colorectal, breast, and lung cancer, suggesting its potential as a therapeutic target. 2. **Neurological disorders:** RHOD may play a role in neurological disorders, such as Alzheimer's disease and Parkinson's disease, which are characterized by abnormal actin cytoskeleton organization and cell migration. 3. **Cardiovascular disease:** RHOD may be involved in the regulation of cardiac function and the development of cardiovascular disease. 4. **Regenerative medicine:** Understanding the role of RHOD in tissue regeneration and repair can provide insights into the development of new therapeutic strategies for tissue engineering and regenerative medicine. In conclusion, RHOD is a critical regulator of various cellular processes, including actin filament organization, cell migration, and signaling. Its dysregulation has been implicated in various diseases, suggesting its potential as a therapeutic target. Further research is needed to fully understand the functions and pathways of RHOD and its role in maintaining tissue homeostasis.

Genular Protein ID: 3518018872

Symbol: RHOD_HUMAN

Name: Rho-related protein HP1

UniProtKB Accession Codes:

O00212

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 3 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9116026

Title: Isolation of a novel human cDNA (rhoHP1) homologous to rho genes.

PubMed ID: 9116026

DOI: 10.1016/s0167-4781(97)00008-0

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12577064

Title: RhoD regulates endosome dynamics through diaphanous-related formin and Src tyrosine kinase.

PubMed ID: 12577064

DOI: 10.1038/ncb935

PubMed ID: 17064668

Title: Multiple Rho proteins regulate the subcellular targeting of PAK5.

PubMed ID: 17064668

DOI: 10.1016/j.bbrc.2006.09.172

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23087206

Title: RhoD regulates cytoskeletal dynamics via the actin nucleation-promoting factor WASp homologue associated with actin Golgi membranes and microtubules.

PubMed ID: 23087206

DOI: 10.1091/mbc.e12-07-0555

PubMed ID: 23454120

Title: Interaction of RhoD and ZIP kinase modulates actin filament assembly and focal adhesion dynamics.

PubMed ID: 23454120

DOI: 10.1016/j.bbrc.2013.02.046

PubMed ID: 24102721

Title: RhoD binds the Rab5 effector Rabankyrin-5 and has a role in trafficking of the platelet-derived growth factor receptor.

PubMed ID: 24102721

DOI: 10.1111/tra.12121

Sequence Information:

  • Length: 210
  • Mass: 23466
  • Checksum: 7B960AE8863C6DA5
  • Sequence:
    • MTAAQAAGEE APPGVRSVKV VLVGDGGCGK TSLLMVFADG AFPESYTPTV FERYMVNLQV 
KGKPVHLHIW DTAGQDDYDR LRPLFYPDAS VLLLCFDVTS PNSFDNIFNR WYPEVNHFCK 
KVPIIVVGCK TDLRKDKSLV NKLRRNGLEP VTYHRGQEMA RSVGAVAYLE CSARLHDNVH 
AVFQEAAEVA LSSRGRNFWR RITQGFCVVT

Genular Protein ID: 988389667

Symbol: E9PIG5_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PIG5

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SMART 3 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

Sequence Information:

  • Length: 144
  • Mass: 15746
  • Checksum: 20FE503BFEA76A17
  • Sequence:
    • MTAAQAAGEE APPGVRSVKV VLVGDGGCGK TSLLMVFADG AFPEWYPEVN HFCKKVPIIV 
VGCKTDLRKD KSLVNKLRRN GLEPVTYHRG QEMARSVGAV AYLECSARLH DNVHAVFQEA 
AEVALSSRGR NFWRRITQGF CVVT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.