Details for: HAL

Gene ID: 3034

Symbol: HAL

Ensembl ID: ENSG00000084110

Description: histidine ammonia-lyase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 25.4386
    Cell Significance Index: 427.8600
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 11.0579
    Cell Significance Index: -1.7200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 6.5052
    Cell Significance Index: -1.6500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 3.9050
    Cell Significance Index: 65.7800
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 1.6831
    Cell Significance Index: 4.4400
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.4112
    Cell Significance Index: 5.3200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 1.3950
    Cell Significance Index: -1.7200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 1.3032
    Cell Significance Index: 18.2900
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.9967
    Cell Significance Index: 5.7400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9564
    Cell Significance Index: 182.0100
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.7141
    Cell Significance Index: 1.6100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6100
    Cell Significance Index: 60.3500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5571
    Cell Significance Index: 503.0100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.4824
    Cell Significance Index: 7.1200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 0.4435
    Cell Significance Index: -1.7500
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.4379
    Cell Significance Index: 2.9100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3391
    Cell Significance Index: 36.8800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3290
    Cell Significance Index: 53.5100
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.3070
    Cell Significance Index: 1.9600
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.2949
    Cell Significance Index: 0.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2922
    Cell Significance Index: 57.9800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2440
    Cell Significance Index: 14.6500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2336
    Cell Significance Index: 4.8500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2094
    Cell Significance Index: 5.6000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2023
    Cell Significance Index: 13.9900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1835
    Cell Significance Index: 1.6900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1529
    Cell Significance Index: 2.1900
  • Cell Name: T follicular regulatory cell (CL0009113)
    Fold Change: 0.1056
    Cell Significance Index: 0.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0540
    Cell Significance Index: 1.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0373
    Cell Significance Index: 1.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0368
    Cell Significance Index: 1.0600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0346
    Cell Significance Index: 0.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0327
    Cell Significance Index: 17.8500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0318
    Cell Significance Index: 4.6200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0317
    Cell Significance Index: 0.8500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0245
    Cell Significance Index: 0.5300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0216
    Cell Significance Index: 0.5400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0173
    Cell Significance Index: 3.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0155
    Cell Significance Index: 1.9100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0145
    Cell Significance Index: 0.1500
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.0132
    Cell Significance Index: 0.1300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0116
    Cell Significance Index: 3.3300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0086
    Cell Significance Index: 0.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0079
    Cell Significance Index: 0.3600
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.0076
    Cell Significance Index: 0.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0027
    Cell Significance Index: 0.5400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0009
    Cell Significance Index: 1.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0007
    Cell Significance Index: 0.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0003
    Cell Significance Index: 0.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0001
    Cell Significance Index: 0.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0002
    Cell Significance Index: -0.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0008
    Cell Significance Index: -0.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0010
    Cell Significance Index: -1.3700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0021
    Cell Significance Index: -1.5900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0022
    Cell Significance Index: -0.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0024
    Cell Significance Index: -1.7600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0028
    Cell Significance Index: -1.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0028
    Cell Significance Index: -1.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0029
    Cell Significance Index: -1.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0036
    Cell Significance Index: -1.6400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0036
    Cell Significance Index: -0.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0066
    Cell Significance Index: -1.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0070
    Cell Significance Index: -0.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0072
    Cell Significance Index: -0.4400
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0084
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0085
    Cell Significance Index: -1.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0108
    Cell Significance Index: -1.2400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0112
    Cell Significance Index: -0.1600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0124
    Cell Significance Index: -0.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0132
    Cell Significance Index: -1.5600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0144
    Cell Significance Index: -0.4600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0148
    Cell Significance Index: -1.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0156
    Cell Significance Index: -1.6000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0160
    Cell Significance Index: -0.6500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0178
    Cell Significance Index: -1.2600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0195
    Cell Significance Index: -1.2600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0204
    Cell Significance Index: -0.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0206
    Cell Significance Index: -1.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0210
    Cell Significance Index: -0.9900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0220
    Cell Significance Index: -1.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0238
    Cell Significance Index: -1.6000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0258
    Cell Significance Index: -1.1200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0273
    Cell Significance Index: -1.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0273
    Cell Significance Index: -1.5300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0281
    Cell Significance Index: -0.3900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0297
    Cell Significance Index: -0.4900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0306
    Cell Significance Index: -0.7700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0311
    Cell Significance Index: -1.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0331
    Cell Significance Index: -1.1600
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0350
    Cell Significance Index: -0.3200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0377
    Cell Significance Index: -1.2000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0379
    Cell Significance Index: -1.2400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0380
    Cell Significance Index: -0.4700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0394
    Cell Significance Index: -0.7700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0402
    Cell Significance Index: -1.7800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0420
    Cell Significance Index: -1.5400
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0437
    Cell Significance Index: -0.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0442
    Cell Significance Index: -1.1800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0443
    Cell Significance Index: -1.3100
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0446
    Cell Significance Index: -0.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Histidine ammonia-lyase is a cytosolic enzyme belonging to the class of aminotransferases. It is a key component of the histidine catabolic pathway, which is essential for the degradation of histidine. The enzyme has a high affinity for histidine, allowing it to efficiently catalyze the conversion of histidine into glutamate and formamide or formate. HAL is also involved in the metabolism of amino acids and derivatives, underscoring its importance in various cellular processes. **Pathways and Functions:** The histidine catabolic pathway, in which HAL plays a central role, involves the conversion of histidine into glutamate and formamide or formate. This process occurs in the cytosol and is mediated by the enzyme histidine ammonia-lyase. The products of this reaction, glutamate and formamide or formate, can then be further metabolized to produce energy, amino acids, and other essential compounds. HAL is also involved in the regulation of histidine levels in the body, which is critical for maintaining proper amino acid homeostasis. **Clinical Significance:** Histidine ammonia-lyase has been implicated in various diseases and disorders, including neurological and metabolic disorders. For example, alterations in HAL activity have been linked to neurodegenerative diseases such as Alzheimer's and Parkinson's. Additionally, defects in the histidine catabolic pathway, which involve HAL, have been associated with metabolic disorders, such as histidine intolerance. Furthermore, HAL has been shown to play a role in the regulation of histidine levels in the brain, which is essential for maintaining proper cognitive function. **Significantly Expressed Cells:** HAL is significantly expressed in various tissues, including: * Hepatoblasts: liver progenitor cells * Colon goblet cells: epithelial cells in the colon * Periportal region hepatocytes: liver cells surrounding the portal vein * Midzonal region hepatocytes: liver cells in the midzonal region * Kidney proximal convoluted tubule epithelial cells: epithelial cells in the kidney * Glandular epithelial cells: epithelial cells in various glands * Early T lineage precursor: precursor cells to T cells * Cerebral cortex GABAergic interneuron: neurons in the cerebral cortex that use GABA as a neurotransmitter * Forebrain radial glial cell: cells that provide support to neurons during development * Tuft cell of colon: epithelial cells in the colon In conclusion, histidine ammonia-lyase is a crucial enzyme involved in the breakdown of histidine, with significant implications for various cellular processes. Its role in the histidine catabolic pathway, regulation of histidine levels, and involvement in neurological and metabolic disorders underscores its importance as a key enzyme in human biology.

Genular Protein ID: 3019278246

Symbol: HUTH_HUMAN

Name: Histidine ammonia-lyase

UniProtKB Accession Codes:

P42357 B4DQC1 B4E0V8 F5GXF2 F5H1U5 Q4VB92 Q4VB93

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 3 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 10 Ensembl 3 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7916645

Title: Molecular cloning of a cDNA encoding human histidase.

PubMed ID: 7916645

DOI: 10.1016/0167-4781(93)90157-9

PubMed ID: 8530107

Title: Molecular cloning and structural characterization of the human histidase gene (HAL).

PubMed ID: 8530107

DOI: 10.1006/geno.1995.1219

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 15806399

Title: Molecular characterization of histidinemia: identification of four missense mutations in the histidase gene.

PubMed ID: 15806399

DOI: 10.1007/s00439-004-1232-5

Sequence Information:

  • Length: 657
  • Mass: 72698
  • Checksum: 6B9FF97C066FB8F1
  • Sequence:
    • MPRYTVHVRG EWLAVPCQDA QLTVGWLGRE AVRRYIKNKP DNGGFTSVDD AHFLVRRCKG 
LGLLDNEDRL EVALENNEFV EVVIEGDAMS PDFIPSQPEG VYLYSKYREP EKYIELDGDR 
LTTEDLVNLG KGRYKIKLTP TAEKRVQKSR EVIDSIIKEK TVVYGITTGF GKFARTVIPI 
NKLQELQVNL VRSHSSGVGK PLSPERCRML LALRINVLAK GYSGISLETL KQVIEMFNAS 
CLPYVPEKGT VGASGDLAPL SHLALGLVGE GKMWSPKSGW ADAKYVLEAH GLKPVILKPK 
EGLALINGTQ MITSLGCEAV ERASAIARQA DIVAALTLEV LKGTTKAFDT DIHALRPHRG 
QIEVAFRFRS LLDSDHHPSE IAESHRFCDR VQDAYTLRCC PQVHGVVNDT IAFVKNIITT 
ELNSATDNPM VFANRGETVS GGNFHGEYPA KALDYLAIGI HELAAISERR IERLCNPSLS 
ELPAFLVAEG GLNSGFMIAH CTAAALVSEN KALCHPSSVD SLSTSAATED HVSMGGWAAR 
KALRVIEHVE QVLAIELLAA CQGIEFLRPL KTTTPLEKVY DLVRSVVRPW IKDRFMAPDI 
EAAHRLLLEQ KVWEVAAPYI EKYRMEHIPE SRPLSPTAFS LQFLHKKSTK IPESEDL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.