Details for: HAL

Gene ID: 3034

Symbol: HAL

Ensembl ID: ENSG00000084110

Description: histidine ammonia-lyase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 5.14
    Marker Score: 16832
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1171
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.49
    Marker Score: 8034
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.45
    Marker Score: 6249
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.32
    Marker Score: 2722
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.09
    Marker Score: 2687.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 798
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71832
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48057
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.95
    Marker Score: 645
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.94
    Marker Score: 388
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5335
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 696
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2924
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.68
    Marker Score: 4361
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.6
    Marker Score: 412
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.57
    Marker Score: 364.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.53
    Marker Score: 569
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.49
    Marker Score: 926
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.48
    Marker Score: 181
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.48
    Marker Score: 299
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.38
    Marker Score: 885
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.38
    Marker Score: 934
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.33
    Marker Score: 666
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.3
    Marker Score: 304
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.28
    Marker Score: 4396
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.27
    Marker Score: 83
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.26
    Marker Score: 161
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.26
    Marker Score: 14286
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.24
    Marker Score: 61
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.24
    Marker Score: 568
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.23
    Marker Score: 226
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.22
    Marker Score: 139
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.21
    Marker Score: 80
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.21
    Marker Score: 56
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.21
    Marker Score: 97
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.2
    Marker Score: 118
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.2
    Marker Score: 62
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.19
    Marker Score: 121
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.19
    Marker Score: 96
  • Cell Name: T follicular regulatory cell (CL0009113)
    Fold Change: 0.18
    Marker Score: 50
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.17
    Marker Score: 694.5
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.16
    Marker Score: 67
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.15
    Marker Score: 44
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.15
    Marker Score: 41
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.14
    Marker Score: 84
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.14
    Marker Score: 45
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.14
    Marker Score: 43
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.14
    Marker Score: 34
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.13
    Marker Score: 202
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.12
    Marker Score: 58
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.12
    Marker Score: 326
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.11
    Marker Score: 221
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.11
    Marker Score: 99
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.11
    Marker Score: 111
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.11
    Marker Score: 56
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.1
    Marker Score: 165
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.1
    Marker Score: 45
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.1
    Marker Score: 58
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.1
    Marker Score: 127
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.1
    Marker Score: 45
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.09
    Marker Score: 30
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.09
    Marker Score: 18
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.09
    Marker Score: 49
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.08
    Marker Score: 58
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.08
    Marker Score: 982
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.08
    Marker Score: 41
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.08
    Marker Score: 35
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.08
    Marker Score: 40
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.08
    Marker Score: 144
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.08
    Marker Score: 46
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.08
    Marker Score: 35
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.07
    Marker Score: 72
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.07
    Marker Score: 35
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.07
    Marker Score: 223
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.07
    Marker Score: 76
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.07
    Marker Score: 441
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.07
    Marker Score: 26
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.06
    Marker Score: 36
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.06
    Marker Score: 2229
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.06
    Marker Score: 1029

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Other Information

**Key characteristics:** * Gene name: HAL * Ensembl ID: ENSG00000084110 * Protein: HUTH_HUMAN (Histidine ammonia-lyase) * Pathway: Histidine catabolic process * Expression: Highly expressed in hepatoblast, colon goblet cell, periportal region hepatocyte, midzonal region hepatocyte, kidney proximal convoluted tubule epithelial cell, glandular epithelial cell, early T lineage precursor, cerebral cortex GABAergic interneuron, forebrain radial glial cell, and tuft cell of colon **Pathways and functions:** * **Histidine catabolic process:** The HAL gene is involved in the catabolism of histidine, a precursor to various metabolites, including glutamate and formate. * **Histidine catabolic process to glutamate and formate:** This pathway is responsible for the deamination of histidine to glutamate and the subsequent production of formate. * **Histidine catabolism:** The HAL gene also participates in the overall metabolism of histidine, including the conversion of histidine to ornithine and the subsequent synthesis of urea. **Clinical significance:** Mutations in the HAL gene have been linked to several human diseases, including hepatic disorders and neurological conditions. For example, mutations in the HAL gene have been associated with hepatic fibrosis, cirrhosis, and hepatocellular carcinoma. Furthermore, mutations in the HAL gene have been linked to the development of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases.

Genular Protein ID: 3019278246

Symbol: HUTH_HUMAN

Name: Histidine ammonia-lyase

UniProtKB Accession Codes:

P42357 B4DQC1 B4E0V8 F5GXF2 F5H1U5 Q4VB92 Q4VB93

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 3 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 10 Ensembl 3 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7916645

Title: Molecular cloning of a cDNA encoding human histidase.

PubMed ID: 7916645

DOI: 10.1016/0167-4781(93)90157-9

PubMed ID: 8530107

Title: Molecular cloning and structural characterization of the human histidase gene (HAL).

PubMed ID: 8530107

DOI: 10.1006/geno.1995.1219

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 15806399

Title: Molecular characterization of histidinemia: identification of four missense mutations in the histidase gene.

PubMed ID: 15806399

DOI: 10.1007/s00439-004-1232-5

Sequence Information:

  • Length: 657
  • Mass: 72698
  • Checksum: 6B9FF97C066FB8F1
  • Sequence:
    • MPRYTVHVRG EWLAVPCQDA QLTVGWLGRE AVRRYIKNKP DNGGFTSVDD AHFLVRRCKG 
LGLLDNEDRL EVALENNEFV EVVIEGDAMS PDFIPSQPEG VYLYSKYREP EKYIELDGDR 
LTTEDLVNLG KGRYKIKLTP TAEKRVQKSR EVIDSIIKEK TVVYGITTGF GKFARTVIPI 
NKLQELQVNL VRSHSSGVGK PLSPERCRML LALRINVLAK GYSGISLETL KQVIEMFNAS 
CLPYVPEKGT VGASGDLAPL SHLALGLVGE GKMWSPKSGW ADAKYVLEAH GLKPVILKPK 
EGLALINGTQ MITSLGCEAV ERASAIARQA DIVAALTLEV LKGTTKAFDT DIHALRPHRG 
QIEVAFRFRS LLDSDHHPSE IAESHRFCDR VQDAYTLRCC PQVHGVVNDT IAFVKNIITT 
ELNSATDNPM VFANRGETVS GGNFHGEYPA KALDYLAIGI HELAAISERR IERLCNPSLS 
ELPAFLVAEG GLNSGFMIAH CTAAALVSEN KALCHPSSVD SLSTSAATED HVSMGGWAAR 
KALRVIEHVE QVLAIELLAA CQGIEFLRPL KTTTPLEKVY DLVRSVVRPW IKDRFMAPDI 
EAAHRLLLEQ KVWEVAAPYI EKYRMEHIPE SRPLSPTAFS LQFLHKKSTK IPESEDL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.