Details for: CFH
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 180.0762
Cell Significance Index: -28.0100 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 106.1727
Cell Significance Index: -26.9300 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 54.0239
Cell Significance Index: -22.2600 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 51.4061
Cell Significance Index: -24.2700 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 22.7218
Cell Significance Index: -28.0200 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 18.9736
Cell Significance Index: 319.6100 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 8.8894
Cell Significance Index: 60.2300 - Cell Name: liver dendritic cell (CL2000055)
Fold Change: 8.3379
Cell Significance Index: 22.0000 - Cell Name: theca cell (CL0000503)
Fold Change: 7.2902
Cell Significance Index: 42.8300 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 6.9411
Cell Significance Index: -27.3900 - Cell Name: odontoblast (CL0000060)
Fold Change: 5.9378
Cell Significance Index: 761.1900 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 5.2616
Cell Significance Index: 75.5600 - Cell Name: preadipocyte (CL0002334)
Fold Change: 4.1353
Cell Significance Index: 80.7100 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 3.0786
Cell Significance Index: 88.2500 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 2.5205
Cell Significance Index: 14.5200 - Cell Name: keratocyte (CL0002363)
Fold Change: 2.2093
Cell Significance Index: 35.0500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 2.2089
Cell Significance Index: 271.6000 - Cell Name: hepatoblast (CL0005026)
Fold Change: 2.0756
Cell Significance Index: 34.9100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 2.0316
Cell Significance Index: 366.2400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.8563
Cell Significance Index: 368.3800 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 1.7422
Cell Significance Index: 88.0500 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.2595
Cell Significance Index: 18.5900 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.9408
Cell Significance Index: 48.8700 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.5059
Cell Significance Index: 13.7700 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.3182
Cell Significance Index: 2.9300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1213
Cell Significance Index: 3.3900 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.0446
Cell Significance Index: 0.6900 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.0440
Cell Significance Index: 0.5000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0279
Cell Significance Index: 52.5800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0023
Cell Significance Index: 1.2300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0060
Cell Significance Index: -3.8300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0117
Cell Significance Index: -6.5800 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0160
Cell Significance Index: -11.8200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0174
Cell Significance Index: -13.1900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0183
Cell Significance Index: -33.7300 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0194
Cell Significance Index: -12.1200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0217
Cell Significance Index: -33.4200 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0253
Cell Significance Index: -34.3900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0263
Cell Significance Index: -11.9500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0290
Cell Significance Index: -21.2800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0297
Cell Significance Index: -4.0800 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.0515
Cell Significance Index: -0.5600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0710
Cell Significance Index: -25.4700 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0729
Cell Significance Index: -8.5000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0780
Cell Significance Index: -13.3200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0854
Cell Significance Index: -24.5800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0902
Cell Significance Index: -13.1100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0939
Cell Significance Index: -19.7700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.1100
Cell Significance Index: -22.0800 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1432
Cell Significance Index: -14.6300 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1605
Cell Significance Index: -2.1900 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1701
Cell Significance Index: -21.9800 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1871
Cell Significance Index: -19.4800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1960
Cell Significance Index: -9.2100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1983
Cell Significance Index: -23.3900 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2069
Cell Significance Index: -23.6200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2202
Cell Significance Index: -25.2300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2225
Cell Significance Index: -17.0800 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.2247
Cell Significance Index: -3.9700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2698
Cell Significance Index: -20.1100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2898
Cell Significance Index: -13.5100 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.3059
Cell Significance Index: -5.1200 - Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: -0.3372
Cell Significance Index: -1.2700 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.3701
Cell Significance Index: -23.8800 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -0.3740
Cell Significance Index: -5.6900 - Cell Name: fibroblast of breast (CL4006000)
Fold Change: -0.3769
Cell Significance Index: -2.3700 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.4002
Cell Significance Index: -24.6000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4048
Cell Significance Index: -24.8200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.4079
Cell Significance Index: -27.4300 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.4299
Cell Significance Index: -10.4900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.4312
Cell Significance Index: -27.1800 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.4494
Cell Significance Index: -5.7600 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.4753
Cell Significance Index: -14.0000 - Cell Name: respiratory goblet cell (CL0002370)
Fold Change: -0.4779
Cell Significance Index: -4.9300 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.5253
Cell Significance Index: -19.2900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.5569
Cell Significance Index: -31.2500 - Cell Name: preosteoblast (CL0007010)
Fold Change: -0.5675
Cell Significance Index: -5.1500 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.5754
Cell Significance Index: -14.7000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.6303
Cell Significance Index: -33.1000 - Cell Name: skin fibroblast (CL0002620)
Fold Change: -0.6323
Cell Significance Index: -1.4600 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.6369
Cell Significance Index: -5.3500 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.6377
Cell Significance Index: -22.1600 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.7050
Cell Significance Index: -20.7100 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.7245
Cell Significance Index: -23.7200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.7400
Cell Significance Index: -32.7300 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.7546
Cell Significance Index: -26.4400 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.7683
Cell Significance Index: -11.0500 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.7801
Cell Significance Index: -18.9000 - Cell Name: connective tissue cell (CL0002320)
Fold Change: -0.7966
Cell Significance Index: -7.6800 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.8369
Cell Significance Index: -17.0300 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.8401
Cell Significance Index: -20.9500 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: -0.8473
Cell Significance Index: -8.7400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.8662
Cell Significance Index: -32.8000 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.8754
Cell Significance Index: -27.8800 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.8882
Cell Significance Index: -23.8000 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.8886
Cell Significance Index: -22.8400 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: -0.8890
Cell Significance Index: -5.4900 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.8920
Cell Significance Index: -38.7900 - Cell Name: fibroblast (CL0000057)
Fold Change: -0.9539
Cell Significance Index: -8.9600 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.9606
Cell Significance Index: -25.2600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 397786447
Symbol: CFAH_HUMAN
Name: Complement factor H
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2963625
Title: The complete amino acid sequence of human complement factor H.
PubMed ID: 2963625
DOI: 10.1042/bj2490593
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2946589
Title: Human complement factor H: isolation of cDNA clones and partial cDNA sequence of the 38-kDa tryptic fragment containing the binding site for C3b.
PubMed ID: 2946589
PubMed ID: 2937845
Title: Structural analysis of human complement protein H: homology with C4b binding protein, beta 2-glycoprotein I, and the Ba fragment of B2.
PubMed ID: 2937845
PubMed ID: 1826708
Title: Cloning of the 1.4-kb mRNA species of human complement factor H reveals a novel member of the short consensus repeat family related to the carboxy terminal of the classical 150-kDa molecule.
PubMed ID: 1826708
PubMed ID: 6215918
Title: Purification and structural studies on the complement-system control protein beta 1H (Factor H).
PubMed ID: 6215918
DOI: 10.1042/bj2050285
PubMed ID: 6444659
Title: Biosynthesis of the complement components and the regulatory proteins of the alternative complement pathway by human peripheral blood monocytes.
PubMed ID: 6444659
PubMed ID: 2968404
Title: Synthesis and regulation of complement protein factor H in human skin fibroblasts.
PubMed ID: 2968404
PubMed ID: 2139673
Title: Differential regulation of complement factor H and C3 production in human umbilical vein endothelial cells by IFN-gamma and IL-1.
PubMed ID: 2139673
PubMed ID: 9558116
Title: Human polymorphonuclear leukocytes adhere to complement factor H through an interaction that involves alphaMbeta2 (CD11b/CD18).
PubMed ID: 9558116
PubMed ID: 14760718
Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.
PubMed ID: 14760718
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 17591618
Title: Site-specific N-glycan characterization of human complement factor H.
PubMed ID: 17591618
PubMed ID: 19112495
Title: The Staphylococcus aureus protein Sbi acts as a complement inhibitor and forms a tripartite complex with host complement Factor H and C3b.
PubMed ID: 19112495
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 19139490
Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.
PubMed ID: 19139490
PubMed ID: 19838169
Title: Enrichment of glycopeptides for glycan structure and attachment site identification.
PubMed ID: 19838169
DOI: 10.1038/nmeth.1392
PubMed ID: 20008295
Title: Factor H and factor H-related protein 1 bind to human neutrophils via complement receptor 3, mediate attachment to Candida albicans, and enhance neutrophil antimicrobial activity.
PubMed ID: 20008295
PubMed ID: 23332154
Title: Malaria parasites co-opt human factor H to prevent complement-mediated lysis in the mosquito midgut.
PubMed ID: 23332154
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25136834
Title: Complement factor H, vitronectin, and opticin are tyrosine-sulfated proteins of the retinal pigment epithelium.
PubMed ID: 25136834
PubMed ID: 26700768
Title: Recruitment of Factor H as a Novel Complement Evasion Strategy for Blood-Stage Plasmodium falciparum Infection.
PubMed ID: 26700768
PubMed ID: 1829116
Title: Three-dimensional structure of a complement control protein module in solution.
PubMed ID: 1829116
PubMed ID: 1533152
Title: Solution structure of the fifth repeat of factor H: a second example of the complement control protein module.
PubMed ID: 1533152
DOI: 10.1021/bi00129a011
PubMed ID: 8331663
Title: Solution structure of a pair of complement modules by nuclear magnetic resonance.
PubMed ID: 8331663
PubMed ID: 9312129
Title: Human factor H deficiency. Mutations in framework cysteine residues and block in H protein secretion and intracellular catabolism.
PubMed ID: 9312129
PubMed ID: 9551389
Title: Genetic studies into inherited and sporadic hemolytic uremic syndrome.
PubMed ID: 9551389
PubMed ID: 10577907
Title: Complement factor H gene mutation associated with autosomal recessive atypical hemolytic uremic syndrome.
PubMed ID: 10577907
DOI: 10.1086/302673
PubMed ID: 10762557
Title: Complement factor H gene mutation associated with autosomal recessive atypical hemolytic uremic syndrome.
PubMed ID: 10762557
DOI: 10.1086/302877
PubMed ID: 10803850
Title: Molecular basis for factor H and FHL-1 deficiency in an Italian family.
PubMed ID: 10803850
PubMed ID: 11170895
Title: Clustering of missense mutations in the C-terminal region of factor H in atypical hemolytic uremic syndrome.
PubMed ID: 11170895
DOI: 10.1086/318201
PubMed ID: 11170896
Title: Factor H mutations in hemolytic uremic syndrome cluster in exons 18-20, a domain important for host cell recognition.
PubMed ID: 11170896
DOI: 10.1086/318203
PubMed ID: 11158219
Title: The molecular basis of familial hemolytic uremic syndrome: mutation analysis of factor H gene reveals a hot spot in short consensus repeat 20.
PubMed ID: 11158219
DOI: 10.1681/asn.v122297
PubMed ID: 11851332
Title: Molecular modelling of the C-terminal domains of factor H of human complement: a correlation between haemolytic uraemic syndrome and a predicted heparin binding site.
PubMed ID: 11851332
PubMed ID: 12020532
Title: Combined kidney and liver transplantation for familial haemolytic uraemic syndrome.
PubMed ID: 12020532
PubMed ID: 14583443
Title: Complement factor H mutations and gene polymorphisms in haemolytic uraemic syndrome: the C-257T, the A2089G and the G2881T polymorphisms are strongly associated with the disease.
PubMed ID: 14583443
DOI: 10.1093/hmg/ddg363
PubMed ID: 12960213
Title: Haemolytic uraemic syndrome and mutations of the factor H gene: a registry-based study of German speaking countries.
PubMed ID: 12960213
DOI: 10.1136/jmg.40.9.676
PubMed ID: 14978182
Title: Heterozygous and homozygous factor H deficiencies associated with hemolytic uremic syndrome or membranoproliferative glomerulonephritis: report and genetic analysis of 16 cases.
PubMed ID: 14978182
PubMed ID: 15895326
Title: Strong association of the Y402H variant in complement factor H at 1q32 with susceptibility to age-related macular degeneration.
PubMed ID: 15895326
DOI: 10.1086/431426
PubMed ID: 15870199
Title: A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration.
PubMed ID: 15870199
PubMed ID: 15761122
Title: Complement factor H polymorphism in age-related macular degeneration.
PubMed ID: 15761122
PubMed ID: 15761120
Title: Complement factor H variant increases the risk of age-related macular degeneration.
PubMed ID: 15761120
PubMed ID: 15761121
Title: Complement factor H polymorphism and age-related macular degeneration.
PubMed ID: 15761121
PubMed ID: 16612335
Title: Deletion of Lys224 in regulatory domain 4 of factor H reveals a novel pathomechanism for dense deposit disease (MPGN II).
PubMed ID: 16612335
PubMed ID: 17132743
Title: West Nile virus nonstructural protein NS1 inhibits complement activation by binding the regulatory protein factor H.
PubMed ID: 17132743
PubMed ID: 18252232
Title: Basal laminar drusen caused by compound heterozygous variants in the CFH gene.
PubMed ID: 18252232
PubMed ID: 20513133
Title: Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome.
PubMed ID: 20513133
DOI: 10.1002/humu.21256
PubMed ID: 22028381
Title: Quantitative detection of single amino acid polymorphisms by targeted proteomics.
PubMed ID: 22028381
DOI: 10.1093/jmcb/mjr024
PubMed ID: 22019782
Title: A rare penetrant mutation in CFH confers high risk of age-related macular degeneration.
PubMed ID: 22019782
DOI: 10.1038/ng.976
PubMed ID: 16601698
Title: Structure of complement factor H carboxyl-terminus reveals molecular basis of atypical haemolytic uremic syndrome.
PubMed ID: 16601698
PubMed ID: 17360715
Title: Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism.
PubMed ID: 17360715
PubMed ID: 17893204
Title: Structural basis for complement factor H linked age-related macular degeneration.
PubMed ID: 17893204
DOI: 10.1084/jem.20071069
PubMed ID: 18252712
Title: Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations.
PubMed ID: 18252712
PubMed ID: 18005991
Title: The regulatory SCR-1/5 and cell surface-binding SCR-16/20 fragments of factor H reveal partially folded-back solution structures and different self-associative properties.
PubMed ID: 18005991
PubMed ID: 19505476
Title: Electrostatic interactions contribute to the folded-back conformation of wild type human factor H.
PubMed ID: 19505476
PubMed ID: 19503104
Title: Structure of complement fragment C3b-factor H and implications for host protection by complement regulators.
PubMed ID: 19503104
DOI: 10.1038/ni.1755
PubMed ID: 19225461
Title: Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates.
PubMed ID: 19225461
DOI: 10.1038/nature07769
PubMed ID: 19835885
Title: The central portion of factor H (modules 10-15) is compact and contains a structurally deviant CCP module.
PubMed ID: 19835885
PubMed ID: 20378178
Title: Both domain 19 and domain 20 of factor H are involved in binding to complement C3b and C3d.
PubMed ID: 20378178
PubMed ID: 21285368
Title: Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement.
PubMed ID: 21285368
PubMed ID: 23133374
Title: Design and evaluation of meningococcal vaccines through structure-based modification of host and pathogen molecules.
PubMed ID: 23133374
PubMed ID: 23017427
Title: Solution structure of CCP modules 10-12 illuminates functional architecture of the complement regulator, factor H.
PubMed ID: 23017427
PubMed ID: 22389686
Title: Structural analysis of the C-terminal region (modules 18-20) of complement regulator factor H (FH).
PubMed ID: 22389686
PubMed ID: 23658013
Title: Structural basis for complement evasion by Lyme disease pathogen Borrelia burgdorferi.
PubMed ID: 23658013
PubMed ID: 23204165
Title: Glycerol-3-phosphate dehydrogenase 2 is a novel factor H-, factor H-like protein 1-, and plasminogen-binding surface protein of Candida albicans.
PubMed ID: 23204165
PubMed ID: 25330773
Title: Structural determinants of host specificity of complement Factor H recruitment by Streptococcus pneumoniae.
PubMed ID: 25330773
DOI: 10.1042/bj20141069
PubMed ID: 25402769
Title: Structural basis for sialic acid-mediated self-recognition by complement factor H.
PubMed ID: 25402769
PubMed ID: 28258151
Title: Staphylococcus aureus SdrE captures complement factor H's C-terminus via a novel 'close, dock, lock and latch' mechanism for complement evasion.
PubMed ID: 28258151
DOI: 10.1042/bcj20170085
PubMed ID: 28671664
Title: Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses.
PubMed ID: 28671664
DOI: 10.1038/nsmb.3427
PubMed ID: 29190743
Title: Crystal structure of a tripartite complex between C3dg, C-terminal domains of factor H and OspE of Borrelia burgdorferi.
PubMed ID: 29190743
PubMed ID: 34986357
Title: Estrogen promotes innate immune evasion of Candida albicans through inactivation of the alternative complement system.
PubMed ID: 34986357
Sequence Information:
- Length: 1231
- Mass: 139096
- Checksum: 3C26D62A2BF9BFEE
- Sequence:
MRLLAKIICL MLWAICVAED CNELPPRRNT EILTGSWSDQ TYPEGTQAIY KCRPGYRSLG NVIMVCRKGE WVALNPLRKC QKRPCGHPGD TPFGTFTLTG GNVFEYGVKA VYTCNEGYQL LGEINYRECD TDGWTNDIPI CEVVKCLPVT APENGKIVSS AMEPDREYHF GQAVRFVCNS GYKIEGDEEM HCSDDGFWSK EKPKCVEISC KSPDVINGSP ISQKIIYKEN ERFQYKCNMG YEYSERGDAV CTESGWRPLP SCEEKSCDNP YIPNGDYSPL RIKHRTGDEI TYQCRNGFYP ATRGNTAKCT STGWIPAPRC TLKPCDYPDI KHGGLYHENM RRPYFPVAVG KYYSYYCDEH FETPSGSYWD HIHCTQDGWS PAVPCLRKCY FPYLENGYNQ NYGRKFVQGK SIDVACHPGY ALPKAQTTVT CMENGWSPTP RCIRVKTCSK SSIDIENGFI SESQYTYALK EKAKYQCKLG YVTADGETSG SITCGKDGWS AQPTCIKSCD IPVFMNARTK NDFTWFKLND TLDYECHDGY ESNTGSTTGS IVCGYNGWSD LPICYERECE LPKIDVHLVP DRKKDQYKVG EVLKFSCKPG FTIVGPNSVQ CYHFGLSPDL PICKEQVQSC GPPPELLNGN VKEKTKEEYG HSEVVEYYCN PRFLMKGPNK IQCVDGEWTT LPVCIVEEST CGDIPELEHG WAQLSSPPYY YGDSVEFNCS ESFTMIGHRS ITCIHGVWTQ LPQCVAIDKL KKCKSSNLII LEEHLKNKKE FDHNSNIRYR CRGKEGWIHT VCINGRWDPE VNCSMAQIQL CPPPPQIPNS HNMTTTLNYR DGEKVSVLCQ ENYLIQEGEE ITCKDGRWQS IPLCVEKIPC SQPPQIEHGT INSSRSSQES YAHGTKLSYT CEGGFRISEE NETTCYMGKW SSPPQCEGLP CKSPPEISHG VVAHMSDSYQ YGEEVTYKCF EGFGIDGPAI AKCLGEKWSH PPSCIKTDCL SLPSFENAIP MGEKKDVYKA GEQVTYTCAT YYKMDGASNV TCINSRWTGR PTCRDTSCVN PPTVQNAYIV SRQMSKYPSG ERVRYQCRSP YEMFGDEEVM CLNGNWTEPP QCKDSTGKCG PPPPIDNGDI TSFPLSVYAP ASSVEYQCQN LYQLEGNKRI TCRNGQWSEP PKCLHPCVIS REIMENYNIA LRWTAKQKLY SRTGESVEFV CKRGYRLSSR SHTLRTTCWD GKLEYPTCAK R
Genular Protein ID: 3465716094
Symbol: A0A0D9SG88_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 449
- Mass: 51008
- Checksum: A9C77F0F155343F7
- Sequence:
MRLLAKIICL MLWAICVAED CNELPPRRNT EILTGSWSDQ TYPEGTQAIY KCRPGYRSLG NVIMVCRKGE WVALNPLRKC QKRPCGHPGD TPFGTFTLTG GNVFEYGVKA VYTCNEGYQL LGEINYRECD TDGWTNDIPI CEVVKCLPVT APENGKIVSS AMEPDREYHF GQAVRFVCNS GYKIEGDEEM HCSDDGFWSK EKPKCVEISC KSPDVINGSP ISQKIIYKEN ERFQYKCNMG YEYSERGDAV CTESGWRPLP SCEEKSCDNP YIPNGDYSPL RIKHRTGDEI TYQCRNGFYP ATRGNTAKCT STGWIPAPRC TLKPCDYPDI KHGGLYHENM RRPYFPVAVG KYYSYYCDEH FETPSGSYWD HIHCTQDGWS PAVPCLRKCY FPYLENGYNQ NHGRKFVQGK SIDVACHPGY ALPKAQTTVT CMENGWSPTP RCIRVSFTL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.