Details for: HUNK

Gene ID: 30811

Symbol: HUNK

Ensembl ID: ENSG00000142149

Description: hormonally up-regulated Neu-associated kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 148.4456
    Cell Significance Index: -23.0900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 91.9007
    Cell Significance Index: -23.3100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.9955
    Cell Significance Index: -21.0000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 5.1885
    Cell Significance Index: 113.6100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.6644
    Cell Significance Index: 45.4500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.3440
    Cell Significance Index: -5.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.2174
    Cell Significance Index: 440.0500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.3893
    Cell Significance Index: 33.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.1922
    Cell Significance Index: 66.9000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.0958
    Cell Significance Index: 31.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0815
    Cell Significance Index: 216.9400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.0232
    Cell Significance Index: 62.8900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8270
    Cell Significance Index: 157.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6926
    Cell Significance Index: 68.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.6690
    Cell Significance Index: 44.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5888
    Cell Significance Index: 26.6900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3768
    Cell Significance Index: 10.8600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3677
    Cell Significance Index: 40.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3534
    Cell Significance Index: 57.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3423
    Cell Significance Index: 122.7800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2341
    Cell Significance Index: 211.4000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2278
    Cell Significance Index: 157.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1895
    Cell Significance Index: 8.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1656
    Cell Significance Index: 2.2600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1616
    Cell Significance Index: 2.7700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1317
    Cell Significance Index: 58.2400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1225
    Cell Significance Index: 2.3900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1128
    Cell Significance Index: 4.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1041
    Cell Significance Index: 2.9100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0823
    Cell Significance Index: 5.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0714
    Cell Significance Index: 1.5200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0709
    Cell Significance Index: 1.4700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0685
    Cell Significance Index: 129.0300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.0682
    Cell Significance Index: 0.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0644
    Cell Significance Index: 11.6100
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.0593
    Cell Significance Index: 0.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0555
    Cell Significance Index: 1.9500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0466
    Cell Significance Index: 1.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0198
    Cell Significance Index: 36.4300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0180
    Cell Significance Index: 11.4600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0151
    Cell Significance Index: 0.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0146
    Cell Significance Index: 2.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0118
    Cell Significance Index: 18.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0019
    Cell Significance Index: 2.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0138
    Cell Significance Index: -2.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0301
    Cell Significance Index: -22.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0312
    Cell Significance Index: -17.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0321
    Cell Significance Index: -24.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0325
    Cell Significance Index: -24.0800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0415
    Cell Significance Index: -0.6000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0419
    Cell Significance Index: -26.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0453
    Cell Significance Index: -20.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0463
    Cell Significance Index: -26.0900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0469
    Cell Significance Index: -2.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0586
    Cell Significance Index: -16.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0612
    Cell Significance Index: -6.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0727
    Cell Significance Index: -8.9400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0748
    Cell Significance Index: -1.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0932
    Cell Significance Index: -10.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1190
    Cell Significance Index: -15.2600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1306
    Cell Significance Index: -27.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1418
    Cell Significance Index: -16.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1442
    Cell Significance Index: -19.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1791
    Cell Significance Index: -23.1400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1856
    Cell Significance Index: -4.7700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1923
    Cell Significance Index: -10.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1925
    Cell Significance Index: -5.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1988
    Cell Significance Index: -20.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2106
    Cell Significance Index: -16.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2123
    Cell Significance Index: -25.0400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2340
    Cell Significance Index: -5.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2528
    Cell Significance Index: -15.5000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2572
    Cell Significance Index: -18.1900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2613
    Cell Significance Index: -8.3700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2647
    Cell Significance Index: -8.4300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2817
    Cell Significance Index: -5.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2863
    Cell Significance Index: -14.8700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2996
    Cell Significance Index: -23.7300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3108
    Cell Significance Index: -6.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3117
    Cell Significance Index: -23.2300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3928
    Cell Significance Index: -24.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3952
    Cell Significance Index: -25.5000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.4029
    Cell Significance Index: -2.7300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4156
    Cell Significance Index: -8.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4305
    Cell Significance Index: -20.0700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4334
    Cell Significance Index: -14.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4334
    Cell Significance Index: -20.3700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4389
    Cell Significance Index: -15.2500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4767
    Cell Significance Index: -16.7000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4953
    Cell Significance Index: -8.2900
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.5066
    Cell Significance Index: -4.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5496
    Cell Significance Index: -14.9600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5536
    Cell Significance Index: -15.8700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.5713
    Cell Significance Index: -5.4200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.5828
    Cell Significance Index: -8.7800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.5863
    Cell Significance Index: -6.8400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6167
    Cell Significance Index: -16.2200
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.6261
    Cell Significance Index: -5.6600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.6286
    Cell Significance Index: -3.7300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.6567
    Cell Significance Index: -7.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Key characteristics of the HUNK gene include: 1. **Serine/threonine kinase activity**: HUNK is a protein kinase that phosphorylates serine and threonine residues on target proteins, influencing their activity and localization. 2. **Hormone-regulated expression**: The gene is up-regulated by hormones, indicating a potential role in cellular responses to hormonal signals. 3. **Nervous system and immune system expression**: HUNK is highly expressed in cells of the nervous system, immune system, and other tissues, suggesting its involvement in cellular signaling and regulation. 4. **Cellular localization**: The gene is localized to the cytoplasm and nucleus, where it can interact with other proteins and influence signaling pathways. **Pathways and Functions** HUNK is involved in several signaling pathways, including: 1. **Intracellular signal transduction**: HUNK phosphorylates and regulates proteins involved in intracellular signaling, influencing cellular responses to hormonal signals. 2. **Phosphorylation**: The kinase activity of HUNK phosphorylates serine and threonine residues on target proteins, influencing their activity and localization. 3. **Protein binding**: HUNK interacts with other proteins, influencing their activity and localization. 4. **ATP binding**: The gene is involved in ATP binding and utilization, suggesting a role in energy metabolism and cellular signaling. **Clinical Significance** The clinical significance of the HUNK gene is not yet fully understood, but its involvement in various cellular processes suggests potential implications for: 1. **Neurological disorders**: HUNK's expression in nervous system cells suggests its potential role in neurological disorders, such as neurodegenerative diseases and developmental disorders. 2. **Immune system disorders**: The gene's expression in immune system cells implies its potential role in immune system disorders, such as autoimmune diseases and immunodeficiency disorders. 3. **Cancer**: HUNK's kinase activity and expression in various tissues suggest its potential role in cancer development and progression. 4. **Hormonal disorders**: The gene's hormone-regulated expression suggests its potential role in hormonal disorders, such as hormone-sensitive cancers and metabolic disorders. Further research is needed to fully understand the clinical significance of the HUNK gene and its role in various cellular processes.

Genular Protein ID: 689583959

Symbol: HUNK_HUMAN

Name: Hormonally up-regulated neu tumor-associated kinase

UniProtKB Accession Codes:

P57058

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 3 EMBL 1 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 714
  • Mass: 79686
  • Checksum: 87FC85C67D838AA7
  • Sequence:
    • MPAAAGDGLL GEPAAPGGGG GAEDAARPAA ACEGSFLPAW VSGVPRERLR DFQHHKRVGN 
YLIGSRKLGE GSFAKVREGL HVLTGEKVAI KVIDKKRAKK DTYVTKNLRR EGQIQQMIRH 
PNITQLLDIL ETENSYYLVM ELCPGGNLMH KIYEKKRLEE SEARRYIRQL ISAVEHLHRA 
GVVHRDLKIE NLLLDEDNNI KLIDFGLSNC AGILGYSDPF STQCGSPAYA APELLARKKY 
GPKIDVWSIG VNMYAMLTGT LPFTVEPFSL RALYQKMVDK EMNPLPTQLS TGAISFLRSL 
LEPDPVKRPN IQQALANRWL NENYTGKVPC NVTYPNRISL EDLSPSVVLH MTEKLGYKNS 
DVINTVLSNR ACHILAIYFL LNKKLERYLS GKSDIQDSLC YKTRLYQIEK YRAPKESYEA 
SLDTWTRDLE FHAVQDKKPK EQEKRGDFLH RPFSKKLDKN LPSHKQPSGS LMTQIQNTKA 
LLKDRKASKS SFPDKDSFGC RNIFRKTSDS NCVASSSMEF IPVPPPRTPR IVKKPEPHQP 
GPGSTGIPHK EDPLMLDMVR SFESVDRDDH VEVLSPSHHY RILNSPVSLA RRNSSERTLS 
PGLPSGSMSP LHTPLHPTLV SFAHEDKNSP PKEEGLCCPP PVPSNGPMQP LGSPNCVKSR 
GRFPMMGIGQ MLRKRHQSLQ PSADRPLEAS LPPLQPLAPV NLAFDMADGV KTQC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.