Details for: ADGRE2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 22.3011
Cell Significance Index: -9.0600 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 18.6825
Cell Significance Index: -9.6100 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 3.1871
Cell Significance Index: 49.3100 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.6659
Cell Significance Index: 30.7900 - Cell Name: pro-T cell (CL0000827)
Fold Change: 1.2546
Cell Significance Index: 32.0500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.1538
Cell Significance Index: 74.4400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.8987
Cell Significance Index: 22.4700 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.7920
Cell Significance Index: 7.0300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2318
Cell Significance Index: 44.1200 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.2127
Cell Significance Index: 5.6900 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1444
Cell Significance Index: 8.6700 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.0639
Cell Significance Index: 1.4000 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.0560
Cell Significance Index: 6.1000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0330
Cell Significance Index: 6.6200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0263
Cell Significance Index: 23.7500 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0121
Cell Significance Index: 0.8400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0112
Cell Significance Index: 2.2200 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0091
Cell Significance Index: 1.6400 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0091
Cell Significance Index: 1.4800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0005
Cell Significance Index: 0.9700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0007
Cell Significance Index: -1.1400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0008
Cell Significance Index: -1.4900 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0040
Cell Significance Index: -5.3900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0046
Cell Significance Index: -0.1600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0049
Cell Significance Index: -0.1400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0049
Cell Significance Index: -1.7700 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0094
Cell Significance Index: -0.4700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0095
Cell Significance Index: -7.1800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0122
Cell Significance Index: -7.7600 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0123
Cell Significance Index: -6.7400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0125
Cell Significance Index: -9.2600 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0126
Cell Significance Index: -9.2300 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0129
Cell Significance Index: -0.2800 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0132
Cell Significance Index: -0.8100 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0145
Cell Significance Index: -6.4200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0170
Cell Significance Index: -9.5800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0175
Cell Significance Index: -7.9200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.0177
Cell Significance Index: -1.7600 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0203
Cell Significance Index: -0.9200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0214
Cell Significance Index: -2.1900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0217
Cell Significance Index: -2.9800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0226
Cell Significance Index: -1.0600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0236
Cell Significance Index: -6.8000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0350
Cell Significance Index: -4.3000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0367
Cell Significance Index: -5.3300 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: -0.0407
Cell Significance Index: -0.3300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0457
Cell Significance Index: -9.6300 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0498
Cell Significance Index: -0.7500 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0502
Cell Significance Index: -6.4900 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0506
Cell Significance Index: -1.0500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0507
Cell Significance Index: -5.9100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0576
Cell Significance Index: -1.8500 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0576
Cell Significance Index: -7.3900 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0659
Cell Significance Index: -1.4000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0675
Cell Significance Index: -11.5200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0726
Cell Significance Index: -2.0300 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0733
Cell Significance Index: -7.6300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0735
Cell Significance Index: -3.8200 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0759
Cell Significance Index: -1.3000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0798
Cell Significance Index: -9.4100 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0815
Cell Significance Index: -3.5500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0900
Cell Significance Index: -6.9100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0911
Cell Significance Index: -10.4400 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1012
Cell Significance Index: -7.5500 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1075
Cell Significance Index: -7.2300 - Cell Name: thymocyte (CL0000893)
Fold Change: -0.1136
Cell Significance Index: -1.4400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1158
Cell Significance Index: -8.1900 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.1165
Cell Significance Index: -0.9500 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1258
Cell Significance Index: -5.1500 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.1289
Cell Significance Index: -2.5200 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1331
Cell Significance Index: -8.1800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1379
Cell Significance Index: -6.4300 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.1391
Cell Significance Index: -1.7200 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.1406
Cell Significance Index: -1.3000 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1481
Cell Significance Index: -4.0300 - Cell Name: myeloid cell (CL0000763)
Fold Change: -0.1558
Cell Significance Index: -2.0700 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1564
Cell Significance Index: -5.4800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1590
Cell Significance Index: -8.9200 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1688
Cell Significance Index: -5.3800 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1722
Cell Significance Index: -8.9700 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1735
Cell Significance Index: -2.4900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1768
Cell Significance Index: -11.1400 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.1771
Cell Significance Index: -2.5900 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1805
Cell Significance Index: -9.4800 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.1812
Cell Significance Index: -4.3900 - Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: -0.1822
Cell Significance Index: -1.5400 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1845
Cell Significance Index: -8.1600 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1878
Cell Significance Index: -6.1500 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.1931
Cell Significance Index: -2.7100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2105
Cell Significance Index: -7.9700 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.2239
Cell Significance Index: -3.2500 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2326
Cell Significance Index: -8.5400 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.2349
Cell Significance Index: -5.8600 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.2379
Cell Significance Index: -3.0200 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.2384
Cell Significance Index: -7.5400 - Cell Name: classical monocyte (CL0000860)
Fold Change: -0.2390
Cell Significance Index: -2.2300 - Cell Name: leukocyte (CL0000738)
Fold Change: -0.2408
Cell Significance Index: -4.0900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.2494
Cell Significance Index: -6.6600 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.2565
Cell Significance Index: -7.3200 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2696
Cell Significance Index: -9.3700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2168137239
Symbol: AGRE2_HUMAN
Name: EGF-like module receptor 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10903844
Title: Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97.
PubMed ID: 10903844
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 12860403
Title: Proteolytic cleavage of the EMR2 receptor requires both the extracellular stalk and the GPS motif.
PubMed ID: 12860403
PubMed ID: 11994511
Title: The human EGF-TM7 family member EMR2 is a heterodimeric receptor expressed on myeloid cells.
PubMed ID: 11994511
PubMed ID: 12829604
Title: The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans.
PubMed ID: 12829604
PubMed ID: 15150276
Title: Autocatalytic cleavage of the EMR2 receptor occurs at a conserved G protein-coupled receptor proteolytic site motif.
PubMed ID: 15150276
PubMed ID: 17928360
Title: Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function.
PubMed ID: 17928360
PubMed ID: 22575658
Title: Signaling property study of adhesion G-protein-coupled receptors.
PubMed ID: 22575658
PubMed ID: 22310662
Title: Activation of myeloid cell-specific adhesion class G protein-coupled receptor EMR2 via ligation-induced translocation and interaction of receptor subunits in lipid raft microdomains.
PubMed ID: 22310662
DOI: 10.1128/mcb.06557-11
PubMed ID: 25713288
Title: International union of basic and clinical pharmacology. XCIV. Adhesion G protein-coupled receptors.
PubMed ID: 25713288
PubMed ID: 26841242
Title: Vibratory urticaria associated with a missense variant in ADGRE2.
PubMed ID: 26841242
PubMed ID: 17449467
Title: Structural and functional characterization of a novel T cell receptor co-regulatory protein complex, CD97-CD55.
PubMed ID: 17449467
Sequence Information:
- Length: 823
- Mass: 90472
- Checksum: 4D38C30A07B46FF4
- Sequence:
MGGRVFLVFL AFCVWLTLPG AETQDSRGCA RWCPQDSSCV NATACRCNPG FSSFSEIITT PMETCDDINE CATLSKVSCG KFSDCWNTEG SYDCVCSPGY EPVSGAKTFK NESENTCQDV DECQQNPRLC KSYGTCVNTL GSYTCQCLPG FKLKPEDPKL CTDVNECTSG QNPCHSSTHC LNNVGSYQCR CRPGWQPIPG SPNGPNNTVC EDVDECSSGQ HQCDSSTVCF NTVGSYSCRC RPGWKPRHGI PNNQKDTVCE DMTFSTWTPP PGVHSQTLSR FFDKVQDLGR DYKPGLANNT IQSILQALDE LLEAPGDLET LPRLQQHCVA SHLLDGLEDV LRGLSKNLSN GLLNFSYPAG TELSLEVQKQ VDRSVTLRQN QAVMQLDWNQ AQKSGDPGPS VVGLVSIPGM GKLLAEAPLV LEPEKQMLLH ETHQGLLQDG SPILLSDVIS AFLSNNDTQN LSSPVTFTFS HRSVIPRQKV LCVFWEHGQN GCGHWATTGC STIGTRDTST ICRCTHLSSF AVLMAHYDVQ EEDPVLTVIT YMGLSVSLLC LLLAALTFLL CKAIQNTSTS LHLQLSLCLF LAHLLFLVAI DQTGHKVLCS IIAGTLHYLY LATLTWMLLE ALYLFLTARN LTVVNYSSIN RFMKKLMFPV GYGVPAVTVA ISAASRPHLY GTPSRCWLQP EKGFIWGFLG PVCAIFSVNL VLFLVTLWIL KNRLSSLNSE VSTLRNTRML AFKATAQLFI LGCTWCLGIL QVGPAARVMA YLFTIINSLQ GVFIFLVYCL LSQQVREQYG KWSKGIRKLK TESEMHTLSS SAKADTSKPS TVN
Genular Protein ID: 2360427962
Symbol: A0JNV7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 823
- Mass: 90505
- Checksum: F0CDE9107231EF4E
- Sequence:
MGGRVFLVFL AFCVWLTLPG AETQDSRGCA RWCPQDSSCV NATACRCNPG FSSFSEIITT PMETCDDINE CATLSKVSCG KFSDCWNTEG SYDCVCSPGY EPVSGAKTFK NESENTCQDV DECQQNPRLC KSYGTCVNTL GSYTCQCLPG FKFIPEDPKV CTDVNECTSG QNPCHSSTHC LNNVGSYQCR CRPGWQPIPG SPNGPNNTVC EDVDECSSGQ HQCDSSTVCF NTVGSYSCRC RPGWKPRHGI PNNQKDTVCE DMTFSTWTPP PGVHSQTLSR FFDKVQDLGR DYKPGLANNT IQSILQALDE LLEVPGDLET LPRLQQHCVA SHLLDGLEDV LRGLSKNLSN GLLNFSYPAG TELSLEVQKQ VDRSVTLRQN QAVMQLDWNQ AQKSGDPGPS VVGLVSIPGM GKLLAEAPLV LEPEKQMLLH ETHQGLLQDG SPILLSDVIS AFLSNNDTQN LSSPVTFTFS HRSVIPRQKV LCVFWEHGQN GCGHWATTGC STIGTRDTST ICRCTHLSSF AVLMAHYDVQ EEDPVLTVIT YMGLSVSLLC LLLAALTFLL CKAIQNTSTS LHLQLSLCLF LAHLLFLVAI DQTGHKVLCS IIAGTLHYLY LATLTWMLLE ALYLFLTARN LTVVNYSSIN RFMKKLMFPV GYGVPAVTVA ISAASRPHLY GTPSRCWLQP EKGFIWGFLG PVCAIFSVNL VLFLVTLWIL KNRLSSLNSE VSTLRNTRML AFKATAQLFI LGCTWCLGIL QVGPAARVMA YLFTIINSLQ GVFIFLVYCL LSQQVREQYG KWSKGIRKLK TESEMHTLSS SAKADTSKPS TVN
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.