Details for: SOCS7

Gene ID: 30837

Symbol: SOCS7

Ensembl ID: ENSG00000274211

Description: suppressor of cytokine signaling 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 53.3760
    Cell Significance Index: -25.2000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 47.2115
    Cell Significance Index: -19.1800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.0620
    Cell Significance Index: -8.8900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.5670
    Cell Significance Index: 42.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6955
    Cell Significance Index: 340.1100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.5875
    Cell Significance Index: 21.6600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.5370
    Cell Significance Index: 26.3400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9412
    Cell Significance Index: 93.1100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7517
    Cell Significance Index: 519.9200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7442
    Cell Significance Index: 266.9500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7315
    Cell Significance Index: 660.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7135
    Cell Significance Index: 141.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7069
    Cell Significance Index: 31.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6856
    Cell Significance Index: 19.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6692
    Cell Significance Index: 25.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6350
    Cell Significance Index: 35.6400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.6344
    Cell Significance Index: 4.8900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.5503
    Cell Significance Index: 12.0500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4720
    Cell Significance Index: 51.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4651
    Cell Significance Index: 75.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4388
    Cell Significance Index: 33.6700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4087
    Cell Significance Index: 25.7600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.4076
    Cell Significance Index: 5.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3104
    Cell Significance Index: 55.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2520
    Cell Significance Index: 7.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2467
    Cell Significance Index: 30.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2105
    Cell Significance Index: 4.5600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1919
    Cell Significance Index: 13.2700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1572
    Cell Significance Index: 3.3600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1383
    Cell Significance Index: 6.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1229
    Cell Significance Index: 20.9800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1214
    Cell Significance Index: 53.6600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1159
    Cell Significance Index: 1.6500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.1109
    Cell Significance Index: 1.4800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1081
    Cell Significance Index: 5.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0872
    Cell Significance Index: 47.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0698
    Cell Significance Index: 13.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0545
    Cell Significance Index: 7.4900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0459
    Cell Significance Index: 86.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0260
    Cell Significance Index: 11.8000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0246
    Cell Significance Index: 15.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0204
    Cell Significance Index: 31.4100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0191
    Cell Significance Index: 0.9900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0122
    Cell Significance Index: 0.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0112
    Cell Significance Index: 15.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0078
    Cell Significance Index: 14.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0021
    Cell Significance Index: -1.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0026
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0069
    Cell Significance Index: -5.1100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0105
    Cell Significance Index: -0.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0106
    Cell Significance Index: -1.0800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0127
    Cell Significance Index: -0.4500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0188
    Cell Significance Index: -13.8100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0209
    Cell Significance Index: -15.8300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0245
    Cell Significance Index: -13.8000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0345
    Cell Significance Index: -3.9400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0422
    Cell Significance Index: -8.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0629
    Cell Significance Index: -9.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0755
    Cell Significance Index: -8.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0789
    Cell Significance Index: -22.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0793
    Cell Significance Index: -9.0800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0807
    Cell Significance Index: -10.3400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1124
    Cell Significance Index: -1.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1195
    Cell Significance Index: -15.4400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1216
    Cell Significance Index: -8.6000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1355
    Cell Significance Index: -2.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1500
    Cell Significance Index: -7.8800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1554
    Cell Significance Index: -3.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1562
    Cell Significance Index: -10.0800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1654
    Cell Significance Index: -19.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1772
    Cell Significance Index: -18.4500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1972
    Cell Significance Index: -14.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2134
    Cell Significance Index: -10.0300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2285
    Cell Significance Index: -7.4800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2351
    Cell Significance Index: -6.4000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2396
    Cell Significance Index: -7.6300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2591
    Cell Significance Index: -20.5200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2869
    Cell Significance Index: -9.1900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2913
    Cell Significance Index: -17.8600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3081
    Cell Significance Index: -6.5400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3367
    Cell Significance Index: -4.9700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3413
    Cell Significance Index: -17.7800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3442
    Cell Significance Index: -11.9600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3677
    Cell Significance Index: -7.2700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3681
    Cell Significance Index: -4.5900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3977
    Cell Significance Index: -5.7000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4109
    Cell Significance Index: -8.2500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4216
    Cell Significance Index: -14.7700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4362
    Cell Significance Index: -10.8800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4442
    Cell Significance Index: -8.6700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4500
    Cell Significance Index: -11.8300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.4542
    Cell Significance Index: -6.3800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4593
    Cell Significance Index: -11.4800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4773
    Cell Significance Index: -5.2000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.4785
    Cell Significance Index: -5.8000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4897
    Cell Significance Index: -10.5800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4928
    Cell Significance Index: -6.2200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5410
    Cell Significance Index: -19.8600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.5414
    Cell Significance Index: -11.3000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5588
    Cell Significance Index: -16.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** SOCS7 is highly expressed in various cell types, including kidney proximal convoluted tubule epithelial cells, cardiac muscle cells, and glutamatergic cortical neurons. 2. **Function:** SOCS7 acts as a negative regulator of signal transduction pathways, particularly the PI3K pathway, which is involved in cellular processes such as cell growth, differentiation, and survival. 3. **Molecular Mechanism:** SOCS7 interacts with key components of the PI3K pathway, including PI3K and phosphatidylinositol 3-kinase regulatory subunits (PI3KR1), to inhibit the activation of downstream signaling molecules. 4. **Protein Binding:** SOCS7 interacts with various proteins, including PI3KR1, phosphatidylinositol 3-phosphatase (PTEN), and protein tyrosine phosphatase (PTP), to regulate their activity. **Pathways and Functions:** 1. **PI3K Pathway:** SOCS7 negatively regulates the PI3K pathway, which is involved in cellular processes such as cell growth, differentiation, and survival. 2. **Negative Regulation of Signal Transduction:** SOCS7 acts as a negative regulator of signal transduction pathways, including the PI3K pathway, to prevent excessive or uncontrolled signaling. 3. **Intracellular Signaling Regulation:** SOCS7 regulates intracellular signaling pathways, including the PI3K pathway, to modulate cellular responses to various stimuli. 4. **Immune Response Regulation:** SOCS7 regulates immune responses by modulating the activity of key immune cells, including T cells and macrophages. **Clinical Significance:** 1. **Immune Disorders:** Dysfunction of SOCS7 has been implicated in various immune disorders, including autoimmune diseases and inflammatory disorders. 2. **Neurological Disorders:** SOCS7 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 3. **Cancer:** SOCS7 has been implicated in the regulation of cancer cell growth and survival, and its dysregulation has been associated with various types of cancer. 4. **Therapeutic Implications:** Targeting SOCS7 or its regulatory pathways may provide new therapeutic opportunities for the treatment of immune disorders and neurological disorders. In conclusion, SOCS7 plays a critical role in regulating intracellular signaling pathways, particularly those involved in immune responses and neuronal function. Its dysregulation has been implicated in various human diseases, and its therapeutic potential is an area of active research. Further studies are needed to fully understand the role of SOCS7 in human health and disease and to explore its therapeutic potential.

Genular Protein ID: 46145318

Symbol: SOCS7_HUMAN

Name: N/A

UniProtKB Accession Codes:

O14512 A2VCU2 Q0IJ63

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9344857

Title: A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs.

PubMed ID: 9344857

DOI: 10.1006/bbrc.1997.7492

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10969179

Title: Expression of SOCS genes in normal and leukemic human leukocytes stimulated by prolactin, growth hormone and cytokines.

PubMed ID: 10969179

DOI: 10.1016/s0165-5728(00)00300-3

PubMed ID: 15242778

Title: The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin.

PubMed ID: 15242778

DOI: 10.1016/j.yexcr.2004.04.002

PubMed ID: 15677474

Title: Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation.

PubMed ID: 15677474

DOI: 10.1074/jbc.m411596200

PubMed ID: 16127460

Title: Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans.

PubMed ID: 16127460

DOI: 10.1172/jci23853

PubMed ID: 17803907

Title: Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7.

PubMed ID: 17803907

DOI: 10.1016/j.cell.2007.06.053

Sequence Information:

  • Length: 581
  • Mass: 62969
  • Checksum: 3F326532262AF6AA
  • Sequence:
    • MVFRNVGRPP EEEDVEAAPE PGPSELLCPR HRCALDPKAL PPGLALERTW GPAAGLEAQL 
AALGLGQPAG PGVKTVGGGC CPCPCPPQPP PPQPQPPAAA PQAGEDPTET SDALLVLEGL 
ESEAESLETN SCSEEELSSP GRGGGGGGRL LLQPPGPELP PVPFPLQDLV PLGRLSRGEQ 
QQQQQQQPPP PPPPPGPLRP LAGPSRKGSF KIRLSRLFRT KSCNGGSGGG DGTGKRPSGE 
LAASAASLTD MGGSAGRELD AGRKPKLTRT QSAFSPVSFS PLFTGETVSL VDVDISQRGL 
TSPHPPTPPP PPRRSLSLLD DISGTLPTSV LVAPMGSSLQ SFPLPPPPPP HAPDAFPRIA 
PIRAAESLHS QPPQHLQCPL YRPDSSSFAA SLRELEKCGW YWGPMNWEDA EMKLKGKPDG 
SFLVRDSSDP RYILSLSFRS QGITHHTRME HYRGTFSLWC HPKFEDRCQS VVEFIKRAIM 
HSKNGKFLYF LRSRVPGLPP TPVQLLYPVS RFSNVKSLQH LCRFRIRQLV RIDHIPDLPL 
PKPLISYIRK FYYYDPQEEV YLSLKEAQLI SKQKQEVEPS T

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.