Details for: CDR2L

Gene ID: 30850

Symbol: CDR2L

Ensembl ID: ENSG00000109089

Description: cerebellar degeneration related protein 2 like

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 59.5324
    Cell Significance Index: -15.1000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 32.0468
    Cell Significance Index: -15.1300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.8342
    Cell Significance Index: -15.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.1528
    Cell Significance Index: 62.0300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.4110
    Cell Significance Index: 30.5700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3779
    Cell Significance Index: 18.8000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.1621
    Cell Significance Index: 19.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7490
    Cell Significance Index: 74.1000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6835
    Cell Significance Index: 617.1300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6522
    Cell Significance Index: 33.8800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6290
    Cell Significance Index: 37.7600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6160
    Cell Significance Index: 13.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5368
    Cell Significance Index: 58.3900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4390
    Cell Significance Index: 71.4000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3032
    Cell Significance Index: 20.9700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1808
    Cell Significance Index: 4.5200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1326
    Cell Significance Index: 25.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1216
    Cell Significance Index: 66.4100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1124
    Cell Significance Index: 3.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0766
    Cell Significance Index: 15.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0626
    Cell Significance Index: 7.1700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0613
    Cell Significance Index: 42.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0525
    Cell Significance Index: 9.4600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0327
    Cell Significance Index: 0.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0205
    Cell Significance Index: 2.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0159
    Cell Significance Index: 5.7000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0148
    Cell Significance Index: 1.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0073
    Cell Significance Index: 1.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0011
    Cell Significance Index: 0.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0031
    Cell Significance Index: -1.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0058
    Cell Significance Index: -11.0000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0072
    Cell Significance Index: -4.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0088
    Cell Significance Index: -6.5000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0109
    Cell Significance Index: -20.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0128
    Cell Significance Index: -19.7600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0134
    Cell Significance Index: -9.8000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0137
    Cell Significance Index: -2.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0146
    Cell Significance Index: -1.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0159
    Cell Significance Index: -21.5600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0187
    Cell Significance Index: -14.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0189
    Cell Significance Index: -12.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0206
    Cell Significance Index: -11.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0228
    Cell Significance Index: -4.5200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0233
    Cell Significance Index: -2.6600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0235
    Cell Significance Index: -3.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0301
    Cell Significance Index: -13.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0353
    Cell Significance Index: -6.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0418
    Cell Significance Index: -12.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0437
    Cell Significance Index: -5.0900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0493
    Cell Significance Index: -1.5800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0608
    Cell Significance Index: -0.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0630
    Cell Significance Index: -1.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0641
    Cell Significance Index: -2.9900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0677
    Cell Significance Index: -0.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0790
    Cell Significance Index: -11.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0798
    Cell Significance Index: -6.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0868
    Cell Significance Index: -6.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1044
    Cell Significance Index: -10.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1219
    Cell Significance Index: -5.7300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1347
    Cell Significance Index: -8.2600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1380
    Cell Significance Index: -16.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1395
    Cell Significance Index: -7.8300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1416
    Cell Significance Index: -4.0600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1438
    Cell Significance Index: -14.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1497
    Cell Significance Index: -9.2000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1801
    Cell Significance Index: -14.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1834
    Cell Significance Index: -12.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1890
    Cell Significance Index: -11.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2057
    Cell Significance Index: -10.8000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2087
    Cell Significance Index: -4.3300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2128
    Cell Significance Index: -4.6600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2449
    Cell Significance Index: -10.6500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2459
    Cell Significance Index: -4.1200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2485
    Cell Significance Index: -16.0300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2543
    Cell Significance Index: -6.1600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2610
    Cell Significance Index: -6.7100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2714
    Cell Significance Index: -5.6800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2893
    Cell Significance Index: -1.9600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2951
    Cell Significance Index: -7.8800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3062
    Cell Significance Index: -1.8500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3121
    Cell Significance Index: -8.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3154
    Cell Significance Index: -13.9500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3160
    Cell Significance Index: -4.8000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3350
    Cell Significance Index: -11.6400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3404
    Cell Significance Index: -8.9500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3656
    Cell Significance Index: -7.7600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3667
    Cell Significance Index: -10.8000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3671
    Cell Significance Index: -13.9000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3772
    Cell Significance Index: -13.2200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3877
    Cell Significance Index: -4.4100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3922
    Cell Significance Index: -19.8200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4171
    Cell Significance Index: -15.3100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4267
    Cell Significance Index: -6.4300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4446
    Cell Significance Index: -9.2800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4458
    Cell Significance Index: -14.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4468
    Cell Significance Index: -14.2300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4617
    Cell Significance Index: -12.3500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4651
    Cell Significance Index: -19.0600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4734
    Cell Significance Index: -10.1200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4853
    Cell Significance Index: -13.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Genomic Location:** The CDR2L gene is located on the human genome, with an Ensembl ID of ENSG00000109089. 2. **Expression Patterns:** CDR2L is significantly expressed in various cell types, including fallopian tube secretory epithelial cells, cerebral cortex GABAergic interneurons, forebrain radial glial cells, cardiac muscle myoblasts, absorptive cells, enterocytes of the colon, tuft cells of the colon, BEST4+ intestinal epithelial cells, human intestinal crypt stem cells, and abnormal cells. 3. **Protein Binding:** CDR2L has been shown to interact with other proteins, including identical proteins, which suggests its involvement in protein-protein interactions. 4. **Transport Mechanisms:** CDR2L is involved in the transport of proteins and vesicles along microtubules, which is essential for various cellular processes. **Pathways and Functions:** 1. **Cytoplasmic and Golgi Apparatus-Mediated Transport:** CDR2L plays a crucial role in the transport of proteins and vesicles along microtubules, which is essential for various cellular processes, including protein synthesis, secretion, and degradation. 2. **Identical Protein Binding:** CDR2L interacts with other proteins, including identical proteins, which suggests its involvement in protein-protein interactions. 3. **Vesicle Transport:** CDR2L is involved in the transport of vesicles along microtubules, which is essential for various cellular processes, including cell signaling, cell migration, and cell division. 4. **Cellular Signaling:** CDR2L may play a role in cellular signaling pathways, including the regulation of gene expression, cell growth, and cell differentiation. **Clinical Significance:** 1. **Cerebellar Degeneration:** CDR2L has been linked to cerebellar degeneration-related protein 2-like functions, which suggests its involvement in neurodegenerative diseases, such as ataxia and Parkinson's disease. 2. **Immunological Disorders:** CDR2L may play a role in immunological disorders, including autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer:** CDR2L has been identified as a potential biomarker for cancer, particularly in the context of intestinal cancer. 4. **Neurological Disorders:** CDR2L may be involved in the regulation of neurological disorders, including Alzheimer's disease and Huntington's disease. In conclusion, the CDR2L gene is a complex and multifunctional gene that plays a crucial role in various cellular processes, including cytoplasmic and Golgi apparatus-mediated transport, identical protein binding, and vesicle transport along microtubules. Further research is necessary to fully understand the role of CDR2L in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 3532853671

Symbol: CDR2L_HUMAN

Name: Cerebellar degeneration-related protein 2-like

UniProtKB Accession Codes:

Q86X02 B4DFA7 Q15175

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 465
  • Mass: 53010
  • Checksum: E9231122B2378B71
  • Sequence:
    • MRRAAGMEDF SAEEEESWYD QQDLEQDLHL AAELGKTLLE RNKELEGSLQ QMYSTNEEQV 
QEIEYLTKQL DTLRHVNEQH AKVYEQLDLT ARDLELTNHR LVLESKAAQQ KIHGLTETIE 
RLQAQVEELQ AQVEQLRGLE QLRVLREKRE RRRTIHTFPC LKELCTSPRC KDAFRLHSSS 
LELGPRPLEQ ENERLQTLVG ALRSQVSQER QRKERAEREY TAVLQEYSEL ERQLCEMEAC 
RLRVQELEAE LLELQQMKQA KTYLLGPDDH LAEALLAPLT QAPEADDPQP GRGDDLGAQD 
GVSSPAASPG HVVRKSCSDT ALNAIVAKDP ASRHAGNLTL HANSVRKRGM SILREVDEQY 
HALLEKYEEL LSKCRQHGAG VRHAGVQTSR PISRDSSWRD LRGGEEGQGE VKAGEKSLSQ 
HVEAVDKRLE QSQPEYKALF KEIFSRIQKT KADINATKVK THSSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.