Details for: HIP1

Gene ID: 3092

Symbol: HIP1

Ensembl ID: ENSG00000127946

Description: huntingtin interacting protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 308.9134
    Cell Significance Index: -48.0500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 188.6901
    Cell Significance Index: -47.8600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 118.3167
    Cell Significance Index: -55.8600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 103.6290
    Cell Significance Index: -42.1000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 44.2632
    Cell Significance Index: -42.2600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 39.2918
    Cell Significance Index: -48.4500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 19.1996
    Cell Significance Index: -42.0200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.0603
    Cell Significance Index: -51.0600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.2836
    Cell Significance Index: -40.8000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.3617
    Cell Significance Index: -48.7800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.8813
    Cell Significance Index: 63.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6251
    Cell Significance Index: 322.5100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.4759
    Cell Significance Index: 41.2500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.4378
    Cell Significance Index: 80.6800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0554
    Cell Significance Index: 200.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8871
    Cell Significance Index: 68.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8816
    Cell Significance Index: 316.2300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.7787
    Cell Significance Index: 11.2000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.7091
    Cell Significance Index: 13.8400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7043
    Cell Significance Index: 43.2900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6217
    Cell Significance Index: 429.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5934
    Cell Significance Index: 535.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5619
    Cell Significance Index: 55.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3369
    Cell Significance Index: 8.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3057
    Cell Significance Index: 61.3200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2588
    Cell Significance Index: 42.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2344
    Cell Significance Index: 432.3100
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.2274
    Cell Significance Index: 2.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2071
    Cell Significance Index: 318.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1884
    Cell Significance Index: 33.9600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1561
    Cell Significance Index: 21.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1556
    Cell Significance Index: 84.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1542
    Cell Significance Index: 69.9700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1336
    Cell Significance Index: 2.2900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.1263
    Cell Significance Index: 1.5900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1149
    Cell Significance Index: 71.7400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0912
    Cell Significance Index: 40.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0722
    Cell Significance Index: 52.9200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0485
    Cell Significance Index: 66.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0449
    Cell Significance Index: 28.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0410
    Cell Significance Index: 77.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0400
    Cell Significance Index: 4.9200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0391
    Cell Significance Index: 2.5200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0174
    Cell Significance Index: 1.9000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0146
    Cell Significance Index: 0.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0275
    Cell Significance Index: -20.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0405
    Cell Significance Index: -30.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0611
    Cell Significance Index: -1.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0713
    Cell Significance Index: -9.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0719
    Cell Significance Index: -40.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0953
    Cell Significance Index: -3.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1549
    Cell Significance Index: -22.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1644
    Cell Significance Index: -28.0800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1719
    Cell Significance Index: -36.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1820
    Cell Significance Index: -52.3700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1829
    Cell Significance Index: -21.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1836
    Cell Significance Index: -21.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2681
    Cell Significance Index: -12.1500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2940
    Cell Significance Index: -34.6700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3137
    Cell Significance Index: -32.0400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3201
    Cell Significance Index: -2.6100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.3442
    Cell Significance Index: -3.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3489
    Cell Significance Index: -23.4600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3504
    Cell Significance Index: -36.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3579
    Cell Significance Index: -46.2400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3623
    Cell Significance Index: -41.3600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3658
    Cell Significance Index: -7.9300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3959
    Cell Significance Index: -23.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4232
    Cell Significance Index: -33.5200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4447
    Cell Significance Index: -9.5100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4781
    Cell Significance Index: -11.9500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4965
    Cell Significance Index: -3.0000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5084
    Cell Significance Index: -26.4800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5170
    Cell Significance Index: -22.8700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.5303
    Cell Significance Index: -36.6700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5541
    Cell Significance Index: -39.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5626
    Cell Significance Index: -41.9300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5652
    Cell Significance Index: -8.3500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6317
    Cell Significance Index: -39.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6532
    Cell Significance Index: -30.7000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6712
    Cell Significance Index: -41.1500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6927
    Cell Significance Index: -14.3700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7011
    Cell Significance Index: -26.5500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7284
    Cell Significance Index: -25.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7815
    Cell Significance Index: -25.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7991
    Cell Significance Index: -41.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.8307
    Cell Significance Index: -38.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8658
    Cell Significance Index: -45.4600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9802
    Cell Significance Index: -26.2200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.0964
    Cell Significance Index: -18.3500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.1004
    Cell Significance Index: -38.5500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.1005
    Cell Significance Index: -36.0300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.1078
    Cell Significance Index: -22.2400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.1181
    Cell Significance Index: -35.6100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.1464
    Cell Significance Index: -24.4200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.1883
    Cell Significance Index: -33.9100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.2075
    Cell Significance Index: -30.1200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.2290
    Cell Significance Index: -17.6000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -1.2514
    Cell Significance Index: -17.9700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.2542
    Cell Significance Index: -15.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HIP1 is a cytosolic protein that exhibits a high degree of structural homology with the huntingtin protein. It contains a conserved region that interacts with huntingtin, and its expression is often associated with the huntingtin gene. HIP1 is characterized by its ability to bind to various receptors, including those involved in cell signaling, endocytosis, and apoptosis. The protein's interaction with clathrin-coated vesicles and its role in regulating endocytosis and apoptosis make it an important regulator of cellular processes. HIP1's ability to form homodimers and heterodimers with other proteins further highlights its versatility and importance in cellular signaling. **Pathways and Functions** HIP1 is involved in various signaling pathways, including: 1. **Apoptotic signaling pathway**: HIP1 regulates apoptosis by interacting with pro-apoptotic and anti-apoptotic proteins, modulating the activity of caspases and other key enzymes involved in apoptosis. 2. **Endocytosis**: HIP1's interaction with clathrin-coated vesicles regulates endocytosis, a process essential for cellular signaling, protein degradation, and membrane trafficking. 3. **Signaling by growth factor receptors**: HIP1 binds to receptors such as the epidermal growth factor receptor, regulating their signaling pathways and promoting cell growth and differentiation. 4. **Neurotransmitter receptor transport**: HIP1 is involved in the regulation of neurotransmitter receptor transport, modulating synaptic plasticity and neuronal function. 5. **Clathrin-mediated endocytosis**: HIP1's interaction with clathrin-coated vesicles regulates the internalization of receptors and other molecules, influencing cellular signaling and membrane trafficking. **Clinical Significance** HIP1's dysregulation has been implicated in various diseases, including: 1. **Huntington's disease**: HIP1's interaction with huntingtin is thought to contribute to the pathogenesis of Huntington's disease, a neurodegenerative disorder characterized by motor dysfunction, cognitive decline, and psychiatric symptoms. 2. **Cardiovascular disease**: HIP1's role in regulating endocytosis and apoptosis in cardiac cells makes it a potential target for the development of cardiovascular therapies. 3. **Cancer**: HIP1's involvement in signaling pathways regulated by growth factor receptors and its ability to form homodimers and heterodimers with other proteins make it a potential target for cancer therapy. 4. **Neurodegenerative disorders**: HIP1's role in regulating neurotransmitter receptor transport and synaptic plasticity suggests its involvement in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. In conclusion, HIP1 is a multifunctional protein that plays a crucial role in various cellular processes, including cell signaling, endocytosis, and apoptosis. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its functions and mechanisms of action. Further research is needed to fully elucidate the role of HIP1 in human disease and to develop therapeutic strategies targeting this protein.

Genular Protein ID: 4255163162

Symbol: HIP1_HUMAN

Name: Huntingtin-interacting protein 1

UniProtKB Accession Codes:

O00291 B4E3I7 E7ES17 O00328 Q2TB58 Q8TDL4 V5LU97

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 11 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 47 Gene3D 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 4 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11788820

Title: Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi.

PubMed ID: 11788820

DOI: 10.1038/ncb735

PubMed ID: 9140394

Title: HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain.

PubMed ID: 9140394

DOI: 10.1038/ng0597-44

PubMed ID: 9147654

Title: HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system.

PubMed ID: 9147654

DOI: 10.1093/hmg/6.3.487

PubMed ID: 9616134

Title: Fusion of Huntingtin interacting protein 1 to platelet-derived growth factor beta receptor (PDGFbetaR) in chronic myelomonocytic leukemia with t(5;7)(q33;q11.2).

PubMed ID: 9616134

PubMed ID: 11007801

Title: Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain.

PubMed ID: 11007801

DOI: 10.1074/jbc.m008408200

PubMed ID: 11063258

Title: HIP12 is a non-proapoptotic member of a gene family including HIP1, an interacting protein with huntingtin.

PubMed ID: 11063258

DOI: 10.1007/s003350010195

PubMed ID: 11532990

Title: The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis.

PubMed ID: 11532990

DOI: 10.1093/hmg/10.17.1807

PubMed ID: 11517213

Title: HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2.

PubMed ID: 11517213

DOI: 10.1074/jbc.c100401200

PubMed ID: 11577110

Title: Clathrin- and AP-2-binding sites in HIP1 uncover a general assembly role for endocytic accessory proteins.

PubMed ID: 11577110

DOI: 10.1074/jbc.m108177200

PubMed ID: 11889126

Title: HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain.

PubMed ID: 11889126

DOI: 10.1074/jbc.m112310200

PubMed ID: 12163454

Title: Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival.

PubMed ID: 12163454

DOI: 10.1172/jci15529

PubMed ID: 14732715

Title: HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains.

PubMed ID: 14732715

DOI: 10.1074/jbc.m312645200

PubMed ID: 15533940

Title: Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo.

PubMed ID: 15533940

DOI: 10.1074/jbc.m408454200

PubMed ID: 16027218

Title: Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors.

PubMed ID: 16027218

DOI: 10.1083/jcb.200503106

PubMed ID: 18790740

Title: Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain.

PubMed ID: 18790740

DOI: 10.1074/jbc.m802863200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 17257618

Title: Crystal structure at 2.8 A of the DLLRKN-containing coiled-coil domain of huntingtin-interacting protein 1 (HIP1) reveals a surface suitable for clathrin light chain binding.

PubMed ID: 17257618

DOI: 10.1016/j.jmb.2006.12.052

PubMed ID: 18155047

Title: Crystal structure at 2.8 A of Huntingtin-interacting protein 1 (HIP1) coiled-coil domain reveals a charged surface suitable for HIP1 protein interactor (HIPPI).

PubMed ID: 18155047

DOI: 10.1016/j.jmb.2007.11.036

Sequence Information:

  • Length: 1037
  • Mass: 116221
  • Checksum: F8C0369DBF0A836F
  • Sequence:
    • MDRMASSMKQ VPNPLPKVLS RRGVGAGLEA AERESFERTQ TVSINKAINT QEVAVKEKHA 
RTCILGTHHE KGAQTFWSVV NRLPLSSNAV LCWKFCHVFH KLLRDGHPNV LKDSLRYRNE 
LSDMSRMWGH LSEGYGQLCS IYLKLLRTKM EYHTKNPRFP GNLQMSDRQL DEAGESDVNN 
FFQLTVEMFD YLECELNLFQ TVFNSLDMSR SVSVTAAGQC RLAPLIQVIL DCSHLYDYTV 
KLLFKLHSCL PADTLQGHRD RFMEQFTKLK DLFYRSSNLQ YFKRLIQIPQ LPENPPNFLR 
ASALSEHISP VVVIPAEASS PDSEPVLEKD DLMDMDASQQ NLFDNKFDDI FGSSFSSDPF 
NFNSQNGVNK DEKDHLIERL YREISGLKAQ LENMKTESQR VVLQLKGHVS ELEADLAEQQ 
HLRQQAADDC EFLRAELDEL RRQREDTEKA QRSLSEIERK AQANEQRYSK LKEKYSELVQ 
NHADLLRKNA EVTKQVSMAR QAQVDLEREK KELEDSLERI SDQGQRKTQE QLEVLESLKQ 
ELATSQRELQ VLQGSLETSA QSEANWAAEF AELEKERDSL VSGAAHREEE LSALRKELQD 
TQLKLASTEE SMCQLAKDQR KMLLVGSRKA AEQVIQDALN QLEEPPLISC AGSADHLLST 
VTSISSCIEQ LEKSWSQYLA CPEDISGLLH SITLLAHLTS DAIAHGATTC LRAPPEPADS 
LTEACKQYGR ETLAYLASLE EEGSLENADS TAMRNCLSKI KAIGEELLPR GLDIKQEELG 
DLVDKEMAAT SAAIETATAR IEEMLSKSRA GDTGVKLEVN ERILGCCTSL MQAIQVLIVA 
SKDLQREIVE SGRGTASPKE FYAKNSRWTE GLISASKAVG WGATVMVDAA DLVVQGRGKF 
EELMVCSHEI AASTAQLVAA SKVKADKDSP NLAQLQQASR GVNQATAGVV ASTISGKSQI 
EETDNMDFSS MTLTQIKRQE MDSQVRVLEL ENELQKERQK LGELRKKHYE LAGVAEGWEE 
GTEASPPTLQ EVVTEKE

Genular Protein ID: 3048173480

Symbol: B4DK46_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DK46

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 11 Gene3D 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 2 SAM 2 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 152
  • Mass: 16632
  • Checksum: 5FBA71958609CE3F
  • Sequence:
    • MVDAADLVVQ GRGKFEELMV CSHEIAASTA QLVAASKVKA DKDSPNLAQL QQASRGVNQA 
TAGVVASTIS GKSQIEETDN MDFSSMTLTQ IKRQEMDSQV RVLELENELQ KERQKLGELR 
KKHYELAGVA EGWEEGTEAS PPTLQEVVTE KE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.