Details for: HIP1

Gene ID: 3092

Symbol: HIP1

Ensembl ID: ENSG00000127946

Description: huntingtin interacting protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: contractile cell (CL0000183)
    Fold Change: 4.96
    Marker Score: 2685
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 3.59
    Marker Score: 47688
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 3.34
    Marker Score: 3180
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.96
    Marker Score: 3686
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.74
    Marker Score: 1523
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.61
    Marker Score: 5024
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.51
    Marker Score: 1220
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.3
    Marker Score: 5511
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.17
    Marker Score: 2919
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 2.14
    Marker Score: 1301
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.1
    Marker Score: 2417.5
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.94
    Marker Score: 2349
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.86
    Marker Score: 581
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.79
    Marker Score: 3940
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.75
    Marker Score: 1345
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.73
    Marker Score: 1958
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.65
    Marker Score: 983
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.61
    Marker Score: 517
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.59
    Marker Score: 60556
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.55
    Marker Score: 11893
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.49
    Marker Score: 3991
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.47
    Marker Score: 31441.5
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168214
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.46
    Marker Score: 535
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.46
    Marker Score: 13746
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.45
    Marker Score: 5614
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.42
    Marker Score: 829
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.41
    Marker Score: 1739
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.28
    Marker Score: 714
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.27
    Marker Score: 530
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.26
    Marker Score: 757
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.25
    Marker Score: 4454
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.25
    Marker Score: 700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.25
    Marker Score: 19513.5
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.24
    Marker Score: 819
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.23
    Marker Score: 2508
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.23
    Marker Score: 474
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.21
    Marker Score: 309
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.2
    Marker Score: 2399
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.19
    Marker Score: 350
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.19
    Marker Score: 2812
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.18
    Marker Score: 430
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 1.14
    Marker Score: 590
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.14
    Marker Score: 1220
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.13
    Marker Score: 4020.5
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.13
    Marker Score: 1215.5
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.1
    Marker Score: 24600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.09
    Marker Score: 1689
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.09
    Marker Score: 1106
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.09
    Marker Score: 1139.5
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.09
    Marker Score: 410
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.09
    Marker Score: 261
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.07
    Marker Score: 704
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.07
    Marker Score: 292
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.07
    Marker Score: 1286
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.05
    Marker Score: 6852.5
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.04
    Marker Score: 925
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.04
    Marker Score: 891
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.03
    Marker Score: 1286
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.03
    Marker Score: 379
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71728.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47953
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.99
    Marker Score: 288
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30396
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.98
    Marker Score: 2407
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.98
    Marker Score: 254
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.98
    Marker Score: 781
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.97
    Marker Score: 463
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.96
    Marker Score: 871
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.96
    Marker Score: 475
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.95
    Marker Score: 221
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.95
    Marker Score: 1375
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.95
    Marker Score: 4981
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 484
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 440
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.93
    Marker Score: 255.5
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.92
    Marker Score: 345
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.92
    Marker Score: 5504
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.92
    Marker Score: 482
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2711
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.89
    Marker Score: 282
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.89
    Marker Score: 355.5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.88
    Marker Score: 1252
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.88
    Marker Score: 2244
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.88
    Marker Score: 787
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.88
    Marker Score: 1275
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.88
    Marker Score: 421
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.86
    Marker Score: 612
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4893
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.86
    Marker Score: 497.5
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.85
    Marker Score: 308
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.85
    Marker Score: 12741
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.85
    Marker Score: 851.5
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.85
    Marker Score: 1595
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.85
    Marker Score: 220
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.84
    Marker Score: 347
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.83
    Marker Score: 167

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Other Information

**Key characteristics:** * HIP1 is a transmembrane protein with a molecular weight of approximately 130 kDa. * It is a member of the HIP1 family of proteins, which are characterized by a conserved cysteine-rich domain. * HIP1 is expressed in a variety of cell types, including contractile cell, cardiac muscle cell, renal interstitial pericyte, cardiac neuron, alveolar type 2 fibroblast cell, kidney interstitial fibroblast, epicardial adipocyte, oligodendrocyte, and anterior lens cell. **Pathways and functions:** * HIP1 is involved in the regulation of the clathrin-mediated endocytosis pathway. * This pathway is responsible for the internalization of growth factors and other extracellular signals. * HIP1 is a key component of the clathrin-mediated endocytosis pathway, and it is required for the internalization of growth factors such as EGF. * HIP1 also plays a role in the regulation of the cytoskeleton. * It is a structural constituent of the plasma membrane, and it is involved in the maintenance of the cell's shape and structure. **Clinical significance:** * Mutations in the HIP1 gene have been linked to a number of human diseases, including cancer and neurodegenerative disorders. * These diseases are characterized by abnormal cell growth and migration, which is often mediated by growth factors. * HIP1 is a potential target for the treatment of these diseases.

Genular Protein ID: 4255163162

Symbol: HIP1_HUMAN

Name: Huntingtin-interacting protein 1

UniProtKB Accession Codes:

O00291 B4E3I7 E7ES17 O00328 Q2TB58 Q8TDL4 V5LU97

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 11 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 46 Gene3D 4 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 3 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 4 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 2 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11788820

Title: Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi.

PubMed ID: 11788820

DOI: 10.1038/ncb735

PubMed ID: 9140394

Title: HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain.

PubMed ID: 9140394

DOI: 10.1038/ng0597-44

PubMed ID: 9147654

Title: HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system.

PubMed ID: 9147654

DOI: 10.1093/hmg/6.3.487

PubMed ID: 9616134

Title: Fusion of Huntingtin interacting protein 1 to platelet-derived growth factor beta receptor (PDGFbetaR) in chronic myelomonocytic leukemia with t(5;7)(q33;q11.2).

PubMed ID: 9616134

PubMed ID: 11007801

Title: Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain.

PubMed ID: 11007801

DOI: 10.1074/jbc.m008408200

PubMed ID: 11063258

Title: HIP12 is a non-proapoptotic member of a gene family including HIP1, an interacting protein with huntingtin.

PubMed ID: 11063258

DOI: 10.1007/s003350010195

PubMed ID: 11532990

Title: The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis.

PubMed ID: 11532990

DOI: 10.1093/hmg/10.17.1807

PubMed ID: 11517213

Title: HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2.

PubMed ID: 11517213

DOI: 10.1074/jbc.c100401200

PubMed ID: 11577110

Title: Clathrin- and AP-2-binding sites in HIP1 uncover a general assembly role for endocytic accessory proteins.

PubMed ID: 11577110

DOI: 10.1074/jbc.m108177200

PubMed ID: 11889126

Title: HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain.

PubMed ID: 11889126

DOI: 10.1074/jbc.m112310200

PubMed ID: 12163454

Title: Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival.

PubMed ID: 12163454

DOI: 10.1172/jci15529

PubMed ID: 14732715

Title: HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains.

PubMed ID: 14732715

DOI: 10.1074/jbc.m312645200

PubMed ID: 15533940

Title: Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo.

PubMed ID: 15533940

DOI: 10.1074/jbc.m408454200

PubMed ID: 16027218

Title: Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors.

PubMed ID: 16027218

DOI: 10.1083/jcb.200503106

PubMed ID: 18790740

Title: Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain.

PubMed ID: 18790740

DOI: 10.1074/jbc.m802863200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 17257618

Title: Crystal structure at 2.8 A of the DLLRKN-containing coiled-coil domain of huntingtin-interacting protein 1 (HIP1) reveals a surface suitable for clathrin light chain binding.

PubMed ID: 17257618

DOI: 10.1016/j.jmb.2006.12.052

PubMed ID: 18155047

Title: Crystal structure at 2.8 A of Huntingtin-interacting protein 1 (HIP1) coiled-coil domain reveals a charged surface suitable for HIP1 protein interactor (HIPPI).

PubMed ID: 18155047

DOI: 10.1016/j.jmb.2007.11.036

Sequence Information:

  • Length: 1037
  • Mass: 116221
  • Checksum: F8C0369DBF0A836F
  • Sequence:
    • MDRMASSMKQ VPNPLPKVLS RRGVGAGLEA AERESFERTQ TVSINKAINT QEVAVKEKHA 
RTCILGTHHE KGAQTFWSVV NRLPLSSNAV LCWKFCHVFH KLLRDGHPNV LKDSLRYRNE 
LSDMSRMWGH LSEGYGQLCS IYLKLLRTKM EYHTKNPRFP GNLQMSDRQL DEAGESDVNN 
FFQLTVEMFD YLECELNLFQ TVFNSLDMSR SVSVTAAGQC RLAPLIQVIL DCSHLYDYTV 
KLLFKLHSCL PADTLQGHRD RFMEQFTKLK DLFYRSSNLQ YFKRLIQIPQ LPENPPNFLR 
ASALSEHISP VVVIPAEASS PDSEPVLEKD DLMDMDASQQ NLFDNKFDDI FGSSFSSDPF 
NFNSQNGVNK DEKDHLIERL YREISGLKAQ LENMKTESQR VVLQLKGHVS ELEADLAEQQ 
HLRQQAADDC EFLRAELDEL RRQREDTEKA QRSLSEIERK AQANEQRYSK LKEKYSELVQ 
NHADLLRKNA EVTKQVSMAR QAQVDLEREK KELEDSLERI SDQGQRKTQE QLEVLESLKQ 
ELATSQRELQ VLQGSLETSA QSEANWAAEF AELEKERDSL VSGAAHREEE LSALRKELQD 
TQLKLASTEE SMCQLAKDQR KMLLVGSRKA AEQVIQDALN QLEEPPLISC AGSADHLLST 
VTSISSCIEQ LEKSWSQYLA CPEDISGLLH SITLLAHLTS DAIAHGATTC LRAPPEPADS 
LTEACKQYGR ETLAYLASLE EEGSLENADS TAMRNCLSKI KAIGEELLPR GLDIKQEELG 
DLVDKEMAAT SAAIETATAR IEEMLSKSRA GDTGVKLEVN ERILGCCTSL MQAIQVLIVA 
SKDLQREIVE SGRGTASPKE FYAKNSRWTE GLISASKAVG WGATVMVDAA DLVVQGRGKF 
EELMVCSHEI AASTAQLVAA SKVKADKDSP NLAQLQQASR GVNQATAGVV ASTISGKSQI 
EETDNMDFSS MTLTQIKRQE MDSQVRVLEL ENELQKERQK LGELRKKHYE LAGVAEGWEE 
GTEASPPTLQ EVVTEKE

Genular Protein ID: 3048173480

Symbol: B4DK46_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DK46

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 4 Gene3D 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 2 SAM 2 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 152
  • Mass: 16632
  • Checksum: 5FBA71958609CE3F
  • Sequence:
    • MVDAADLVVQ GRGKFEELMV CSHEIAASTA QLVAASKVKA DKDSPNLAQL QQASRGVNQA 
TAGVVASTIS GKSQIEETDN MDFSSMTLTQ IKRQEMDSQV RVLELENELQ KERQKLGELR 
KKHYELAGVA EGWEEGTEAS PPTLQEVVTE KE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.