Details for: ZBTB48

Gene ID: 3104

Symbol: ZBTB48

Ensembl ID: ENSG00000204859

Description: zinc finger and BTB domain containing 48

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.2
    Marker Score: 958
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.07
    Marker Score: 987
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71751
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47974
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30401
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.98
    Marker Score: 15331
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 483
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2717
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.88
    Marker Score: 2067
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4975
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.76
    Marker Score: 1090
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 561
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.73
    Marker Score: 209
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.7
    Marker Score: 279
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.68
    Marker Score: 1055
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2856.5
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.66
    Marker Score: 829
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 169
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.6
    Marker Score: 6166
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.59
    Marker Score: 189
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.57
    Marker Score: 364
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.56
    Marker Score: 1135.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.54
    Marker Score: 4692
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 427
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.52
    Marker Score: 213
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.52
    Marker Score: 31963.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.52
    Marker Score: 162
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.51
    Marker Score: 4369
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.51
    Marker Score: 280
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.5
    Marker Score: 4732.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.49
    Marker Score: 449
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.48
    Marker Score: 315
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.48
    Marker Score: 472
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.47
    Marker Score: 3045
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.47
    Marker Score: 1744
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.47
    Marker Score: 2031
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.46
    Marker Score: 122
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.45
    Marker Score: 302
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.45
    Marker Score: 225
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.45
    Marker Score: 2692
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.44
    Marker Score: 475.5
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.44
    Marker Score: 2355.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.43
    Marker Score: 258
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.43
    Marker Score: 208
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.43
    Marker Score: 3187.5
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.43
    Marker Score: 210
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.42
    Marker Score: 3957
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.42
    Marker Score: 612
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.41
    Marker Score: 200
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.41
    Marker Score: 195
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.41
    Marker Score: 356
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.41
    Marker Score: 278
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.41
    Marker Score: 432
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.41
    Marker Score: 89
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.41
    Marker Score: 186.5
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.41
    Marker Score: 1272
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.4
    Marker Score: 141
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.4
    Marker Score: 488
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.4
    Marker Score: 839
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.4
    Marker Score: 150.5
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.4
    Marker Score: 1367
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.4
    Marker Score: 14596
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.39
    Marker Score: 250
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.39
    Marker Score: 1603
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.39
    Marker Score: 88
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.39
    Marker Score: 145.5
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.39
    Marker Score: 428
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.39
    Marker Score: 90
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.39
    Marker Score: 417
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.39
    Marker Score: 216
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.38
    Marker Score: 278
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.38
    Marker Score: 287
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.38
    Marker Score: 99
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.38
    Marker Score: 94
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.38
    Marker Score: 89
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.38
    Marker Score: 622
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.38
    Marker Score: 718.5
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.38
    Marker Score: 379
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.38
    Marker Score: 84
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.38
    Marker Score: 255
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.37
    Marker Score: 92
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.37
    Marker Score: 1017
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.37
    Marker Score: 20913
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.37
    Marker Score: 178
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.37
    Marker Score: 360
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.37
    Marker Score: 633
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 375
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.37
    Marker Score: 247
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.37
    Marker Score: 1550
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.37
    Marker Score: 402
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.37
    Marker Score: 118
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.37
    Marker Score: 193
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.36
    Marker Score: 3694
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.36
    Marker Score: 152

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Other Information

**Key characteristics:** - ZBTB48 is a transcription factor that is highly expressed in cells of the central nervous system (CNS), particularly in neurons and glial cells. - It is involved in the regulation of telomere length, DNA-binding, and transcription. - ZBTB48 is a key regulator of gene expression in neurons, with its expression being highly correlated with the cellular and physiological properties of neurons. **Pathways and functions:** - ZBTB48 is involved in multiple cellular processes, including: - Telomere maintenance: ZBTB48 plays a critical role in maintaining telomere length by binding to the telomeric repeat sequence 5'-TTAGGG-3' and regulating the expression of telomere maintenance genes. - Transcription regulation: ZBTB48 is involved in regulating transcription by binding to DNA sequences involved in transcription initiation and elongation. - Regulation of cell proliferation: ZBTB48 is involved in regulating cell proliferation by interacting with DNA-binding transcription factors that control the expression of proliferation-related genes. **Clinical significance:** - Mutations in the ZBTB48 gene have been linked to several neurodegenerative diseases, including Alzheimer's disease and amyotrophic lateral sclerosis. - Overexpression of ZBTB48 has been observed in several neurological disorders, including autism, schizophrenia, and Alzheimer's disease. - Inhibition of ZBTB48 has been shown to have neuroprotective effects in models of neurodegenerative diseases, indicating that ZBTB48 is a potential therapeutic target for these disorders.

Genular Protein ID: 2863491937

Symbol: TZAP_HUMAN

Name: N/A

UniProtKB Accession Codes:

P10074 Q5SY19

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 ChEBI 16 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7969177

Title: A factor that regulates the class II major histocompatibility complex gene DPA is a member of a subfamily of zinc finger proteins that includes a Drosophila developmental control protein.

PubMed ID: 7969177

DOI: 10.1128/mcb.14.12.8438-8450.1994

PubMed ID: 9516840

Title: Human Kruppel-related 3 (HKR3): a candidate for the 1p36 neuroblastoma tumour suppressor gene?

PubMed ID: 9516840

DOI: 10.1016/s0959-8049(97)00279-7

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2850480

Title: The GLI-Kruppel family of human genes.

PubMed ID: 2850480

DOI: 10.1128/mcb.8.8.3104-3113.1988

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24382891

Title: Human Kruppel-related 3 (HKR3) is a novel transcription activator of alternate reading frame (ARF) gene.

PubMed ID: 24382891

DOI: 10.1074/jbc.m113.526855

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28500257

Title: ZBTB48 is both a vertebrate telomere-binding protein and a transcriptional activator.

PubMed ID: 28500257

DOI: 10.15252/embr.201744095

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28082411

Title: TZAP: A telomere-associated protein involved in telomere length control.

PubMed ID: 28082411

DOI: 10.1126/science.aah6752

Sequence Information:

  • Length: 688
  • Mass: 77054
  • Checksum: EBECCE3D6CBBD524
  • Sequence:
    • MDGSFVQHSV RVLQELNKQR EKGQYCDATL DVGGLVFKAH WSVLACCSHF FQSLYGDGSG 
GSVVLPAGFA EIFGLLLDFF YTGHLALTSG NRDQVLLAAR ELRVPEAVEL CQSFKPKTSV 
GQAAGGQSGL GPPASQNVNS HVKEPAGLEE EEVSRTLGLV PRDQEPRGSH SPQRPQLHSP 
AQSEGPSSLC GKLKQALKPC PLEDKKPEDC KVPPRPLEAE GAQLQGGSNE WEVVVQVEDD 
GDGDYMSEPE AVLTRRKSNV IRKPCAAEPA LSAGSLAAEP AENRKGTAVP VECPTCHKKF 
LSKYYLKVHN RKHTGEKPFE CPKCGKCYFR KENLLEHEAR NCMNRSEQVF TCSVCQETFR 
RRMELRVHMV SHTGEMPYKC SSCSQQFMQK KDLQSHMIKL HGAPKPHACP TCAKCFLSRT 
ELQLHEAFKH RGEKLFVCEE CGHRASSRNG LQMHIKAKHR NERPHVCEFC SHAFTQKANL 
NMHLRTHTGE KPFQCHLCGK TFRTQASLDK HNRTHTGERP FSCEFCEQRF TEKGPLLRHV 
ASRHQEGRPH FCQICGKTFK AVEQLRVHVR RHKGVRKFEC TECGYKFTRQ AHLRRHMEIH 
DRVENYNPRQ RKLRNLIIED EKMVVVALQP PAELEVGSAE VIVESLAQGG LASQLPGQRL 
CAEESFTGPG VLEPSLIITA AVPEDCDT

Genular Protein ID: 1680396202

Symbol: A8K291_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K291

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 DNASU 1 EMBL 2 Gene3D 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 688
  • Mass: 77103
  • Checksum: 63300DDD15DC7A79
  • Sequence:
    • MDGSFVQHSV RVLQELNKQR EKGQYCDATL DVGGLVFKAH WSVLACCSHF FQSLYGDGSG 
GSVVLPAGFA EIFGLLLDFF YTGHLALTSG NRDQVLLAAR ELRVPEAVEL CQSFKPKTSV 
GQAAGGQSGL GPPASQNVNS HVKEPAGLEE EEVSRTLGLV PRDQEPRGSH SPQRPQLHSP 
AQSEGPSSLC GKLKQALKPC PLEDKKPEDC KVPPRPLEAE GAQLQGGSNE WEVVVQVEDD 
GDGDYMSEPE AVLTRRKSNV IRKPCAAEPA LSAGSLAAEP AEYRKGTAVP VECPTCHKKF 
LSKYYLKVHN RKHTGEKPFE CPKCGKCYFR KENLLEHEAR NCMNRSEQVF TCSVCQETFR 
RRMELRVHMV SHTGEMPYKC SSCSQQFMQK KDLQSHMIKL HGAPKPHACP TCAKCFLSRT 
ELQLHEAFKH RGEKLFVCEE CGHRASSRNG LQMHIKAKHR NERPHVCEFC SHAFTQKANL 
NMHLRTHTGE KPFQCHLCGK TFRTQASLDK HNRTHTGERP FSCEFCEQRF TEKGPLLRHV 
ASRHQEGRPH FCQICGKTFK AVEQLRVHVR RHKGVRKFEC TECGYKFTRQ AHLRRHMEIH 
DRVENYNPRQ RKLRNLIIED EKMVVVALQP PAELEVGSAE VIVESLAQGG LASQLPGQRL 
CAEESFTGPG VLEPSLIITA AVPEDCDT

Genular Protein ID: 2084003774

Symbol: B2R702_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R702

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 DNASU 1 EMBL 2 Gene3D 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 688
  • Mass: 77070
  • Checksum: EBECCACE5557D524
  • Sequence:
    • MDGSFVQHSV RVLQELNKQR EKGQYCDATL DVGGLVFKAH WSVLACCSHF FQSLYGDGSG 
GSVVLPAGFA EIFGLLLDFF YTGHLALTSG NRDQVLLAAR ELRVPEAVEL CQSFKPKTSV 
GQAAGGQSGL GPPASQNVNS HVKEPAGLEE EEVSRTLGLV PRDQELRGSH SPQRPQLHSP 
AQSEGPSSLC GKLKQALKPC PLEDKKPEDC KVPPRPLEAE GAQLQGGSNE WEVVVQVEDD 
GDGDYMSEPE AVLTRRKSNV IRKPCAAEPA LSAGSLAAEP AENRKGTAVP VECPTCHKKF 
LSKYYLKVHN RKHTGEKPFE CPKCGKCYFR KENLLEHEAR NCMNRSEQVF TCSVCQETFR 
RRMELRVHMV SHTGEMPYKC SSCSQQFMQK KDLQSHMIKL HGAPKPHACP TCAKCFLSRT 
ELQLHEAFKH RGEKLFVCEE CGHRASSRNG LQMHIKAKHR NERPHVCEFC SHAFTQKANL 
NMHLRTHTGE KPFQCHLCGK TFRTQASLDK HNRTHTGERP FSCEFCEQRF TEKGPLLRHV 
ASRHQEGRPH FCQICGKTFK AVEQLRVHVR RHKGVRKFEC TECGYKFTRQ AHLRRHMEIH 
DRVENYNPRQ RKLRNLIIED EKMVVVALQP PAELEVGSAE VIVESLAQGG LASQLPGQRL 
CAEESFTGPG VLEPSLIITA AVPEDCDT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.