Details for: HPCAL1

Gene ID: 3241

Symbol: HPCAL1

Ensembl ID: ENSG00000115756

Description: hippocalcin like 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 225.9150
    Cell Significance Index: -35.1400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 124.5055
    Cell Significance Index: -31.5800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 84.4047
    Cell Significance Index: -34.2900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 79.6827
    Cell Significance Index: -37.6200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 73.9718
    Cell Significance Index: -38.0500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 55.6912
    Cell Significance Index: -37.3700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 36.5543
    Cell Significance Index: -34.9000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 28.6304
    Cell Significance Index: -35.3000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.0734
    Cell Significance Index: -30.9400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.8811
    Cell Significance Index: -26.4700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.1332
    Cell Significance Index: -36.0400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.0684
    Cell Significance Index: 281.3500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.0771
    Cell Significance Index: 225.9200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.8919
    Cell Significance Index: 113.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6000
    Cell Significance Index: 317.5200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.4851
    Cell Significance Index: 21.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.3208
    Cell Significance Index: 68.8000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.1207
    Cell Significance Index: 24.5400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.1057
    Cell Significance Index: 6.8700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.0777
    Cell Significance Index: 17.2900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.0727
    Cell Significance Index: 18.0700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.9587
    Cell Significance Index: 16.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9372
    Cell Significance Index: 336.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8995
    Cell Significance Index: 88.9800
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.8793
    Cell Significance Index: 8.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8608
    Cell Significance Index: 55.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8106
    Cell Significance Index: 731.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6070
    Cell Significance Index: 121.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5381
    Cell Significance Index: 15.5100
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.3845
    Cell Significance Index: 1.8700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3644
    Cell Significance Index: 6.7400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3606
    Cell Significance Index: 68.6300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3541
    Cell Significance Index: 10.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3305
    Cell Significance Index: 18.5500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2890
    Cell Significance Index: 7.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2831
    Cell Significance Index: 435.8300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2682
    Cell Significance Index: 4.7400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2477
    Cell Significance Index: 171.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2325
    Cell Significance Index: 428.7800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2289
    Cell Significance Index: 125.0300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2230
    Cell Significance Index: 28.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2211
    Cell Significance Index: 10.3900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2138
    Cell Significance Index: 9.6900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1770
    Cell Significance Index: 112.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1714
    Cell Significance Index: 322.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1333
    Cell Significance Index: 18.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1080
    Cell Significance Index: 19.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1026
    Cell Significance Index: 17.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0955
    Cell Significance Index: 12.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0947
    Cell Significance Index: 11.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0779
    Cell Significance Index: 5.9800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0734
    Cell Significance Index: 99.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0725
    Cell Significance Index: 54.8800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.0519
    Cell Significance Index: 0.4000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0401
    Cell Significance Index: 17.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0181
    Cell Significance Index: -2.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0189
    Cell Significance Index: -13.8500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0198
    Cell Significance Index: -12.3800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0230
    Cell Significance Index: -0.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0233
    Cell Significance Index: -1.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0257
    Cell Significance Index: -19.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0283
    Cell Significance Index: -0.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0380
    Cell Significance Index: -17.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0415
    Cell Significance Index: -23.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0451
    Cell Significance Index: -4.6100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0935
    Cell Significance Index: -1.1200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1049
    Cell Significance Index: -30.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1132
    Cell Significance Index: -16.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1186
    Cell Significance Index: -24.9800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1199
    Cell Significance Index: -7.3700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1250
    Cell Significance Index: -14.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1288
    Cell Significance Index: -8.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1396
    Cell Significance Index: -7.3300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1440
    Cell Significance Index: -0.8700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1648
    Cell Significance Index: -2.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1771
    Cell Significance Index: -20.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1816
    Cell Significance Index: -4.5400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1891
    Cell Significance Index: -21.5800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1903
    Cell Significance Index: -1.9700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2087
    Cell Significance Index: -3.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2251
    Cell Significance Index: -16.7800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2363
    Cell Significance Index: -6.3200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2415
    Cell Significance Index: -6.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3138
    Cell Significance Index: -10.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3158
    Cell Significance Index: -32.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3721
    Cell Significance Index: -10.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3775
    Cell Significance Index: -17.6000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3792
    Cell Significance Index: -30.0300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3794
    Cell Significance Index: -26.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4482
    Cell Significance Index: -15.7500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4630
    Cell Significance Index: -24.0500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4993
    Cell Significance Index: -13.5900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5249
    Cell Significance Index: -11.3400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5562
    Cell Significance Index: -18.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6072
    Cell Significance Index: -37.2300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6213
    Cell Significance Index: -17.7300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.6451
    Cell Significance Index: -10.8500
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.7195
    Cell Significance Index: -5.5000
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.7453
    Cell Significance Index: -8.4200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7681
    Cell Significance Index: -26.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HPCAL1 is a member of the hippocalcin family, which consists of proteins that interact with calcium ions. The protein sequence of HPCAL1 shows a high degree of similarity to hippocalcin, a protein known for its role in regulating cell growth and differentiation. Notably, HPCAL1 is expressed in a wide range of cell types, including type I pneumocytes, alveolar capillary type 1 endothelial cells, and ovarian surface epithelial cells. These findings suggest that HPCAL1 may play a role in maintaining tissue homeostasis and regulating cellular processes in various organs. **Pathways and Functions:** The calcium-binding properties of HPCAL1 are thought to play a crucial role in its function. Calcium ions are essential for various cellular processes, including cell signaling, gene expression, and protein function. HPCAL1 may interact with other proteins to regulate these processes, potentially influencing cell growth, differentiation, and survival. The protein's expression in cell types involved in gas exchange, ion transport, and sensory perception suggests that HPCAL1 may also play a role in regulating these processes. In addition, HPCAL1 may be involved in the regulation of gene expression, particularly in response to calcium signals. This could have implications for our understanding of cellular responses to environmental changes, such as changes in calcium levels. **Clinical Significance:** The expression of HPCAL1 in various tissues and cell types suggests that it may play a role in maintaining tissue homeostasis and regulating cellular processes. Abnormal expression of HPCAL1 has been linked to several diseases, including lung disease, ovarian cancer, and neurological disorders. For example, alterations in HPCAL1 expression have been observed in the lungs of patients with chronic obstructive pulmonary disease (COPD), suggesting that HPCAL1 may play a role in regulating lung function and responding to environmental stressors. Similarly, HPCAL1 has been implicated in the development of ovarian cancer, with some studies suggesting that the protein may act as a tumor suppressor. In the nervous system, HPCAL1 has been shown to interact with GABAergic cortical interneurons, suggesting that it may play a role in regulating neuronal function and synaptic transmission. Further research is needed to fully understand the clinical significance of HPCAL1 and its potential applications in disease diagnosis and treatment. **Conclusion:** In conclusion, HPCAL1 is a protein with calcium-binding properties that is expressed in a wide range of cell types. Its potential role in regulating cellular processes, including cell growth, differentiation, and survival, makes it an interesting target for further research. Further studies are needed to fully understand the functions of HPCAL1 and its clinical significance, particularly in the context of disease diagnosis and treatment.

Genular Protein ID: 1851232190

Symbol: HPCL1_HUMAN

Name: Hippocalcin-like protein 1

UniProtKB Accession Codes:

P37235 Q969S5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 5 ExpressionAtlas 1 GO 2 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 16 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8038222

Title: Molecular cloning of a novel calcium-binding protein structurally related to hippocalcin from human brain and chromosomal mapping of its gene.

PubMed ID: 8038222

DOI: 10.1016/0167-4889(94)90062-0

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

Sequence Information:

  • Length: 193
  • Mass: 22313
  • Checksum: 87DCE938DCAD5E1F
  • Sequence:
    • MGKQNSKLRP EVLQDLRENT EFTDHELQEW YKGFLKDCPT GHLTVDEFKK IYANFFPYGD 
ASKFAEHVFR TFDTNGDGTI DFREFIIALS VTSRGKLEQK LKWAFSMYDL DGNGYISRSE 
MLEIVQAIYK MVSSVMKMPE DESTPEKRTD KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV 
RLLQCDPSSA SQF

Genular Protein ID: 787598604

Symbol: O75544_HUMAN

Name: N/A

UniProtKB Accession Codes:

O75544

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 1 Gene3D 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 5 SMART 1 SUPFAM 1

Citations:

PubMed ID: 8619474

Title: A "double adaptor" method for improved shotgun library construction.

PubMed ID: 8619474

DOI: 10.1006/abio.1996.0138

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

Sequence Information:

  • Length: 110
  • Mass: 12548
  • Checksum: AC516D6CB2059928
  • Sequence:
    • EFIIALSVTS RGKLEQKLKW AFSMYDLDGN GYISRSEMLE IVQAIYKMVS SVMKMPEDES 
TPEKRTDKIF RQMDTNNDGK LSLEEFIRGA KSDPSIVRLL QCDPSSASQF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.