Details for: HPCAL1

Gene ID: 3241

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: HPCAL1

Ensembl ID: ENSG00000115756

Description: hippocalcin like 1

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 37.27
    rCSI 62.56%
    PRS 20.22
  • intestine goblet cell CL0019031
    CSI 34.59
    rCSI 30.7%
    PRS 31.76
  • small intestine goblet cell CL1000495
    CSI 33.1
    rCSI 72.49%
    PRS 41.24
  • BEST4+ enteroycte CL4030026
    CSI 31.13
    rCSI 38.72%
    PRS 34.29
  • alveolar type 1 fibroblast cell CL4028004
    CSI 26.72
    rCSI 29.26%
    PRS 35.48
  • extravillous trophoblast CL0008036
    CSI 26.25
    rCSI 32.47%
    PRS 28.6
  • colon goblet cell CL0009039
    CSI 21.68
    rCSI 51.54%
    PRS 44.23
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 20.86
    rCSI 25.19%
    PRS 38.19
  • hepatocyte CL0000182
    CSI 20.83
    rCSI 37.29%
    PRS 30.32
  • L6b glutamatergic cortical neuron CL4023038
    CSI 20.1
    rCSI 62.81%
    PRS 21.18
  • epithelial cell of lung CL0000082
    CSI 16.54
    rCSI 13.72%
    PRS 30.57
  • secretory cell CL0000151
    CSI 16.4
    rCSI 17.11%
    PRS 32.64
  • retina horizontal cell CL0000745
    CSI 15.42
    rCSI 23.51%
    PRS 29.75
  • innate lymphoid cell CL0001065
    CSI 13.76
    rCSI 28.41%
    PRS 41.58
  • paneth cell of epithelium of small intestine CL1000343
    CSI 12.85
    rCSI 36.01%
    PRS 46.46
  • goblet cell CL0000160
    CSI 12.76
    rCSI 12.06%
    PRS 33.21
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 12.24
    rCSI 26.55%
    PRS 24.98
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI 12.06
    rCSI 10.99%
    PRS 46.18
  • cerebellar granule cell CL0001031
    CSI 11.88
    rCSI 17.46%
    PRS 29.82
  • plasmacytoid dendritic cell, human CL0001058
    CSI 11.84
    rCSI 8.27%
    PRS 33.63
  • naive T cell CL0000898
    CSI 11.48
    rCSI 7.99%
    PRS 43.38
  • H1 horizontal cell CL0004217
    CSI 9.78
    rCSI 38.72%
    PRS 37.65
  • endothelial cell of pericentral hepatic sinusoid CL0019022
    CSI 9.62
    rCSI 29.63%
    PRS 44.02
  • paneth cell CL0000510
    CSI 9.19
    rCSI 13.57%
    PRS 47.55
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 7.88
    rCSI 19.15%
    PRS 19.68
  • pulmonary alveolar type 1 cell CL0002062
    CSI 7.61
    rCSI 43.88%
    PRS 36.27
  • retinal ganglion cell CL0000740
    CSI 7.2
    rCSI 15.91%
    PRS 23.35
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI 7.12
    rCSI 20.43%
    PRS 46.89
  • colon epithelial cell CL0011108
    CSI 7
    rCSI 7.33%
    PRS 29.92
  • renal interstitial pericyte CL1001318
    CSI 6.76
    rCSI 18.62%
    PRS 30.02
  • immature B cell CL0000816
    CSI 6.63
    rCSI 4.93%
    PRS 44.26
  • epithelial cell of proximal tubule CL0002306
    CSI 6.53
    rCSI 15.94%
    PRS 30.14
  • placental villous trophoblast CL2000060
    CSI 5.72
    rCSI 8.84%
    PRS 30.34
  • regular ventricular cardiac myocyte CL0002131
    CSI 5.71
    rCSI 35.68%
    PRS 26.3
  • ON-bipolar cell CL0000749
    CSI 5.45
    rCSI 8.1%
    PRS 35.55
  • lung resident memory CD8-positive, alpha-beta T cell CL4033039
    CSI 5.44
    rCSI 14.07%
    PRS 64.97
  • fibroblast of lung CL0002553
    CSI 5.04
    rCSI 4.69%
    PRS 32
  • double negative thymocyte CL0002489
    CSI 5.01
    rCSI 3.48%
    PRS 38.62
  • retinal rod cell CL0000604
    CSI 4.93
    rCSI 8.7%
    PRS 31.23
  • CD14-positive monocyte CL0001054
    CSI 4.77
    rCSI 5.94%
    PRS 42.53
  • dopaminergic neuron CL0000700
    CSI 4.72
    rCSI 26.67%
    PRS 21.26
  • central memory CD4-positive, alpha-beta T cell CL0000904
    CSI 4.63
    rCSI 2.74%
    PRS 44.3
  • cholangiocyte CL1000488
    CSI 4.56
    rCSI 27.35%
    PRS 48.28
  • enterocyte CL0000584
    CSI 4.56
    rCSI 7.36%
    PRS 43.02
  • mature alpha-beta T cell CL0000791
    CSI 4.48
    rCSI 16.23%
    PRS 50.13
  • fallopian tube secretory epithelial cell CL4030006
    CSI 4.44
    rCSI 4.27%
    PRS 32.92
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 4.34
    rCSI 16.4%
    PRS 21.01
  • progenitor cell CL0011026
    CSI 4.28
    rCSI 9.11%
    PRS 40.27
  • Mueller cell CL0000636
    CSI 4.23
    rCSI 9.66%
    PRS 27.56
  • renal alpha-intercalated cell CL0005011
    CSI 4.19
    rCSI 5.6%
    PRS 39.41
  • enteroendocrine cell of small intestine CL0009006
    CSI 4.18
    rCSI 9.19%
    PRS 45.76
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 4.08
    rCSI 11.01%
    PRS 40.48
  • rod bipolar cell CL0000751
    CSI 4.07
    rCSI 7.31%
    PRS 27.05
  • lung macrophage CL1001603
    CSI 4.06
    rCSI 9.06%
    PRS 37.3
  • CD4-positive, alpha-beta thymocyte CL0000810
    CSI 3.87
    rCSI 3.1%
    PRS 52.31
  • myeloid leukocyte CL0000766
    CSI 3.84
    rCSI 3.55%
    PRS 33.13
  • pro-B cell CL0000826
    CSI 3.7
    rCSI 3.06%
    PRS 32.65
  • choroid plexus epithelial cell CL0000706
    CSI 3.69
    rCSI 6.04%
    PRS 25.19
  • melanocyte CL0000148
    CSI 3.66
    rCSI 2.71%
    PRS 27.57
  • mononuclear phagocyte CL0000113
    CSI 3.64
    rCSI 8.01%
    PRS 35.82
  • type L enteroendocrine cell CL0002279
    CSI 3.58
    rCSI 6.72%
    PRS 53.15
  • brush cell of tracheobronchial tree CL0002075
    CSI 3.53
    rCSI 10.49%
    PRS 42.36
  • activated CD4-positive, alpha-beta T cell CL0000896
    CSI 3.52
    rCSI 3.25%
    PRS 51.85
  • T follicular helper cell CL0002038
    CSI 3.51
    rCSI 2.63%
    PRS 46.13
  • megakaryocyte CL0000556
    CSI 3.49
    rCSI 15.14%
    PRS 48.48
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 3.45
    rCSI 4.42%
    PRS 30.64
  • unswitched memory B cell CL0000970
    CSI 3.42
    rCSI 2.88%
    PRS 47.75
  • elicited macrophage CL0000861
    CSI 3.37
    rCSI 3.09%
    PRS 37.97
  • blood vessel endothelial cell CL0000071
    CSI 3.35
    rCSI 6.96%
    PRS 31.26
  • effector CD8-positive, alpha-beta T cell CL0001050
    CSI 3.31
    rCSI 2.52%
    PRS 41.56
  • CD4-positive, alpha-beta memory T cell CL0000897
    CSI 3.28
    rCSI 2.35%
    PRS 42.94
  • pulmonary artery endothelial cell CL1001568
    CSI 3.27
    rCSI 4.45%
    PRS 44.35
  • enteroendocrine cell CL0000164
    CSI 3.24
    rCSI 4.43%
    PRS 34.79
  • retinal pigment epithelial cell CL0002586
    CSI 3.23
    rCSI 6.42%
    PRS 32.46
  • endothelial cell of vascular tree CL0002139
    CSI 3.2
    rCSI 17.48%
    PRS 39.73
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 3.18
    rCSI 2.15%
    PRS 40.02
  • platelet CL0000233
    CSI 3.12
    rCSI 12.94%
    PRS 44.36
  • cytotoxic T cell CL0000910
    CSI 3.07
    rCSI 17.62%
    PRS 44.16
  • vascular leptomeningeal cell CL4023051
    CSI 3.04
    rCSI 5.33%
    PRS 25.79
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 2.96
    rCSI 9.72%
    PRS 23.57
  • CD16-positive, CD56-dim natural killer cell, human CL0000939
    CSI 2.95
    rCSI 1.97%
    PRS 60.37
  • Kupffer cell CL0000091
    CSI 2.93
    rCSI 6.7%
    PRS 31.58
  • parietal epithelial cell CL1000452
    CSI 2.92
    rCSI 7.81%
    PRS 27.08
  • inflammatory macrophage CL0000863
    CSI 2.9
    rCSI 4.95%
    PRS 57.81
  • pulmonary capillary endothelial cell CL4028001
    CSI 2.89
    rCSI 5.52%
    PRS 47.76
  • activated type II NK T cell CL0000931
    CSI 2.86
    rCSI 3.22%
    PRS 47.34
  • neural crest cell CL0011012
    CSI 2.81
    rCSI 2.22%
    PRS 22.55
  • inhibitory interneuron CL0000498
    CSI 2.78
    rCSI 6.43%
    PRS 26.44
  • plasmablast CL0000980
    CSI 2.75
    rCSI 2.16%
    PRS 37.83
  • effector memory CD4-positive, alpha-beta T cell CL0000905
    CSI 2.74
    rCSI 3.73%
    PRS 60.9
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI 2.74
    rCSI 2.69%
    PRS 46.24
  • hepatic stellate cell CL0000632
    CSI 2.66
    rCSI 9.97%
    PRS 27.23
  • cerebral cortex neuron CL0010012
    CSI 2.6
    rCSI 10.58%
    PRS 31.83
  • granulocyte CL0000094
    CSI 2.57
    rCSI 3.93%
    PRS 40.23
  • neutrophil CL0000775
    CSI 2.57
    rCSI 14.36%
    PRS 47.1
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 2.56
    rCSI 3.63%
    PRS 29.87
  • myofibroblast cell CL0000186
    CSI 2.46
    rCSI 3.4%
    PRS 39.19
  • astrocyte of the cerebral cortex CL0002605
    CSI 2.43
    rCSI 5.45%
    PRS 20.75
  • OFF-bipolar cell CL0000750
    CSI 2.35
    rCSI 3.21%
    PRS 43.52
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 2.3
    rCSI 2.65%
    PRS 28.04
  • paneth cell of colon CL0009009
    CSI 0.2
    rCSI 2.1%
    PRS 61.2%
  • vein endothelial cell of respiratory system CL4033008
    CSI 0.2
    rCSI 1.7%
    PRS 52.8%
  • central nervous system neuron CL2000029
    CSI 0.3
    rCSI 2.1%
    PRS 22.3%
  • pancreatic acinar cell CL0002064
    CSI 0.4
    rCSI 0.5%
    PRS 35.4%
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 0.4
    rCSI 1.4%
    PRS 19.2%
  • parietal cell CL0000162
    CSI 0.4
    rCSI 3.5%
    PRS 76.5%
  • follicular dendritic cell CL0000442
    CSI 0.5
    rCSI 7.4%
    PRS 77.1%
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 0.6
    rCSI 2.8%
    PRS 41.3%
  • endothelial cell of uterus CL0009095
    CSI 0.7
    rCSI 4.9%
    PRS 62.8%
  • retinal cone cell CL0000573
    CSI 0.7
    rCSI 1.1%
    PRS 25.0%
  • serotonergic neuron CL0000850
    CSI 0.7
    rCSI 3.0%
    PRS 22.8%
  • endothelial cell of placenta CL0009092
    CSI 0.7
    rCSI 3.4%
    PRS 42.1%
  • Hofbauer cell CL3000001
    CSI 0.7
    rCSI 1.3%
    PRS 40.5%
  • transit amplifying cell of small intestine CL0009012
    CSI 0.7
    rCSI 3.1%
    PRS 52.0%
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 0.7
    rCSI 0.7%
    PRS 29.4%
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 0.7
    rCSI 0.9%
    PRS 33.5%
  • germinal center B cell CL0000844
    CSI 0.8
    rCSI 2.4%
    PRS 57.3%
  • H2 horizontal cell CL0004218
    CSI 0.8
    rCSI 4.1%
    PRS 33.4%
  • colon macrophage CL0009038
    CSI 0.8
    rCSI 3.9%
    PRS 55.5%
  • mammary gland epithelial cell CL0002327
    CSI 0.9
    rCSI 3.1%
    PRS 48.8%
  • vasa recta ascending limb cell CL1001131
    CSI 0.9
    rCSI 4.1%
    PRS 66.2%
  • neural progenitor cell CL0011020
    CSI 0.9
    rCSI 4.1%
    PRS 28.1%
  • intestinal tuft cell CL0019032
    CSI 1.0
    rCSI 1.5%
    PRS 36.3%
  • dendritic cell, human CL0001056
    CSI 1.0
    rCSI 1.5%
    PRS 37.7%
  • glial cell CL0000125
    CSI 1.0
    rCSI 3.7%
    PRS 28.6%
  • fraction A pre-pro B cell CL0002045
    CSI 1.0
    rCSI 1.1%
    PRS 55.4%
  • lung microvascular endothelial cell CL2000016
    CSI 1.0
    rCSI 19.1%
    PRS 61.9%
  • IgG plasma cell CL0000985
    CSI 1.0
    rCSI 1.2%
    PRS 50.3%
  • enteroendocrine cell of colon CL0009042
    CSI 1.0
    rCSI 4.8%
    PRS 61.1%
  • pancreatic ductal cell CL0002079
    CSI 1.0
    rCSI 2.0%
    PRS 33.3%
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 1.0
    rCSI 11.1%
    PRS 36.2%
  • transit amplifying cell CL0009010
    CSI 1.1
    rCSI 1.6%
    PRS 48.1%
  • cerebellar neuron CL1001611
    CSI 1.1
    rCSI 9.4%
    PRS 23.6%
  • podocyte CL0000653
    CSI 1.1
    rCSI 4.8%
    PRS 30.9%
  • promonocyte CL0000559
    CSI 1.2
    rCSI 2.0%
    PRS 41.1%
  • retinal blood vessel endothelial cell CL0002585
    CSI 1.2
    rCSI 1.9%
    PRS 34.9%
  • cardiac muscle cell CL0000746
    CSI 1.2
    rCSI 1.8%
    PRS 25.5%
  • lung secretory cell CL1000272
    CSI 1.2
    rCSI 3.1%
    PRS 30.3%
  • helper T cell CL0000912
    CSI 1.3
    rCSI 1.8%
    PRS 42.0%
  • double-positive, alpha-beta thymocyte CL0000809
    CSI 1.3
    rCSI 1.4%
    PRS 43.9%
  • kidney connecting tubule epithelial cell CL1000768
    CSI 1.4
    rCSI 3.6%
    PRS 25.0%
  • M cell of gut CL0000682
    CSI 1.4
    rCSI 1.5%
    PRS 48.0%
  • lung ciliated cell CL1000271
    CSI 1.4
    rCSI 1.6%
    PRS 24.2%
  • brush cell CL0002204
    CSI 1.4
    rCSI 2.8%
    PRS 60.9%
  • renal principal cell CL0005009
    CSI 1.4
    rCSI 3.7%
    PRS 38.1%
  • alternatively activated macrophage CL0000890
    CSI 1.4
    rCSI 1.8%
    PRS 45.1%
  • T-helper 17 cell CL0000899
    CSI 1.5
    rCSI 1.2%
    PRS 52.5%
  • common lymphoid progenitor CL0000051
    CSI 1.5
    rCSI 2.0%
    PRS 54.1%
  • syncytiotrophoblast cell CL0000525
    CSI 1.5
    rCSI 4.4%
    PRS 51.0%
  • common myeloid progenitor CL0000049
    CSI 1.5
    rCSI 1.3%
    PRS 32.3%
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 1.5
    rCSI 1.2%
    PRS 30.5%
  • type EC enteroendocrine cell CL0000577
    CSI 1.5
    rCSI 5.5%
    PRS 46.4%
  • interneuron CL0000099
    CSI 1.6
    rCSI 3.1%
    PRS 24.3%
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI 1.6
    rCSI 1.9%
    PRS 51.0%
  • Bergmann glial cell CL0000644
    CSI 1.6
    rCSI 2.2%
    PRS 30.7%
  • epithelial cell of lower respiratory tract CL0002632
    CSI 1.6
    rCSI 1.3%
    PRS 31.6%
  • vascular associated smooth muscle cell CL0000359
    CSI 1.7
    rCSI 5.4%
    PRS 36.3%
  • intermediate monocyte CL0002393
    CSI 1.7
    rCSI 2.5%
    PRS 33.2%
  • endothelial cell of periportal hepatic sinusoid CL0019021
    CSI 1.7
    rCSI 7.8%
    PRS 55.9%
  • foveolar cell of stomach CL0002179
    CSI 1.7
    rCSI 3.6%
    PRS 46.7%
  • promyelocyte CL0000836
    CSI 1.7
    rCSI 2.5%
    PRS 41.7%
  • retinal bipolar neuron CL0000748
    CSI 1.7
    rCSI 3.2%
    PRS 24.2%
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 1.8
    rCSI 4.6%
    PRS 29.4%
  • cardiac endothelial cell CL0010008
    CSI 1.8
    rCSI 7.2%
    PRS 30.8%
  • early lymphoid progenitor CL0000936
    CSI 1.8
    rCSI 1.6%
    PRS 36.4%
  • lung neuroendocrine cell CL1000223
    CSI 1.8
    rCSI 2.7%
    PRS 36.2%
  • colonocyte CL1000347
    CSI 1.8
    rCSI 2.6%
    PRS 39.9%
  • centrilobular region hepatocyte CL0019029
    CSI 1.8
    rCSI 4.8%
    PRS 42.6%
  • common dendritic progenitor CL0001029
    CSI 1.8
    rCSI 2.3%
    PRS 40.5%
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 1.9
    rCSI 4.8%
    PRS 31.1%
  • mature B cell CL0000785
    CSI 1.9
    rCSI 1.6%
    PRS 39.7%
  • group 3 innate lymphoid cell CL0001071
    CSI 1.9
    rCSI 1.4%
    PRS 34.4%
  • chondrocyte CL0000138
    CSI 1.9
    rCSI 3.0%
    PRS 27.1%
  • bronchus fibroblast of lung CL2000093
    CSI 1.9
    rCSI 1.5%
    PRS 33.0%
  • intestinal epithelial cell CL0002563
    CSI 1.9
    rCSI 2.0%
    PRS 32.5%
  • alveolar macrophage CL0000583
    CSI 1.9
    rCSI 3.1%
    PRS 36.9%
  • mucous neck cell CL0000651
    CSI 1.9
    rCSI 2.8%
    PRS 45.8%
  • mature T cell CL0002419
    CSI 2.0
    rCSI 1.5%
    PRS 46.3%
  • transit amplifying cell of colon CL0009011
    CSI 2.0
    rCSI 2.3%
    PRS 35.7%
  • intrahepatic cholangiocyte CL0002538
    CSI 2.0
    rCSI 4.8%
    PRS 49.5%
  • pulmonary alveolar type 2 cell CL0002063
    CSI 2.0
    rCSI 3.1%
    PRS 43.0%
  • conjunctival epithelial cell CL1000432
    CSI 2.0
    rCSI 3.1%
    PRS 32.5%
  • lung endothelial cell CL1001567
    CSI 2.0
    rCSI 4.7%
    PRS 59.9%
  • granulocyte monocyte progenitor cell CL0000557
    CSI 2.1
    rCSI 1.8%
    PRS 35.4%
  • GABAergic neuron CL0000617
    CSI 2.1
    rCSI 6.9%
    PRS 23.9%
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 2.1
    rCSI 2.7%
    PRS 43.8%
  • midzonal region hepatocyte CL0019028
    CSI 2.1
    rCSI 5.0%
    PRS 42.1%
  • myeloid dendritic cell CL0000782
    CSI 2.2
    rCSI 3.1%
    PRS 46.6%
  • cerebral cortex endothelial cell CL1001602
    CSI 2.2
    rCSI 3.8%
    PRS 24.9%
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 2.2
    rCSI 3.9%
    PRS 19.6%
  • sncg GABAergic cortical interneuron CL4023015
    CSI 2.2
    rCSI 3.5%
    PRS 22.0%
  • stem cell CL0000034
    CSI 2.2
    rCSI 2.1%
    PRS 24.6%
  • peripheral nervous system neuron CL2000032
    CSI 2.2
    rCSI 3.1%
    PRS 27.7%
  • VIP GABAergic cortical interneuron CL4023016
    CSI 2.3
    rCSI 2.7%
    PRS 20.1%
  • periportal region hepatocyte CL0019026
    CSI 2.3
    rCSI 8.9%
    PRS 41.5%
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 2.3
    rCSI 2.7%
    PRS 28.0%
  • OFF-bipolar cell CL0000750
    CSI 2.4
    rCSI 3.2%
    PRS 43.5%
  • astrocyte of the cerebral cortex CL0002605
    CSI 2.4
    rCSI 5.5%
    PRS 20.8%
  • myofibroblast cell CL0000186
    CSI 2.5
    rCSI 3.4%
    PRS 39.2%
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 2.6
    rCSI 3.6%
    PRS 29.9%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [HPCAL1](/details-gene/3241) (hippocalcin like 1) is a protein-coding gene located on chromosome 2p25.1. It encodes a calcium-binding protein that is a member of the hippocalcin family of neuronal calcium sensors [Link](https://doi.org/10.1016/0167-4889(94)90062-0). Functionally, [HPCAL1](/details-gene/3241) is implicated in the [regulation of signal transduction](/details-ontology/GO0009966) through its ability to bind calcium ions ([GO:0005509](/details-ontology/GO0005509)). **Overall**, expression data reveals its significance not only in specific neuronal populations such as [lamp5 GABAergic cortical interneuron](/details-cell/CL4023011) but also in a surprisingly diverse array of non-neuronal cell types, most notably secretory epithelial cells of the intestine, including [intestine goblet cell](/details-cell/CL0019031) and [BEST4+ enteroycte](/details-cell/CL4030026). This broad but specific expression pattern suggests that [HPCAL1](/details-gene/3241) acts as a key calcium-dependent signaling modulator in a variety of distinct biological contexts. ## Cellular Roles and Expression Landscape The expression profile of [HPCAL1](/details-gene/3241) highlights its importance across multiple organ systems. **Overall**, its most significant expression is observed in a functionally diverse set of cells. In the nervous system, [HPCAL1](/details-gene/3241) is a significant marker for specific neuronal subtypes, including [lamp5 GABAergic cortical interneuron](/details-cell/CL4023011) (CSI: 37.27), [L6b glutamatergic cortical neuron](/details-cell/CL4023038) (CSI: 20.10), and [retina horizontal cell](/details-cell/CL0000745) (CSI: 15.42). This is consistent with its initial characterization as a brain-enriched calcium sensor [Link](https://doi.org/10.1016/0167-4889(94)90062-0) and suggests a role in modulating cell-type-specific neuronal activity. A prominent feature of its expression landscape is its high significance in secretory epithelial cells of the gastrointestinal tract. This includes exceptionally high CSI values in [intestine goblet cell](/details-cell/CL0019031) (CSI: 34.59), [small intestine goblet cell](/details-cell/CL1000495) (CSI: 33.10), and [colon goblet cell](/details-cell/CL0009039) (CSI: 21.68), as well as [BEST4+ enteroycte](/details-cell/CL4030026) (CSI: 31.13) and [paneth cell of epithelium of small intestine](/details-cell/CL1000343) (CSI: 12.85). This strong pattern implicates [HPCAL1](/details-gene/3241) in calcium-mediated processes essential for gut homeostasis, such as mucus and antimicrobial peptide secretion. Furthermore, [HPCAL1](/details-gene/3241) shows notable expression in other specialized cell types, including [hepatocyte](/details-cell/CL0000182) (CSI: 20.83), [epithelial cell of lung](/details-cell/CL0000082) (CSI: 16.54), and immune cells like [CD1c-positive myeloid dendritic cell](/details-cell/CL0002399) (CSI: 20.86) and [innate lymphoid cell](/details-cell/CL0001065) (CSI: 13.76). This indicates a broader functional repertoire for [HPCAL1](/details-gene/3241) beyond its established role in the nervous system. ## Pathways and Molecular Function [HPCAL1](/details-gene/3241) is a well-established [calcium ion binding](/details-ontology/GO0005509) protein. This core molecular function enables its participation in the broader biological process of [regulation of signal transduction](/details-ontology/GO0009966). Its localization to the [membrane](/details-ontology/GO0016020) suggests it acts as a sensor that translates fluctuations in intracellular calcium concentrations into downstream signaling events at or near the cell surface. This function is highly consistent with its observed cellular expression. In neurons, calcium signaling is fundamental to neurotransmitter release and synaptic plasticity. In the secretory goblet and paneth cells of the intestine, calcium fluxes are critical triggers for the exocytosis of mucus granules and antimicrobial peptides. Similarly, in immune cells like dendritic cells, calcium signaling is central to processes such as antigen presentation and cytokine release. The ability to bind other proteins ([GO:0005515](/details-ontology/GO0005515)) further suggests that [HPCAL1](/details-gene/3241) functions by forming calcium-dependent complexes that regulate the activity of other effector molecules. ## Research Directions The widespread yet cell-type-specific expression of [HPCAL1](/details-gene/3241) opens several avenues for future investigation. Its clinical relevance is noted in OMIM ([600207](https://omim.org/entry/600207)), but its precise role in disease remains to be fully elucidated. ### Proposed Hypotheses 1. **[HPCAL1](/details-gene/3241) is a critical mediator of intestinal barrier function.** Given its exceptionally high significance in multiple intestinal secretory cell types ([intestine goblet cell](/details-cell/CL0019031), [paneth cell of epithelium of small intestine](/details-cell/CL1000343)), we hypothesize that it regulates the calcium-dependent exocytosis of mucins and antimicrobial peptides. Its dysregulation could therefore contribute to the pathogenesis of inflammatory bowel diseases. 2. **[HPCAL1](/details-gene/3241) modulates the function of specific dendritic cell subsets.** Its high expression in [CD1c-positive myeloid dendritic cell](/details-cell/CL0002399) suggests a role in regulating calcium-dependent processes unique to this lineage, such as lipid antigen presentation or the initiation of T-cell responses. 3. **In the brain, [HPCAL1](/details-gene/3241) fine-tunes the activity of inhibitory interneurons.** The top-ranked expression in [lamp5 GABAergic cortical interneuron](/details-cell/CL4023011) suggests it may regulate the calcium dynamics that control GABA release, thereby playing a key role in cortical network inhibition and stability. ### Key Experimental Approach To test the hypothesis that [HPCAL1](/details-gene/3241) is a key regulator of intestinal secretion (Hypothesis 1), a powerful approach would be to use a conditional knockout mouse model where *Hpcal1* is specifically deleted in intestinal epithelial cells. Intestinal organoids could be generated from these mice and their wild-type littermates. Following stimulation with a secretagogue like carbachol, secretion of the primary goblet cell mucin, MUC2, could be quantified using immunofluorescence imaging and ELISA. A significant reduction in MUC2 secretion in the knockout organoids would provide direct evidence for the essential role of [HPCAL1](/details-gene/3241) in this process. ### Therapeutic Potential The broad expression of [HPCAL1](/details-gene/3241) in critical cell types, including neurons, hepatocytes, and intestinal epithelium, suggests that systemic targeting would likely cause significant off-target effects. Therefore, it may be a challenging therapeutic target. However, if its dysfunction is linked to a localized pathology, such as chronic inflammation in the gut, developing locally-delivered inhibitors could be a viable strategy. As a calcium sensor that mediates downstream signaling, inhibition, rather than activation, would likely be the therapeutic goal in a disease state characterized by excessive or inappropriate cellular secretion or activation.

Genular Protein ID: 1851232190

Symbol: HPCL1_HUMAN

Name: Hippocalcin-like protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8038222

Title: Molecular cloning of a novel calcium-binding protein structurally related to hippocalcin from human brain and chromosomal mapping of its gene.

PubMed ID: 8038222

DOI: 10.1016/0167-4889(94)90062-0

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

Sequence Information:

  • Length: 193
  • Mass: 22313
  • Checksum: 87DCE938DCAD5E1F
  • Sequence:
  • MGKQNSKLRP EVLQDLRENT EFTDHELQEW YKGFLKDCPT GHLTVDEFKK IYANFFPYGD 
    ASKFAEHVFR TFDTNGDGTI DFREFIIALS VTSRGKLEQK LKWAFSMYDL DGNGYISRSE 
    MLEIVQAIYK MVSSVMKMPE DESTPEKRTD KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV 
    RLLQCDPSSA SQF

Genular Protein ID: 787598604

Symbol: O75544_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8619474

Title: A "double adaptor" method for improved shotgun library construction.

PubMed ID: 8619474

DOI: 10.1006/abio.1996.0138

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

Sequence Information:

  • Length: 110
  • Mass: 12548
  • Checksum: AC516D6CB2059928
  • Sequence:
  • EFIIALSVTS RGKLEQKLKW AFSMYDLDGN GYISRSEMLE IVQAIYKMVS SVMKMPEDES 
    TPEKRTDKIF RQMDTNNDGK LSLEEFIRGA KSDPSIVRLL QCDPSSASQF