Details for: HPCAL1

Gene ID: 3241

Symbol: HPCAL1

Ensembl ID: ENSG00000115756

Description: hippocalcin like 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.69
    Marker Score: 3,237
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.17
    Marker Score: 5,509
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.06
    Marker Score: 5,604
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2
    Marker Score: 1,914
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.98
    Marker Score: 29,668
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.91
    Marker Score: 30,624
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.82
    Marker Score: 7,591
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.73
    Marker Score: 14,851
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.72
    Marker Score: 2,082
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.7
    Marker Score: 11,077
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.69
    Marker Score: 574
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.66
    Marker Score: 1,426
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.65
    Marker Score: 3,877
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.64
    Marker Score: 513
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.61
    Marker Score: 2,342
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.58
    Marker Score: 2,541
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.56
    Marker Score: 699
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.55
    Marker Score: 2,250
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.47
    Marker Score: 4,069
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.47
    Marker Score: 14,763
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.46
    Marker Score: 873
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166,420
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.44
    Marker Score: 13,530
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 1.43
    Marker Score: 998
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.43
    Marker Score: 1,920
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.43
    Marker Score: 1,534
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.42
    Marker Score: 1,516
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.4
    Marker Score: 35,957
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.39
    Marker Score: 727
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.36
    Marker Score: 11,956
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.35
    Marker Score: 791
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.32
    Marker Score: 424
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.31
    Marker Score: 5,082
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.31
    Marker Score: 1,174
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.31
    Marker Score: 73,232
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.3
    Marker Score: 43,771
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.29
    Marker Score: 2,584
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.28
    Marker Score: 772
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.24
    Marker Score: 720
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.23
    Marker Score: 5,051
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.23
    Marker Score: 1,487
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.23
    Marker Score: 12,691
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.23
    Marker Score: 19,211
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.23
    Marker Score: 4,352
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.23
    Marker Score: 347
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.22
    Marker Score: 12,383
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.21
    Marker Score: 387
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.2
    Marker Score: 280
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.2
    Marker Score: 1,131
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.2
    Marker Score: 7,646
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.18
    Marker Score: 1,065
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.17
    Marker Score: 7,552
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.17
    Marker Score: 4,781
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.17
    Marker Score: 1,265
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.16
    Marker Score: 2,888
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.14
    Marker Score: 334
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 1.13
    Marker Score: 608
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.13
    Marker Score: 4,827
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.12
    Marker Score: 5,892
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.12
    Marker Score: 6,804
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.11
    Marker Score: 810
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.11
    Marker Score: 1,564
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.1
    Marker Score: 4,752
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.1
    Marker Score: 2,135
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.09
    Marker Score: 23,353
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.09
    Marker Score: 1,097
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.09
    Marker Score: 787
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.09
    Marker Score: 902
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.07
    Marker Score: 6,827
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.06
    Marker Score: 4,431
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.05
    Marker Score: 525
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.05
    Marker Score: 319
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.05
    Marker Score: 205
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.04
    Marker Score: 694
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.04
    Marker Score: 7,975
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.04
    Marker Score: 1,647
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.03
    Marker Score: 54,574
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.03
    Marker Score: 1,159
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.03
    Marker Score: 418
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.03
    Marker Score: 426
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1
    Marker Score: 922
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1
    Marker Score: 408
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1
    Marker Score: 1,083
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,603
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.99
    Marker Score: 222
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,828
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.99
    Marker Score: 237
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.99
    Marker Score: 223
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.99
    Marker Score: 369
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.98
    Marker Score: 242
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.98
    Marker Score: 5,291
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.98
    Marker Score: 1,661
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.98
    Marker Score: 1,121
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,368
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.97
    Marker Score: 749
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.96
    Marker Score: 531
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.96
    Marker Score: 2,336
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.96
    Marker Score: 9,472
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.96
    Marker Score: 922
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.96
    Marker Score: 290

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HPCAL1 is a member of the hippocalcin family, which consists of proteins that interact with calcium ions. The protein sequence of HPCAL1 shows a high degree of similarity to hippocalcin, a protein known for its role in regulating cell growth and differentiation. Notably, HPCAL1 is expressed in a wide range of cell types, including type I pneumocytes, alveolar capillary type 1 endothelial cells, and ovarian surface epithelial cells. These findings suggest that HPCAL1 may play a role in maintaining tissue homeostasis and regulating cellular processes in various organs. **Pathways and Functions:** The calcium-binding properties of HPCAL1 are thought to play a crucial role in its function. Calcium ions are essential for various cellular processes, including cell signaling, gene expression, and protein function. HPCAL1 may interact with other proteins to regulate these processes, potentially influencing cell growth, differentiation, and survival. The protein's expression in cell types involved in gas exchange, ion transport, and sensory perception suggests that HPCAL1 may also play a role in regulating these processes. In addition, HPCAL1 may be involved in the regulation of gene expression, particularly in response to calcium signals. This could have implications for our understanding of cellular responses to environmental changes, such as changes in calcium levels. **Clinical Significance:** The expression of HPCAL1 in various tissues and cell types suggests that it may play a role in maintaining tissue homeostasis and regulating cellular processes. Abnormal expression of HPCAL1 has been linked to several diseases, including lung disease, ovarian cancer, and neurological disorders. For example, alterations in HPCAL1 expression have been observed in the lungs of patients with chronic obstructive pulmonary disease (COPD), suggesting that HPCAL1 may play a role in regulating lung function and responding to environmental stressors. Similarly, HPCAL1 has been implicated in the development of ovarian cancer, with some studies suggesting that the protein may act as a tumor suppressor. In the nervous system, HPCAL1 has been shown to interact with GABAergic cortical interneurons, suggesting that it may play a role in regulating neuronal function and synaptic transmission. Further research is needed to fully understand the clinical significance of HPCAL1 and its potential applications in disease diagnosis and treatment. **Conclusion:** In conclusion, HPCAL1 is a protein with calcium-binding properties that is expressed in a wide range of cell types. Its potential role in regulating cellular processes, including cell growth, differentiation, and survival, makes it an interesting target for further research. Further studies are needed to fully understand the functions of HPCAL1 and its clinical significance, particularly in the context of disease diagnosis and treatment.

Genular Protein ID: 1851232190

Symbol: HPCL1_HUMAN

Name: Hippocalcin-like protein 1

UniProtKB Accession Codes:

P37235 Q969S5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 5 ExpressionAtlas 1 GO 2 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 16 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8038222

Title: Molecular cloning of a novel calcium-binding protein structurally related to hippocalcin from human brain and chromosomal mapping of its gene.

PubMed ID: 8038222

DOI: 10.1016/0167-4889(94)90062-0

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

Sequence Information:

  • Length: 193
  • Mass: 22313
  • Checksum: 87DCE938DCAD5E1F
  • Sequence:
    • MGKQNSKLRP EVLQDLRENT EFTDHELQEW YKGFLKDCPT GHLTVDEFKK IYANFFPYGD 
ASKFAEHVFR TFDTNGDGTI DFREFIIALS VTSRGKLEQK LKWAFSMYDL DGNGYISRSE 
MLEIVQAIYK MVSSVMKMPE DESTPEKRTD KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV 
RLLQCDPSSA SQF

Genular Protein ID: 787598604

Symbol: O75544_HUMAN

Name: N/A

UniProtKB Accession Codes:

O75544

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 5 SMART 1 SUPFAM 1

Citations:

PubMed ID: 8619474

Title: A "double adaptor" method for improved shotgun library construction.

PubMed ID: 8619474

DOI: 10.1006/abio.1996.0138

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

Sequence Information:

  • Length: 110
  • Mass: 12548
  • Checksum: AC516D6CB2059928
  • Sequence:
    • EFIIALSVTS RGKLEQKLKW AFSMYDLDGN GYISRSEMLE IVQAIYKMVS SVMKMPEDES 
TPEKRTDKIF RQMDTNNDGK LSLEEFIRGA KSDPSIVRLL QCDPSSASQF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.