Details for: HPCAL1

Gene ID: 3241

Symbol: HPCAL1

Ensembl ID: ENSG00000115756

Description: hippocalcin like 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.69
    Marker Score: 3237
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.17
    Marker Score: 5509
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.06
    Marker Score: 5604
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2
    Marker Score: 1914
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.98
    Marker Score: 29668
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.91
    Marker Score: 30624
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.82
    Marker Score: 7591
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.73
    Marker Score: 14851
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.72
    Marker Score: 2082
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.7
    Marker Score: 11077
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.69
    Marker Score: 574
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.66
    Marker Score: 1426
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.65
    Marker Score: 3877
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.64
    Marker Score: 513
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.61
    Marker Score: 2342
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.58
    Marker Score: 2541
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.56
    Marker Score: 699
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.55
    Marker Score: 2250
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.47
    Marker Score: 4069
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.47
    Marker Score: 14763
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.46
    Marker Score: 873
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166420
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.44
    Marker Score: 13530
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 1.43
    Marker Score: 998
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.43
    Marker Score: 1920
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.43
    Marker Score: 1534
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.42
    Marker Score: 1515.5
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.4
    Marker Score: 35957
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.39
    Marker Score: 727
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.36
    Marker Score: 11956
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.35
    Marker Score: 791
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.32
    Marker Score: 424
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.31
    Marker Score: 5082
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.31
    Marker Score: 1174
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.31
    Marker Score: 73232
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.3
    Marker Score: 43771
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.29
    Marker Score: 2584
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.28
    Marker Score: 772
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.24
    Marker Score: 720
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.23
    Marker Score: 5051
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.23
    Marker Score: 1486.5
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.23
    Marker Score: 12691
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.23
    Marker Score: 19211
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.23
    Marker Score: 4352
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.23
    Marker Score: 347
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.22
    Marker Score: 12383
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.21
    Marker Score: 387
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.2
    Marker Score: 280
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.2
    Marker Score: 1131
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.2
    Marker Score: 7646
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.18
    Marker Score: 1065
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.17
    Marker Score: 7552
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.17
    Marker Score: 4780.5
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.17
    Marker Score: 1265
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.16
    Marker Score: 2888
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.14
    Marker Score: 334
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 1.13
    Marker Score: 608
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.13
    Marker Score: 4827
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.12
    Marker Score: 5892
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.12
    Marker Score: 6804
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.11
    Marker Score: 810
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.11
    Marker Score: 1564
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.1
    Marker Score: 4752
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.1
    Marker Score: 2135
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.09
    Marker Score: 23353
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.09
    Marker Score: 1097
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.09
    Marker Score: 787
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.09
    Marker Score: 902
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.07
    Marker Score: 6827
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.06
    Marker Score: 4431
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.05
    Marker Score: 525
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.05
    Marker Score: 319
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.05
    Marker Score: 205
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.04
    Marker Score: 694
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.04
    Marker Score: 7975
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.04
    Marker Score: 1647
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.03
    Marker Score: 54574
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.03
    Marker Score: 1158.5
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.03
    Marker Score: 418
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.03
    Marker Score: 426
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1
    Marker Score: 922
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1
    Marker Score: 408
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1
    Marker Score: 1083
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71603
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.99
    Marker Score: 222
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47828
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.99
    Marker Score: 237
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.99
    Marker Score: 223
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.99
    Marker Score: 369
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.98
    Marker Score: 242
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.98
    Marker Score: 5291
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.98
    Marker Score: 1661
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.98
    Marker Score: 1121
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30368
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.97
    Marker Score: 749
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.96
    Marker Score: 531
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.96
    Marker Score: 2336
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.96
    Marker Score: 9472
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.96
    Marker Score: 922
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.96
    Marker Score: 290

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Other Information

**Key characteristics** * HPCAL1 is a transmembrane protein that is composed of 144 amino acids. * It is expressed in a variety of cell types, including type I pneumocyte, alveolar capillary type 1 endothelial cell, ovarian surface epithelial cell, intestine goblet cell, lamp5 GABAergic cortical interneuron, lactocyte, epithelial cell of lower respiratory tract, L6b glutamatergic cortical neuron, lens epithelial cell, and type II pneumocyte. * It is a calcium-binding protein that is involved in the regulation of calcium signaling. **Pathways and functions** HPCAL1 is involved in the regulation of calcium signaling through a variety of pathways. These pathways include: * Calcium ion binding * Membrane-bound protein binding HPCAL1 is a key regulator of calcium signaling in the body. It is involved in the regulation of a variety of cellular processes, including cell proliferation, migration, differentiation, and survival. **Clinical significance** HPCAL1 is a gene that is linked to a number of human diseases. Mutations in HPCAL1 have been linked to a number of diseases, including pulmonary hypertension, asthma, and heart failure.

Genular Protein ID: 1851232190

Symbol: HPCL1_HUMAN

Name: Hippocalcin-like protein 1

UniProtKB Accession Codes:

P37235 Q969S5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 5 ExpressionAtlas 1 GO 2 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 16 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8038222

Title: Molecular cloning of a novel calcium-binding protein structurally related to hippocalcin from human brain and chromosomal mapping of its gene.

PubMed ID: 8038222

DOI: 10.1016/0167-4889(94)90062-0

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

Sequence Information:

  • Length: 193
  • Mass: 22313
  • Checksum: 87DCE938DCAD5E1F
  • Sequence:
    • MGKQNSKLRP EVLQDLRENT EFTDHELQEW YKGFLKDCPT GHLTVDEFKK IYANFFPYGD 
ASKFAEHVFR TFDTNGDGTI DFREFIIALS VTSRGKLEQK LKWAFSMYDL DGNGYISRSE 
MLEIVQAIYK MVSSVMKMPE DESTPEKRTD KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV 
RLLQCDPSSA SQF

Genular Protein ID: 787598604

Symbol: O75544_HUMAN

Name: N/A

UniProtKB Accession Codes:

O75544

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 5 SMART 1 SUPFAM 1

Citations:

PubMed ID: 8619474

Title: A "double adaptor" method for improved shotgun library construction.

PubMed ID: 8619474

DOI: 10.1006/abio.1996.0138

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

Sequence Information:

  • Length: 110
  • Mass: 12548
  • Checksum: AC516D6CB2059928
  • Sequence:
    • EFIIALSVTS RGKLEQKLKW AFSMYDLDGN GYISRSEMLE IVQAIYKMVS SVMKMPEDES 
TPEKRTDKIF RQMDTNNDGK LSLEEFIRGA KSDPSIVRLL QCDPSSASQF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.