Details for: HTR1B

Gene ID: 3351

Symbol: HTR1B

Ensembl ID: ENSG00000135312

Description: 5-hydroxytryptamine receptor 1B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2276
    Cell Significance Index: 3.2600
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: 0.1112
    Cell Significance Index: 0.9200
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.0291
    Cell Significance Index: 0.3000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0181
    Cell Significance Index: 0.2300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0045
    Cell Significance Index: 3.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0009
    Cell Significance Index: 0.1900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0008
    Cell Significance Index: -1.4500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0014
    Cell Significance Index: -0.7900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0025
    Cell Significance Index: -1.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0030
    Cell Significance Index: -1.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0039
    Cell Significance Index: -0.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0042
    Cell Significance Index: -1.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0057
    Cell Significance Index: -1.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0061
    Cell Significance Index: -0.7000
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0091
    Cell Significance Index: -0.0800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0127
    Cell Significance Index: -0.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0130
    Cell Significance Index: -1.5100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0132
    Cell Significance Index: -1.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0139
    Cell Significance Index: -2.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0185
    Cell Significance Index: -0.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0202
    Cell Significance Index: -0.9400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0222
    Cell Significance Index: -0.8400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0231
    Cell Significance Index: -0.3200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0276
    Cell Significance Index: -0.4500
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0282
    Cell Significance Index: -0.3800
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0301
    Cell Significance Index: -0.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0312
    Cell Significance Index: -1.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0322
    Cell Significance Index: -1.9800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0342
    Cell Significance Index: -0.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0355
    Cell Significance Index: -1.9900
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0364
    Cell Significance Index: -0.4700
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0373
    Cell Significance Index: -0.4300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0382
    Cell Significance Index: -0.8000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0437
    Cell Significance Index: -1.5300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0449
    Cell Significance Index: -1.1200
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0513
    Cell Significance Index: -0.5500
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.0519
    Cell Significance Index: -0.4900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0546
    Cell Significance Index: -1.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0609
    Cell Significance Index: -1.6300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0620
    Cell Significance Index: -2.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0665
    Cell Significance Index: -1.8100
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0669
    Cell Significance Index: -0.7800
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.0688
    Cell Significance Index: -0.8200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0700
    Cell Significance Index: -1.8800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0704
    Cell Significance Index: -1.0400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0713
    Cell Significance Index: -1.4100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0718
    Cell Significance Index: -2.0500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0719
    Cell Significance Index: -2.0600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0734
    Cell Significance Index: -1.9300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0801
    Cell Significance Index: -1.6300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0812
    Cell Significance Index: -2.0700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0822
    Cell Significance Index: -2.0500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0824
    Cell Significance Index: -1.0400
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0829
    Cell Significance Index: -0.7800
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: -0.0834
    Cell Significance Index: -0.5000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0855
    Cell Significance Index: -2.0500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0863
    Cell Significance Index: -1.7200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0874
    Cell Significance Index: -0.9500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0881
    Cell Significance Index: -2.2000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0889
    Cell Significance Index: -1.9000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0897
    Cell Significance Index: -1.9700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0904
    Cell Significance Index: -2.1900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0905
    Cell Significance Index: -0.7000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0930
    Cell Significance Index: -2.0100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0936
    Cell Significance Index: -1.0200
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0936
    Cell Significance Index: -0.6100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0966
    Cell Significance Index: -1.9400
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.0966
    Cell Significance Index: -0.9100
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.0967
    Cell Significance Index: -0.9500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0975
    Cell Significance Index: -2.0700
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0977
    Cell Significance Index: -1.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0992
    Cell Significance Index: -1.6600
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0992
    Cell Significance Index: -0.9400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1001
    Cell Significance Index: -2.0900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1014
    Cell Significance Index: -2.0000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1021
    Cell Significance Index: -1.2000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1080
    Cell Significance Index: -1.4400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1089
    Cell Significance Index: -2.1300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1094
    Cell Significance Index: -1.8700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1115
    Cell Significance Index: -1.3900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1157
    Cell Significance Index: -1.4600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1161
    Cell Significance Index: -1.5800
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1182
    Cell Significance Index: -1.9000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1186
    Cell Significance Index: -2.0500
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.1191
    Cell Significance Index: -1.5000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1197
    Cell Significance Index: -1.4900
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1205
    Cell Significance Index: -1.4000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1223
    Cell Significance Index: -1.6000
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1231
    Cell Significance Index: -1.6600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1238
    Cell Significance Index: -1.7000
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.1248
    Cell Significance Index: -1.3000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1267
    Cell Significance Index: -1.5300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1284
    Cell Significance Index: -2.1800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1284
    Cell Significance Index: -1.0600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1286
    Cell Significance Index: -1.6300
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.1289
    Cell Significance Index: -0.6000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1297
    Cell Significance Index: -2.1000
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.1303
    Cell Significance Index: -1.4800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1340
    Cell Significance Index: -1.6300
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.1348
    Cell Significance Index: -1.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HTR1B is a member of the serotonin receptor family, which is composed of seven transmembrane GPCRs. The receptor is characterized by its high affinity for serotonin (5-HT) and its ability to modulate various signaling pathways. Key characteristics of HTR1B include: * High expression levels in the brain, particularly in regions involved in mood regulation, such as the cerebral cortex and hippocampus * Association with various signaling pathways, including adenylate cyclase-inhibiting and G alpha (i) signaling events * Involvement in regulating neurotransmitter release, including serotonin and gamma-aminobutyric acid (GABA) * Role in modulating behavior, including drinking behavior and regulation of dopamine secretion * Expression in various cell types, including progenitor cells, blood vessel endothelial cells, and goblet cells **Pathways and Functions** HTR1B is involved in regulating various signaling pathways, including: 1. **Adenylate cyclase-inhibiting GPCR signaling pathway**: HTR1B modulates the activity of adenylate cyclase, a key enzyme involved in regulating cAMP levels, which in turn affects various cellular processes, including neurotransmission and cell proliferation. 2. **Serotonin receptor signaling pathway**: HTR1B is the primary receptor responsible for mediating serotonin's effects on the brain and body, including regulating mood, appetite, and sleep. 3. **Protein kinase C-activating GPCR signaling pathway**: HTR1B activates protein kinase C (PKC), a key enzyme involved in regulating various cellular processes, including cell proliferation and differentiation. 4. **G protein-coupled receptor signaling pathway**: HTR1B modulates the activity of G proteins, which in turn affect various signaling pathways, including those involved in neurotransmission and cell proliferation. **Clinical Significance** HTR1B has been implicated in various diseases, including: 1. **Psychiatric disorders**: HTR1B has been associated with depression, anxiety disorders, and attention-deficit/hyperactivity disorder (ADHD). 2. **Cardiovascular diseases**: HTR1B has been implicated in hypertension, heart failure, and atherosclerosis. 3. **Gastrointestinal disorders**: HTR1B has been associated with irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and gastroesophageal reflux disease (GERD). 4. **Cancer**: HTR1B has been implicated in various types of cancer, including breast, lung, and colon cancer. Overall, HTR1B plays a critical role in regulating various physiological and pathological processes, and its dysregulation has been implicated in several diseases. Further research is needed to fully understand the mechanisms by which HTR1B influences disease progression and to develop effective therapeutic strategies for targeting this receptor.

Genular Protein ID: 1809438707

Symbol: 5HT1B_HUMAN

Name: Serotonin receptor 1B

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1315531

Title: Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity.

PubMed ID: 1315531

DOI: 10.1016/0006-291x(92)90654-4

PubMed ID: 1610347

Title: Cloning and expression of the human 5-HT1B-type receptor gene.

PubMed ID: 1610347

DOI: 10.1016/0006-291x(92)91655-a

PubMed ID: 1348246

Title: Characterization of the human 5-hydroxytryptamine1B receptor.

PubMed ID: 1348246

DOI: 10.1016/s0021-9258(18)42612-9

PubMed ID: 1559993

Title: Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype.

PubMed ID: 1559993

DOI: 10.1016/s0021-9258(18)42552-5

PubMed ID: 1565658

Title: Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta.

PubMed ID: 1565658

DOI: 10.1073/pnas.89.8.3630

PubMed ID: 1351684

Title: A human serotonin 1D receptor variant (5HT1D beta) encoded by an intronless gene on chromosome 6.

PubMed ID: 1351684

DOI: 10.1073/pnas.89.12.5522

PubMed ID: 1328844

Title: Cloning and pharmacological characterization of a novel human 5-hydroxytryptamine1D receptor subtype.

PubMed ID: 1328844

PubMed ID: 15014171

Title: Human-specific amino acid changes found in 103 protein-coding genes.

PubMed ID: 15014171

DOI: 10.1093/molbev/msh100

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8218242

Title: Human serotonin1B receptor expression in Sf9 cells: phosphorylation, palmitoylation, and adenylyl cyclase inhibition.

PubMed ID: 8218242

DOI: 10.1021/bi00094a032

PubMed ID: 10452531

Title: Serotonin 5-HT1B and 5-HT1D receptors form homodimers when expressed alone and heterodimers when co-expressed.

PubMed ID: 10452531

DOI: 10.1016/s0014-5793(99)00918-7

PubMed ID: 15853772

Title: Triptan-induced contractile (5-HT1B receptor) responses in human cerebral and coronary arteries: relationship to clinical effect.

PubMed ID: 15853772

DOI: 10.1042/cs20050016

PubMed ID: 18476671

Title: Serotonin receptors.

PubMed ID: 18476671

DOI: 10.1021/cr078224o

PubMed ID: 20945968

Title: Serotonin receptors - from molecular biology to clinical applications.

PubMed ID: 20945968

DOI: 10.33549/physiolres.931903

PubMed ID: 23519215

Title: Structural features for functional selectivity at serotonin receptors.

PubMed ID: 23519215

DOI: 10.1126/science.1232808

PubMed ID: 35610220

Title: Structural insights into the ligand binding and Gi coupling of serotonin receptor 5-HT5A.

PubMed ID: 35610220

DOI: 10.1038/s41421-022-00412-3

PubMed ID: 23519210

Title: Structural basis for molecular recognition at serotonin receptors.

PubMed ID: 23519210

DOI: 10.1126/science.1232807

PubMed ID: 29925951

Title: Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go.

PubMed ID: 29925951

DOI: 10.1038/s41586-018-0241-9

PubMed ID: 7802650

Title: Identification of genetic variation in the human serotonin 1D beta receptor gene.

PubMed ID: 7802650

DOI: 10.1006/bbrc.1994.2792

Sequence Information:

  • Length: 390
  • Mass: 43568
  • Checksum: CD874DC7EB44CF12
  • Sequence:
  • MEEPGAQCAP PPPAGSETWV PQANLSSAPS QNCSAKDYIY QDSISLPWKV LLVMLLALIT 
    LATTLSNAFV IATVYRTRKL HTPANYLIAS LAVTDLLVSI LVMPISTMYT VTGRWTLGQV 
    VCDFWLSSDI TCCTASILHL CVIALDRYWA ITDAVEYSAK RTPKRAAVMI ALVWVFSISI 
    SLPPFFWRQA KAEEEVSECV VNTDHILYTV YSTVGAFYFP TLLLIALYGR IYVEARSRIL 
    KQTPNRTGKR LTRAQLITDS PGSTSSVTSI NSRVPDVPSE SGSPVYVNQV KVRVSDALLE 
    KKKLMAARER KATKTLGIIL GAFIVCWLPF FIISLVMPIC KDACWFHLAI FDFFTWLGYL 
    NSLINPIIYT MSNEDFKQAF HKLIRFKCTS

Genular Protein ID: 831448172

Symbol: A8K215_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 390
  • Mass: 43598
  • Checksum: 2238E8DD41F4C4B8
  • Sequence:
  • MEEPGAQCAP PPPAGSETWV PQANLSSAPS QNCSAKDYIY QDSISLPWKV LLVMLLALIT 
    LATTLSNAFV IATVYRTRKL HTPANYLIAS LAVTDLLVSI LVMPISTMYT VTGRWTLGQV 
    VCDFWLSSDI TCCTASILHL CVIALDRYWA ITDAVEYSAK RTPKRAAVMI ALVWVFSISI 
    SLPPFFWRQA KAEEEVSECV VNTDHILYTV YSTVGTFYFP TLLLIALYGR IYVEARSRIL 
    KQTPNRTGKR LTRAQLITDS PGSTSSVTSI NSRVPDVPSE SGSPVYVNQV KVRVSDALLE 
    KKKLMAARER KATKTLGIIL GAFIVCWLPF FIISLVMPIC KDACWFHLAI FDFFTWLGYL 
    NSLINPIIYT MSNEDFKQAF HKLIRFKCTS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.