Details for: HTR1B
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.2276
Cell Significance Index: 3.2600 - Cell Name: pulmonary alveolar type 2 cell (CL0002063)
Fold Change: 0.1112
Cell Significance Index: 0.9200 - Cell Name: ionocyte (CL0005006)
Fold Change: 0.0291
Cell Significance Index: 0.3000 - Cell Name: thymocyte (CL0000893)
Fold Change: 0.0181
Cell Significance Index: 0.2300 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0045
Cell Significance Index: 3.1100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0009
Cell Significance Index: 0.1900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0008
Cell Significance Index: -1.4500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0014
Cell Significance Index: -0.7900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0025
Cell Significance Index: -1.1400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0030
Cell Significance Index: -1.9000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0039
Cell Significance Index: -0.6600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0042
Cell Significance Index: -1.5200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0057
Cell Significance Index: -1.6500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0061
Cell Significance Index: -0.7000 - Cell Name: goblet cell (CL0000160)
Fold Change: -0.0091
Cell Significance Index: -0.0800 - Cell Name: neuron (CL0000540)
Fold Change: -0.0127
Cell Significance Index: -0.1200 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0130
Cell Significance Index: -1.5100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0132
Cell Significance Index: -1.8100 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0139
Cell Significance Index: -2.0200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0185
Cell Significance Index: -0.8200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0202
Cell Significance Index: -0.9400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0222
Cell Significance Index: -0.8400 - Cell Name: hepatocyte (CL0000182)
Fold Change: -0.0231
Cell Significance Index: -0.3200 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.0276
Cell Significance Index: -0.4500 - Cell Name: medium spiny neuron (CL1001474)
Fold Change: -0.0282
Cell Significance Index: -0.3800 - Cell Name: acinar cell (CL0000622)
Fold Change: -0.0301
Cell Significance Index: -0.3800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0312
Cell Significance Index: -1.6200 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0322
Cell Significance Index: -1.9800 - Cell Name: ciliated cell (CL0000064)
Fold Change: -0.0342
Cell Significance Index: -0.3700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0355
Cell Significance Index: -1.9900 - Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: -0.0364
Cell Significance Index: -0.4700 - Cell Name: myometrial cell (CL0002366)
Fold Change: -0.0373
Cell Significance Index: -0.4300 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0382
Cell Significance Index: -0.8000 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0437
Cell Significance Index: -1.5300 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0449
Cell Significance Index: -1.1200 - Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: -0.0513
Cell Significance Index: -0.5500 - Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: -0.0519
Cell Significance Index: -0.4900 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0546
Cell Significance Index: -1.7400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0609
Cell Significance Index: -1.6300 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0620
Cell Significance Index: -2.0300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0665
Cell Significance Index: -1.8100 - Cell Name: neural cell (CL0002319)
Fold Change: -0.0669
Cell Significance Index: -0.7800 - Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
Fold Change: -0.0688
Cell Significance Index: -0.8200 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0700
Cell Significance Index: -1.8800 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.0704
Cell Significance Index: -1.0400 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0713
Cell Significance Index: -1.4100 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0718
Cell Significance Index: -2.0500 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0719
Cell Significance Index: -2.0600 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0734
Cell Significance Index: -1.9300 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.0801
Cell Significance Index: -1.6300 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0812
Cell Significance Index: -2.0700 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0822
Cell Significance Index: -2.0500 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.0824
Cell Significance Index: -1.0400 - Cell Name: epithelial cell of lung (CL0000082)
Fold Change: -0.0829
Cell Significance Index: -0.7800 - Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: -0.0834
Cell Significance Index: -0.5000 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0855
Cell Significance Index: -2.0500 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.0863
Cell Significance Index: -1.7200 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.0874
Cell Significance Index: -0.9500 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0881
Cell Significance Index: -2.2000 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.0889
Cell Significance Index: -1.9000 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0897
Cell Significance Index: -1.9700 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0904
Cell Significance Index: -2.1900 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -0.0905
Cell Significance Index: -0.7000 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0930
Cell Significance Index: -2.0100 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0936
Cell Significance Index: -1.0200 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.0936
Cell Significance Index: -0.6100 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0966
Cell Significance Index: -1.9400 - Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: -0.0966
Cell Significance Index: -0.9100 - Cell Name: myoblast (CL0000056)
Fold Change: -0.0967
Cell Significance Index: -0.9500 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0975
Cell Significance Index: -2.0700 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.0977
Cell Significance Index: -1.1500 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0992
Cell Significance Index: -1.6600 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -0.0992
Cell Significance Index: -0.9400 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.1001
Cell Significance Index: -2.0900 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.1014
Cell Significance Index: -2.0000 - Cell Name: microglial cell (CL0000129)
Fold Change: -0.1021
Cell Significance Index: -1.2000 - Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.1080
Cell Significance Index: -1.4400 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.1089
Cell Significance Index: -2.1300 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.1094
Cell Significance Index: -1.8700 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.1115
Cell Significance Index: -1.3900 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.1157
Cell Significance Index: -1.4600 - Cell Name: lymphocyte (CL0000542)
Fold Change: -0.1161
Cell Significance Index: -1.5800 - Cell Name: suprabasal keratinocyte (CL4033013)
Fold Change: -0.1182
Cell Significance Index: -1.9000 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.1186
Cell Significance Index: -2.0500 - Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: -0.1191
Cell Significance Index: -1.5000 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.1197
Cell Significance Index: -1.4900 - Cell Name: smooth muscle cell (CL0000192)
Fold Change: -0.1205
Cell Significance Index: -1.4000 - Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.1223
Cell Significance Index: -1.6000 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: -0.1231
Cell Significance Index: -1.6600 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: -0.1238
Cell Significance Index: -1.7000 - Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: -0.1248
Cell Significance Index: -1.3000 - Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.1267
Cell Significance Index: -1.5300 - Cell Name: leukocyte (CL0000738)
Fold Change: -0.1284
Cell Significance Index: -2.1800 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: -0.1284
Cell Significance Index: -1.0600 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.1286
Cell Significance Index: -1.6300 - Cell Name: perivascular cell (CL4033054)
Fold Change: -0.1289
Cell Significance Index: -0.6000 - Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.1297
Cell Significance Index: -2.1000 - Cell Name: stellate neuron (CL0000122)
Fold Change: -0.1303
Cell Significance Index: -1.4800 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.1340
Cell Significance Index: -1.6300 - Cell Name: neuroplacodal cell (CL0000032)
Fold Change: -0.1348
Cell Significance Index: -1.6600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1809438707
Symbol: 5HT1B_HUMAN
Name: Serotonin receptor 1B
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1315531
Title: Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity.
PubMed ID: 1315531
PubMed ID: 1610347
Title: Cloning and expression of the human 5-HT1B-type receptor gene.
PubMed ID: 1610347
PubMed ID: 1348246
Title: Characterization of the human 5-hydroxytryptamine1B receptor.
PubMed ID: 1348246
PubMed ID: 1559993
Title: Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype.
PubMed ID: 1559993
PubMed ID: 1565658
Title: Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta.
PubMed ID: 1565658
PubMed ID: 1351684
Title: A human serotonin 1D receptor variant (5HT1D beta) encoded by an intronless gene on chromosome 6.
PubMed ID: 1351684
PubMed ID: 1328844
Title: Cloning and pharmacological characterization of a novel human 5-hydroxytryptamine1D receptor subtype.
PubMed ID: 1328844
PubMed ID: 15014171
Title: Human-specific amino acid changes found in 103 protein-coding genes.
PubMed ID: 15014171
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8218242
Title: Human serotonin1B receptor expression in Sf9 cells: phosphorylation, palmitoylation, and adenylyl cyclase inhibition.
PubMed ID: 8218242
DOI: 10.1021/bi00094a032
PubMed ID: 10452531
Title: Serotonin 5-HT1B and 5-HT1D receptors form homodimers when expressed alone and heterodimers when co-expressed.
PubMed ID: 10452531
PubMed ID: 15853772
Title: Triptan-induced contractile (5-HT1B receptor) responses in human cerebral and coronary arteries: relationship to clinical effect.
PubMed ID: 15853772
DOI: 10.1042/cs20050016
PubMed ID: 18476671
PubMed ID: 20945968
Title: Serotonin receptors - from molecular biology to clinical applications.
PubMed ID: 20945968
PubMed ID: 23519215
Title: Structural features for functional selectivity at serotonin receptors.
PubMed ID: 23519215
PubMed ID: 35610220
Title: Structural insights into the ligand binding and Gi coupling of serotonin receptor 5-HT5A.
PubMed ID: 35610220
PubMed ID: 23519210
Title: Structural basis for molecular recognition at serotonin receptors.
PubMed ID: 23519210
PubMed ID: 29925951
Title: Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go.
PubMed ID: 29925951
PubMed ID: 7802650
Title: Identification of genetic variation in the human serotonin 1D beta receptor gene.
PubMed ID: 7802650
Sequence Information:
- Length: 390
- Mass: 43568
- Checksum: CD874DC7EB44CF12
- Sequence:
MEEPGAQCAP PPPAGSETWV PQANLSSAPS QNCSAKDYIY QDSISLPWKV LLVMLLALIT LATTLSNAFV IATVYRTRKL HTPANYLIAS LAVTDLLVSI LVMPISTMYT VTGRWTLGQV VCDFWLSSDI TCCTASILHL CVIALDRYWA ITDAVEYSAK RTPKRAAVMI ALVWVFSISI SLPPFFWRQA KAEEEVSECV VNTDHILYTV YSTVGAFYFP TLLLIALYGR IYVEARSRIL KQTPNRTGKR LTRAQLITDS PGSTSSVTSI NSRVPDVPSE SGSPVYVNQV KVRVSDALLE KKKLMAARER KATKTLGIIL GAFIVCWLPF FIISLVMPIC KDACWFHLAI FDFFTWLGYL NSLINPIIYT MSNEDFKQAF HKLIRFKCTS
Genular Protein ID: 831448172
Symbol: A8K215_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 390
- Mass: 43598
- Checksum: 2238E8DD41F4C4B8
- Sequence:
MEEPGAQCAP PPPAGSETWV PQANLSSAPS QNCSAKDYIY QDSISLPWKV LLVMLLALIT LATTLSNAFV IATVYRTRKL HTPANYLIAS LAVTDLLVSI LVMPISTMYT VTGRWTLGQV VCDFWLSSDI TCCTASILHL CVIALDRYWA ITDAVEYSAK RTPKRAAVMI ALVWVFSISI SLPPFFWRQA KAEEEVSECV VNTDHILYTV YSTVGTFYFP TLLLIALYGR IYVEARSRIL KQTPNRTGKR LTRAQLITDS PGSTSSVTSI NSRVPDVPSE SGSPVYVNQV KVRVSDALLE KKKLMAARER KATKTLGIIL GAFIVCWLPF FIISLVMPIC KDACWFHLAI FDFFTWLGYL NSLINPIIYT MSNEDFKQAF HKLIRFKCTS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.