Details for: COX8C

Gene ID: 341947

Symbol: COX8C

Ensembl ID: ENSG00000187581

Description: cytochrome c oxidase subunit 8C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 12.1036
    Cell Significance Index: -3.0700
  • Cell Name: germ cell (CL0000586)
    Fold Change: 3.6116
    Cell Significance Index: 27.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1327
    Cell Significance Index: 1.8100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1274
    Cell Significance Index: 1.8500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0387
    Cell Significance Index: 0.5500
  • Cell Name: tongue muscle cell (CL0002673)
    Fold Change: 0.0160
    Cell Significance Index: 0.1200
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.0145
    Cell Significance Index: 0.1500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.0089
    Cell Significance Index: 0.0600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0063
    Cell Significance Index: 0.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0050
    Cell Significance Index: 0.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0038
    Cell Significance Index: 2.0600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0002
    Cell Significance Index: -0.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0011
    Cell Significance Index: -0.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0019
    Cell Significance Index: -0.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0025
    Cell Significance Index: -0.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0040
    Cell Significance Index: -3.0100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0051
    Cell Significance Index: -0.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0052
    Cell Significance Index: -2.9300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0058
    Cell Significance Index: -4.3100
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0065
    Cell Significance Index: -0.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0066
    Cell Significance Index: -2.3600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0073
    Cell Significance Index: -0.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0076
    Cell Significance Index: -1.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0081
    Cell Significance Index: -0.5200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0087
    Cell Significance Index: -0.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0094
    Cell Significance Index: -1.6900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0137
    Cell Significance Index: -0.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0155
    Cell Significance Index: -1.9000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0165
    Cell Significance Index: -1.6900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0167
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0197
    Cell Significance Index: -3.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0200
    Cell Significance Index: -2.7500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0214
    Cell Significance Index: -4.5000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0219
    Cell Significance Index: -0.1300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0221
    Cell Significance Index: -0.4400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0236
    Cell Significance Index: -0.5000
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0245
    Cell Significance Index: -0.2300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0259
    Cell Significance Index: -0.3500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0268
    Cell Significance Index: -3.0700
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.0322
    Cell Significance Index: -0.3000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0331
    Cell Significance Index: -0.3600
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0337
    Cell Significance Index: -0.3200
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0354
    Cell Significance Index: -0.4900
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0358
    Cell Significance Index: -0.3700
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0377
    Cell Significance Index: -0.2500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0380
    Cell Significance Index: -0.6600
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0383
    Cell Significance Index: -0.4000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0398
    Cell Significance Index: -2.0900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0412
    Cell Significance Index: -0.5500
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0412
    Cell Significance Index: -0.5600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0424
    Cell Significance Index: -0.4400
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0441
    Cell Significance Index: -0.5100
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.0441
    Cell Significance Index: -0.5000
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0449
    Cell Significance Index: -0.4900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0461
    Cell Significance Index: -0.5200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0463
    Cell Significance Index: -1.2400
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0464
    Cell Significance Index: -0.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0468
    Cell Significance Index: -1.4900
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0480
    Cell Significance Index: -0.5300
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0487
    Cell Significance Index: -0.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0495
    Cell Significance Index: -3.8000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0505
    Cell Significance Index: -0.5100
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0517
    Cell Significance Index: -0.5700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0529
    Cell Significance Index: -0.8900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0551
    Cell Significance Index: -1.8100
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.0560
    Cell Significance Index: -0.5500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0562
    Cell Significance Index: -1.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0574
    Cell Significance Index: -1.5100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0582
    Cell Significance Index: -2.0400
  • Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
    Fold Change: -0.0584
    Cell Significance Index: -0.5900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0591
    Cell Significance Index: -1.5800
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0591
    Cell Significance Index: -0.5700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0594
    Cell Significance Index: -2.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0594
    Cell Significance Index: -3.3400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0638
    Cell Significance Index: -0.7400
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0648
    Cell Significance Index: -0.9100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0664
    Cell Significance Index: -0.9800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0672
    Cell Significance Index: -3.1600
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0675
    Cell Significance Index: -0.8500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0689
    Cell Significance Index: -0.8700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0704
    Cell Significance Index: -1.7600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0715
    Cell Significance Index: -0.7400
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0743
    Cell Significance Index: -0.4600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0763
    Cell Significance Index: -1.6700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0778
    Cell Significance Index: -2.4600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0782
    Cell Significance Index: -1.6900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0798
    Cell Significance Index: -0.5200
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0800
    Cell Significance Index: -0.4900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0803
    Cell Significance Index: -0.9600
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0826
    Cell Significance Index: -0.7600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0830
    Cell Significance Index: -0.9400
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.0886
    Cell Significance Index: -0.5200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0928
    Cell Significance Index: -1.9700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0945
    Cell Significance Index: -1.6100
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.0946
    Cell Significance Index: -0.5900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0951
    Cell Significance Index: -3.4900
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0973
    Cell Significance Index: -0.7000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0979
    Cell Significance Index: -1.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** COX8C is a mitochondrial-encoded gene, meaning its product is synthesized within the mitochondria and integrated into the mitochondrial respiratory chain complex IV. This subunit is specifically associated with the cytochrome c oxidase enzyme, which is responsible for the final step of the electron transport chain, resulting in the production of water and ATP. COX8C is expressed in various cell types, including germ cells, endothelial cells, and hematopoietic progenitor cells, highlighting its widespread role in cellular function. **Pathways and Functions:** The COX8C gene is involved in several key pathways, including: 1. **Mitochondrial electron transport:** COX8C plays a critical role in the electron transport chain, facilitating the transfer of electrons from cytochrome c to oxygen. 2. **Cytochrome c to oxygen:** COX8C is essential for the production of water and ATP through the cytochrome c oxidase enzyme. 3. **Mitochondrial respiratory chain complex IV:** COX8C is a component of complex IV, the final enzyme complex in the electron transport chain. 4. **Mitochondrion:** COX8C is localized within the mitochondria, highlighting its role in mitochondrial function and biogenesis. **Clinical Significance:** While COX8C is a relatively understudied gene, its dysregulation has been implicated in various diseases. Some of the clinical significance of COX8C includes: 1. **Mitochondrial disorders:** Mutations in COX8C have been linked to mitochondrial disorders, including Leber's hereditary optic neuropathy and Kearns-Sayre syndrome. 2. **Cancer:** Aberrant expression of COX8C has been observed in various types of cancer, suggesting its potential role in tumorigenesis. 3. **Inflammatory diseases:** COX8C has been implicated in the regulation of inflammation, with its expression altered in conditions such as atherosclerosis and rheumatoid arthritis. 4. **Neurodegenerative diseases:** Dysregulation of COX8C has been linked to neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. In conclusion, the COX8C gene is a critical component of the mitochondrial respiratory chain, with far-reaching implications for cellular function and disease. Further research is necessary to fully understand the role of COX8C in human health and disease, and to explore its potential as a therapeutic target for various conditions.

Genular Protein ID: 644413587

Symbol: COX8C_HUMAN

Name: Cytochrome c oxidase subunit 8C, mitochondrial

UniProtKB Accession Codes:

Q7Z4L0 Q495K7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 EMBL 3 Ensembl 2 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 4 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TCDB 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 12909344

Title: A third isoform of cytochrome c oxidase subunit VIII is present in mammals.

PubMed ID: 12909344

DOI: 10.1016/s0378-1119(03)00604-8

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 72
  • Mass: 8129
  • Checksum: 53C47863EC761638
  • Sequence:
    • MPLLRGRCPA RRHYRRLALL GLQPAPRFAH SGPPRQRPLS AAEMAVGLVV FFTTFLTPAA 
YVLGNLKQFR RN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.