Details for: IL1RAP

Gene ID: 3556

Symbol: IL1RAP

Ensembl ID: ENSG00000196083

Description: interleukin 1 receptor accessory protein

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.29
    Marker Score: 7497
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.88
    Marker Score: 28063
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.85
    Marker Score: 9936
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.84
    Marker Score: 2222.5
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.76
    Marker Score: 11338
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.75
    Marker Score: 18114
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.66
    Marker Score: 7184
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.66
    Marker Score: 61171
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.59
    Marker Score: 3234.5
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.53
    Marker Score: 1900
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.52
    Marker Score: 1877
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.52
    Marker Score: 57565
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168520
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.38
    Marker Score: 497
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.34
    Marker Score: 1522
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.23
    Marker Score: 19298
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.22
    Marker Score: 392
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.18
    Marker Score: 72873
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.18
    Marker Score: 589
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.11
    Marker Score: 984
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.05
    Marker Score: 1199
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1
    Marker Score: 600
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71773
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47999
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.99
    Marker Score: 8528
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.99
    Marker Score: 673
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 493
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 447
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.94
    Marker Score: 1007
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.94
    Marker Score: 8943
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.94
    Marker Score: 346
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.93
    Marker Score: 858
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.93
    Marker Score: 8719
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.92
    Marker Score: 23544
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2725
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 361
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5044
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 315
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.88
    Marker Score: 330
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.87
    Marker Score: 486
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.82
    Marker Score: 4907
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.81
    Marker Score: 857
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.81
    Marker Score: 1254
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.81
    Marker Score: 302
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 614
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.8
    Marker Score: 249
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.78
    Marker Score: 1429
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.78
    Marker Score: 290
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1256
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.77
    Marker Score: 3216
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.76
    Marker Score: 976
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.76
    Marker Score: 1781
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.75
    Marker Score: 807
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.74
    Marker Score: 1930
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 383
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.73
    Marker Score: 730
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 641
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.69
    Marker Score: 363
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.69
    Marker Score: 252
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.67
    Marker Score: 1910
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.65
    Marker Score: 226
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.65
    Marker Score: 4957
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.64
    Marker Score: 14289
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.62
    Marker Score: 275
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.61
    Marker Score: 292
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.61
    Marker Score: 205
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.6
    Marker Score: 415
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.6
    Marker Score: 239
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.59
    Marker Score: 387
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.58
    Marker Score: 2360
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.57
    Marker Score: 921
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.56
    Marker Score: 290
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.56
    Marker Score: 809
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.56
    Marker Score: 2308
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.54
    Marker Score: 1307
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.54
    Marker Score: 221
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.54
    Marker Score: 368
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.54
    Marker Score: 3998
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.52
    Marker Score: 3189
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.52
    Marker Score: 150
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.52
    Marker Score: 577
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.52
    Marker Score: 2383
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.51
    Marker Score: 8186
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5
    Marker Score: 339
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.5
    Marker Score: 444
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5
    Marker Score: 361
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.5
    Marker Score: 906
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.5
    Marker Score: 547
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.48
    Marker Score: 306.5
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.48
    Marker Score: 155
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.48
    Marker Score: 4159
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.48
    Marker Score: 26956
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.48
    Marker Score: 1990
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.48
    Marker Score: 291
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.47
    Marker Score: 198

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Other Information

**Key characteristics:** * IL1RAP is a protein of 120 amino acids. * It is a member of the interleukin-1 receptor accessory protein (IL1RAP) family of proteins. * It is expressed in many cell types, including hepatocytes, neurons, and immune cells. * It binds to the interleukin-1 receptor, which is a key regulator of inflammation. * By binding to the IL1 receptor, IL1RAP inhibits the IL1 receptor, which leads to a decrease in the production of inflammatory cytokines. **Pathways and functions:** * IL1RAP is involved in the regulation of inflammation. * It interacts with the IL1 receptor, which is a key regulator of inflammation. * By binding to the IL1 receptor, IL1RAP inhibits the IL1 receptor, which leads to a decrease in the production of inflammatory cytokines. * This helps to prevent the inflammatory response from becoming too strong. **Clinical significance:** * Mutations in the IL1RAP gene have been linked to several autoimmune diseases, including systemic sclerosis, rheumatoid arthritis, and Crohn's disease. * These mutations can lead to the overproduction of inflammatory cytokines, which can damage tissues and organs. * IL1RAP is a potential target for the treatment of autoimmune diseases. **Additional information:** * IL1RAP is a key regulator of the immune system. * It is involved in the regulation of inflammation, cell migration, and differentiation. * It is a promising target for the treatment of autoimmune diseases.

Genular Protein ID: 1142602972

Symbol: IL1AP_HUMAN

Name: Interleukin-1 receptor accessory protein

UniProtKB Accession Codes:

Q9NPH3 B1NLD0 D3DNW0 O14915 Q86WJ7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 3 CORUM 1 CPTAC 1 CTD 1 ChEBI 5 ChEMBL 2 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 1 EMBL 31 EPD 1 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 3 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 6 RefSeq 6 Rhea 2 SAM 1 SASBDB 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9371760

Title: Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein.

PubMed ID: 9371760

DOI: 10.1073/pnas.94.24.12829

PubMed ID: 10799889

Title: IL-1 signaling cascade in liver cells and the involvement of a soluble form of the IL-1 receptor accessory protein.

PubMed ID: 10799889

DOI: 10.4049/jimmunol.164.10.5277

PubMed ID: 12781872

Title: Expression of alternatively spliced interleukin-1 receptor accessory protein mRNAs is differentially regulated during inflammation and apoptosis.

PubMed ID: 12781872

DOI: 10.1016/s0898-6568(03)00039-1

PubMed ID: 17949817

Title: A novel alternatively spliced interleukin-1 receptor accessory protein mIL-1RAcP687.

PubMed ID: 17949817

DOI: 10.1016/j.molimm.2007.09.002

PubMed ID: 19481478

Title: A central nervous system-restricted isoform of the interleukin-1 receptor accessory protein modulates neuronal responses to interleukin-1.

PubMed ID: 19481478

DOI: 10.1016/j.immuni.2009.03.020

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9479509

Title: The human gene encoding the interleukin-1 receptor accessory protein (IL1RAP) maps to chromosome 3q28 by fluorescence in situ hybridization and radiation hybrid mapping.

PubMed ID: 9479509

DOI: 10.1006/geno.1997.5113

PubMed ID: 9862719

Title: The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness.

PubMed ID: 9862719

PubMed ID: 10653850

Title: IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells.

PubMed ID: 10653850

DOI: 10.1093/intimm/12.2.151

PubMed ID: 12659850

Title: Characterization of a cascade of protein interactions initiated at the IL-1 receptor.

PubMed ID: 12659850

DOI: 10.1016/s0006-291x(03)00385-1

PubMed ID: 12530978

Title: The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action.

PubMed ID: 12530978

DOI: 10.1016/s1074-7613(02)00514-9

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19836339

Title: Structure of IL-33 and its interaction with the ST2 and IL-1RAcP receptors--insight into heterotrimeric IL-1 signaling complexes.

PubMed ID: 19836339

DOI: 10.1016/j.str.2009.08.009

PubMed ID: 20805474

Title: Isolation and killing of candidate chronic myeloid leukemia stem cells by antibody targeting of IL-1 receptor accessory protein.

PubMed ID: 20805474

DOI: 10.1073/pnas.1004408107

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22723552

Title: Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS.

PubMed ID: 22723552

DOI: 10.1182/blood-2012-01-404699

PubMed ID: 23479569

Title: Selective killing of candidate AML stem cells by antibody targeting of IL1RAP.

PubMed ID: 23479569

DOI: 10.1182/blood-2012-09-458935

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25595648

Title: Increased IL-33 expression in chronic obstructive pulmonary disease.

PubMed ID: 25595648

DOI: 10.1152/ajplung.00305.2014

PubMed ID: 20802483

Title: Structural insights into the assembly and activation of IL-1beta with its receptors.

PubMed ID: 20802483

DOI: 10.1038/ni.1925

Sequence Information:

  • Length: 570
  • Mass: 65418
  • Checksum: 5F47F8D0ECA98B8A
  • Sequence:
    • MTLLWCVVSL YFYGILQSDA SERCDDWGLD TMRQIQVFED EPARIKCPLF EHFLKFNYST 
AHSAGLTLIW YWTRQDRDLE EPINFRLPEN RISKEKDVLW FRPTLLNDTG NYTCMLRNTT 
YCSKVAFPLE VVQKDSCFNS PMKLPVHKLY IEYGIQRITC PNVDGYFPSS VKPTITWYMG 
CYKIQNFNNV IPEGMNLSFL IALISNNGNY TCVVTYPENG RTFHLTRTLT VKVVGSPKNA 
VPPVIHSPND HVVYEKEPGE ELLIPCTVYF SFLMDSRNEV WWTIDGKKPD DITIDVTINE 
SISHSRTEDE TRTQILSIKK VTSEDLKRSY VCHARSAKGE VAKAAKVKQK VPAPRYTVEL 
ACGFGATVLL VVILIVVYHV YWLEMVLFYR AHFGTDETIL DGKEYDIYVS YARNAEEEEF 
VLLTLRGVLE NEFGYKLCIF DRDSLPGGIV TDETLSFIQK SRRLLVVLSP NYVLQGTQAL 
LELKAGLENM ASRGNINVIL VQYKAVKETK VKELKRAKTV LTVIKWKGEK SKYPQGRFWK 
QLQVAMPVKK SPRRSSSDEQ GLSYSSLKNV

Genular Protein ID: 678961637

Symbol: A8K6K4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K6K4

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 DNASU 1 EMBL 2 GO 4 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 9 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 4 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 3 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 570
  • Mass: 65433
  • Checksum: 2F37FFD79E8EABAA
  • Sequence:
    • MTLLWCVVSL YFYGILQSDA SERCDDWGLD TMRQIQVFED EPARIKCPLF EHFLKFNYST 
AHSAGLTLIW YWTRQDRDLE EPINFRLPEN RISKEKDVLW FRPTLLNDTG NYTCMLRNTT 
YCSKVAFPLE VVQKDSCFNS PMKLPVHKLY IEYGIQRITC PNVDGYFPSS VKPTITWYMG 
CYKIQNFNNV IPEGMNLSFL IALISNNGNY TCVVTYPENG RTFHLTRTLT VKVVGSPKNA 
VPPVIHSPND HVVYEKEPGE ELLIPCTVYF SFLMDSRNEV WWTIDGKKPD DITIDVTINE 
SISHSRTEDE TRTQILSIKK VTSEDLKRSY VCHARSAKGE VAKAAKVKQK VPAPRYTVEL 
ACGFGATVLL VVILIVVYHV YWLEMVLFYR AHFGTDETIL DGKEYDIYVS YARKAEEEEF 
VLLTLRGVLE NEFGYKLCIF DRDSLPGGIV TDETLSFIQK SRRLLVVLSP NYVLQGTQAL 
LELKAGLENM ASRGNINVIL VQYKAVKETK VKELKRAKTV LTVIKWKGEK SKYPQGRFWK 
QLQVAMPVKK SPRRSSSDEQ GLSYSSLKNV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.