Details for: IL1RAP

Gene ID: 3556

Symbol: IL1RAP

Ensembl ID: ENSG00000196083

Description: interleukin 1 receptor accessory protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 145.2311
    Cell Significance Index: -22.5900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 87.7610
    Cell Significance Index: -22.2600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 47.7530
    Cell Significance Index: -19.4000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.3301
    Cell Significance Index: -19.4100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.3299
    Cell Significance Index: -22.6000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 10.7534
    Cell Significance Index: 181.1400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.0971
    Cell Significance Index: -24.8700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 6.6968
    Cell Significance Index: 41.6100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.7703
    Cell Significance Index: -22.7700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.6827
    Cell Significance Index: -8.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.8661
    Cell Significance Index: 52.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.8062
    Cell Significance Index: 121.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3638
    Cell Significance Index: 270.6500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.0134
    Cell Significance Index: 16.7000
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.9947
    Cell Significance Index: 8.8300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9699
    Cell Significance Index: 184.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7452
    Cell Significance Index: 149.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6655
    Cell Significance Index: 51.0700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6449
    Cell Significance Index: 63.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5669
    Cell Significance Index: 511.8400
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.4793
    Cell Significance Index: 2.7600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.4465
    Cell Significance Index: 6.5900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4298
    Cell Significance Index: 297.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3288
    Cell Significance Index: 53.4700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3073
    Cell Significance Index: 37.7800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3021
    Cell Significance Index: 8.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2805
    Cell Significance Index: 7.4900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2367
    Cell Significance Index: 6.7600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2226
    Cell Significance Index: 24.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1813
    Cell Significance Index: 32.6900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1797
    Cell Significance Index: 98.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1009
    Cell Significance Index: 44.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0966
    Cell Significance Index: 34.6500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0579
    Cell Significance Index: 0.3500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0268
    Cell Significance Index: 0.4500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0114
    Cell Significance Index: 0.7900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0022
    Cell Significance Index: 4.0100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0007
    Cell Significance Index: -0.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0021
    Cell Significance Index: -3.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0028
    Cell Significance Index: -0.0800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0037
    Cell Significance Index: -0.1900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0043
    Cell Significance Index: -8.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0122
    Cell Significance Index: -0.4300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0135
    Cell Significance Index: -0.1100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0154
    Cell Significance Index: -0.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0181
    Cell Significance Index: -24.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0214
    Cell Significance Index: -13.6000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0214
    Cell Significance Index: -16.2000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0273
    Cell Significance Index: -20.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0282
    Cell Significance Index: -20.8700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0328
    Cell Significance Index: -0.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0378
    Cell Significance Index: -17.1700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0394
    Cell Significance Index: -0.6100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0403
    Cell Significance Index: -25.1700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0418
    Cell Significance Index: -0.8900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0419
    Cell Significance Index: -23.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0437
    Cell Significance Index: -1.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0508
    Cell Significance Index: -1.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0651
    Cell Significance Index: -18.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0665
    Cell Significance Index: -7.7500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0732
    Cell Significance Index: -3.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0755
    Cell Significance Index: -10.9700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0875
    Cell Significance Index: -14.9400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0933
    Cell Significance Index: -1.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0933
    Cell Significance Index: -12.8100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0953
    Cell Significance Index: -9.7400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1222
    Cell Significance Index: -25.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1224
    Cell Significance Index: -1.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1332
    Cell Significance Index: -8.1900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1377
    Cell Significance Index: -17.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1553
    Cell Significance Index: -7.2400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1606
    Cell Significance Index: -2.4200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1648
    Cell Significance Index: -6.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1712
    Cell Significance Index: -19.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1761
    Cell Significance Index: -11.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1777
    Cell Significance Index: -20.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1921
    Cell Significance Index: -24.6300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1940
    Cell Significance Index: -2.7900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2039
    Cell Significance Index: -2.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2116
    Cell Significance Index: -22.0400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2203
    Cell Significance Index: -4.7600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2222
    Cell Significance Index: -4.6100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2268
    Cell Significance Index: -5.2400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2487
    Cell Significance Index: -15.2500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2660
    Cell Significance Index: -18.8200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2686
    Cell Significance Index: -21.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2753
    Cell Significance Index: -20.5200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2826
    Cell Significance Index: -9.0500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2836
    Cell Significance Index: -7.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2855
    Cell Significance Index: -13.4200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2856
    Cell Significance Index: -9.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2857
    Cell Significance Index: -16.0300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3064
    Cell Significance Index: -15.9600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3168
    Cell Significance Index: -6.3600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3248
    Cell Significance Index: -7.7900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3579
    Cell Significance Index: -6.6200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3631
    Cell Significance Index: -5.3600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3750
    Cell Significance Index: -19.6900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3821
    Cell Significance Index: -12.1700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4559
    Cell Significance Index: -15.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IL1RAP exhibits several key characteristics that highlight its importance in immune and neuronal functions: 1. **Coreceptor activity**: IL1RAP acts as a coreceptor, enhancing the affinity of IL-1 for its receptor, and facilitating the recruitment of signaling molecules necessary for the activation of downstream pathways. 2. **Cytokine signaling**: IL1RAP is involved in the signaling of multiple cytokines, including IL-1, IL-33, and IL-36, which are critical for the regulation of immune responses, inflammation, and tissue homeostasis. 3. **Innate and adaptive immunity**: IL1RAP is expressed in various immune cells, including innate lymphoid cells, and plays a role in the regulation of both innate and adaptive immune responses. 4. **Neuronal functions**: IL1RAP is also expressed in neurons, where it participates in the regulation of synaptic transmission and plasticity, highlighting the protein's role in neuronal function and behavior. **Pathways and Functions** IL1RAP is involved in several signaling pathways, including: 1. **IL-1 signaling pathway**: IL1RAP facilitates the association of IL-1 with its receptor, leading to the activation of downstream signaling molecules, such as JNK and NF-κB. 2. **Cytokine signaling**: IL1RAP participates in the signaling of multiple cytokines, including IL-1, IL-33, and IL-36, which regulate immune responses, inflammation, and tissue homeostasis. 3. **Neuronal signaling**: IL1RAP is involved in the regulation of synaptic transmission and plasticity, highlighting its role in neuronal function and behavior. 4. **Innate immune response**: IL1RAP is expressed in innate lymphoid cells and plays a role in the regulation of innate immune responses. **Clinical Significance** Dysregulation of IL1RAP has been implicated in various diseases, including: 1. **Autoimmune disorders**: IL1RAP dysfunction has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus, where excessive IL-1 activity contributes to tissue damage and inflammation. 2. **Neurological disorders**: IL1RAP has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where dysregulation of IL-1 signaling contributes to neuronal damage and dysfunction. 3. **Cancer**: IL1RAP has been shown to be overexpressed in certain types of cancer, where it may contribute to tumorigenesis and cancer progression. In conclusion, IL1RAP is a critical component of the IL-1 signaling pathway, playing a significant role in the regulation of immune responses, inflammation, and neuronal function. Dysregulation of IL1RAP has been implicated in various diseases, highlighting the importance of understanding its biological functions and clinical significance.

Genular Protein ID: 1142602972

Symbol: IL1AP_HUMAN

Name: Interleukin-1 receptor accessory protein

UniProtKB Accession Codes:

Q9NPH3 B1NLD0 D3DNW0 O14915 Q86WJ7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 3 CORUM 1 CPTAC 1 CTD 1 ChEBI 5 ChEMBL 2 ChiTaRS 1 ComplexPortal 8 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 1 EMBL 31 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 6 RefSeq 6 Rhea 2 SASBDB 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9371760

Title: Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein.

PubMed ID: 9371760

DOI: 10.1073/pnas.94.24.12829

PubMed ID: 10799889

Title: IL-1 signaling cascade in liver cells and the involvement of a soluble form of the IL-1 receptor accessory protein.

PubMed ID: 10799889

DOI: 10.4049/jimmunol.164.10.5277

PubMed ID: 12781872

Title: Expression of alternatively spliced interleukin-1 receptor accessory protein mRNAs is differentially regulated during inflammation and apoptosis.

PubMed ID: 12781872

DOI: 10.1016/s0898-6568(03)00039-1

PubMed ID: 17949817

Title: A novel alternatively spliced interleukin-1 receptor accessory protein mIL-1RAcP687.

PubMed ID: 17949817

DOI: 10.1016/j.molimm.2007.09.002

PubMed ID: 19481478

Title: A central nervous system-restricted isoform of the interleukin-1 receptor accessory protein modulates neuronal responses to interleukin-1.

PubMed ID: 19481478

DOI: 10.1016/j.immuni.2009.03.020

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9479509

Title: The human gene encoding the interleukin-1 receptor accessory protein (IL1RAP) maps to chromosome 3q28 by fluorescence in situ hybridization and radiation hybrid mapping.

PubMed ID: 9479509

DOI: 10.1006/geno.1997.5113

PubMed ID: 9862719

Title: The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness.

PubMed ID: 9862719

PubMed ID: 10653850

Title: IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells.

PubMed ID: 10653850

DOI: 10.1093/intimm/12.2.151

PubMed ID: 12659850

Title: Characterization of a cascade of protein interactions initiated at the IL-1 receptor.

PubMed ID: 12659850

DOI: 10.1016/s0006-291x(03)00385-1

PubMed ID: 12530978

Title: The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action.

PubMed ID: 12530978

DOI: 10.1016/s1074-7613(02)00514-9

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19836339

Title: Structure of IL-33 and its interaction with the ST2 and IL-1RAcP receptors--insight into heterotrimeric IL-1 signaling complexes.

PubMed ID: 19836339

DOI: 10.1016/j.str.2009.08.009

PubMed ID: 20805474

Title: Isolation and killing of candidate chronic myeloid leukemia stem cells by antibody targeting of IL-1 receptor accessory protein.

PubMed ID: 20805474

DOI: 10.1073/pnas.1004408107

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22723552

Title: Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS.

PubMed ID: 22723552

DOI: 10.1182/blood-2012-01-404699

PubMed ID: 23479569

Title: Selective killing of candidate AML stem cells by antibody targeting of IL1RAP.

PubMed ID: 23479569

DOI: 10.1182/blood-2012-09-458935

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25595648

Title: Increased IL-33 expression in chronic obstructive pulmonary disease.

PubMed ID: 25595648

DOI: 10.1152/ajplung.00305.2014

PubMed ID: 20802483

Title: Structural insights into the assembly and activation of IL-1beta with its receptors.

PubMed ID: 20802483

DOI: 10.1038/ni.1925

Sequence Information:

  • Length: 570
  • Mass: 65418
  • Checksum: 5F47F8D0ECA98B8A
  • Sequence:
    • MTLLWCVVSL YFYGILQSDA SERCDDWGLD TMRQIQVFED EPARIKCPLF EHFLKFNYST 
AHSAGLTLIW YWTRQDRDLE EPINFRLPEN RISKEKDVLW FRPTLLNDTG NYTCMLRNTT 
YCSKVAFPLE VVQKDSCFNS PMKLPVHKLY IEYGIQRITC PNVDGYFPSS VKPTITWYMG 
CYKIQNFNNV IPEGMNLSFL IALISNNGNY TCVVTYPENG RTFHLTRTLT VKVVGSPKNA 
VPPVIHSPND HVVYEKEPGE ELLIPCTVYF SFLMDSRNEV WWTIDGKKPD DITIDVTINE 
SISHSRTEDE TRTQILSIKK VTSEDLKRSY VCHARSAKGE VAKAAKVKQK VPAPRYTVEL 
ACGFGATVLL VVILIVVYHV YWLEMVLFYR AHFGTDETIL DGKEYDIYVS YARNAEEEEF 
VLLTLRGVLE NEFGYKLCIF DRDSLPGGIV TDETLSFIQK SRRLLVVLSP NYVLQGTQAL 
LELKAGLENM ASRGNINVIL VQYKAVKETK VKELKRAKTV LTVIKWKGEK SKYPQGRFWK 
QLQVAMPVKK SPRRSSSDEQ GLSYSSLKNV

Genular Protein ID: 678961637

Symbol: A8K6K4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K6K4

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 2 InterPro 9 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 4 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 3 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 570
  • Mass: 65433
  • Checksum: 2F37FFD79E8EABAA
  • Sequence:
    • MTLLWCVVSL YFYGILQSDA SERCDDWGLD TMRQIQVFED EPARIKCPLF EHFLKFNYST 
AHSAGLTLIW YWTRQDRDLE EPINFRLPEN RISKEKDVLW FRPTLLNDTG NYTCMLRNTT 
YCSKVAFPLE VVQKDSCFNS PMKLPVHKLY IEYGIQRITC PNVDGYFPSS VKPTITWYMG 
CYKIQNFNNV IPEGMNLSFL IALISNNGNY TCVVTYPENG RTFHLTRTLT VKVVGSPKNA 
VPPVIHSPND HVVYEKEPGE ELLIPCTVYF SFLMDSRNEV WWTIDGKKPD DITIDVTINE 
SISHSRTEDE TRTQILSIKK VTSEDLKRSY VCHARSAKGE VAKAAKVKQK VPAPRYTVEL 
ACGFGATVLL VVILIVVYHV YWLEMVLFYR AHFGTDETIL DGKEYDIYVS YARKAEEEEF 
VLLTLRGVLE NEFGYKLCIF DRDSLPGGIV TDETLSFIQK SRRLLVVLSP NYVLQGTQAL 
LELKAGLENM ASRGNINVIL VQYKAVKETK VKELKRAKTV LTVIKWKGEK SKYPQGRFWK 
QLQVAMPVKK SPRRSSSDEQ GLSYSSLKNV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.