Details for: IL2RA

Gene ID: 3559

Symbol: IL2RA

Ensembl ID: ENSG00000134460

Description: interleukin 2 receptor subunit alpha

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.91
    Marker Score: 12209
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.85
    Marker Score: 828
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.71
    Marker Score: 3233
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 170029
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.35
    Marker Score: 2738
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.34
    Marker Score: 890
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 1.07
    Marker Score: 3081.5
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.04
    Marker Score: 316
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.02
    Marker Score: 356
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.01
    Marker Score: 317
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71810.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48034
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5338
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.85
    Marker Score: 224.5
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.83
    Marker Score: 2423
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 591.5
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.77
    Marker Score: 856
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 701
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.75
    Marker Score: 240
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.73
    Marker Score: 367
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.71
    Marker Score: 511
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.67
    Marker Score: 2135
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.64
    Marker Score: 325
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.62
    Marker Score: 487
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.54
    Marker Score: 144
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.53
    Marker Score: 658.5
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.5
    Marker Score: 483.5
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.49
    Marker Score: 260
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.48
    Marker Score: 287
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.47
    Marker Score: 147
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.47
    Marker Score: 7389
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.45
    Marker Score: 1934.5
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.45
    Marker Score: 160
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.38
    Marker Score: 422
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.36
    Marker Score: 19161
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.36
    Marker Score: 262
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.35
    Marker Score: 3490
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.35
    Marker Score: 232
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.35
    Marker Score: 396
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.34
    Marker Score: 89
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.34
    Marker Score: 142
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.33
    Marker Score: 156
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.32
    Marker Score: 181
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.32
    Marker Score: 183
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.31
    Marker Score: 288
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.31
    Marker Score: 195
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.29
    Marker Score: 107
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.29
    Marker Score: 294
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.29
    Marker Score: 412
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.29
    Marker Score: 273
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.28
    Marker Score: 272
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.28
    Marker Score: 184
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.28
    Marker Score: 143
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.27
    Marker Score: 702
  • Cell Name: group 3 innate lymphoid cell, human (CL0001078)
    Fold Change: 0.27
    Marker Score: 95
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.25
    Marker Score: 90
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.25
    Marker Score: 274
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.24
    Marker Score: 390
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.24
    Marker Score: 139
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.24
    Marker Score: 142
  • Cell Name: group 2 innate lymphoid cell (CL0001069)
    Fold Change: 0.24
    Marker Score: 80
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.24
    Marker Score: 140.5
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.23
    Marker Score: 460
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.23
    Marker Score: 528
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.23
    Marker Score: 250
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.23
    Marker Score: 181
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.23
    Marker Score: 100
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.22
    Marker Score: 133
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.22
    Marker Score: 79
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.22
    Marker Score: 168
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.21
    Marker Score: 198
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.2
    Marker Score: 63
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.2
    Marker Score: 202.5
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.2
    Marker Score: 94
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.2
    Marker Score: 83
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.2
    Marker Score: 113
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.19
    Marker Score: 42
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.19
    Marker Score: 1149
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.19
    Marker Score: 167
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.19
    Marker Score: 65
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.18
    Marker Score: 434
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.18
    Marker Score: 67
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.18
    Marker Score: 122
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.18
    Marker Score: 2059
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.18
    Marker Score: 134
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.18
    Marker Score: 133
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 0.17
    Marker Score: 52.5
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.17
    Marker Score: 105
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.17
    Marker Score: 183
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.17
    Marker Score: 38
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.17
    Marker Score: 58

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Other Information

**Key characteristics** * IL2RA is a cell surface protein that is expressed on activated T cells. * It is a member of the interleukin-2 receptor family, which is a group of cell surface receptors that are involved in the signaling of cytokines. * IL2RA is a key regulator of T cell activity. * It is involved in the regulation of immune responses to cytokines such as IL-2, IL-4, and IL-13. * It also plays a role in the regulation of the differentiation and function of regulatory T cells (Tregs). **Pathways and functions** * IL2RA signaling is initiated by the binding of IL-2 to its receptor on T cells. * This binding activates the IL2RA receptor, which then recruits the cytoplasmic domain of the IL2RA protein to the cell surface. * This complex is then translocated to the nucleus, where it activates the transcription factor STAT3. * STAT3 then regulates the expression of a number of target genes, including those involved in T cell activation, proliferation, and differentiation. * In addition to its role in T cell regulation, IL2RA has also been shown to play a role in the regulation of other immune cells, such as dendritic cells and macrophages. **Clinical significance** * Mutations in the IL2RA gene have been linked to several human diseases, including asthma, allergies, and autoimmune diseases. * In these diseases, IL2RA signaling is often dysregulated, leading to an overactive immune response. * Therefore, IL2RA is a promising target for the treatment of inflammatory diseases. **Additional notes** * The IL2RA gene is located on chromosome 1. * It is a relatively large gene, with a length of approximately 30 exons. * It is expressed in a variety of cell types, including immune cells, epithelial cells, and endothelial cells.

Genular Protein ID: 2323127

Symbol: IL2RA_HUMAN

Name: Interleukin-2 receptor subunit alpha

UniProtKB Accession Codes:

P01589 Q5W007

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 DrugCentral 1 EMBL 24 EMDB 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 9 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 6090949

Title: Molecular cloning of cDNA encoding human interleukin-2 receptor.

PubMed ID: 6090949

DOI: 10.1038/311631a0

PubMed ID: 6090948

Title: Molecular cloning and expression of cDNAs for the human interleukin-2 receptor.

PubMed ID: 6090948

DOI: 10.1038/311626a0

PubMed ID: 2999698

Title: Molecular cloning and structure of the human interleukin 2 receptor gene.

PubMed ID: 2999698

DOI: 10.1093/nar/13.21.7579

PubMed ID: 2996141

Title: Structure of the human interleukin-2 receptor gene.

PubMed ID: 2996141

DOI: 10.1126/science.2996141

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 3030566

Title: Regulation of the human interleukin-2 receptor alpha chain promoter: activation of a nonfunctional promoter by the transactivator gene of HTLV-I.

PubMed ID: 3030566

DOI: 10.1016/0092-8674(87)90754-9

PubMed ID: 3134887

Title: Structural analysis of recombinant soluble human interleukin-2 receptor. Primary structure, assignment of disulfide bonds and core IL-2 binding structure.

PubMed ID: 3134887

DOI: 10.1016/0006-291x(88)90695-x

PubMed ID: 7529123

Title: The interleukin-2 and interleukin-4 receptors studied by molecular modelling.

PubMed ID: 7529123

DOI: 10.1016/s0969-2126(94)00085-9

PubMed ID: 16293754

Title: Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors.

PubMed ID: 16293754

DOI: 10.1126/science.1117893

PubMed ID: 16477002

Title: Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor.

PubMed ID: 16477002

DOI: 10.1073/pnas.0511161103

PubMed ID: 17676041

Title: Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.

PubMed ID: 17676041

DOI: 10.1038/ng2102

PubMed ID: 23416241

Title: Human IL2RA null mutation mediates immunodeficiency with lymphoproliferation and autoimmunity.

PubMed ID: 23416241

DOI: 10.1016/j.clim.2013.01.004

PubMed ID: 24116927

Title: Follicular bronchiolitis as phenotype associated with CD25 deficiency.

PubMed ID: 24116927

DOI: 10.1111/cei.12214

Sequence Information:

  • Length: 272
  • Mass: 30819
  • Checksum: 83D907C8C81D2C0E
  • Sequence:
    • MDSYLLMWGL LTFIMVPGCQ AELCDDDPPE IPHATFKAMA YKEGTMLNCE CKRGFRRIKS 
GSLYMLCTGN SSHSSWDNQC QCTSSATRNT TKQVTPQPEE QKERKTTEMQ SPMQPVDQAS 
LPGHCREPPP WENEATERIY HFVVGQMVYY QCVQGYRALH RGPAESVCKM THGKTRWTQP 
QLICTGEMET SQFPGEEKPQ ASPEGRPESE TSCLVTTTDF QIQTEMAATM ETSIFTTEYQ 
VAVAGCVFLL ISVLLLSGLT WQRRQRKSRR TI

Genular Protein ID: 1715763074

Symbol: Q5W005_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5W005

Database IDs:

ARBA 13 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 3 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 Proteomes 2 RefSeq 1 SAM 3 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

Sequence Information:

  • Length: 200
  • Mass: 22454
  • Checksum: 7793254ABA60CEB6
  • Sequence:
    • MDSYLLMWGL LTFIMVPGCQ AELCDDDPPE IPHATFKAMA YKEGTMLNCE CKRGFRRIKS 
GSLYMLCTGN SSHSSWDNQC QCTSSATRNT TKQVTPQPEE QKERKTTEMQ SPMQPVDQAS 
LPGEEKPQAS PEGRPESETS CLVTTTDFQI QTEMAATMET SIFTTEYQVA VAGCVFLLIS 
VLLLSGLTWQ RRQRKSRRTI

Genular Protein ID: 785125499

Symbol: H0Y5Z0_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0Y5Z0

Database IDs:

ARBA 13 Antibodypedia 1 Bgee 1 CTD 1 ChiTaRS 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 3 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 2 Pfam 2 Proteomes 2 RefSeq 1 SAM 3 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

Sequence Information:

  • Length: 176
  • Mass: 19938
  • Checksum: 436F64DF08882879
  • Sequence:
    • MDSYLLMWGL LTFIMVPGCQ AELCDDDPPE IPHATFKAMA YKEGTMLNCE CKRGFRRIKS 
GSLYMLCTGN SSHSSWDNQC QCTSSATRNT TKQVTPQPEE QKERKTTEMQ SPMQPVDQAS 
LPDFQIQTEM AATMETSIFT TEYQVAVAGC VFLLISVLLL SGLTWQRRQR KSRRTI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.