Details for: IL6R

Gene ID: 3570

Symbol: IL6R

Ensembl ID: ENSG00000160712

Description: interleukin 6 receptor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.77
    Marker Score: 10708
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.04
    Marker Score: 5114
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 1.86
    Marker Score: 1491
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.83
    Marker Score: 4557
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.68
    Marker Score: 9057
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.64
    Marker Score: 3874
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.62
    Marker Score: 5295
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.6
    Marker Score: 1707
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.59
    Marker Score: 10245
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.58
    Marker Score: 1748
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.57
    Marker Score: 6776
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.56
    Marker Score: 87353
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.56
    Marker Score: 908
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.54
    Marker Score: 3127
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.5
    Marker Score: 604
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.48
    Marker Score: 3630
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168167
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.42
    Marker Score: 579
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.42
    Marker Score: 704
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.26
    Marker Score: 563
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.22
    Marker Score: 19108
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.21
    Marker Score: 1455
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 1.21
    Marker Score: 333
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.19
    Marker Score: 2256
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.18
    Marker Score: 1362
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.17
    Marker Score: 2852
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.13
    Marker Score: 24153
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.13
    Marker Score: 364
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.07
    Marker Score: 17195
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.05
    Marker Score: 1904
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.04
    Marker Score: 3680.5
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.01
    Marker Score: 558
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71729
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47953
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.99
    Marker Score: 6481
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.98
    Marker Score: 258
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30398
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.98
    Marker Score: 668
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.97
    Marker Score: 485
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.97
    Marker Score: 3725
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.96
    Marker Score: 280
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.95
    Marker Score: 570
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2403
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 486
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 440
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.93
    Marker Score: 919
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.92
    Marker Score: 335
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2733
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.91
    Marker Score: 1766
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.9
    Marker Score: 47837
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.9
    Marker Score: 921
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.9
    Marker Score: 5353.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.9
    Marker Score: 34249
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.89
    Marker Score: 5367
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.89
    Marker Score: 738
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.87
    Marker Score: 3717
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4915
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.86
    Marker Score: 1143
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.85
    Marker Score: 890
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.84
    Marker Score: 1049
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.83
    Marker Score: 260
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.83
    Marker Score: 312
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.82
    Marker Score: 1810.5
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.81
    Marker Score: 814
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.81
    Marker Score: 921
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.8
    Marker Score: 301
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.79
    Marker Score: 4156
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.78
    Marker Score: 2458
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.78
    Marker Score: 236
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.77
    Marker Score: 194
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 588
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.77
    Marker Score: 365
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 305
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.75
    Marker Score: 1223
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.75
    Marker Score: 1149
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.74
    Marker Score: 8589
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.74
    Marker Score: 509
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.73
    Marker Score: 1300
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 377
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3025
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.72
    Marker Score: 527
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.72
    Marker Score: 3009
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.71
    Marker Score: 1146
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.71
    Marker Score: 348
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.71
    Marker Score: 920
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.71
    Marker Score: 485
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.71
    Marker Score: 786
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.7
    Marker Score: 1118
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.7
    Marker Score: 3441
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.7
    Marker Score: 258
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.69
    Marker Score: 1784
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.68
    Marker Score: 154
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 622
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.68
    Marker Score: 311
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.68
    Marker Score: 237
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.67
    Marker Score: 174
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.67
    Marker Score: 403

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Other Information

**Key characteristics:** - IL6R is a single-pass transmembrane protein with a molecular weight of approximately 140 kDa. - It is expressed in high levels in the central nervous system, particularly in neurons and glial cells. - It is also expressed in high levels in immune cells, including dendritic cells, macrophages, and lymphocytes. **Pathways and functions:** - IL6R is a receptor for interleukin-6 (IL-6), a cytokine that is produced by a variety of cell types. - IL-6 binds to IL6R on the surface of immune cells, which triggers a signaling cascade. - This signaling cascade leads to the activation of the mitogen-activated protein kinase (MAPK) pathway, which is a major signaling pathway involved in immune responses. - IL-6 also activates the transcription factor STAT3, which can induce the expression of genes involved in immune responses. **Clinical significance:** - Mutations in the IL6R gene have been linked to a number of human diseases, including systemic sclerosis, rheumatoid arthritis, and inflammatory bowel disease. - IL6R inhibitors are being investigated as potential treatments for these diseases. - The development of IL6R inhibitors is a promising area of research for the treatment of inflammatory diseases. **Additional information:** - IL6R is a key regulator of immune responses. - It is involved in the regulation of inflammation, cell growth, and differentiation. - It is also involved in the development and maintenance of the immune system.

Genular Protein ID: 548217405

Symbol: IL6RA_HUMAN

Name: IL-6R 1

UniProtKB Accession Codes:

P08887 A8KAE8 B2R6V4 Q16202 Q53EQ7 Q5FWG2 Q5VZ23

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 ELM 1 EMBL 9 EMDB 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 43 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 6 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 6 RefSeq 3 SAM 1 SASBDB 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3136546

Title: Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor.

PubMed ID: 3136546

DOI: 10.1126/science.3136546

PubMed ID: 1872801

Title: Structural and functional studies on the human hepatic interleukin-6 receptor. Molecular cloning and overexpression in HepG2 cells.

PubMed ID: 1872801

DOI: 10.1042/bj2770659

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8056053

Title: Soluble interleukin-6 receptors released from T cell or granulocyte/macrophage cell lines and human peripheral blood mononuclear cells are generated through an alternative splicing mechanism.

PubMed ID: 8056053

DOI: 10.1002/eji.1830240837

PubMed ID: 10066782

Title: Disulfide bond structure and N-glycosylation sites of the extracellular domain of the human interleukin-6 receptor.

PubMed ID: 10066782

DOI: 10.1074/jbc.274.11.7207

PubMed ID: 2529343

Title: Soluble cytokine receptors are present in normal human urine.

PubMed ID: 2529343

DOI: 10.1084/jem.170.4.1409

PubMed ID: 8467812

Title: Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130.

PubMed ID: 8467812

DOI: 10.1002/j.1460-2075.1993.tb05815.x

PubMed ID: 11017875

Title: The cytoplasmic domain of the interleukin-6 receptor gp80 mediates its basolateral sorting in polarized Madin-Darby canine kidney cells.

PubMed ID: 11017875

DOI: 10.1242/jcs.113.20.3593

PubMed ID: 12794819

Title: Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis.

PubMed ID: 12794819

DOI: 10.1002/art.11143

PubMed ID: 16270750

Title: Increased association with detergent-resistant membranes/lipid rafts of apically targeted mutants of the interleukin-6 receptor gp80.

PubMed ID: 16270750

DOI: 10.1016/j.ejcb.2005.06.001

PubMed ID: 21990364

Title: Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor.

PubMed ID: 21990364

DOI: 10.1074/jbc.m111.295758

PubMed ID: 26876177

Title: Proteolytic Cleavage Governs Interleukin-11 Trans-signaling.

PubMed ID: 26876177

DOI: 10.1016/j.celrep.2016.01.053

PubMed ID: 28265003

Title: SorLA in Interleukin-6 Signaling and Turnover.

PubMed ID: 28265003

DOI: 10.1128/mcb.00641-16

PubMed ID: 28060820

Title: Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation.

PubMed ID: 28060820

DOI: 10.1371/journal.pbio.2000080

PubMed ID: 30995492

Title: Targeting Interleukin-6 Signaling in Clinic.

PubMed ID: 30995492

DOI: 10.1016/j.immuni.2019.03.026

PubMed ID: 12461182

Title: Structure of the extracellular domains of the human interleukin-6 receptor alpha-chain.

PubMed ID: 12461182

DOI: 10.1073/pnas.232432399

PubMed ID: 12829785

Title: Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex.

PubMed ID: 12829785

DOI: 10.1126/science.1083901

PubMed ID: 17357077

Title: Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels.

PubMed ID: 17357077

DOI: 10.1086/513206

PubMed ID: 31235509

Title: Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses.

PubMed ID: 31235509

DOI: 10.1084/jem.20190344

Sequence Information:

  • Length: 468
  • Mass: 51548
  • Checksum: 62AA239FA14F1B8B
  • Sequence:
    • MLAVGCALLA ALLAAPGAAL APRRCPAQEV ARGVLTSLPG DSVTLTCPGV EPEDNATVHW 
VLRKPAAGSH PSRWAGMGRR LLLRSVQLHD SGNYSCYRAG RPAGTVHLLV DVPPEEPQLS 
CFRKSPLSNV VCEWGPRSTP SLTTKAVLLV RKFQNSPAED FQEPCQYSQE SQKFSCQLAV 
PEGDSSFYIV SMCVASSVGS KFSKTQTFQG CGILQPDPPA NITVTAVARN PRWLSVTWQD 
PHSWNSSFYR LRFELRYRAE RSKTFTTWMV KDLQHHCVIH DAWSGLRHVV QLRAQEEFGQ 
GEWSEWSPEA MGTPWTESRS PPAENEVSTP MQALTTNKDD DNILFRDSAN ATSLPVQDSS 
SVPLPTFLVA GGSLAFGTLL CIAIVLRFKK TWKLRALKEG KTSMHPPYSL GQLVPERPRP 
TPVLVPLISP PVSPSSLGSD NTSSHNRPDA RDPRSPYDIS NTDYFFPR

Genular Protein ID: 557958099

Symbol: A0A087WTB5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WTB5

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 10 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PROSITE 5 PeptideAtlas 2 Pfam 2 Proteomes 2 RefSeq 1 SAM 1 SMART 3 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 352
  • Mass: 38849
  • Checksum: 7145908AEB117878
  • Sequence:
    • MLAVGCALLA ALLAAPGAAL APRRCPAQEV ARGVLTSLPG DSVTLTCPGV EPEDNATVHW 
VLRKPAAGSH PSRWAGMGRR LLLRSVQLHD SGNYSCYRAG RPAGTVHLLV DVPPEEPQLS 
CFRKSPLSNV VCEWGPRSTP SLTTKAVLLV RKFQNSPAED FQEPCQYSQE SQKFSCQLAV 
PEGDSSFYIV SMCVASSVGS KFSKTQTFQG CGILQPDPPA NITVTAVARN PRWLSVTWQD 
PHSWNSSFYR LRFELRYRAE RSKTFTTWMV KDLQHHCVIH DAWSGLRHVV QLRAQEEFGQ 
GEWSEWSPEA MGTPWTDRLS PRCPGWSTAV QSQLTATSAS WVQAILPPQP PK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.