Details for: IL6R
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 133.2088
Cell Significance Index: -20.7200 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 71.1235
Cell Significance Index: -18.0400 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 48.0238
Cell Significance Index: -19.5100 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 46.4498
Cell Significance Index: -21.9300 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 42.2057
Cell Significance Index: -21.7100 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 16.8700
Cell Significance Index: -20.8000 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 6.1274
Cell Significance Index: -18.8200 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 5.6155
Cell Significance Index: -12.2900 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 5.5859
Cell Significance Index: 94.1000 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 5.3218
Cell Significance Index: -21.0000 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.4070
Cell Significance Index: 32.8400 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 2.1830
Cell Significance Index: 53.2700 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.9267
Cell Significance Index: 35.6100 - Cell Name: late promyelocyte (CL0002151)
Fold Change: 1.9113
Cell Significance Index: 12.6800 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.3950
Cell Significance Index: 37.9700 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.2460
Cell Significance Index: 10.1600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.1965
Cell Significance Index: 237.4500 - Cell Name: type II muscle cell (CL0002212)
Fold Change: 1.1776
Cell Significance Index: 19.0000 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.0502
Cell Significance Index: 12.9900 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.9220
Cell Significance Index: 23.7000 - Cell Name: hepatoblast (CL0005026)
Fold Change: 0.8294
Cell Significance Index: 13.9500 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.6789
Cell Significance Index: 87.7100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.6767
Cell Significance Index: 50.4400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.6506
Cell Significance Index: 18.7500 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.6155
Cell Significance Index: 27.9000 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.5788
Cell Significance Index: 5.9900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.5635
Cell Significance Index: 43.2400 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.5449
Cell Significance Index: 32.7100 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4514
Cell Significance Index: 407.5400 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.4393
Cell Significance Index: 9.3900 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.4282
Cell Significance Index: 21.6400 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.3997
Cell Significance Index: 5.9000 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.3925
Cell Significance Index: 7.6600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3854
Cell Significance Index: 8.3500 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3737
Cell Significance Index: 36.9700 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3251
Cell Significance Index: 35.3600 - Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.3123
Cell Significance Index: 4.3800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.2440
Cell Significance Index: 11.4700 - Cell Name: peg cell (CL4033014)
Fold Change: 0.2413
Cell Significance Index: 5.5800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2275
Cell Significance Index: 37.0000 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2100
Cell Significance Index: 5.8700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.2020
Cell Significance Index: 40.5200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1997
Cell Significance Index: 13.8100 - Cell Name: early promyelocyte (CL0002154)
Fold Change: 0.1997
Cell Significance Index: 1.2800 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.1849
Cell Significance Index: 4.9500 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.1752
Cell Significance Index: 2.6400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.1442
Cell Significance Index: 16.8100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1241
Cell Significance Index: 67.7600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1232
Cell Significance Index: 4.3300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1172
Cell Significance Index: 74.4500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1096
Cell Significance Index: 20.8600 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.1040
Cell Significance Index: 1.4800 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0936
Cell Significance Index: 2.3400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0650
Cell Significance Index: 8.0000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0568
Cell Significance Index: 107.0200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0422
Cell Significance Index: 15.1300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0390
Cell Significance Index: 6.6600 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0313
Cell Significance Index: 21.6600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0306
Cell Significance Index: 13.9000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0118
Cell Significance Index: 0.3100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0003
Cell Significance Index: 0.0600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.0000
Cell Significance Index: -0.0200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0036
Cell Significance Index: -2.7000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0040
Cell Significance Index: -3.0000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0061
Cell Significance Index: -3.7900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0095
Cell Significance Index: -17.5700 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0099
Cell Significance Index: -4.3600 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.0111
Cell Significance Index: -0.1600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0112
Cell Significance Index: -17.2800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0143
Cell Significance Index: -19.4400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0233
Cell Significance Index: -17.0800 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0295
Cell Significance Index: -3.0100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0329
Cell Significance Index: -4.5200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0391
Cell Significance Index: -8.2300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0400
Cell Significance Index: -2.0800 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0429
Cell Significance Index: -1.2300 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0576
Cell Significance Index: -2.6900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0650
Cell Significance Index: -18.6900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0720
Cell Significance Index: -10.4700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0933
Cell Significance Index: -10.6900 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.1255
Cell Significance Index: -3.9700 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1295
Cell Significance Index: -14.7900 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.1360
Cell Significance Index: -17.4400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1384
Cell Significance Index: -16.3200 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.1655
Cell Significance Index: -1.3900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1823
Cell Significance Index: -18.9900 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1883
Cell Significance Index: -4.0100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2137
Cell Significance Index: -14.3700 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2272
Cell Significance Index: -14.6600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2448
Cell Significance Index: -19.3900 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.2466
Cell Significance Index: -17.4400 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.2504
Cell Significance Index: -4.4300 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2832
Cell Significance Index: -17.3600 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.3046
Cell Significance Index: -8.9500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3444
Cell Significance Index: -21.1700 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.3634
Cell Significance Index: -22.9100 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.3703
Cell Significance Index: -19.2900 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.3850
Cell Significance Index: -7.7300 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3921
Cell Significance Index: -22.0000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3935
Cell Significance Index: -20.6600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 548217405
Symbol: IL6RA_HUMAN
Name: IL-6R 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3136546
Title: Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor.
PubMed ID: 3136546
PubMed ID: 1872801
Title: Structural and functional studies on the human hepatic interleukin-6 receptor. Molecular cloning and overexpression in HepG2 cells.
PubMed ID: 1872801
DOI: 10.1042/bj2770659
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8056053
Title: Soluble interleukin-6 receptors released from T cell or granulocyte/macrophage cell lines and human peripheral blood mononuclear cells are generated through an alternative splicing mechanism.
PubMed ID: 8056053
PubMed ID: 10066782
Title: Disulfide bond structure and N-glycosylation sites of the extracellular domain of the human interleukin-6 receptor.
PubMed ID: 10066782
PubMed ID: 2529343
Title: Soluble cytokine receptors are present in normal human urine.
PubMed ID: 2529343
PubMed ID: 8467812
Title: Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130.
PubMed ID: 8467812
PubMed ID: 11017875
Title: The cytoplasmic domain of the interleukin-6 receptor gp80 mediates its basolateral sorting in polarized Madin-Darby canine kidney cells.
PubMed ID: 11017875
PubMed ID: 12794819
Title: Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis.
PubMed ID: 12794819
DOI: 10.1002/art.11143
PubMed ID: 16270750
Title: Increased association with detergent-resistant membranes/lipid rafts of apically targeted mutants of the interleukin-6 receptor gp80.
PubMed ID: 16270750
PubMed ID: 21990364
Title: Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor.
PubMed ID: 21990364
PubMed ID: 26876177
Title: Proteolytic Cleavage Governs Interleukin-11 Trans-signaling.
PubMed ID: 26876177
PubMed ID: 28265003
PubMed ID: 28060820
Title: Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation.
PubMed ID: 28060820
PubMed ID: 30995492
Title: Targeting Interleukin-6 Signaling in Clinic.
PubMed ID: 30995492
PubMed ID: 12461182
Title: Structure of the extracellular domains of the human interleukin-6 receptor alpha-chain.
PubMed ID: 12461182
PubMed ID: 12829785
Title: Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex.
PubMed ID: 12829785
PubMed ID: 17357077
Title: Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels.
PubMed ID: 17357077
DOI: 10.1086/513206
PubMed ID: 31235509
Title: Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses.
PubMed ID: 31235509
DOI: 10.1084/jem.20190344
Sequence Information:
- Length: 468
- Mass: 51548
- Checksum: 62AA239FA14F1B8B
- Sequence:
MLAVGCALLA ALLAAPGAAL APRRCPAQEV ARGVLTSLPG DSVTLTCPGV EPEDNATVHW VLRKPAAGSH PSRWAGMGRR LLLRSVQLHD SGNYSCYRAG RPAGTVHLLV DVPPEEPQLS CFRKSPLSNV VCEWGPRSTP SLTTKAVLLV RKFQNSPAED FQEPCQYSQE SQKFSCQLAV PEGDSSFYIV SMCVASSVGS KFSKTQTFQG CGILQPDPPA NITVTAVARN PRWLSVTWQD PHSWNSSFYR LRFELRYRAE RSKTFTTWMV KDLQHHCVIH DAWSGLRHVV QLRAQEEFGQ GEWSEWSPEA MGTPWTESRS PPAENEVSTP MQALTTNKDD DNILFRDSAN ATSLPVQDSS SVPLPTFLVA GGSLAFGTLL CIAIVLRFKK TWKLRALKEG KTSMHPPYSL GQLVPERPRP TPVLVPLISP PVSPSSLGSD NTSSHNRPDA RDPRSPYDIS NTDYFFPR
Genular Protein ID: 557958099
Symbol: A0A087WTB5_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
Sequence Information:
- Length: 352
- Mass: 38849
- Checksum: 7145908AEB117878
- Sequence:
MLAVGCALLA ALLAAPGAAL APRRCPAQEV ARGVLTSLPG DSVTLTCPGV EPEDNATVHW VLRKPAAGSH PSRWAGMGRR LLLRSVQLHD SGNYSCYRAG RPAGTVHLLV DVPPEEPQLS CFRKSPLSNV VCEWGPRSTP SLTTKAVLLV RKFQNSPAED FQEPCQYSQE SQKFSCQLAV PEGDSSFYIV SMCVASSVGS KFSKTQTFQG CGILQPDPPA NITVTAVARN PRWLSVTWQD PHSWNSSFYR LRFELRYRAE RSKTFTTWMV KDLQHHCVIH DAWSGLRHVV QLRAQEEFGQ GEWSEWSPEA MGTPWTDRLS PRCPGWSTAV QSQLTATSAS WVQAILPPQP PK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.