Details for: IL10

Gene ID: 3586

Symbol: IL10

Ensembl ID: ENSG00000136634

Description: interleukin 10

Associated with

  • Anti-inflammatory response favouring leishmania parasite infection
    (R-HSA-9662851)
  • Cd163 mediating an anti-inflammatory response
    (R-HSA-9662834)
  • Cytokine signaling in immune system
    (R-HSA-1280215)
  • Disease
    (R-HSA-1643685)
  • Diseases of signal transduction by growth factor receptors and second messengers
    (R-HSA-5663202)
  • Fcgr3a-mediated il10 synthesis
    (R-HSA-9664323)
  • Gene and protein expression by jak-stat signaling after interleukin-12 stimulation
    (R-HSA-8950505)
  • Immune system
    (R-HSA-168256)
  • Infectious disease
    (R-HSA-5663205)
  • Interleukin-4 and interleukin-13 signaling
    (R-HSA-6785807)
  • Interleukin-10 signaling
    (R-HSA-6783783)
  • Interleukin-12 family signaling
    (R-HSA-447115)
  • Interleukin-12 signaling
    (R-HSA-9020591)
  • Leishmania infection
    (R-HSA-9658195)
  • Leishmania parasite growth and survival
    (R-HSA-9664433)
  • Parasitic infection pathways
    (R-HSA-9824443)
  • Signaling by alk fusions and activated point mutants
    (R-HSA-9725370)
  • Signaling by alk in cancer
    (R-HSA-9700206)
  • Signaling by interleukins
    (R-HSA-449147)
  • B cell differentiation
    (GO:0030183)
  • B cell proliferation
    (GO:0042100)
  • Branching involved in labyrinthine layer morphogenesis
    (GO:0060670)
  • Cellular response to estradiol stimulus
    (GO:0071392)
  • Cellular response to hepatocyte growth factor stimulus
    (GO:0035729)
  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Chronic inflammatory response to antigenic stimulus
    (GO:0002439)
  • Cytokine activity
    (GO:0005125)
  • Cytoplasmic sequestering of nf-kappab
    (GO:0007253)
  • Defense response to bacterium
    (GO:0042742)
  • Defense response to protozoan
    (GO:0042832)
  • Endothelial cell apoptotic process
    (GO:0072577)
  • Growth factor activity
    (GO:0008083)
  • Hemopoiesis
    (GO:0030097)
  • Interleukin-10 receptor binding
    (GO:0005141)
  • Interleukin-10-mediated signaling pathway
    (GO:0140105)
  • Leukocyte chemotaxis
    (GO:0030595)
  • Liver regeneration
    (GO:0097421)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of autophagy
    (GO:0010507)
  • Negative regulation of b cell proliferation
    (GO:0030889)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of chemokine (c-c motif) ligand 5 production
    (GO:0071650)
  • Negative regulation of chronic inflammatory response to antigenic stimulus
    (GO:0002875)
  • Negative regulation of cytokine activity
    (GO:0060302)
  • Negative regulation of cytokine production
    (GO:0001818)
  • Negative regulation of cytokine production involved in immune response
    (GO:0002719)
  • Negative regulation of heterotypic cell-cell adhesion
    (GO:0034115)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Negative regulation of interferon-alpha production
    (GO:0032687)
  • Negative regulation of interleukin-1 production
    (GO:0032692)
  • Negative regulation of interleukin-6 production
    (GO:0032715)
  • Negative regulation of interleukin-8 production
    (GO:0032717)
  • Negative regulation of interleukin-12 production
    (GO:0032695)
  • Negative regulation of interleukin-18 production
    (GO:0032701)
  • Negative regulation of membrane protein ectodomain proteolysis
    (GO:0051045)
  • Negative regulation of mhc class ii biosynthetic process
    (GO:0045347)
  • Negative regulation of mitotic cell cycle
    (GO:0045930)
  • Negative regulation of myeloid dendritic cell activation
    (GO:0030886)
  • Negative regulation of nitric oxide biosynthetic process
    (GO:0045019)
  • Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
    (GO:1903377)
  • Negative regulation of t cell proliferation
    (GO:0042130)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Negative regulation of type ii interferon production
    (GO:0032689)
  • Negative regulation of vascular associated smooth muscle cell proliferation
    (GO:1904706)
  • Positive regulation of b cell apoptotic process
    (GO:0002904)
  • Positive regulation of cell cycle
    (GO:0045787)
  • Positive regulation of cytokine production
    (GO:0001819)
  • Positive regulation of dna-binding transcription factor activity
    (GO:0051091)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of endothelial cell proliferation
    (GO:0001938)
  • Positive regulation of heterotypic cell-cell adhesion
    (GO:0034116)
  • Positive regulation of immunoglobulin production
    (GO:0002639)
  • Positive regulation of macrophage activation
    (GO:0043032)
  • Positive regulation of mhc class ii biosynthetic process
    (GO:0045348)
  • Positive regulation of mirna transcription
    (GO:1902895)
  • Positive regulation of plasma cell differentiation
    (GO:1900100)
  • Positive regulation of receptor signaling pathway via jak-stat
    (GO:0046427)
  • Positive regulation of sprouting angiogenesis
    (GO:1903672)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Protein dimerization activity
    (GO:0046983)
  • Regulation of complement-dependent cytotoxicity
    (GO:1903659)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of isotype switching
    (GO:0045191)
  • Regulation of response to wounding
    (GO:1903034)
  • Regulation of synapse organization
    (GO:0050807)
  • Response to activity
    (GO:0014823)
  • Response to carbon monoxide
    (GO:0034465)
  • Response to glucocorticoid
    (GO:0051384)
  • Response to inactivity
    (GO:0014854)
  • Response to insulin
    (GO:0032868)
  • Response to molecule of bacterial origin
    (GO:0002237)
  • Response to xenobiotic stimulus
    (GO:0009410)
  • Type 2 immune response
    (GO:0042092)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 14.1782
    Cell Significance Index: -5.7600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.8073
    Cell Significance Index: 120.1700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.9163
    Cell Significance Index: 45.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.6250
    Cell Significance Index: 35.2100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1715
    Cell Significance Index: 222.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8717
    Cell Significance Index: 86.2400
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.8578
    Cell Significance Index: 3.5700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7371
    Cell Significance Index: 665.5700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.7167
    Cell Significance Index: 10.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4506
    Cell Significance Index: 14.4300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4243
    Cell Significance Index: 69.0000
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.3872
    Cell Significance Index: 3.8200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3668
    Cell Significance Index: 39.9000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2163
    Cell Significance Index: 14.9600
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.1868
    Cell Significance Index: 3.2100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1624
    Cell Significance Index: 101.4200
  • Cell Name: T follicular regulatory cell (CL0009113)
    Fold Change: 0.1462
    Cell Significance Index: 0.3600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0941
    Cell Significance Index: 5.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0427
    Cell Significance Index: 0.9100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0417
    Cell Significance Index: 0.3400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0235
    Cell Significance Index: 2.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0146
    Cell Significance Index: 0.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0006
    Cell Significance Index: -0.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0009
    Cell Significance Index: -0.5000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0018
    Cell Significance Index: -1.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0026
    Cell Significance Index: -1.4500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0027
    Cell Significance Index: -0.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0028
    Cell Significance Index: -5.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0034
    Cell Significance Index: -0.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0053
    Cell Significance Index: -4.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0057
    Cell Significance Index: -0.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0059
    Cell Significance Index: -10.8100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0071
    Cell Significance Index: -10.9600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0076
    Cell Significance Index: -5.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0084
    Cell Significance Index: -5.3600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0093
    Cell Significance Index: -0.4200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0093
    Cell Significance Index: -0.3800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0120
    Cell Significance Index: -1.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0128
    Cell Significance Index: -4.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0139
    Cell Significance Index: -2.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0150
    Cell Significance Index: -6.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0179
    Cell Significance Index: -3.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0215
    Cell Significance Index: -6.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0225
    Cell Significance Index: -2.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0225
    Cell Significance Index: -1.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0245
    Cell Significance Index: -2.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0251
    Cell Significance Index: -5.0300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0274
    Cell Significance Index: -1.1900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0356
    Cell Significance Index: -0.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0360
    Cell Significance Index: -5.2400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0376
    Cell Significance Index: -0.5500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0387
    Cell Significance Index: -4.5100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0392
    Cell Significance Index: -5.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0395
    Cell Significance Index: -4.8600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0458
    Cell Significance Index: -1.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0479
    Cell Significance Index: -1.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0493
    Cell Significance Index: -6.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0512
    Cell Significance Index: -2.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0624
    Cell Significance Index: -8.0600
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0673
    Cell Significance Index: -0.5500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0766
    Cell Significance Index: -1.5900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0776
    Cell Significance Index: -2.0800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0842
    Cell Significance Index: -1.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0869
    Cell Significance Index: -5.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0886
    Cell Significance Index: -6.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0995
    Cell Significance Index: -6.4200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1055
    Cell Significance Index: -1.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1065
    Cell Significance Index: -7.9400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1094
    Cell Significance Index: -5.7000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1102
    Cell Significance Index: -1.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1190
    Cell Significance Index: -6.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1240
    Cell Significance Index: -7.6200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1247
    Cell Significance Index: -1.8100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1283
    Cell Significance Index: -5.9800
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1323
    Cell Significance Index: -1.4500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1364
    Cell Significance Index: -7.1600
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1453
    Cell Significance Index: -1.7100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1524
    Cell Significance Index: -5.3400
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1609
    Cell Significance Index: -1.3600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1627
    Cell Significance Index: -5.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1628
    Cell Significance Index: -7.2000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1729
    Cell Significance Index: -5.6600
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.1745
    Cell Significance Index: -2.2100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1762
    Cell Significance Index: -6.4700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1770
    Cell Significance Index: -5.6400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1771
    Cell Significance Index: -11.1600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1780
    Cell Significance Index: -2.0200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1852
    Cell Significance Index: -5.4400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1899
    Cell Significance Index: -3.1300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1908
    Cell Significance Index: -7.2300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1941
    Cell Significance Index: -5.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1989
    Cell Significance Index: -5.2300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2010
    Cell Significance Index: -5.9200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2053
    Cell Significance Index: -5.8600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2165
    Cell Significance Index: -2.2100
  • Cell Name: CD14-positive, CD16-low monocyte (CL0001055)
    Fold Change: -0.2224
    Cell Significance Index: -2.1400
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.2253
    Cell Significance Index: -1.1800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2269
    Cell Significance Index: -5.6600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2314
    Cell Significance Index: -6.1800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2318
    Cell Significance Index: -5.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IL10 is a single-chain cytokine composed of 149 amino acids, with a molecular weight of approximately 16 kDa. It is produced by various cell types, including macrophages, T cells, and dendritic cells, and has a wide range of biological activities. IL10 is characterized by its ability to modulate immune responses, reduce inflammation, and promote tissue repair. **Pathways and Functions:** IL10 exerts its effects through binding to its receptor, IL10R, which is composed of two subunits, IL10R1 and IL10R2. The binding of IL10 to its receptor triggers a signaling cascade that activates various downstream pathways, including: 1. **JAK/STAT signaling**: IL10 activates the JAK/STAT pathway, which regulates gene expression and cell proliferation. 2. **NF-κB pathway**: IL10 inhibits the NF-κB pathway, which is involved in inflammation and immune responses. 3. **Cytokine signaling**: IL10 modulates cytokine production and regulates the immune response. 4. **Apoptosis and autophagy**: IL10 inhibits apoptosis and autophagy, promoting cell survival and tissue homeostasis. IL10's functions include: 1. **Anti-inflammatory response**: IL10 reduces inflammation by inhibiting pro-inflammatory cytokines and promoting anti-inflammatory cytokines. 2. **Immune homeostasis**: IL10 regulates T cell and B cell responses, maintaining immune tolerance and preventing autoimmune diseases. 3. **Tissue repair**: IL10 promotes tissue repair by regulating the production of growth factors and cytokines. 4. **Infectious disease**: IL10 plays a crucial role in controlling infections by regulating the immune response and promoting tissue repair. **Clinical Significance:** Dysregulation of IL10 has been implicated in various human diseases, including: 1. **Autoimmune diseases**: IL10 deficiency or dysfunction is associated with autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: IL10 has been shown to promote tumor growth and metastasis in certain cancers, such as breast and lung cancer. 3. **Infectious diseases**: IL10 is essential for controlling infections, and its dysregulation can lead to severe disease outcomes. 4. **Inflammatory disorders**: IL10 is involved in the pathogenesis of inflammatory disorders, such as asthma and chronic obstructive pulmonary disease (COPD). In conclusion, IL10 is a critical cytokine that regulates immune responses, inflammation, and tissue homeostasis. Its dysregulation has significant implications for human diseases, highlighting the need for further research into the mechanisms of IL10 and its role in various diseases.

Genular Protein ID: 2956531545

Symbol: IL10_HUMAN

Name: Interleukin-10

UniProtKB Accession Codes:

P22301

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 4 EMDB 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 77 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 2 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 6 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 1847510

Title: Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI.

PubMed ID: 1847510

DOI: 10.1073/pnas.88.4.1172

PubMed ID: 9405662

Title: Identification of functional domains on human interleukin 10.

PubMed ID: 9405662

DOI: 10.1073/pnas.94.26.14620

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 1940799

Title: Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

PubMed ID: 1940799

DOI: 10.1084/jem.174.5.1209

PubMed ID: 8364028

Title: Disulfide bond assignments and secondary structure analysis of human and murine interleukin 10.

PubMed ID: 8364028

DOI: 10.1021/bi00085a011

PubMed ID: 7512027

Title: Interleukin-10 inhibits B7 and intercellular adhesion molecule-1 expression on human monocytes.

PubMed ID: 7512027

DOI: 10.1002/eji.1830240435

PubMed ID: 8144879

Title: Antigen presentation in the central nervous system. The inhibitory effect of IL-10 on MHC class II expression and production of cytokines depends on the inducing signals and the type of cell analyzed.

PubMed ID: 8144879

PubMed ID: 11564774

Title: IL-10 inhibits granulocyte-macrophage colony-stimulating factor-dependent human monocyte survival at the early stage of the culture and inhibits the generation of macrophages.

PubMed ID: 11564774

DOI: 10.4049/jimmunol.167.7.3619

PubMed ID: 14657427

Title: Relation of an interleukin-10 promoter polymorphism to graft-versus-host disease and survival after hematopoietic-cell transplantation.

PubMed ID: 14657427

DOI: 10.1056/nejmoa022060

PubMed ID: 16982608

Title: Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex.

PubMed ID: 16982608

DOI: 10.1074/jbc.m606791200

PubMed ID: 18025162

Title: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway.

PubMed ID: 18025162

DOI: 10.4049/jimmunol.179.11.7215

PubMed ID: 7547951

Title: Crystal structure of interleukin 10 reveals an interferon gamma-like fold.

PubMed ID: 7547951

DOI: 10.1021/bi00038a004

PubMed ID: 8590020

Title: Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon gamma.

PubMed ID: 8590020

DOI: 10.1016/s0969-2126(01)00193-9

PubMed ID: 8897595

Title: Crystal structure of human interleukin-10 at 1.6-A resolution and a model of a complex with its soluble receptor.

PubMed ID: 8897595

DOI: 10.1002/pro.5560051001

PubMed ID: 11485736

Title: Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site.

PubMed ID: 11485736

DOI: 10.1016/s1074-7613(01)00169-8

PubMed ID: 12121653

Title: Noncompetitive antibody neutralization of IL-10 revealed by protein engineering and x-ray crystallography.

PubMed ID: 12121653

DOI: 10.1016/s0969-2126(02)00791-8

PubMed ID: 15837194

Title: Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain.

PubMed ID: 15837194

DOI: 10.1016/j.str.2005.01.016

PubMed ID: 12825869

Title: A Gly15Arg mutation in the interleukin-10 gene reduces secretion of interleukin-10 in Crohn disease.

PubMed ID: 12825869

DOI: 10.1080/00365520310003011

Sequence Information:

  • Length: 178
  • Mass: 20517
  • Checksum: 6825E9FA4337CDE4
  • Sequence:
    • MHSSALLCCL VLLTGVRASP GQGTQSENSC THFPGNLPNM LRDLRDAFSR VKTFFQMKDQ 
LDNLLLKESL LEDFKGYLGC QALSEMIQFY LEEVMPQAEN QDPDIKAHVN SLGENLKTLR 
LRLRRCHRFL PCENKSKAVE QVKNAFNKLQ EKGIYKAMSE FDIFINYIEA YMTMKIRN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.