Details for: IL10

Gene ID: 3586

Symbol: IL10

Ensembl ID: ENSG00000136634

Description: interleukin 10

Associated with

  • Anti-inflammatory response favouring leishmania parasite infection
    (R-HSA-9662851)
  • Cd163 mediating an anti-inflammatory response
    (R-HSA-9662834)
  • Cytokine signaling in immune system
    (R-HSA-1280215)
  • Disease
    (R-HSA-1643685)
  • Diseases of signal transduction by growth factor receptors and second messengers
    (R-HSA-5663202)
  • Fcgr3a-mediated il10 synthesis
    (R-HSA-9664323)
  • Gene and protein expression by jak-stat signaling after interleukin-12 stimulation
    (R-HSA-8950505)
  • Immune system
    (R-HSA-168256)
  • Infectious disease
    (R-HSA-5663205)
  • Interleukin-4 and interleukin-13 signaling
    (R-HSA-6785807)
  • Interleukin-10 signaling
    (R-HSA-6783783)
  • Interleukin-12 family signaling
    (R-HSA-447115)
  • Interleukin-12 signaling
    (R-HSA-9020591)
  • Leishmania infection
    (R-HSA-9658195)
  • Leishmania parasite growth and survival
    (R-HSA-9664433)
  • Parasitic infection pathways
    (R-HSA-9824443)
  • Signaling by alk fusions and activated point mutants
    (R-HSA-9725370)
  • Signaling by alk in cancer
    (R-HSA-9700206)
  • Signaling by interleukins
    (R-HSA-449147)
  • B cell differentiation
    (GO:0030183)
  • B cell proliferation
    (GO:0042100)
  • Branching involved in labyrinthine layer morphogenesis
    (GO:0060670)
  • Cellular response to estradiol stimulus
    (GO:0071392)
  • Cellular response to hepatocyte growth factor stimulus
    (GO:0035729)
  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Chronic inflammatory response to antigenic stimulus
    (GO:0002439)
  • Cytokine activity
    (GO:0005125)
  • Cytoplasmic sequestering of nf-kappab
    (GO:0007253)
  • Defense response to bacterium
    (GO:0042742)
  • Defense response to protozoan
    (GO:0042832)
  • Endothelial cell apoptotic process
    (GO:0072577)
  • Growth factor activity
    (GO:0008083)
  • Hemopoiesis
    (GO:0030097)
  • Interleukin-10 receptor binding
    (GO:0005141)
  • Leukocyte chemotaxis
    (GO:0030595)
  • Liver regeneration
    (GO:0097421)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of autophagy
    (GO:0010507)
  • Negative regulation of b cell proliferation
    (GO:0030889)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of chemokine (c-c motif) ligand 5 production
    (GO:0071650)
  • Negative regulation of chronic inflammatory response to antigenic stimulus
    (GO:0002875)
  • Negative regulation of cytokine activity
    (GO:0060302)
  • Negative regulation of cytokine production
    (GO:0001818)
  • Negative regulation of cytokine production involved in immune response
    (GO:0002719)
  • Negative regulation of heterotypic cell-cell adhesion
    (GO:0034115)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Negative regulation of interferon-alpha production
    (GO:0032687)
  • Negative regulation of interleukin-1 production
    (GO:0032692)
  • Negative regulation of interleukin-6 production
    (GO:0032715)
  • Negative regulation of interleukin-8 production
    (GO:0032717)
  • Negative regulation of interleukin-12 production
    (GO:0032695)
  • Negative regulation of interleukin-18 production
    (GO:0032701)
  • Negative regulation of membrane protein ectodomain proteolysis
    (GO:0051045)
  • Negative regulation of mhc class ii biosynthetic process
    (GO:0045347)
  • Negative regulation of mitotic cell cycle
    (GO:0045930)
  • Negative regulation of myeloid dendritic cell activation
    (GO:0030886)
  • Negative regulation of nitric oxide biosynthetic process
    (GO:0045019)
  • Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
    (GO:1903377)
  • Negative regulation of t cell proliferation
    (GO:0042130)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Negative regulation of type ii interferon production
    (GO:0032689)
  • Negative regulation of vascular associated smooth muscle cell proliferation
    (GO:1904706)
  • Positive regulation of b cell apoptotic process
    (GO:0002904)
  • Positive regulation of cell cycle
    (GO:0045787)
  • Positive regulation of cytokine production
    (GO:0001819)
  • Positive regulation of dna-binding transcription factor activity
    (GO:0051091)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of endothelial cell proliferation
    (GO:0001938)
  • Positive regulation of heterotypic cell-cell adhesion
    (GO:0034116)
  • Positive regulation of immunoglobulin production
    (GO:0002639)
  • Positive regulation of macrophage activation
    (GO:0043032)
  • Positive regulation of mhc class ii biosynthetic process
    (GO:0045348)
  • Positive regulation of mirna transcription
    (GO:1902895)
  • Positive regulation of plasma cell differentiation
    (GO:1900100)
  • Positive regulation of receptor signaling pathway via jak-stat
    (GO:0046427)
  • Positive regulation of sprouting angiogenesis
    (GO:1903672)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of vascular associated smooth muscle cell proliferation
    (GO:1904707)
  • Protein binding
    (GO:0005515)
  • Protein dimerization activity
    (GO:0046983)
  • Regulation of complement-dependent cytotoxicity
    (GO:1903659)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of isotype switching
    (GO:0045191)
  • Regulation of response to wounding
    (GO:1903034)
  • Regulation of synapse organization
    (GO:0050807)
  • Response to activity
    (GO:0014823)
  • Response to carbon monoxide
    (GO:0034465)
  • Response to glucocorticoid
    (GO:0051384)
  • Response to inactivity
    (GO:0014854)
  • Response to insulin
    (GO:0032868)
  • Response to molecule of bacterial origin
    (GO:0002237)
  • Response to xenobiotic stimulus
    (GO:0009410)
  • Signal transduction
    (GO:0007165)
  • Type 2 immune response
    (GO:0042092)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1167
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.39
    Marker Score: 2835
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 852
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.22
    Marker Score: 1398
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 484
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.05
    Marker Score: 633
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71824
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48049
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5346
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.87
    Marker Score: 400
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.87
    Marker Score: 866
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.82
    Marker Score: 12811
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 624
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 700
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 459
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2934
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.67
    Marker Score: 1261
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.62
    Marker Score: 3774
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.54
    Marker Score: 144
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.52
    Marker Score: 1344
  • Cell Name: T follicular regulatory cell (CL0009113)
    Fold Change: 0.47
    Marker Score: 128
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.46
    Marker Score: 306
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.46
    Marker Score: 253
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 274
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.43
    Marker Score: 1787
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.42
    Marker Score: 135
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.41
    Marker Score: 179
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.39
    Marker Score: 161
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.36
    Marker Score: 584
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.36
    Marker Score: 241
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.34
    Marker Score: 406
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.34
    Marker Score: 374
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.3
    Marker Score: 555
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.3
    Marker Score: 126
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.3
    Marker Score: 325
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.29
    Marker Score: 295
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.28
    Marker Score: 90
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.25
    Marker Score: 87
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.25
    Marker Score: 120
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.25
    Marker Score: 1648
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.23
    Marker Score: 302
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.23
    Marker Score: 326
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 72
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.21
    Marker Score: 356
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.2
    Marker Score: 282
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.2
    Marker Score: 126
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.19
    Marker Score: 42
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.19
    Marker Score: 194
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.18
    Marker Score: 439
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.18
    Marker Score: 120
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.17
    Marker Score: 48
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.17
    Marker Score: 98
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.16
    Marker Score: 86
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.16
    Marker Score: 310
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.16
    Marker Score: 70
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.16
    Marker Score: 138
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.16
    Marker Score: 1552
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.14
    Marker Score: 60
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.14
    Marker Score: 38
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.14
    Marker Score: 96
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.14
    Marker Score: 135
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.13
    Marker Score: 330
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.13
    Marker Score: 77
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.13
    Marker Score: 124
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.13
    Marker Score: 74
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.13
    Marker Score: 67
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.13
    Marker Score: 27
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.12
    Marker Score: 135
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.12
    Marker Score: 122
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.12
    Marker Score: 26
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.12
    Marker Score: 114
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.11
    Marker Score: 53
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.11
    Marker Score: 25
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.11
    Marker Score: 86
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.11
    Marker Score: 232
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.11
    Marker Score: 204
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.11
    Marker Score: 312
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.11
    Marker Score: 63
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.11
    Marker Score: 108
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.11
    Marker Score: 85
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.11
    Marker Score: 5940
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.11
    Marker Score: 26
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.1
    Marker Score: 100
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.1
    Marker Score: 32
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.1
    Marker Score: 51
  • Cell Name: phagocyte (CL0000234)
    Fold Change: 0.1
    Marker Score: 34

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Other Information

**Key characteristics:** * IL-10 is a cytokine that belongs to the interleukin-10 family. * It is produced by a wide range of cell types, including immune cells, stromal cells, and epithelial cells. * IL-10 has both pro- and anti-inflammatory effects, depending on the context. * In the context of leishmaniasis, IL-10 plays a critical role in the regulation of parasite growth and survival. **Pathways and functions:** * IL-10 signaling is initiated by the binding of its receptor, IL-10R, to its specific receptor complex on immune cells. * This binding triggers a signaling cascade that involves the adaptor protein JAK/STAT. * JAK/STAT signaling leads to the phosphorylation of STAT3, which is a key transcription factor for IL-10 production. * Once STAT3 is phosphorylated, it translocates to the nucleus and activates the expression of IL-10 genes. * IL-10 produced by infected cells helps to promote the differentiation of effector T cells, regulatory T cells, and macrophages, which can help to control the inflammatory response. * IL-10 also has anti-inflammatory effects, and it can inhibit the production of pro-inflammatory cytokines such as TNF-alpha and IL-6. **Clinical significance:** * IL-10 plays a critical role in the pathogenesis of leishmaniasis, a chronic infectious disease caused by the protozoan parasite Leishmania parasites. * IL-10 produced by immune cells within infected macrophages and dendritic cells helps to regulate parasite growth and survival. * Studies have shown that IL-10 therapy can be effective in controlling leishmaniasis in animal models. * Therefore, IL-10 is a promising target for the development of new therapeutic strategies for leishmaniasis.

Genular Protein ID: 2956531545

Symbol: IL10_HUMAN

Name: Interleukin-10

UniProtKB Accession Codes:

P22301

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 4 EMDB 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 76 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 2 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PDB 11 PDBsum 8 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 1847510

Title: Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI.

PubMed ID: 1847510

DOI: 10.1073/pnas.88.4.1172

PubMed ID: 9405662

Title: Identification of functional domains on human interleukin 10.

PubMed ID: 9405662

DOI: 10.1073/pnas.94.26.14620

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 1940799

Title: Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

PubMed ID: 1940799

DOI: 10.1084/jem.174.5.1209

PubMed ID: 8364028

Title: Disulfide bond assignments and secondary structure analysis of human and murine interleukin 10.

PubMed ID: 8364028

DOI: 10.1021/bi00085a011

PubMed ID: 7512027

Title: Interleukin-10 inhibits B7 and intercellular adhesion molecule-1 expression on human monocytes.

PubMed ID: 7512027

DOI: 10.1002/eji.1830240435

PubMed ID: 8144879

Title: Antigen presentation in the central nervous system. The inhibitory effect of IL-10 on MHC class II expression and production of cytokines depends on the inducing signals and the type of cell analyzed.

PubMed ID: 8144879

PubMed ID: 11564774

Title: IL-10 inhibits granulocyte-macrophage colony-stimulating factor-dependent human monocyte survival at the early stage of the culture and inhibits the generation of macrophages.

PubMed ID: 11564774

DOI: 10.4049/jimmunol.167.7.3619

PubMed ID: 14657427

Title: Relation of an interleukin-10 promoter polymorphism to graft-versus-host disease and survival after hematopoietic-cell transplantation.

PubMed ID: 14657427

DOI: 10.1056/nejmoa022060

PubMed ID: 16982608

Title: Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex.

PubMed ID: 16982608

DOI: 10.1074/jbc.m606791200

PubMed ID: 18025162

Title: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway.

PubMed ID: 18025162

DOI: 10.4049/jimmunol.179.11.7215

PubMed ID: 7547951

Title: Crystal structure of interleukin 10 reveals an interferon gamma-like fold.

PubMed ID: 7547951

DOI: 10.1021/bi00038a004

PubMed ID: 8590020

Title: Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon gamma.

PubMed ID: 8590020

DOI: 10.1016/s0969-2126(01)00193-9

PubMed ID: 8897595

Title: Crystal structure of human interleukin-10 at 1.6-A resolution and a model of a complex with its soluble receptor.

PubMed ID: 8897595

DOI: 10.1002/pro.5560051001

PubMed ID: 11485736

Title: Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site.

PubMed ID: 11485736

DOI: 10.1016/s1074-7613(01)00169-8

PubMed ID: 12121653

Title: Noncompetitive antibody neutralization of IL-10 revealed by protein engineering and x-ray crystallography.

PubMed ID: 12121653

DOI: 10.1016/s0969-2126(02)00791-8

PubMed ID: 15837194

Title: Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain.

PubMed ID: 15837194

DOI: 10.1016/j.str.2005.01.016

PubMed ID: 12825869

Title: A Gly15Arg mutation in the interleukin-10 gene reduces secretion of interleukin-10 in Crohn disease.

PubMed ID: 12825869

DOI: 10.1080/00365520310003011

Sequence Information:

  • Length: 178
  • Mass: 20517
  • Checksum: 6825E9FA4337CDE4
  • Sequence:
    • MHSSALLCCL VLLTGVRASP GQGTQSENSC THFPGNLPNM LRDLRDAFSR VKTFFQMKDQ 
LDNLLLKESL LEDFKGYLGC QALSEMIQFY LEEVMPQAEN QDPDIKAHVN SLGENLKTLR 
LRLRRCHRFL PCENKSKAVE QVKNAFNKLQ EKGIYKAMSE FDIFINYIEA YMTMKIRN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.