Details for: IL15RA

Gene ID: 3601

Symbol: IL15RA

Ensembl ID: ENSG00000134470

Description: interleukin 15 receptor subunit alpha

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168994
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.4
    Marker Score: 2157
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.28
    Marker Score: 2607
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.24
    Marker Score: 2622.5
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.24
    Marker Score: 3146
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.22
    Marker Score: 1771
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.21
    Marker Score: 41301
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.19
    Marker Score: 5136
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.01
    Marker Score: 227
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71769
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47993
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.99
    Marker Score: 2601
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.98
    Marker Score: 308
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.96
    Marker Score: 1390
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 490
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.92
    Marker Score: 788
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2723
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.89
    Marker Score: 5340
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.88
    Marker Score: 549
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4992
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5266
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.87
    Marker Score: 421
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.85
    Marker Score: 509
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.85
    Marker Score: 274
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.83
    Marker Score: 524
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.8
    Marker Score: 527
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.77
    Marker Score: 3203
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1231
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 579
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 381
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.73
    Marker Score: 3170
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.73
    Marker Score: 232
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 291.5
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.69
    Marker Score: 173
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.69
    Marker Score: 518
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.69
    Marker Score: 173
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.69
    Marker Score: 5817.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 623
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.68
    Marker Score: 167
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.67
    Marker Score: 372
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.67
    Marker Score: 10425
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2786
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.66
    Marker Score: 376
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.65
    Marker Score: 7317
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.65
    Marker Score: 1297
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.62
    Marker Score: 665
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.61
    Marker Score: 252
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.59
    Marker Score: 1082.5
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.59
    Marker Score: 135
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.58
    Marker Score: 350
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.57
    Marker Score: 764.5
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.56
    Marker Score: 361
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.56
    Marker Score: 774
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.56
    Marker Score: 540
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.56
    Marker Score: 311
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.55
    Marker Score: 205
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.54
    Marker Score: 485
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.52
    Marker Score: 8370
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.52
    Marker Score: 125
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.49
    Marker Score: 236
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.49
    Marker Score: 192
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.49
    Marker Score: 445
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.49
    Marker Score: 141
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.46
    Marker Score: 2970
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.45
    Marker Score: 307
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.45
    Marker Score: 2424
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.44
    Marker Score: 157
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.44
    Marker Score: 2789
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.43
    Marker Score: 490
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.42
    Marker Score: 110
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.42
    Marker Score: 522
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.42
    Marker Score: 116
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.42
    Marker Score: 431.5
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.41
    Marker Score: 417
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.41
    Marker Score: 748
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.4
    Marker Score: 165
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.4
    Marker Score: 455
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.39
    Marker Score: 100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.39
    Marker Score: 3674
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.38
    Marker Score: 102
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.38
    Marker Score: 325
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.38
    Marker Score: 157
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.38
    Marker Score: 891
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.38
    Marker Score: 142
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.38
    Marker Score: 119
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.37
    Marker Score: 129
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.37
    Marker Score: 20889
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.37
    Marker Score: 443
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.37
    Marker Score: 82
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.37
    Marker Score: 93
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.36
    Marker Score: 701
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.36
    Marker Score: 364
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.36
    Marker Score: 83
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.36
    Marker Score: 387

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Other Information

**Key characteristics:** * The IL15RA gene is located on chromosome 1 and is approximately 28,000 base pairs long. * It contains 21 exons and 19 introns. * It is a member of the interleukin-15 receptor family. * The protein encoded by the IL15RA gene is a type I transmembrane receptor that is expressed on a variety of immune cells, including macrophages, dendritic cells, and natural killer cells. **Pathways and functions:** * The IL15RA gene is involved in the regulation of innate immunity. * It is expressed in a variety of immune cells, including macrophages, dendritic cells, and natural killer cells. * IL15RA signaling is important for the regulation of inflammation and immune responses. * IL15RA signaling is involved in the regulation of macrophage function, dendritic cell function, and natural killer cell function. * IL15RA signaling is also involved in the regulation of cell migration, proliferation, and survival. **Clinical significance:** * Mutations in the IL15RA gene have been linked to a number of human diseases, including cancer, autoimmune diseases, and inflammatory diseases. * The development of selective inhibitors of the IL15/IL15RA pathway is an active area of research, as these inhibitors could potentially be used to treat a variety of diseases. **Additional notes:** * The IL15RA gene is also known as CD274. * It is a highly conserved gene, with a similar gene found in other mammals. * The IL15RA gene is expressed in high levels in many types of cancer cells.

Genular Protein ID: 3895243729

Symbol: I15RA_HUMAN

Name: Interleukin-15 receptor subunit alpha

UniProtKB Accession Codes:

Q13261 B4E2C2 Q3B769 Q5JVA1 Q5JVA2 Q5JVA4 Q6B0J2 Q7LDR4 Q7Z609

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 4 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 RNAct 1 Reactome 1 RefSeq 4 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8530383

Title: Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes.

PubMed ID: 8530383

DOI: 10.1074/jbc.270.50.29862

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

DOI: 10.1101/gr.7.4.353

PubMed ID: 10480910

Title: Natural splicing of exon 2 of human interleukin-15 receptor alpha-chain mRNA results in a shortened form with a distinct pattern of expression.

PubMed ID: 10480910

DOI: 10.1074/jbc.274.38.26978

PubMed ID: 11714793

Title: The IL-15R alpha chain signals through association with Syk in human B cells.

PubMed ID: 11714793

DOI: 10.4049/jimmunol.167.11.6292

PubMed ID: 21289315

Title: The IL-15R alpha chain signals through association with Syk in human B cells.

PubMed ID: 21289315

DOI: 10.4049/jimmunol.1090142

PubMed ID: 12114302

Title: Expression of IL-15 and IL-15 receptor isoforms in select structures of human fetal brain.

PubMed ID: 12114302

DOI: 10.1111/j.1749-6632.2002.tb04245.x

PubMed ID: 15039446

Title: Identification of an interleukin-15alpha receptor-binding site on human interleukin-15.

PubMed ID: 15039446

DOI: 10.1074/jbc.m312458200

PubMed ID: 15265897

Title: Natural, proteolytic release of a soluble form of human IL-15 receptor alpha-chain that behaves as a specific, high affinity IL-15 antagonist.

PubMed ID: 15265897

DOI: 10.4049/jimmunol.173.3.1681

PubMed ID: 15123770

Title: Interleukin-15 enhances human neutrophil phagocytosis by a Syk-dependent mechanism: importance of the IL-15Ralpha chain.

PubMed ID: 15123770

DOI: 10.1189/jlb.0605298

PubMed ID: 16377614

Title: The structure of the interleukin-15 alpha receptor and its implications for ligand binding.

PubMed ID: 16377614

DOI: 10.1074/jbc.m513118200

PubMed ID: 17643103

Title: Crystal structure of the IL-15-IL-15Ralpha complex, a cytokine-receptor unit presented in trans.

PubMed ID: 17643103

DOI: 10.1038/ni1492

Sequence Information:

  • Length: 267
  • Mass: 28233
  • Checksum: A9CFC885189E96BE
  • Sequence:
    • MAPRRARGCR TLGLPALLLL LLLRPPATRG ITCPPPMSVE HADIWVKSYS LYSRERYICN 
SGFKRKAGTS SLTECVLNKA TNVAHWTTPS LKCIRDPALV HQRPAPPSTV TTAGVTPQPE 
SLSPSGKEPA ASSPSSNNTA ATTAAIVPGS QLMPSKSPST GTTEISSHES SHGTPSQTTA 
KNWELTASAS HQPPGVYPQG HSDTTVAIST STVLLCGLSA VSLLACYLKS RQTPPLASVE 
MEAMEALPVT WGTSSRDEDL ENCSHHL

Genular Protein ID: 3171314224

Symbol: A0A0A0MS77_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MS77

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 3 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Proteomes 2 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

Sequence Information:

  • Length: 353
  • Mass: 37563
  • Checksum: 27D8761E7B8783EF
  • Sequence:
    • MRLAGRQVPE QRSPPPPGLG SARPGSPAVS CGAAAMAPRR ARGCRTLGLP ALLLLLLLRP 
PATRDARDRL AVLAGRSRIS ESFNHEVQTH EACVRLRTME NCPQCHHHRT SRQQAGITCP 
PPMSVEHADI WVKSYSLYSR ERYICNSGFK RKAGTSSLTE CVLNKATNVA HWTTPSLKCI 
RDPALVHQRP APPSTVTTAG VTPQPESLSP SGKEPAASSP SSNNTAATTA AIVPGSQLMP 
SKSPSTGTTE ISSHESSHGT PSQTTAKNWE LTASASHQPP GVYPQGHSDT TVAISTSTVL 
LCGLSAVSLL ACYLKSRQTP PLASVEMEAM EALPVTWGTS SRDEDLENCS HHL

Genular Protein ID: 57499220

Symbol: G8CVM3_HUMAN

Name: N/A

UniProtKB Accession Codes:

G8CVM3

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 23074221

Title: Paracrine and Transpresentation Functions of IL-15 Are Mediated by Diverse Splice Versions of IL-15R? in Human Monocytes and Dendritic Cells.

PubMed ID: 23074221

DOI: 10.1074/jbc.M112.378612

Sequence Information:

  • Length: 318
  • Mass: 34155
  • Checksum: EF85CD8BA38DF083
  • Sequence:
    • MAPRRARGCR TLGLPALLLL LLLRPPATRD ARDRLAVLAG RSRISESFNH EVQTHEACVR 
LRTMENCPQC HHHRTSRQQA GITCPPPMSV EHADIWVKSY SLYSRERYIC NSGFKRKAGT 
SSLTECVLNK ATNVAHWTTP SLKCIRDPAL VHQRPAPPST VTTAGVTPQP ESLSPSGKEP 
AASSPSSNNT AATTAAIVPG SQLMPSKSPS TGTTEISSHE SSHGTPSQTT AKNWELTASA 
SHQPPGVYPQ GHSDTTVAIS TSTVLLCGLS AVSLLACYLK SRQTPPLASV EMEAMEALPV 
TWGTSSRDED LENCSHHL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.