Details for: IMPA1

Gene ID: 3612

Symbol: IMPA1

Ensembl ID: ENSG00000133731

Description: inositol monophosphatase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.41
    Marker Score: 13400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.36
    Marker Score: 11717
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.3
    Marker Score: 2854.5
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.28
    Marker Score: 1837
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.13
    Marker Score: 3564
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.02
    Marker Score: 10540
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1
    Marker Score: 1549
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71693.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47917
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30394
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.97
    Marker Score: 647
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2398
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.94
    Marker Score: 233
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 475
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2701
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9
    Marker Score: 949
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9
    Marker Score: 55412
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.9
    Marker Score: 1124.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4855
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.83
    Marker Score: 5344.5
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.83
    Marker Score: 335
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.81
    Marker Score: 12726
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.81
    Marker Score: 810
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.81
    Marker Score: 233
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.79
    Marker Score: 226
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.77
    Marker Score: 292
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.77
    Marker Score: 3321
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.77
    Marker Score: 1127.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 304
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 573
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.74
    Marker Score: 471
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.72
    Marker Score: 6226
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.72
    Marker Score: 6253
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.72
    Marker Score: 3453
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.71
    Marker Score: 370
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2941.5
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.7
    Marker Score: 14890
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.69
    Marker Score: 23345
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.67
    Marker Score: 2738
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.67
    Marker Score: 3611
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.66
    Marker Score: 6248
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.66
    Marker Score: 600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.65
    Marker Score: 2248
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.65
    Marker Score: 344
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.64
    Marker Score: 144
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.64
    Marker Score: 436
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.64
    Marker Score: 585
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.64
    Marker Score: 1705
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.63
    Marker Score: 836
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.62
    Marker Score: 233
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.62
    Marker Score: 310
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.61
    Marker Score: 412
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.61
    Marker Score: 248
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.61
    Marker Score: 644
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.61
    Marker Score: 182
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.6
    Marker Score: 413
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.6
    Marker Score: 399
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.6
    Marker Score: 849
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.6
    Marker Score: 175
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6
    Marker Score: 143
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.59
    Marker Score: 147
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.59
    Marker Score: 1201
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.59
    Marker Score: 509
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.59
    Marker Score: 973
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.59
    Marker Score: 658
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.59
    Marker Score: 218
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.58
    Marker Score: 3728
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.58
    Marker Score: 131
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.58
    Marker Score: 126.5
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.58
    Marker Score: 127
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.58
    Marker Score: 563
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.57
    Marker Score: 389
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.57
    Marker Score: 1082.5
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.57
    Marker Score: 3709
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.57
    Marker Score: 474
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.57
    Marker Score: 425.5
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.57
    Marker Score: 569.5
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.57
    Marker Score: 732
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.57
    Marker Score: 570
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.56
    Marker Score: 197
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.56
    Marker Score: 114
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.56
    Marker Score: 129
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 235
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.56
    Marker Score: 122
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.56
    Marker Score: 438
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.56
    Marker Score: 335
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.56
    Marker Score: 3348
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.56
    Marker Score: 256
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.55
    Marker Score: 1361
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.55
    Marker Score: 265
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.55
    Marker Score: 270
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: 0.55
    Marker Score: 153
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.55
    Marker Score: 202
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.54
    Marker Score: 6330

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Other Information

**Key characteristics:** * IMPA1 is a serine/threonine phosphatase that is expressed in a variety of cell types. * It is a key regulator of cell growth and differentiation. * It is involved in the regulation of apoptosis, proliferation, and migration. * It is also involved in the regulation of inflammation. **Pathways and functions:** * IMPA1 is involved in the regulation of cell growth and differentiation. * It is a key regulator of the proliferation of epithelial cells. * It is also involved in the differentiation of neurons. * It is involved in the regulation of inflammation. **Clinical significance:** * Mutations in IMPA1 have been linked to a number of human diseases, including cancer, neurodegenerative diseases, and diabetes. * Inhibition of IMPA1 has been shown to be effective in promoting cell growth and proliferation. * Thus, IMPA1 is a potential target for the treatment of cancer and other diseases that are characterized by abnormal cell growth. **Additional information:** * IMPA1 is a highly conserved protein that is found in mammals and birds. * It is a member of the inositol 1,4,5-trisphosphate receptor (IP3R) family of phosphatases. * It is a key regulator of the PI3K/Akt signaling pathway. * It is a regulator of cell cycle progression.

Genular Protein ID: 682577318

Symbol: IMPA1_HUMAN

Name: Inositol monophosphatase 1

UniProtKB Accession Codes:

P29218 B2R733 B4DLN3 B7Z6Q4 J3KQT7 Q9UK71

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EC 2 EMBL 18 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 13 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 2 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1377913

Title: cDNA cloning of human and rat brain myo-inositol monophosphatase. Expression and characterization of the human recombinant enzyme.

PubMed ID: 1377913

DOI: 10.1042/bj2840749

PubMed ID: 9339367

Title: Genomic structure and chromosomal localization of a human myo-inositol monophosphatase gene (IMPA).

PubMed ID: 9339367

DOI: 10.1006/geno.1997.4862

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9462881

Title: Brain inositol monophosphatase identified as a galactose 1-phosphatase.

PubMed ID: 9462881

DOI: 10.1016/s0006-8993(97)01042-1

PubMed ID: 17068342

Title: Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1.

PubMed ID: 17068342

DOI: 10.1074/jbc.m604474200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26416544

Title: A homozygous loss-of-function mutation in inositol monophosphatase 1 (IMPA1) causes severe intellectual disability.

PubMed ID: 26416544

DOI: 10.1038/mp.2015.150

PubMed ID: 1332026

Title: Structure of inositol monophosphatase, the putative target of lithium therapy.

PubMed ID: 1332026

DOI: 10.1073/pnas.89.21.10031

PubMed ID: 8068620

Title: Structural analysis of inositol monophosphatase complexes with substrates.

PubMed ID: 8068620

DOI: 10.1021/bi00198a011

PubMed ID: 8068621

Title: Structural studies of metal binding by inositol monophosphatase: evidence for two-metal ion catalysis.

PubMed ID: 8068621

DOI: 10.1021/bi00198a012

PubMed ID: 8718889

Title: The contribution of lysine-36 to catalysis by human myo-inositol monophosphatase.

PubMed ID: 8718889

DOI: 10.1021/bi9603837

PubMed ID: 23027737

Title: Cloning, expression, purification, crystallization and X-ray analysis of inositol monophosphatase from Mus musculus and Homo sapiens.

PubMed ID: 23027737

DOI: 10.1107/s1744309112035191

Sequence Information:

  • Length: 277
  • Mass: 30189
  • Checksum: 861D5617E1C04627
  • Sequence:
    • MADPWQECMD YAVTLARQAG EVVCEAIKNE MNVMLKSSPV DLVTATDQKV EKMLISSIKE 
KYPSHSFIGE ESVAAGEKSI LTDNPTWIID PIDGTTNFVH RFPFVAVSIG FAVNKKIEFG 
VVYSCVEGKM YTARKGKGAF CNGQKLQVSQ QEDITKSLLV TELGSSRTPE TVRMVLSNME 
KLFCIPVHGI RSVGTAAVNM CLVATGGADA YYEMGIHCWD VAGAGIIVTE AGGVLMDVTG 
GPFDLMSRRV IAANNRILAE RIAKEIQVIP LQRDDED

Genular Protein ID: 2797699337

Symbol: A0A140VJL8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A140VJL8

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 ChEBI 9 DNASU 1 EC 2 EMBL 2 ExpressionAtlas 1 GO 6 Gene3D 2 GenomeRNAi 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 2 Pfam 1 PhylomeDB 1 RefSeq 1 Rhea 2 RuleBase 1 SMR 1 SUPFAM 1 UniPathway 1 VEuPathDB 1

Sequence Information:

  • Length: 336
  • Mass: 36695
  • Checksum: 5838EB952D0C2FA6
  • Sequence:
    • MGQRPGPVLP AVAVLGQVAK RKVAWLLRWK AVTRTETAGN SSGVYGFGKM KIFVKYFQKM 
ADPWQECMDY AVTLARQAGE VVCEAIKNEM NVMLKSSPVD LVTATDQKVE KMLISSIKEK 
YPSHSFIGEE SVAAGEKSIL TDNPTWIIDP IDGTTNFVHR FPFVAVSIGF AVNKKIEFGV 
VYSCVEGKMY TARKGKGAFC NGQKLQVSQQ EDITKSLLVT ELGSSRTPET VRMVLSNMEK 
LFCIPVHGIR SVGTAAVNMC LVATGGADAY YEMGIHCWDV AGAGIIVTEA GGVLMDVTGG 
PFDLMSRRVI AANNRILAER IAKEIQVIPL QRDDED

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.