Details for: INSRR

Gene ID: 3645

Symbol: INSRR

Ensembl ID: ENSG00000027644

Description: insulin receptor related receptor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 5.08
    Marker Score: 32704
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.37
    Marker Score: 2387
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.62
    Marker Score: 10799
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.59
    Marker Score: 1097
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169572
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 875
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.3
    Marker Score: 411
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.24
    Marker Score: 7501
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.21
    Marker Score: 3629
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.06
    Marker Score: 6364.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32726.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 801
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71834
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48058
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2402
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5344
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9
    Marker Score: 14015
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 736
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.77
    Marker Score: 1450
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 504
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1227
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 234.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.55
    Marker Score: 331
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 436
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.54
    Marker Score: 330.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.49
    Marker Score: 1001
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.48
    Marker Score: 203
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.48
    Marker Score: 1422
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.41
    Marker Score: 392
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.4
    Marker Score: 108
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 375
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.37
    Marker Score: 523
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.37
    Marker Score: 210
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.33
    Marker Score: 157
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.32
    Marker Score: 524
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.31
    Marker Score: 496.5
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.28
    Marker Score: 146
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.27
    Marker Score: 2280
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.26
    Marker Score: 761.5
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.26
    Marker Score: 150
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 118
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.21
    Marker Score: 426
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.19
    Marker Score: 87
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.18
    Marker Score: 1093
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.18
    Marker Score: 90
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.17
    Marker Score: 45
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.17
    Marker Score: 60.5
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.17
    Marker Score: 53
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.16
    Marker Score: 604
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.16
    Marker Score: 160
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.15
    Marker Score: 68
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.14
    Marker Score: 89
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.14
    Marker Score: 63
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.14
    Marker Score: 54.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.13
    Marker Score: 311
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.13
    Marker Score: 42
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.13
    Marker Score: 63
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.13
    Marker Score: 148
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.13
    Marker Score: 40
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.12
    Marker Score: 81.5
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.12
    Marker Score: 71
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.11
    Marker Score: 94
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.1
    Marker Score: 57
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.09
    Marker Score: 220
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.08
    Marker Score: 162
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.08
    Marker Score: 76
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.08
    Marker Score: 132
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.08
    Marker Score: 41
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.07
    Marker Score: 36
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.07
    Marker Score: 34
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.06
    Marker Score: 42
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.06
    Marker Score: 263.5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.06
    Marker Score: 83
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.06
    Marker Score: 15.5
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.06
    Marker Score: 54.5
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.05
    Marker Score: 223.5
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.05
    Marker Score: 206
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.05
    Marker Score: 62
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.05
    Marker Score: 151
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.05
    Marker Score: 83

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Other Information

**Key characteristics:** * The INSRR gene is located on chromosome 15q21.1. * It is a single-exon gene that encodes a protein of approximately 130 kDa. * The INSR gene is expressed in a variety of cell types, including progenitor cell, blood vessel endothelial cell, goblet cell, conventional dendritic cell, mural cell, granulocyte monocyte progenitor cell, renal beta-intercalated cell, neoplastic cell, and abnormal cell. **Pathways and functions:** * The INSR gene is a key regulator of insulin signaling. * Insulin binds to the INSR receptor on the surface of cells, which triggers a cascade of intracellular events that lead to the activation of the insulin signaling pathway. * The insulin signaling pathway is involved in a variety of cellular processes, including glucose transport, cell growth, and differentiation. **Clinical significance:** * Mutations in the INSR gene have been linked to a number of human diseases, including type 1 diabetes, type 2 diabetes, and obesity. * In type 1 diabetes, the immune system mistakenly attacks and destroys the insulin receptors on the surface of cells in the pancreas. This leads to a lack of insulin, which can result in high blood sugar levels and eventually death. * In type 2 diabetes, the immune system produces antibodies that bind to and block the insulin receptors on the surface of cells in the pancreas. This also leads to a lack of insulin, but in this case, the body is unable to make enough insulin to compensate. **Additional information:** * The INSR gene is a highly conserved gene, with a similar gene found in humans, mice, and rats. * The INSR gene is also expressed in a variety of tissues, including the heart, liver, and brain. * The INSR gene is a promising target for the development of new treatments for type 1 diabetes and other insulin-resistant diseases.

Genular Protein ID: 2200938643

Symbol: INSRR_HUMAN

Name: Insulin receptor-related protein

UniProtKB Accession Codes:

P14616 O60724 Q5VZS3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChEBI 7 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 EMBL 4 EMDB 3 EPD 1 Ensembl 1 GO 14 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 16 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 4 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 5 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 Rhea 3 SAM 1 SASBDB 1 SMART 3 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10226785

Title: Cloning and sequencing of the complete cDNA encoding the human insulin receptor related receptor.

PubMed ID: 10226785

DOI: 10.1055/s-2007-978702

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 2768234

Title: Primary structure of a putative receptor for a ligand of the insulin family.

PubMed ID: 2768234

DOI: 10.1016/s0021-9258(18)63737-8

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 21641549

Title: Insulin receptor-related receptor as an extracellular alkali sensor.

PubMed ID: 21641549

DOI: 10.1016/j.cmet.2011.03.022

Sequence Information:

  • Length: 1297
  • Mass: 143720
  • Checksum: BB22C7FF61E3065D
  • Sequence:
    • MAVPSLWPWG ACLPVIFLSL GFGLDTVEVC PSLDIRSEVA ELRQLENCSV VEGHLQILLM 
FTATGEDFRG LSFPRLTQVT DYLLLFRVYG LESLRDLFPN LAVIRGTRLF LGYALVIFEM 
PHLRDVALPA LGAVLRGAVR VEKNQELCHL STIDWGLLQP APGANHIVGN KLGEECADVC 
PGVLGAAGEP CAKTTFSGHT DYRCWTSSHC QRVCPCPHGM ACTARGECCH TECLGGCSQP 
EDPRACVACR HLYFQGACLW ACPPGTYQYE SWRCVTAERC ASLHSVPGRA STFGIHQGSC 
LAQCPSGFTR NSSSIFCHKC EGLCPKECKV GTKTIDSIQA AQDLVGCTHV EGSLILNLRQ 
GYNLEPQLQH SLGLVETITG FLKIKHSFAL VSLGFFKNLK LIRGDAMVDG NYTLYVLDNQ 
NLQQLGSWVA AGLTIPVGKI YFAFNPRLCL EHIYRLEEVT GTRGRQNKAE INPRTNGDRA 
ACQTRTLRFV SNVTEADRIL LRWERYEPLE ARDLLSFIVY YKESPFQNAT EHVGPDACGT 
QSWNLLDVEL PLSRTQEPGV TLASLKPWTQ YAVFVRAITL TTEEDSPHQG AQSPIVYLRT 
LPAAPTVPQD VISTSNSSSH LLVRWKPPTQ RNGNLTYYLV LWQRLAEDGD LYLNDYCHRG 
LRLPTSNNDP RFDGEDGDPE AEMESDCCPC QHPPPGQVLP PLEAQEASFQ KKFENFLHNA 
ITIPISPWKV TSINKSPQRD SGRHRRAAGP LRLGGNSSDF EIQEDKVPRE RAVLSGLRHF 
TEYRIDIHAC NHAAHTVGCS AATFVFARTM PHREADGIPG KVAWEASSKN SVLLRWLEPP 
DPNGLILKYE IKYRRLGEEA TVLCVSRLRY AKFGGVHLAL LPPGNYSARV RATSLAGNGS 
WTDSVAFYIL GPEEEDAGGL HVLLTATPVG LTLLIVLAAL GFFYGKKRNR TLYASVNPEY 
FSASDMYVPD EWEVPREQIS IIRELGQGSF GMVYEGLARG LEAGEESTPV ALKTVNELAS 
PRECIEFLKE ASVMKAFKCH HVVRLLGVVS QGQPTLVIME LMTRGDLKSH LRSLRPEAEN 
NPGLPQPALG EMIQMAGEIA DGMAYLAANK FVHRDLAARN CMVSQDFTVK IGDFGMTRDV 
YETDYYRKGG KGLLPVRWMA PESLKDGIFT THSDVWSFGV VLWEIVTLAE QPYQGLSNEQ 
VLKFVMDGGV LEELEGCPLQ LQELMSRCWQ PNPRLRPSFT HILDSIQEEL RPSFRLLSFY 
YSPECRGARG SLPTTDAEPD SSPTPRDCSP QNGGPGH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.