Details for: INSRR

Gene ID: 3645

Symbol: INSRR

Ensembl ID: ENSG00000027644

Description: insulin receptor related receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.2285
    Cell Significance Index: 13.5400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.0245
    Cell Significance Index: 24.8200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.5033
    Cell Significance Index: 7.3400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.4930
    Cell Significance Index: 7.0600
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.3191
    Cell Significance Index: 2.4800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1200
    Cell Significance Index: 2.5700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1043
    Cell Significance Index: 72.1500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0898
    Cell Significance Index: 1.2900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.0635
    Cell Significance Index: 0.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0618
    Cell Significance Index: 8.9800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0584
    Cell Significance Index: 1.0000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0482
    Cell Significance Index: 0.3300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.0405
    Cell Significance Index: 0.5100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.0388
    Cell Significance Index: 0.3200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0380
    Cell Significance Index: 0.6100
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.0286
    Cell Significance Index: 0.2200
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.0227
    Cell Significance Index: 0.2100
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.0225
    Cell Significance Index: 0.2500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0190
    Cell Significance Index: 0.3700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.0143
    Cell Significance Index: 0.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0136
    Cell Significance Index: 1.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0111
    Cell Significance Index: 2.2200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.0084
    Cell Significance Index: 0.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0057
    Cell Significance Index: 0.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0055
    Cell Significance Index: 0.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0040
    Cell Significance Index: 2.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0021
    Cell Significance Index: 4.0400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0014
    Cell Significance Index: 0.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: -0.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0006
    Cell Significance Index: -0.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0009
    Cell Significance Index: -0.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0022
    Cell Significance Index: -1.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0023
    Cell Significance Index: -0.8100
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.0024
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0028
    Cell Significance Index: -2.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0029
    Cell Significance Index: -2.1700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0030
    Cell Significance Index: -1.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0031
    Cell Significance Index: -0.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0032
    Cell Significance Index: -0.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0040
    Cell Significance Index: -0.8000
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0047
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0066
    Cell Significance Index: -1.1300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0083
    Cell Significance Index: -0.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0091
    Cell Significance Index: -1.9200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0107
    Cell Significance Index: -1.9300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0114
    Cell Significance Index: -0.1600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0125
    Cell Significance Index: -0.3100
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.0129
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0134
    Cell Significance Index: -1.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0139
    Cell Significance Index: -1.4200
  • Cell Name: diffuse bipolar 4 cell (CL4033031)
    Fold Change: -0.0148
    Cell Significance Index: -0.1800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0149
    Cell Significance Index: -1.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0161
    Cell Significance Index: -1.9800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0164
    Cell Significance Index: -0.5200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0189
    Cell Significance Index: -1.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0194
    Cell Significance Index: -0.9100
  • Cell Name: diffuse bipolar 3b cell (CL4033030)
    Fold Change: -0.0207
    Cell Significance Index: -0.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0217
    Cell Significance Index: -0.5900
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0219
    Cell Significance Index: -0.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0222
    Cell Significance Index: -1.4900
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0231
    Cell Significance Index: -0.2200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0242
    Cell Significance Index: -1.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0262
    Cell Significance Index: -1.9600
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0278
    Cell Significance Index: -0.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0291
    Cell Significance Index: -1.7900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0316
    Cell Significance Index: -0.3000
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0335
    Cell Significance Index: -0.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0342
    Cell Significance Index: -1.5500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0370
    Cell Significance Index: -0.4500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0375
    Cell Significance Index: -1.0800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0379
    Cell Significance Index: -0.4100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0406
    Cell Significance Index: -1.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0410
    Cell Significance Index: -1.4400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0416
    Cell Significance Index: -0.8700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0417
    Cell Significance Index: -1.4600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0424
    Cell Significance Index: -1.3500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0448
    Cell Significance Index: -1.1200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0458
    Cell Significance Index: -2.3100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0463
    Cell Significance Index: -1.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0475
    Cell Significance Index: -1.3700
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0478
    Cell Significance Index: -0.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0481
    Cell Significance Index: -1.2900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0491
    Cell Significance Index: -0.7600
  • Cell Name: diffuse bipolar 2 cell (CL4033028)
    Fold Change: -0.0495
    Cell Significance Index: -0.6100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0500
    Cell Significance Index: -0.6200
  • Cell Name: diffuse bipolar 1 cell (CL4033027)
    Fold Change: -0.0507
    Cell Significance Index: -0.6200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0548
    Cell Significance Index: -1.9100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0589
    Cell Significance Index: -1.4700
  • Cell Name: diffuse bipolar 3a cell (CL4033029)
    Fold Change: -0.0598
    Cell Significance Index: -0.7200
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.0626
    Cell Significance Index: -0.6800
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0638
    Cell Significance Index: -0.9600
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0641
    Cell Significance Index: -0.6200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0644
    Cell Significance Index: -1.1100
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.0652
    Cell Significance Index: -0.6900
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.0654
    Cell Significance Index: -0.9300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0654
    Cell Significance Index: -1.6800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0660
    Cell Significance Index: -1.3700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0665
    Cell Significance Index: -1.4400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0669
    Cell Significance Index: -1.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** INSRR shares structural and functional similarities with the insulin receptor, a key player in glucose metabolism and energy homeostasis. Like the insulin receptor, INSRR is a transmembrane receptor tyrosine kinase, composed of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain contains a ligand-binding site, while the intracellular domain harbors the tyrosine kinase activity. INSRR is also characterized by its ability to bind to phosphatidylinositol 3-kinase (PI3K) and other signaling molecules, facilitating the activation of downstream signaling pathways. **Pathways and Functions** INSRR is involved in several signaling pathways, including: 1. **Insulin Receptor Signaling Pathway**: INSRR acts as a co-receptor for insulin, enhancing its signaling through the activation of PI3K and subsequent phosphorylation of downstream targets, such as IRS-1 and AKT. 2. **Cellular Response to Alkaline pH**: INSRR has been implicated in the regulation of cellular pH homeostasis, influencing cell growth, differentiation, and survival. 3. **Actin Cytoskeleton Organization**: INSRR has been shown to regulate actin cytoskeleton dynamics, influencing cell migration, adhesion, and morphology. 4. **Immune Response**: INSRR has been identified as a pattern recognition receptor, recognizing microbial components and activating immune responses. **Clinical Significance** Dysregulation of INSRR has been implicated in various diseases, including: 1. **Type 2 Diabetes**: INSRR is involved in glucose metabolism, and alterations in its expression or function may contribute to insulin resistance and metabolic disorders. 2. **Cancer**: INSRR has been shown to be overexpressed in various types of cancer, including breast, lung, and colon cancer, where it may contribute to tumorigenesis and metastasis. 3. **Neurological Disorders**: INSRR has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's, where it may play a role in neuronal survival and degeneration. In conclusion, INSRR is a multifunctional receptor tyrosine kinase that plays a critical role in various cellular processes, including insulin signaling, cell development, and immune response. Further research is needed to fully understand the mechanisms of action of INSRR and its clinical significance in human diseases.

Genular Protein ID: 2200938643

Symbol: INSRR_HUMAN

Name: Insulin receptor-related protein

UniProtKB Accession Codes:

P14616 O60724 Q5VZS3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChEBI 7 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 EMBL 4 EMDB 3 Ensembl 1 GO 14 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 17 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 Rhea 3 SASBDB 1 SMART 3 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10226785

Title: Cloning and sequencing of the complete cDNA encoding the human insulin receptor related receptor.

PubMed ID: 10226785

DOI: 10.1055/s-2007-978702

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 2768234

Title: Primary structure of a putative receptor for a ligand of the insulin family.

PubMed ID: 2768234

DOI: 10.1016/s0021-9258(18)63737-8

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 21641549

Title: Insulin receptor-related receptor as an extracellular alkali sensor.

PubMed ID: 21641549

DOI: 10.1016/j.cmet.2011.03.022

Sequence Information:

  • Length: 1297
  • Mass: 143720
  • Checksum: BB22C7FF61E3065D
  • Sequence:
    • MAVPSLWPWG ACLPVIFLSL GFGLDTVEVC PSLDIRSEVA ELRQLENCSV VEGHLQILLM 
FTATGEDFRG LSFPRLTQVT DYLLLFRVYG LESLRDLFPN LAVIRGTRLF LGYALVIFEM 
PHLRDVALPA LGAVLRGAVR VEKNQELCHL STIDWGLLQP APGANHIVGN KLGEECADVC 
PGVLGAAGEP CAKTTFSGHT DYRCWTSSHC QRVCPCPHGM ACTARGECCH TECLGGCSQP 
EDPRACVACR HLYFQGACLW ACPPGTYQYE SWRCVTAERC ASLHSVPGRA STFGIHQGSC 
LAQCPSGFTR NSSSIFCHKC EGLCPKECKV GTKTIDSIQA AQDLVGCTHV EGSLILNLRQ 
GYNLEPQLQH SLGLVETITG FLKIKHSFAL VSLGFFKNLK LIRGDAMVDG NYTLYVLDNQ 
NLQQLGSWVA AGLTIPVGKI YFAFNPRLCL EHIYRLEEVT GTRGRQNKAE INPRTNGDRA 
ACQTRTLRFV SNVTEADRIL LRWERYEPLE ARDLLSFIVY YKESPFQNAT EHVGPDACGT 
QSWNLLDVEL PLSRTQEPGV TLASLKPWTQ YAVFVRAITL TTEEDSPHQG AQSPIVYLRT 
LPAAPTVPQD VISTSNSSSH LLVRWKPPTQ RNGNLTYYLV LWQRLAEDGD LYLNDYCHRG 
LRLPTSNNDP RFDGEDGDPE AEMESDCCPC QHPPPGQVLP PLEAQEASFQ KKFENFLHNA 
ITIPISPWKV TSINKSPQRD SGRHRRAAGP LRLGGNSSDF EIQEDKVPRE RAVLSGLRHF 
TEYRIDIHAC NHAAHTVGCS AATFVFARTM PHREADGIPG KVAWEASSKN SVLLRWLEPP 
DPNGLILKYE IKYRRLGEEA TVLCVSRLRY AKFGGVHLAL LPPGNYSARV RATSLAGNGS 
WTDSVAFYIL GPEEEDAGGL HVLLTATPVG LTLLIVLAAL GFFYGKKRNR TLYASVNPEY 
FSASDMYVPD EWEVPREQIS IIRELGQGSF GMVYEGLARG LEAGEESTPV ALKTVNELAS 
PRECIEFLKE ASVMKAFKCH HVVRLLGVVS QGQPTLVIME LMTRGDLKSH LRSLRPEAEN 
NPGLPQPALG EMIQMAGEIA DGMAYLAANK FVHRDLAARN CMVSQDFTVK IGDFGMTRDV 
YETDYYRKGG KGLLPVRWMA PESLKDGIFT THSDVWSFGV VLWEIVTLAE QPYQGLSNEQ 
VLKFVMDGGV LEELEGCPLQ LQELMSRCWQ PNPRLRPSFT HILDSIQEEL RPSFRLLSFY 
YSPECRGARG SLPTTDAEPD SSPTPRDCSP QNGGPGH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.