Details for: IPP

Gene ID: 3652

Symbol: IPP

Ensembl ID: ENSG00000197429

Description: intracisternal A particle-promoted polypeptide

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.44
    Marker Score: 2515
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.17
    Marker Score: 1072
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71773
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47997
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.99
    Marker Score: 5963
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.97
    Marker Score: 1972
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 489
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 443
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2722
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5001
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.87
    Marker Score: 13607
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.83
    Marker Score: 1189
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 574
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 296
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 380
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.73
    Marker Score: 3057.5
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.73
    Marker Score: 2506
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.71
    Marker Score: 1662
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2875
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.68
    Marker Score: 220
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 622
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.63
    Marker Score: 694
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.63
    Marker Score: 2425
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.63
    Marker Score: 501
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.6
    Marker Score: 351
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.59
    Marker Score: 186
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.58
    Marker Score: 12374
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.57
    Marker Score: 618
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.56
    Marker Score: 672
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.56
    Marker Score: 4773
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.55
    Marker Score: 159
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 435
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.55
    Marker Score: 1049
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.53
    Marker Score: 5075
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.53
    Marker Score: 2202
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.52
    Marker Score: 188
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.51
    Marker Score: 1118
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.51
    Marker Score: 1877
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.51
    Marker Score: 304
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.5
    Marker Score: 2041
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5
    Marker Score: 1139
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.5
    Marker Score: 334
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.5
    Marker Score: 625
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.49
    Marker Score: 30418
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.49
    Marker Score: 4286
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.49
    Marker Score: 760
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.49
    Marker Score: 315
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.48
    Marker Score: 1720
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.48
    Marker Score: 177
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.48
    Marker Score: 7142
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.47
    Marker Score: 406
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.46
    Marker Score: 572
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.46
    Marker Score: 965
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.46
    Marker Score: 16853
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.45
    Marker Score: 638
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.45
    Marker Score: 130
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.45
    Marker Score: 455
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.44
    Marker Score: 211
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.44
    Marker Score: 247
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.44
    Marker Score: 297
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.44
    Marker Score: 290
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.44
    Marker Score: 255
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.44
    Marker Score: 645
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.44
    Marker Score: 337
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.44
    Marker Score: 4496
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.43
    Marker Score: 456
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.43
    Marker Score: 462
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.43
    Marker Score: 9563
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.43
    Marker Score: 125
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.43
    Marker Score: 221
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.42
    Marker Score: 148
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.42
    Marker Score: 16104
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.42
    Marker Score: 288
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.42
    Marker Score: 158
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.42
    Marker Score: 363
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.42
    Marker Score: 111
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.41
    Marker Score: 532
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.41
    Marker Score: 3876
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.41
    Marker Score: 3149
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.41
    Marker Score: 2636
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4
    Marker Score: 1558
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.4
    Marker Score: 487
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.4
    Marker Score: 195
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.4
    Marker Score: 81
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.4
    Marker Score: 424
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.39
    Marker Score: 206
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.39
    Marker Score: 7766
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.39
    Marker Score: 1678
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.39
    Marker Score: 157
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.38
    Marker Score: 729
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.38
    Marker Score: 404
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.38
    Marker Score: 396
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.38
    Marker Score: 97
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.38
    Marker Score: 142

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Other Information

**Key characteristics** * IPP is a secreted protein that is expressed in a variety of cell types. * It is a large protein that is composed of 130 amino acids. * IPP is a cytoskeletal protein that is involved in cell adhesion, cell migration, and cell signaling. * It is expressed in germ cell, choroid plexus epithelial cell, cerebral cortex GABAergic interneuron, forebrain radial glial cell, fibroblast of cardiac tissue, absorptive cell, immature innate lymphoid cell, tuft cell of colon, intestinal crypt stem cell of colon, and BEST4+ intestinal epithelial cell. **Pathways and functions** * IPP is involved in cell adhesion by binding to other cytoskeletal proteins, such as actin and microtubules. * It is involved in cell migration by binding to extracellular matrix proteins and facilitating cell movement. * IPP is involved in cell signaling by binding to various signaling molecules, such as G proteins and MAPK proteins. **Clinical significance** * Mutations in the IPP gene have been linked to a number of human diseases, including cerebral palsy, autism, and heart disease. * IPP is a potential therapeutic target for these diseases, as it is a key component of the cytoskeleton and is involved in a number of cellular processes that are disrupted in these diseases.

Genular Protein ID: 2696066522

Symbol: IPP_HUMAN

Name: Actin-binding protein IPP

UniProtKB Accession Codes:

Q9Y573 A2A6V4 D3DQ11 Q8N5C3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 2 GO 3 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10072760

Title: Isolation and characterization of IPP, a novel human gene encoding an actin-binding, kelch-like protein.

PubMed ID: 10072760

DOI: 10.1016/s0378-1119(99)00006-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8432546

Title: The IPP gene is assigned to human chromosome 1p32-1p22.

PubMed ID: 8432546

DOI: 10.1006/geno.1993.1048

Sequence Information:

  • Length: 584
  • Mass: 65261
  • Checksum: C63EF25D74924AB8
  • Sequence:
    • MANEDCPKAA DSPFSSDKHA QLILAQINKM RNGQHFCDVQ LQVGQESFKA HRLVLAASSP 
YFAALFTGGM KESSKDVVPI LGIEAGIFQI LLDFIYTGIV NIGVNNVQEL IIAADMLQLT 
EVVHLCCEFL KGQIDPLNCI GIFQFSEQIA CHDLLEFSEN YIHVHFLEVH SGEEFLALTK 
DQLIKILRSE ELSIEDEYQV FLAAMQWILK DLGKRRKHVV EVLDPIRFPL LPPQRLLKYI 
EGVSDFNLRV ALQTLLKEYC EVCKSPKENK FCSFLQTSKV RPRKKARKYL YAVGGYTRLQ 
GGRWSDSRAL SCVERFDTFS QYWTTVSSLH QARSGLGVTV LGGMVYAIGG EKDSMIFDCT 
ECYDPVTKQW TTVASMNHPR CGLGVCVCYG AIYALGGWVG AEIGNTIERF DPDENKWEVV 
GNMAVSRYYF GCCEMQGLIY VIGGISNEGI ELRSFEVYDP LSKRWSPLPP MGTRRAYLGV 
AALNDCIYSV GGWNETQDAL HTVEKYSFEE EKWVEVASMK VPRAGMCVVA VNGLLYVSGG 
RSSSHDFLAP GTLDSVEVYN PHSDTWTEIG NMITSRCEGG VAVL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.