Details for: IPP

Gene ID: 3652

Symbol: IPP

Ensembl ID: ENSG00000197429

Description: intracisternal A particle-promoted polypeptide

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 97.3350
    Cell Significance Index: -15.1400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 63.8298
    Cell Significance Index: -16.1900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 34.5461
    Cell Significance Index: -16.3100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 34.1163
    Cell Significance Index: -13.8600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.5065
    Cell Significance Index: -13.8500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.1148
    Cell Significance Index: -16.1700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.7534
    Cell Significance Index: -15.4100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.1762
    Cell Significance Index: -9.1400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.1244
    Cell Significance Index: -16.2800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.8223
    Cell Significance Index: -11.7400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0557
    Cell Significance Index: 953.1900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8472
    Cell Significance Index: 92.1500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7586
    Cell Significance Index: 144.3700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7060
    Cell Significance Index: 114.8300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6790
    Cell Significance Index: 18.2000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5496
    Cell Significance Index: 34.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4991
    Cell Significance Index: 99.0500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.4787
    Cell Significance Index: 7.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4509
    Cell Significance Index: 31.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3948
    Cell Significance Index: 20.5100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3616
    Cell Significance Index: 250.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3409
    Cell Significance Index: 7.3900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2947
    Cell Significance Index: 6.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2846
    Cell Significance Index: 57.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2780
    Cell Significance Index: 12.6000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2585
    Cell Significance Index: 19.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2398
    Cell Significance Index: 6.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2118
    Cell Significance Index: 5.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2097
    Cell Significance Index: 25.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2096
    Cell Significance Index: 37.7800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1969
    Cell Significance Index: 5.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1674
    Cell Significance Index: 22.9900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1655
    Cell Significance Index: 3.2300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1605
    Cell Significance Index: 57.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1584
    Cell Significance Index: 8.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1545
    Cell Significance Index: 15.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1403
    Cell Significance Index: 76.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1392
    Cell Significance Index: 6.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1390
    Cell Significance Index: 61.4600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0404
    Cell Significance Index: 1.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0345
    Cell Significance Index: 64.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0293
    Cell Significance Index: 3.7600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0217
    Cell Significance Index: 0.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0217
    Cell Significance Index: 3.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0198
    Cell Significance Index: 12.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0168
    Cell Significance Index: 25.8000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0151
    Cell Significance Index: 0.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0132
    Cell Significance Index: 24.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0106
    Cell Significance Index: 14.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0065
    Cell Significance Index: 2.9300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0020
    Cell Significance Index: -1.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0071
    Cell Significance Index: -0.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0079
    Cell Significance Index: -1.1500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0110
    Cell Significance Index: -0.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0172
    Cell Significance Index: -12.7700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0179
    Cell Significance Index: -13.5300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0210
    Cell Significance Index: -0.3600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0254
    Cell Significance Index: -14.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0260
    Cell Significance Index: -1.6000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0292
    Cell Significance Index: -18.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0312
    Cell Significance Index: -3.5700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0357
    Cell Significance Index: -1.2400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0476
    Cell Significance Index: -5.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0482
    Cell Significance Index: -13.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0537
    Cell Significance Index: -2.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0547
    Cell Significance Index: -2.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0554
    Cell Significance Index: -1.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0619
    Cell Significance Index: -7.2100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0736
    Cell Significance Index: -7.5200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0760
    Cell Significance Index: -1.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0808
    Cell Significance Index: -10.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0829
    Cell Significance Index: -17.4700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0860
    Cell Significance Index: -3.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0863
    Cell Significance Index: -4.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0869
    Cell Significance Index: -5.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1139
    Cell Significance Index: -3.1000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1173
    Cell Significance Index: -2.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1233
    Cell Significance Index: -9.1900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1283
    Cell Significance Index: -1.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1337
    Cell Significance Index: -13.9200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1567
    Cell Significance Index: -2.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1615
    Cell Significance Index: -9.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1632
    Cell Significance Index: -12.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1768
    Cell Significance Index: -11.4100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1789
    Cell Significance Index: -9.3200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1890
    Cell Significance Index: -2.7900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1958
    Cell Significance Index: -6.2700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2205
    Cell Significance Index: -11.1400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2259
    Cell Significance Index: -3.7800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2259
    Cell Significance Index: -1.9200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2298
    Cell Significance Index: -6.7500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2792
    Cell Significance Index: -4.4300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2820
    Cell Significance Index: -7.0500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2921
    Cell Significance Index: -2.6900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2963
    Cell Significance Index: -7.7900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3110
    Cell Significance Index: -6.5100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3287
    Cell Significance Index: -4.0800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3311
    Cell Significance Index: -10.8400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3340
    Cell Significance Index: -8.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3369
    Cell Significance Index: -10.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Actin-binding protein**: IPP is a member of the actin-binding protein family, which are known to regulate cytoskeletal dynamics and cellular movement. 2. **Intracisternal A Particle (ICAP)**: The name "Intracisternal A Particle-Promoted Polypeptide" hints at its association with the ICAP, a retroviral particle that can modulate host cell behavior. 3. **Cellular expression**: IPP is expressed in a wide range of cell types, including germ cells, epithelial cells, and immune cells, highlighting its potential role in various physiological and pathological processes. 4. **Signaling pathways**: IPP has been implicated in regulating signaling pathways, including actin cytoskeleton and cytoplasmic pathways, which are crucial for cellular communication and response to environmental cues. **Pathways and Functions:** 1. **Actin cytoskeleton regulation**: IPP has been shown to regulate actin cytoskeleton dynamics, which is essential for cellular movement, shape, and division. 2. **Immune cell regulation**: IPP has been identified as a regulator of immune cell behavior, including the modulation of immune responses and the promotion of innate lymphoid cell development. 3. **Cell signaling**: IPP has been implicated in regulating various signaling pathways, including those involved in cellular proliferation, differentiation, and survival. 4. **Tissue homeostasis**: IPP's expression in epithelial cells and other cell types underscores its potential role in maintaining tissue homeostasis and overall organismal health. **Clinical Significance:** 1. **Immunological disorders**: IPP's role in regulating immune responses makes it a potential target for the treatment of immunological disorders, such as autoimmune diseases and cancer. 2. **Cancer progression**: IPP's involvement in cellular signaling pathways and immune cell regulation suggests its potential role in cancer progression and metastasis. 3. **Neurological disorders**: IPP's expression in the brain and its potential role in regulating actin cytoskeleton dynamics make it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Infectious diseases**: IPP's role in regulating immune responses and cellular signaling pathways makes it a potential target for the treatment of infectious diseases, such as HIV and tuberculosis. In conclusion, the IPP gene is a fascinating example of how a single gene can have far-reaching implications in various fields, from immunology to cancer research and beyond. Further studies are necessary to unravel the full extent of IPP's functions and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 2696066522

Symbol: IPP_HUMAN

Name: Actin-binding protein IPP

UniProtKB Accession Codes:

Q9Y573 A2A6V4 D3DQ11 Q8N5C3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 GO 3 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10072760

Title: Isolation and characterization of IPP, a novel human gene encoding an actin-binding, kelch-like protein.

PubMed ID: 10072760

DOI: 10.1016/s0378-1119(99)00006-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8432546

Title: The IPP gene is assigned to human chromosome 1p32-1p22.

PubMed ID: 8432546

DOI: 10.1006/geno.1993.1048

Sequence Information:

  • Length: 584
  • Mass: 65261
  • Checksum: C63EF25D74924AB8
  • Sequence:
    • MANEDCPKAA DSPFSSDKHA QLILAQINKM RNGQHFCDVQ LQVGQESFKA HRLVLAASSP 
YFAALFTGGM KESSKDVVPI LGIEAGIFQI LLDFIYTGIV NIGVNNVQEL IIAADMLQLT 
EVVHLCCEFL KGQIDPLNCI GIFQFSEQIA CHDLLEFSEN YIHVHFLEVH SGEEFLALTK 
DQLIKILRSE ELSIEDEYQV FLAAMQWILK DLGKRRKHVV EVLDPIRFPL LPPQRLLKYI 
EGVSDFNLRV ALQTLLKEYC EVCKSPKENK FCSFLQTSKV RPRKKARKYL YAVGGYTRLQ 
GGRWSDSRAL SCVERFDTFS QYWTTVSSLH QARSGLGVTV LGGMVYAIGG EKDSMIFDCT 
ECYDPVTKQW TTVASMNHPR CGLGVCVCYG AIYALGGWVG AEIGNTIERF DPDENKWEVV 
GNMAVSRYYF GCCEMQGLIY VIGGISNEGI ELRSFEVYDP LSKRWSPLPP MGTRRAYLGV 
AALNDCIYSV GGWNETQDAL HTVEKYSFEE EKWVEVASMK VPRAGMCVVA VNGLLYVSGG 
RSSSHDFLAP GTLDSVEVYN PHSDTWTEIG NMITSRCEGG VAVL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.