Details for: IRS1

Gene ID: 3667

Symbol: IRS1

Ensembl ID: ENSG00000169047

Description: insulin receptor substrate 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.6
    Marker Score: 28395
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.57
    Marker Score: 59715
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.54
    Marker Score: 901
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.49
    Marker Score: 784
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168843
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.42
    Marker Score: 3122
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.4
    Marker Score: 1243
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.4
    Marker Score: 1510
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.31
    Marker Score: 20544
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.26
    Marker Score: 1525
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.19
    Marker Score: 2796
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.18
    Marker Score: 2231
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.15
    Marker Score: 11878
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.13
    Marker Score: 8691
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.12
    Marker Score: 4660
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.07
    Marker Score: 2172
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.05
    Marker Score: 15753
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.05
    Marker Score: 8996
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.04
    Marker Score: 4014
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.01
    Marker Score: 369
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1
    Marker Score: 1543
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71790
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48014
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.97
    Marker Score: 35689
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.94
    Marker Score: 5621
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5252
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2729
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.9
    Marker Score: 9082
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9
    Marker Score: 55085
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.9
    Marker Score: 1115
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 317
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.87
    Marker Score: 3218
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.86
    Marker Score: 1661
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.86
    Marker Score: 269
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.84
    Marker Score: 888
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.84
    Marker Score: 970
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.84
    Marker Score: 402
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.84
    Marker Score: 505
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.81
    Marker Score: 207
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.81
    Marker Score: 9150
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.81
    Marker Score: 1188
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8
    Marker Score: 3111
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.8
    Marker Score: 7544
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.79
    Marker Score: 391
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.79
    Marker Score: 7514
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 313
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.78
    Marker Score: 227
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 591.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.76
    Marker Score: 245
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.76
    Marker Score: 26273
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.76
    Marker Score: 694
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 685
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 387
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.75
    Marker Score: 518
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.74
    Marker Score: 2437
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.74
    Marker Score: 3198
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.74
    Marker Score: 210
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.74
    Marker Score: 233
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.72
    Marker Score: 1283
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.72
    Marker Score: 388
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3030
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.72
    Marker Score: 564
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.72
    Marker Score: 14285
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.71
    Marker Score: 4568
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.7
    Marker Score: 505
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.7
    Marker Score: 201
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.69
    Marker Score: 140
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.67
    Marker Score: 1588.5
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.66
    Marker Score: 2850
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.65
    Marker Score: 2650
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.64
    Marker Score: 4187
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.64
    Marker Score: 357
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.64
    Marker Score: 283
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.64
    Marker Score: 202
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.64
    Marker Score: 1710
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.63
    Marker Score: 2439
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.63
    Marker Score: 1540
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.62
    Marker Score: 8225
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.62
    Marker Score: 852
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.61
    Marker Score: 343
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.61
    Marker Score: 843
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.61
    Marker Score: 1148
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.6
    Marker Score: 786
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.6
    Marker Score: 227
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.59
    Marker Score: 566
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.56
    Marker Score: 604
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.56
    Marker Score: 591
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.55
    Marker Score: 1349.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 440
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.55
    Marker Score: 12253
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.55
    Marker Score: 266
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.54
    Marker Score: 526
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171

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Other Information

**Key characteristics:** * The IRS1 gene is located on chromosome 1 in humans. * It is a single-exon gene that encodes a protein of 123 amino acids. * It is a key component of the insulin signaling pathway, which is responsible for regulating metabolism. * It is expressed in high levels in cells that are exposed to insulin, such as the pancreas and the cells of the endocrine pancreas. * It is also expressed in cells that are not exposed to insulin, such as immune cells. * It is a key regulator of inflammation and immune responses. **Pathways and functions:** * The IRS1 gene is a key regulator of the insulin signaling pathway. * The pathway is responsible for regulating the metabolism of glucose, amino acids, and lipids. * It is also involved in regulating inflammation and immune responses. * In the absence of insulin, the IRS1 gene is not expressed and the insulin signaling pathway is inhibited. * This leads to the accumulation of glucose in the blood and the development of hyperglycemia. **Clinical significance:** * Mutations in the IRS1 gene have been linked to a number of human diseases, including diabetes, obesity, and cancer. * These mutations can affect the expression of the IRS1 gene or its regulatory proteins, which can lead to changes in insulin signaling. * This can result in either hyperglycemia or hypoglycemia, depending on the specific mutation. **Conclusion:** The IRS1 gene is a key regulator of the insulin signaling pathway. Its mutations can have a significant impact on human health, and are a major cause of diabetes and other diseases.

Genular Protein ID: 3769148353

Symbol: IRS1_HUMAN

Name: Insulin receptor substrate 1

UniProtKB Accession Codes:

P35568

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 ELM 1 EMBL 3 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 34 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 8 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 17 RefSeq 1 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8513971

Title: Human skeletal muscle insulin receptor substrate-1. Characterization of the cDNA, gene, and chromosomal localization.

PubMed ID: 8513971

DOI: 10.2337/diab.42.7.1041

PubMed ID: 1311924

Title: Cloning and increased expression of an insulin receptor substrate-1-like gene in human hepatocellular carcinoma.

PubMed ID: 1311924

DOI: 10.1016/0006-291x(92)91640-c

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8240352

Title: The insulin receptor substrate (IRS-1) is a PEST protein that is susceptible to calpain degradation in vitro.

PubMed ID: 8240352

DOI: 10.1006/bbrc.1993.2315

PubMed ID: 7541045

Title: Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor.

PubMed ID: 7541045

DOI: 10.1074/jbc.270.26.15639

PubMed ID: 7559478

Title: Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains.

PubMed ID: 7559478

DOI: 10.1074/jbc.270.40.23258

PubMed ID: 7537849

Title: Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain.

PubMed ID: 7537849

DOI: 10.1128/mcb.15.5.2500

PubMed ID: 12624099

Title: Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2.

PubMed ID: 12624099

DOI: 10.1074/jbc.m211770200

PubMed ID: 15364919

Title: Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101).

PubMed ID: 15364919

DOI: 10.1074/jbc.c400186200

PubMed ID: 15226403

Title: ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth.

PubMed ID: 15226403

DOI: 10.1242/jcs.01183

PubMed ID: 16127460

Title: Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans.

PubMed ID: 16127460

DOI: 10.1172/jci23853

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16878150

Title: Recruitment of insulin receptor substrate-1 and activation of NF-kappaB essential for midkine growth signaling through anaplastic lymphoma kinase.

PubMed ID: 16878150

DOI: 10.1038/sj.onc.1209840

PubMed ID: 18952604

Title: S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2.

PubMed ID: 18952604

DOI: 10.1074/jbc.m806480200

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18498745

Title: The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation.

PubMed ID: 18498745

DOI: 10.1016/j.molcel.2008.03.009

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20685959

Title: The double-stranded RNA-dependent protein kinase differentially regulates insulin receptor substrates 1 and 2 in HepG2 cells.

PubMed ID: 20685959

DOI: 10.1091/mbc.e10-06-0481

PubMed ID: 23401856

Title: C1-Ten is a protein tyrosine phosphatase of insulin receptor substrate 1 (IRS-1), regulating IRS-1 stability and muscle atrophy.

PubMed ID: 23401856

DOI: 10.1128/mcb.01447-12

PubMed ID: 25101860

Title: Regulation of C1-Ten protein tyrosine phosphatase by p62/SQSTM1-mediated sequestration and degradation.

PubMed ID: 25101860

DOI: 10.1016/j.cellsig.2014.07.033

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 30092354

Title: Cellular phosphatase activity of C1-Ten/Tensin2 is controlled by Phosphatidylinositol-3,4,5-triphosphate binding through the C1-Ten/Tensin2 SH2 domain.

PubMed ID: 30092354

DOI: 10.1016/j.cellsig.2018.07.009

PubMed ID: 8599766

Title: Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain.

PubMed ID: 8599766

DOI: 10.1038/nsb0496-388

PubMed ID: 10411883

Title: Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1.

PubMed ID: 10411883

DOI: 10.1073/pnas.96.15.8378

PubMed ID: 11694888

Title: Structure and autoregulation of the insulin-like growth factor 1 receptor kinase.

PubMed ID: 11694888

DOI: 10.1038/nsb721

PubMed ID: 8104271

Title: Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus.

PubMed ID: 8104271

DOI: 10.1016/0140-6736(93)92694-o

PubMed ID: 8723689

Title: Deletion of Gly723 in the insulin receptor substrate-1 of a patient with noninsulin-dependent diabetes mellitus.

PubMed ID: 8723689

DOI: 10.1002/(sici)1098-1004(1996)7:4<364::aid-humu13>3.0.co;2-0

PubMed ID: 10206679

Title: Novel allele of the insulin receptor substrate-1 bearing two non-conservative amino acid substitutions in a patient with noninsulin-dependent diabetes mellitus.

PubMed ID: 10206679

DOI: 10.1002/(sici)1098-1004(1998)11:5<411::aid-humu11>3.0.co;2-2

PubMed ID: 10843189

Title: The Gly-->Arg(972) amino acid polymorphism in insulin receptor substrate-1 affects glucose metabolism in skeletal muscle cells.

PubMed ID: 10843189

DOI: 10.1210/jcem.85.5.6608

PubMed ID: 12843189

Title: The Arg(972) variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patients.

PubMed ID: 12843189

DOI: 10.1210/jc.2002-021716

PubMed ID: 14671192

Title: Genetic polymorphism PC-1 K121Q and ethnic susceptibility to insulin resistance.

PubMed ID: 14671192

DOI: 10.1210/jc.2003-030453

PubMed ID: 12679424

Title: A novel T608R missense mutation in insulin receptor substrate-1 identified in a subject with type 2 diabetes impairs metabolic insulin signaling.

PubMed ID: 12679424

DOI: 10.1210/jc.2002-020933

PubMed ID: 14707024

Title: G972R IRS-1 variant impairs insulin regulation of endothelial nitric oxide synthase in cultured human endothelial cells.

PubMed ID: 14707024

DOI: 10.1161/01.cir.0000109498.77895.6f

PubMed ID: 15590636

Title: Human insulin receptor substrate-1 (IRS-1) polymorphism G972R causes IRS-1 to associate with the insulin receptor and inhibit receptor autophosphorylation.

PubMed ID: 15590636

DOI: 10.1074/jbc.m412300200

Sequence Information:

  • Length: 1242
  • Mass: 131591
  • Checksum: 3C0EFD9E32B3E64A
  • Sequence:
    • MASPPESDGF SDVRKVGYLR KPKSMHKRFF VLRAASEAGG PARLEYYENE KKWRHKSSAP 
KRSIPLESCF NINKRADSKN KHLVALYTRD EHFAIAADSE AEQDSWYQAL LQLHNRAKGH 
HDGAAALGAG GGGGSCSGSS GLGEAGEDLS YGDVPPGPAF KEVWQVILKP KGLGQTKNLI 
GIYRLCLTSK TISFVKLNSE AAAVVLQLMN IRRCGHSENF FFIEVGRSAV TGPGEFWMQV 
DDSVVAQNMH ETILEAMRAM SDEFRPRSKS QSSSNCSNPI SVPLRRHHLN NPPPSQVGLT 
RRSRTESITA TSPASMVGGK PGSFRVRASS DGEGTMSRPA SVDGSPVSPS TNRTHAHRHR 
GSARLHPPLN HSRSIPMPAS RCSPSATSPV SLSSSSTSGH GSTSDCLFPR RSSASVSGSP 
SDGGFISSDE YGSSPCDFRS SFRSVTPDSL GHTPPARGEE ELSNYICMGG KGPSTLTAPN 
GHYILSRGGN GHRCTPGTGL GTSPALAGDE AASAADLDNR FRKRTHSAGT SPTITHQKTP 
SQSSVASIEE YTEMMPAYPP GGGSGGRLPG HRHSAFVPTR SYPEEGLEMH PLERRGGHHR 
PDSSTLHTDD GYMPMSPGVA PVPSGRKGSG DYMPMSPKSV SAPQQIINPI RRHPQRVDPN 
GYMMMSPSGG CSPDIGGGPS SSSSSSNAVP SGTSYGKLWT NGVGGHHSHV LPHPKPPVES 
SGGKLLPCTG DYMNMSPVGD SNTSSPSDCY YGPEDPQHKP VLSYYSLPRS FKHTQRPGEP 
EEGARHQHLR LSTSSGRLLY AATADDSSSS TSSDSLGGGY CGARLEPSLP HPHHQVLQPH 
LPRKVDTAAQ TNSRLARPTR LSLGDPKAST LPRAREQQQQ QQPLLHPPEP KSPGEYVNIE 
FGSDQSGYLS GPVAFHSSPS VRCPSQLQPA PREEETGTEE YMKMDLGPGR RAAWQESTGV 
EMGRLGPAPP GAASICRPTR AVPSSRGDYM TMQMSCPRQS YVDTSPAAPV SYADMRTGIA 
AEEVSLPRAT MAAASSSSAA SASPTGPQGA AELAAHSSLL GGPQGPGGMS AFTRVNLSPN 
RNQSAKVIRA DPQGCRRRHS SETFSSTPSA TRVGNTVPFG AGAAVGGGGG SSSSSEDVKR 
HSSASFENVW LRPGELGGAP KEPAKLCGAA GGLENGLNYI DLDLVKDFKQ CPQECTPEPQ 
PPPPPPPHQP LGSGESSSTR RSSEDLSAYA SISFQKQPED RQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.