Details for: IRS1

Gene ID: 3667

Symbol: IRS1

Ensembl ID: ENSG00000169047

Description: insulin receptor substrate 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 154.8103
    Cell Significance Index: -24.0800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 95.8827
    Cell Significance Index: -24.3200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 50.2624
    Cell Significance Index: -23.7300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 49.8453
    Cell Significance Index: -20.2500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.2099
    Cell Significance Index: -20.2500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.5546
    Cell Significance Index: -24.1100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.1505
    Cell Significance Index: -24.2700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.9552
    Cell Significance Index: 79.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.1752
    Cell Significance Index: 431.6800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.0848
    Cell Significance Index: 12.8300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.9137
    Cell Significance Index: 26.1100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.8419
    Cell Significance Index: 19.5700
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.8363
    Cell Significance Index: 16.3000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4740
    Cell Significance Index: 40.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.4672
    Cell Significance Index: 38.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.0512
    Cell Significance Index: 58.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0439
    Cell Significance Index: 54.2300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9759
    Cell Significance Index: 96.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8744
    Cell Significance Index: 789.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7416
    Cell Significance Index: 55.2700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7294
    Cell Significance Index: 43.7900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6845
    Cell Significance Index: 94.0000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6511
    Cell Significance Index: 70.8200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5657
    Cell Significance Index: 11.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5608
    Cell Significance Index: 112.4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5540
    Cell Significance Index: 90.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5328
    Cell Significance Index: 65.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4417
    Cell Significance Index: 241.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4415
    Cell Significance Index: 12.7200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.4120
    Cell Significance Index: 6.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3749
    Cell Significance Index: 134.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3674
    Cell Significance Index: 28.1900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3551
    Cell Significance Index: 24.5600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3256
    Cell Significance Index: 14.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2165
    Cell Significance Index: 95.7400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2012
    Cell Significance Index: 4.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1985
    Cell Significance Index: 35.7800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1401
    Cell Significance Index: 3.6000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1341
    Cell Significance Index: 92.7300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.1142
    Cell Significance Index: 1.6400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1083
    Cell Significance Index: 49.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0873
    Cell Significance Index: 118.7000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0779
    Cell Significance Index: 1.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0720
    Cell Significance Index: 12.3000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0635
    Cell Significance Index: 12.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0564
    Cell Significance Index: 35.8000
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.0230
    Cell Significance Index: 0.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0199
    Cell Significance Index: 2.5500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0146
    Cell Significance Index: 22.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0113
    Cell Significance Index: 0.5300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0109
    Cell Significance Index: 20.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0054
    Cell Significance Index: 0.1900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0042
    Cell Significance Index: 0.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0012
    Cell Significance Index: 2.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0005
    Cell Significance Index: 0.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0093
    Cell Significance Index: -6.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0101
    Cell Significance Index: -6.3300
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.0119
    Cell Significance Index: -0.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0135
    Cell Significance Index: -0.8300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0161
    Cell Significance Index: -1.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0277
    Cell Significance Index: -15.6000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0279
    Cell Significance Index: -21.0900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0314
    Cell Significance Index: -0.5300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0336
    Cell Significance Index: -0.5800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0395
    Cell Significance Index: -1.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0526
    Cell Significance Index: -3.2300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0532
    Cell Significance Index: -6.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0577
    Cell Significance Index: -16.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0609
    Cell Significance Index: -12.8300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0641
    Cell Significance Index: -7.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0656
    Cell Significance Index: -8.4700
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0669
    Cell Significance Index: -0.7700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0700
    Cell Significance Index: -1.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0962
    Cell Significance Index: -2.5700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1007
    Cell Significance Index: -14.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1010
    Cell Significance Index: -5.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1079
    Cell Significance Index: -12.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1401
    Cell Significance Index: -14.3100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1402
    Cell Significance Index: -2.0700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1475
    Cell Significance Index: -16.8400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1639
    Cell Significance Index: -3.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1691
    Cell Significance Index: -5.4200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1899
    Cell Significance Index: -2.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2036
    Cell Significance Index: -5.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2167
    Cell Significance Index: -22.5600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2219
    Cell Significance Index: -4.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2279
    Cell Significance Index: -18.0500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2284
    Cell Significance Index: -11.9900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2442
    Cell Significance Index: -5.0700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2589
    Cell Significance Index: -5.4200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2777
    Cell Significance Index: -14.0300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2791
    Cell Significance Index: -4.1200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2893
    Cell Significance Index: -3.0000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2945
    Cell Significance Index: -19.0000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3227
    Cell Significance Index: -7.7400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3233
    Cell Significance Index: -14.3000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3520
    Cell Significance Index: -7.4700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3952
    Cell Significance Index: -24.9100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3959
    Cell Significance Index: -4.9100
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.3960
    Cell Significance Index: -2.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Insulin Receptor Substrate:** IRS1 is a cytoplasmic protein that binds to the insulin receptor (IR) and phosphatidylinositol 3-kinase (PI3K) upon insulin binding, triggering a cascade of downstream effects. 2. **Phosphorylation and Tyrosine Binding:** IRS1 is phosphorylated at tyrosine residues, which facilitates its interaction with other signaling proteins, including PI3K, AKT, and the insulin receptor. 3. **PI3K/AKT Signaling:** IRS1's binding to PI3K activates the PI3K/AKT pathway, which regulates cell survival, proliferation, and metabolism. 4. **Cross-Talk with Other Signaling Pathways:** IRS1 interacts with various signaling pathways, including the MAPK, NF-κB, and JAK/STAT pathways, modulating cellular responses to growth factors, cytokines, and stress. **Pathways and Functions:** 1. **Insulin Signaling:** IRS1 mediates insulin-induced glucose uptake, glycogen synthesis, and glycogenolysis, regulating glucose homeostasis. 2. **Growth Factor Signaling:** IRS1 interacts with growth factor receptors, such as IGF-1R, TRKA, and TRKC, influencing cell growth, differentiation, and survival. 3. **Lipid Metabolism:** IRS1 regulates fatty acid synthesis and beta-oxidation, impacting lipid metabolism and energy homeostasis. 4. **Immune System:** IRS1 modulates immune responses to cytokines and growth factors, influencing inflammation and immune cell function. **Clinical Significance:** 1. **Diabetes and Metabolic Disorders:** IRS1 dysfunction is associated with insulin resistance, type 2 diabetes, and metabolic syndrome. 2. **Cancer:** IRS1's role in cancer is complex, with both oncogenic and tumor-suppressive functions, depending on the context and cellular context. 3. **Neurological Disorders:** IRS1's involvement in neurodegenerative diseases, such as Alzheimer's and Parkinson's, is emerging, highlighting its potential as a therapeutic target. 4. **Cardiovascular Disease:** IRS1's regulation of lipid metabolism and cardiovascular function makes it a potential target for the prevention and treatment of cardiovascular disease. In conclusion, IRS1 is a multifunctional protein that plays a central role in insulin signaling and beyond, influencing glucose homeostasis, cell growth, and differentiation, lipid metabolism, and immune system function. Its dysregulation contributes to various human diseases, highlighting the need for further research into the molecular mechanisms underlying IRS1's complex functions.

Genular Protein ID: 3769148353

Symbol: IRS1_HUMAN

Name: Insulin receptor substrate 1

UniProtKB Accession Codes:

P35568

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 ELM 1 EMBL 3 Ensembl 1 EvolutionaryTrace 1 GO 35 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 18 RefSeq 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8513971

Title: Human skeletal muscle insulin receptor substrate-1. Characterization of the cDNA, gene, and chromosomal localization.

PubMed ID: 8513971

DOI: 10.2337/diab.42.7.1041

PubMed ID: 1311924

Title: Cloning and increased expression of an insulin receptor substrate-1-like gene in human hepatocellular carcinoma.

PubMed ID: 1311924

DOI: 10.1016/0006-291x(92)91640-c

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8240352

Title: The insulin receptor substrate (IRS-1) is a PEST protein that is susceptible to calpain degradation in vitro.

PubMed ID: 8240352

DOI: 10.1006/bbrc.1993.2315

PubMed ID: 7541045

Title: Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor.

PubMed ID: 7541045

DOI: 10.1074/jbc.270.26.15639

PubMed ID: 7559478

Title: Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains.

PubMed ID: 7559478

DOI: 10.1074/jbc.270.40.23258

PubMed ID: 7537849

Title: Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain.

PubMed ID: 7537849

DOI: 10.1128/mcb.15.5.2500

PubMed ID: 12624099

Title: Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2.

PubMed ID: 12624099

DOI: 10.1074/jbc.m211770200

PubMed ID: 15364919

Title: Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101).

PubMed ID: 15364919

DOI: 10.1074/jbc.c400186200

PubMed ID: 15226403

Title: ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth.

PubMed ID: 15226403

DOI: 10.1242/jcs.01183

PubMed ID: 16127460

Title: Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans.

PubMed ID: 16127460

DOI: 10.1172/jci23853

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16878150

Title: Recruitment of insulin receptor substrate-1 and activation of NF-kappaB essential for midkine growth signaling through anaplastic lymphoma kinase.

PubMed ID: 16878150

DOI: 10.1038/sj.onc.1209840

PubMed ID: 18952604

Title: S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2.

PubMed ID: 18952604

DOI: 10.1074/jbc.m806480200

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18498745

Title: The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation.

PubMed ID: 18498745

DOI: 10.1016/j.molcel.2008.03.009

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20685959

Title: The double-stranded RNA-dependent protein kinase differentially regulates insulin receptor substrates 1 and 2 in HepG2 cells.

PubMed ID: 20685959

DOI: 10.1091/mbc.e10-06-0481

PubMed ID: 23401856

Title: C1-Ten is a protein tyrosine phosphatase of insulin receptor substrate 1 (IRS-1), regulating IRS-1 stability and muscle atrophy.

PubMed ID: 23401856

DOI: 10.1128/mcb.01447-12

PubMed ID: 25101860

Title: Regulation of C1-Ten protein tyrosine phosphatase by p62/SQSTM1-mediated sequestration and degradation.

PubMed ID: 25101860

DOI: 10.1016/j.cellsig.2014.07.033

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 30092354

Title: Cellular phosphatase activity of C1-Ten/Tensin2 is controlled by Phosphatidylinositol-3,4,5-triphosphate binding through the C1-Ten/Tensin2 SH2 domain.

PubMed ID: 30092354

DOI: 10.1016/j.cellsig.2018.07.009

PubMed ID: 38056462

Title: An enzyme that selectively S-nitrosylates proteins to regulate insulin signaling.

PubMed ID: 38056462

DOI: 10.1016/j.cell.2023.11.009

PubMed ID: 8599766

Title: Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain.

PubMed ID: 8599766

DOI: 10.1038/nsb0496-388

PubMed ID: 10411883

Title: Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1.

PubMed ID: 10411883

DOI: 10.1073/pnas.96.15.8378

PubMed ID: 11694888

Title: Structure and autoregulation of the insulin-like growth factor 1 receptor kinase.

PubMed ID: 11694888

DOI: 10.1038/nsb721

PubMed ID: 8104271

Title: Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus.

PubMed ID: 8104271

DOI: 10.1016/0140-6736(93)92694-o

PubMed ID: 8723689

Title: Deletion of Gly723 in the insulin receptor substrate-1 of a patient with noninsulin-dependent diabetes mellitus.

PubMed ID: 8723689

DOI: 10.1002/(sici)1098-1004(1996)7:4<364::aid-humu13>3.0.co;2-0

PubMed ID: 10206679

Title: Novel allele of the insulin receptor substrate-1 bearing two non-conservative amino acid substitutions in a patient with noninsulin-dependent diabetes mellitus.

PubMed ID: 10206679

DOI: 10.1002/(sici)1098-1004(1998)11:5<411::aid-humu11>3.0.co;2-2

PubMed ID: 10843189

Title: The Gly-->Arg(972) amino acid polymorphism in insulin receptor substrate-1 affects glucose metabolism in skeletal muscle cells.

PubMed ID: 10843189

DOI: 10.1210/jcem.85.5.6608

PubMed ID: 12843189

Title: The Arg(972) variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patients.

PubMed ID: 12843189

DOI: 10.1210/jc.2002-021716

PubMed ID: 14671192

Title: Genetic polymorphism PC-1 K121Q and ethnic susceptibility to insulin resistance.

PubMed ID: 14671192

DOI: 10.1210/jc.2003-030453

PubMed ID: 12679424

Title: A novel T608R missense mutation in insulin receptor substrate-1 identified in a subject with type 2 diabetes impairs metabolic insulin signaling.

PubMed ID: 12679424

DOI: 10.1210/jc.2002-020933

PubMed ID: 14707024

Title: G972R IRS-1 variant impairs insulin regulation of endothelial nitric oxide synthase in cultured human endothelial cells.

PubMed ID: 14707024

DOI: 10.1161/01.cir.0000109498.77895.6f

PubMed ID: 15590636

Title: Human insulin receptor substrate-1 (IRS-1) polymorphism G972R causes IRS-1 to associate with the insulin receptor and inhibit receptor autophosphorylation.

PubMed ID: 15590636

DOI: 10.1074/jbc.m412300200

Sequence Information:

  • Length: 1242
  • Mass: 131591
  • Checksum: 3C0EFD9E32B3E64A
  • Sequence:
    • MASPPESDGF SDVRKVGYLR KPKSMHKRFF VLRAASEAGG PARLEYYENE KKWRHKSSAP 
KRSIPLESCF NINKRADSKN KHLVALYTRD EHFAIAADSE AEQDSWYQAL LQLHNRAKGH 
HDGAAALGAG GGGGSCSGSS GLGEAGEDLS YGDVPPGPAF KEVWQVILKP KGLGQTKNLI 
GIYRLCLTSK TISFVKLNSE AAAVVLQLMN IRRCGHSENF FFIEVGRSAV TGPGEFWMQV 
DDSVVAQNMH ETILEAMRAM SDEFRPRSKS QSSSNCSNPI SVPLRRHHLN NPPPSQVGLT 
RRSRTESITA TSPASMVGGK PGSFRVRASS DGEGTMSRPA SVDGSPVSPS TNRTHAHRHR 
GSARLHPPLN HSRSIPMPAS RCSPSATSPV SLSSSSTSGH GSTSDCLFPR RSSASVSGSP 
SDGGFISSDE YGSSPCDFRS SFRSVTPDSL GHTPPARGEE ELSNYICMGG KGPSTLTAPN 
GHYILSRGGN GHRCTPGTGL GTSPALAGDE AASAADLDNR FRKRTHSAGT SPTITHQKTP 
SQSSVASIEE YTEMMPAYPP GGGSGGRLPG HRHSAFVPTR SYPEEGLEMH PLERRGGHHR 
PDSSTLHTDD GYMPMSPGVA PVPSGRKGSG DYMPMSPKSV SAPQQIINPI RRHPQRVDPN 
GYMMMSPSGG CSPDIGGGPS SSSSSSNAVP SGTSYGKLWT NGVGGHHSHV LPHPKPPVES 
SGGKLLPCTG DYMNMSPVGD SNTSSPSDCY YGPEDPQHKP VLSYYSLPRS FKHTQRPGEP 
EEGARHQHLR LSTSSGRLLY AATADDSSSS TSSDSLGGGY CGARLEPSLP HPHHQVLQPH 
LPRKVDTAAQ TNSRLARPTR LSLGDPKAST LPRAREQQQQ QQPLLHPPEP KSPGEYVNIE 
FGSDQSGYLS GPVAFHSSPS VRCPSQLQPA PREEETGTEE YMKMDLGPGR RAAWQESTGV 
EMGRLGPAPP GAASICRPTR AVPSSRGDYM TMQMSCPRQS YVDTSPAAPV SYADMRTGIA 
AEEVSLPRAT MAAASSSSAA SASPTGPQGA AELAAHSSLL GGPQGPGGMS AFTRVNLSPN 
RNQSAKVIRA DPQGCRRRHS SETFSSTPSA TRVGNTVPFG AGAAVGGGGG SSSSSEDVKR 
HSSASFENVW LRPGELGGAP KEPAKLCGAA GGLENGLNYI DLDLVKDFKQ CPQECTPEPQ 
PPPPPPPHQP LGSGESSSTR RSSEDLSAYA SISFQKQPED RQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.