Details for: ITGAX

Gene ID: 3687

Symbol: ITGAX

Ensembl ID: ENSG00000140678

Description: integrin subunit alpha X

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.74
    Marker Score: 7564
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 2.68
    Marker Score: 2142
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.28
    Marker Score: 751
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.19
    Marker Score: 4272
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.09
    Marker Score: 1038
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.92
    Marker Score: 830
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.84
    Marker Score: 102703
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.65
    Marker Score: 3988
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1158
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.38
    Marker Score: 5729
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.37
    Marker Score: 1573
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.36
    Marker Score: 1390
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.35
    Marker Score: 564
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.35
    Marker Score: 488
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.33
    Marker Score: 34006
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.31
    Marker Score: 2655
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.27
    Marker Score: 7743
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.25
    Marker Score: 541
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 845
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4795
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.13
    Marker Score: 2814
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.12
    Marker Score: 280
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.09
    Marker Score: 2834
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.08
    Marker Score: 496
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251784
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.01
    Marker Score: 694
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71803
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48027
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.93
    Marker Score: 385
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5296
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 369
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2734
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.9
    Marker Score: 1632
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.87
    Marker Score: 357
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5282
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 621.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.78
    Marker Score: 251
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.78
    Marker Score: 9054
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1255
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 701
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.71
    Marker Score: 793
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 456
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.68
    Marker Score: 1086
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.65
    Marker Score: 840
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.58
    Marker Score: 175
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.56
    Marker Score: 1623
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.55
    Marker Score: 336
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.54
    Marker Score: 380
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.53
    Marker Score: 320
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.5
    Marker Score: 320
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.5
    Marker Score: 503
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5
    Marker Score: 7757
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.5
    Marker Score: 171
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.49
    Marker Score: 928
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.49
    Marker Score: 399
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.47
    Marker Score: 285
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.47
    Marker Score: 272
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.46
    Marker Score: 559
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.46
    Marker Score: 162
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.44
    Marker Score: 574
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.44
    Marker Score: 197
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.42
    Marker Score: 290
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.42
    Marker Score: 419
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.41
    Marker Score: 209
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.41
    Marker Score: 179
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.4
    Marker Score: 260
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.39
    Marker Score: 203
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.39
    Marker Score: 379
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.38
    Marker Score: 556
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.38
    Marker Score: 291
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.37
    Marker Score: 218
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.35
    Marker Score: 172
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.35
    Marker Score: 198
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.34
    Marker Score: 226
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.33
    Marker Score: 2193
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.33
    Marker Score: 90
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.32
    Marker Score: 85
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.32
    Marker Score: 99
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.3
    Marker Score: 956
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.29
    Marker Score: 106
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.28
    Marker Score: 282
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.28
    Marker Score: 265
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.28
    Marker Score: 95
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.26
    Marker Score: 66
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.26
    Marker Score: 153
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 88
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.25
    Marker Score: 182
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.25
    Marker Score: 114
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.24
    Marker Score: 236
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.24
    Marker Score: 144
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.23
    Marker Score: 182

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Other Information

**Key characteristics:** - ITGAX is a transmembrane protein with a single extracellular domain and a cytoplasmic tail. - It is expressed in a wide range of cell types, including endothelial cells, immune cells, and tumor cells. - It is a member of the integrin family of cell adhesion molecules. - It is known to interact with various extracellular matrix proteins, including collagen, elastin, and fibronectin. **Pathways and functions:** - ITGAX is involved in cell-matrix adhesion by interacting with extracellular matrix proteins. - It plays a crucial role in leukocyte adhesion to the endothelium of blood vessels, facilitating the extravasation of immune cells into tissues. - It is involved in cell adhesion and migration by interacting with extracellular matrix proteins and other cell adhesion molecules. - ITGAX also participates in cytokine signaling through the interaction of its cytoplasmic tail with cytokine receptors. - It is involved in the regulation of inflammation and immune responses. **Clinical significance:** - Mutations in ITGAX have been linked to various human diseases, including cancer, autoimmune diseases, and vascular disorders. - ITGAX inhibitors have been investigated as potential therapeutic agents for cancer and inflammatory diseases. **Additional notes:** - ITGAX is a highly conserved protein with homologs in other species. - It is a promising target for cancer immunotherapy due to its involvement in cell adhesion, migration, and inflammation. - Further research is needed to fully understand the role of ITGAX in human health and disease.

Genular Protein ID: 376676123

Symbol: ITAX_HUMAN

Name: Integrin alpha-X

UniProtKB Accession Codes:

P20702 Q8IVA6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChEBI 15 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 9 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 27 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 8 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3327687

Title: cDNA cloning and complete primary structure of the alpha subunit of a leukocyte adhesion glycoprotein, p150,95.

PubMed ID: 3327687

DOI: 10.1002/j.1460-2075.1987.tb02746.x

PubMed ID: 2303426

Title: Genomic structure of an integrin alpha subunit, the leukocyte p150,95 molecule.

PubMed ID: 2303426

DOI: 10.1016/s0021-9258(19)39870-9

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3549901

Title: Purification and alpha subunit N-terminal sequences of human Mac-1 and p150,95 leukocyte adhesion proteins.

PubMed ID: 3549901

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 20033057

Title: Structure of an integrin with an alphaI domain, complement receptor type 4.

PubMed ID: 20033057

DOI: 10.1038/emboj.2009.367

PubMed ID: 22844534

Title: Structure and binding interface of the cytosolic tails of alphaXbeta2 integrin.

PubMed ID: 22844534

DOI: 10.1371/journal.pone.0041924

PubMed ID: 21763482

Title: VPS35 mutations in Parkinson disease.

PubMed ID: 21763482

DOI: 10.1016/j.ajhg.2011.06.001

Sequence Information:

  • Length: 1163
  • Mass: 127829
  • Checksum: 8947288C43E76BE2
  • Sequence:
    • MTRTRAALLL FTALATSLGF NLDTEELTAF RVDSAGFGDS VVQYANSWVV VGAPQKITAA 
NQTGGLYQCG YSTGACEPIG LQVPPEAVNM SLGLSLASTT SPSQLLACGP TVHHECGRNM 
YLTGLCFLLG PTQLTQRLPV SRQECPRQEQ DIVFLIDGSG SISSRNFATM MNFVRAVISQ 
FQRPSTQFSL MQFSNKFQTH FTFEEFRRSS NPLSLLASVH QLQGFTYTAT AIQNVVHRLF 
HASYGARRDA AKILIVITDG KKEGDSLDYK DVIPMADAAG IIRYAIGVGL AFQNRNSWKE 
LNDIASKPSQ EHIFKVEDFD ALKDIQNQLK EKIFAIEGTE TTSSSSFELE MAQEGFSAVF 
TPDGPVLGAV GSFTWSGGAF LYPPNMSPTF INMSQENVDM RDSYLGYSTE LALWKGVQSL 
VLGAPRYQHT GKAVIFTQVS RQWRMKAEVT GTQIGSYFGA SLCSVDVDSD GSTDLVLIGA 
PHYYEQTRGG QVSVCPLPRG WRRWWCDAVL YGEQGHPWGR FGAALTVLGD VNGDKLTDVV 
IGAPGEEENR GAVYLFHGVL GPSISPSHSQ RIAGSQLSSR LQYFGQALSG GQDLTQDGLV 
DLAVGARGQV LLLRTRPVLW VGVSMQFIPA EIPRSAFECR EQVVSEQTLV QSNICLYIDK 
RSKNLLGSRD LQSSVTLDLA LDPGRLSPRA TFQETKNRSL SRVRVLGLKA HCENFNLLLP 
SCVEDSVTPI TLRLNFTLVG KPLLAFRNLR PMLAADAQRY FTASLPFEKN CGADHICQDN 
LGISFSFPGL KSLLVGSNLE LNAEVMVWND GEDSYGTTIT FSHPAGLSYR YVAEGQKQGQ 
LRSLHLTCDS APVGSQGTWS TSCRINHLIF RGGAQITFLA TFDVSPKAVL GDRLLLTANV 
SSENNTPRTS KTTFQLELPV KYAVYTVVSS HEQFTKYLNF SESEEKESHV AMHRYQVNNL 
GQRDLPVSIN FWVPVELNQE AVWMDVEVSH PQNPSLRCSS EKIAPPASDF LAHIQKNPVL 
DCSIAGCLRF RCDVPSFSVQ EELDFTLKGN LSFGWVRQIL QKKVSVVSVA EITFDTSVYS 
QLPGQEAFMR AQTTTVLEKY KVHNPTPLIV GSSIGGLLLL ALITAVLYKV GFFKRQYKEM 
MEEANGQIAP ENGTQTPSPP SEK

Genular Protein ID: 2292553503

Symbol: H3BN02_HUMAN

Name: N/A

UniProtKB Accession Codes:

H3BN02

Database IDs:

ARBA 14 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 5 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 11 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 6 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

Sequence Information:

  • Length: 1169
  • Mass: 128537
  • Checksum: 0E4C64E082AADB8B
  • Sequence:
    • MTRTRAALLL FTALATSLGF NLDTEELTAF RVDSAGFGDS VVQYANSWVV VGAPQKITAA 
NQTGGLYQCG YSTGACEPIG LQVPPEAVNM SLGLSLASTT SPSQLLACGP TVHHECGRNM 
YLTGLCFLLG PTQLTQRLPV SRQECPRQEQ DIVFLIDGSG SISSRNFATM MNFVRAVISQ 
FQRPSTQFSL MQFSNKFQTH FTFEEFRRSS NPLSLLASVH QLQGFTYTAT AIQNVVHRLF 
HASYGARRDA AKILIVITDG KKEGDSLDYK DVIPMADAAG IIRYAIGVGL AFQNRNSWKE 
LNDIASKPSQ EHIFKVEDFD ALKDIQNQLK EKIFAIEGTE TTSSSSFELE MAQEGFSAVF 
TPDGPVLGAV GSFTWSGGAF LYPPNMSPTF INMSQENVDM RDSYLGYSTE LALWKGVQSL 
VLGAPRYQHT GKAVIFTQVS RQWRMKAEVT GTQIGSYFGA SLCSVDVDSD GSTDLVLIGA 
PHYYEQTRGG QVSVCPLPRG WRRWWCDAVL YGEQGHPWGR FGAALTVLGD VNGDKLTDVV 
IGAPGEEENR GAVYLFHGVL GPSISPSHSQ RIAGSQLSSR LQYFGQALSG GQDLTQDGLV 
DLAVGARGQV LLLRTRPVLW VGVSMQFIPA EIPRSAFECR EQVVSEQTLV QSNICLYIDK 
RSKNLLGSRD LQSSVTLDLA LDPGRLSPRA TFQETKNRSL SRVRVLGLKA HCENFNLLLP 
SCVEDSVTPI TLRLNFTLVG KPLLAFRNLR PMLAADAQRY FTASLPFEKN CGADHICQDN 
LGISFSFPGL KSLLVGSNLE LNAEVMVWND GEDSYGTTIT FSHPAGLSYR YVAEGQKQGQ 
LRSLHLTCDS APVGSQGTWS TSCRINHLIF RGGAQITFLA TFDVSPKAVL GDRLLLTANV 
SSENNTPRTS KTTFQLELPV KYAVYTVVSS HEQFTKYLNF SESEEKESHV AMHRYQVNNL 
GQRDLPVSIN FWVPVELNQE AVWMDVEVSH PQNPSLRCSS EKIAPPASDF LAHIQKNPVL 
DCSIAGCLRF RCDVPSFSVQ EELDFTLKGN LSFGWVRQIL QKKVSVVSVA EITFDTSVYS 
QLPGQEAFMR AQTTTVLEKY KVHNPTPLIV GSSIGGLLLL ALITAVLYKV GFFKRQYKEM 
MEEANGQIAP ENGTQTPSPP TPHYPQDNV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.