Details for: ITGB7

Gene ID: 3695

Symbol: ITGB7

Ensembl ID: ENSG00000139626

Description: integrin subunit beta 7

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.23
    Marker Score: 14242
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.76
    Marker Score: 2589
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.76
    Marker Score: 5539
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.72
    Marker Score: 1909
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.7
    Marker Score: 1492
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.57
    Marker Score: 4577
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.56
    Marker Score: 6673
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.49
    Marker Score: 4114
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 1.41
    Marker Score: 371
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.38
    Marker Score: 13709
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.38
    Marker Score: 3374
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.35
    Marker Score: 1372
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.31
    Marker Score: 957
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 1.3
    Marker Score: 359
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.3
    Marker Score: 1220
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.23
    Marker Score: 831
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.21
    Marker Score: 1033
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.2
    Marker Score: 63555
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.19
    Marker Score: 261
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4768
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.11
    Marker Score: 666.5
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.1
    Marker Score: 647
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.08
    Marker Score: 381
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.05
    Marker Score: 1823
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.03
    Marker Score: 566
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.02
    Marker Score: 2875
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.02
    Marker Score: 1106
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.02
    Marker Score: 860
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.02
    Marker Score: 356
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.01
    Marker Score: 232
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71767
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47992
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.98
    Marker Score: 342
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.98
    Marker Score: 222
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 492
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 448
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.93
    Marker Score: 872
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.93
    Marker Score: 385
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2727
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 363
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.9
    Marker Score: 1246
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.9
    Marker Score: 297
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.9
    Marker Score: 1196.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5031
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.87
    Marker Score: 502
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5269
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.87
    Marker Score: 534
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.86
    Marker Score: 629.5
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.85
    Marker Score: 258
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.84
    Marker Score: 410
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.84
    Marker Score: 212
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.83
    Marker Score: 488
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.79
    Marker Score: 242
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.78
    Marker Score: 1395
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1239
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.76
    Marker Score: 552
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.76
    Marker Score: 490
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 580
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 384.5
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.74
    Marker Score: 510
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.74
    Marker Score: 1399
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.73
    Marker Score: 1255
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.72
    Marker Score: 1707
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.71
    Marker Score: 2004
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.7
    Marker Score: 597
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7
    Marker Score: 448
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 630
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.69
    Marker Score: 10753
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.68
    Marker Score: 513
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.66
    Marker Score: 7628
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.65
    Marker Score: 148
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.64
    Marker Score: 527
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.61
    Marker Score: 261
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.6
    Marker Score: 307
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.6
    Marker Score: 1344
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.59
    Marker Score: 293
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.58
    Marker Score: 139
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.56
    Marker Score: 726
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.56
    Marker Score: 1441.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.55
    Marker Score: 191
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.54
    Marker Score: 326
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.54
    Marker Score: 390
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.54
    Marker Score: 166
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.53
    Marker Score: 471
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.53
    Marker Score: 233
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.53
    Marker Score: 299
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.52
    Marker Score: 847
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.52
    Marker Score: 203
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.52
    Marker Score: 379
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5
    Marker Score: 362
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.49
    Marker Score: 250
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.49
    Marker Score: 170.5
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.49
    Marker Score: 550
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.49
    Marker Score: 321

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Other Information

## Summary ITGB7, also known as CD112, is a cell adhesion molecule that plays a significant role in various physiological and pathological processes. It is expressed on a wide range of cell types, including immune cells, epithelial cells, and cancer cells. ## Key characteristics * ITGB7 is a type I transmembrane protein that belongs to the integrin family of cell adhesion molecules. * It is expressed on the cell surface of various immune cells, including T cells, B cells, and macrophages. * ITGB7 is a critical component of the cell adhesion complex, which is responsible for cell-cell and cell-extracellular matrix interactions. * It is involved in various cellular processes, including cell migration, adhesion, and signaling. ## Pathways and functions * ITGB7 is involved in cell adhesion by interacting with its ligand, E-cadherin. * It is also involved in cell migration by binding to extracellular matrix proteins and facilitating cell adhesion to the extracellular matrix. * ITGB7 plays a role in immune regulation by interacting with other cell adhesion molecules and signaling pathways. * It is involved in the development and maintenance of immune tolerance and is expressed on regulatory T cells. ## Clinical significance * Mutations in ITGB7 have been linked to several autoimmune diseases, including rheumatoid arthritis, psoriasis, and inflammatory bowel disease. * ITGB7 inhibitors are being investigated as potential therapeutics for these diseases. * ITGB7 is also involved in cancer, where it is expressed on tumor cells and immune cells. * Targeting ITGB7 has been shown to inhibit tumor growth and metastasis. ITGB7 is a versatile cell adhesion molecule that plays a critical role in various physiological and pathological processes. Its clinical significance highlights the importance of understanding its functions and developing targeted therapies for diseases that are characterized by impaired cell adhesion and immune regulation.

Genular Protein ID: 3254550297

Symbol: ITB7_HUMAN

Name: Integrin beta-7

UniProtKB Accession Codes:

P26010 Q9UCP7 Q9UCS7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 ELM 1 EMBL 32 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 3 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 3 SAM 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2083230

Title: Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains.

PubMed ID: 2083230

DOI: 10.1093/intimm/2.11.1097

PubMed ID: 1777426

Title: Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains.

PubMed ID: 1777426

DOI: 10.1093/intimm/3.12.1373

PubMed ID: 2040616

Title: Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes.

PubMed ID: 2040616

DOI: 10.1016/s0021-9258(18)99120-9

PubMed ID: 1382574

Title: The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1.

PubMed ID: 1382574

DOI: 10.1093/intimm/4.9.1031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1542691

Title: A family of beta 7 integrins on human mucosal lymphocytes.

PubMed ID: 1542691

DOI: 10.1073/pnas.89.5.1924

PubMed ID: 1750505

Title: HML-1 antigen on mucosa-associated T cells, activated cells, and hairy leukemic cells is a new integrin containing the beta 7 subunit.

PubMed ID: 1750505

PubMed ID: 10837471

Title: The role of alpha and beta chains in ligand recognition by beta 7 integrins.

PubMed ID: 10837471

DOI: 10.1074/jbc.m001228200

PubMed ID: 12297042

Title: Integrins: bidirectional, allosteric signaling machines.

PubMed ID: 12297042

DOI: 10.1016/s0092-8674(02)00971-6

PubMed ID: 14608374

Title: Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster.

PubMed ID: 14608374

DOI: 10.1038/nsb1011

PubMed ID: 18264102

Title: HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells.

PubMed ID: 18264102

DOI: 10.1038/ni1566

PubMed ID: 19828450

Title: Identification and characterization of multiple similar ligand-binding repeats in filamin: implication on filamin-mediated receptor clustering and cross-talk.

PubMed ID: 19828450

DOI: 10.1074/jbc.m109.060954

PubMed ID: 16455489

Title: The molecular basis of filamin binding to integrins and competition with talin.

PubMed ID: 16455489

DOI: 10.1016/j.molcel.2006.01.011

PubMed ID: 22232704

Title: Structural specializations of alpha(4)beta(7), an integrin that mediates rolling adhesion.

PubMed ID: 22232704

DOI: 10.1083/jcb.201110023

Sequence Information:

  • Length: 798
  • Mass: 86903
  • Checksum: CBE275E0E9992385
  • Sequence:
    • MVALPMVLVL LLVLSRGESE LDAKIPSTGD ATEWRNPHLS MLGSCQPAPS CQKCILSHPS 
CAWCKQLNFT ASGEAEARRC ARREELLARG CPLEELEEPR GQQEVLQDQP LSQGARGEGA 
TQLAPQRVRV TLRPGEPQQL QVRFLRAEGY PVDLYYLMDL SYSMKDDLER VRQLGHALLV 
RLQEVTHSVR IGFGSFVDKT VLPFVSTVPS KLRHPCPTRL ERCQSPFSFH HVLSLTGDAQ 
AFEREVGRQS VSGNLDSPEG GFDAILQAAL CQEQIGWRNV SRLLVFTSDD TFHTAGDGKL 
GGIFMPSDGH CHLDSNGLYS RSTEFDYPSV GQVAQALSAA NIQPIFAVTS AALPVYQELS 
KLIPKSAVGE LSEDSSNVVQ LIMDAYNSLS STVTLEHSSL PPGVHISYES QCEGPEKREG 
KAEDRGQCNH VRINQTVTFW VSLQATHCLP EPHLLRLRAL GFSEELIVEL HTLCDCNCSD 
TQPQAPHCSD GQGHLQCGVC SCAPGRLGRL CECSVAELSS PDLESGCRAP NGTGPLCSGK 
GHCQCGRCSC SGQSSGHLCE CDDASCERHE GILCGGFGRC QCGVCHCHAN RTGRACECSG 
DMDSCISPEG GLCSGHGRCK CNRCQCLDGY YGALCDQCPG CKTPCERHRD CAECGAFRTG 
PLATNCSTAC AHTNVTLALA PILDDGWCKE RTLDNQLFFF LVEDDARGTV VLRVRPQEKG 
ADHTQAIVLG CVGGIVAVGL GLVLAYRLSV EIYDRREYSR FEKEQQQLNW KQDSNPLYKS 
AITTTINPRF QEADSPTL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.