Details for: KCNS1

Gene ID: 3787

Symbol: KCNS1

Ensembl ID: ENSG00000124134

Description: potassium voltage-gated channel modifier subfamily S member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.29
    Marker Score: 2308
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.2
    Marker Score: 1518
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7692
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.09
    Marker Score: 689
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.08
    Marker Score: 2051
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71835
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48059
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.97
    Marker Score: 2474
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.96
    Marker Score: 1951.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5352
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.83
    Marker Score: 12947
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.83
    Marker Score: 496
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 626
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.61
    Marker Score: 402
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 462
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.55
    Marker Score: 321.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.54
    Marker Score: 3219
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.51
    Marker Score: 297
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 479
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.49
    Marker Score: 216
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.44
    Marker Score: 252
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.37
    Marker Score: 601
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 375
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.37
    Marker Score: 195
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.37
    Marker Score: 762
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.37
    Marker Score: 97
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.36
    Marker Score: 152
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.36
    Marker Score: 377
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.35
    Marker Score: 169
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.31
    Marker Score: 19081
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.28
    Marker Score: 438
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.28
    Marker Score: 268
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.21
    Marker Score: 595
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.2
    Marker Score: 108
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.19
    Marker Score: 60
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.19
    Marker Score: 112
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.18
    Marker Score: 216
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.18
    Marker Score: 1691
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.17
    Marker Score: 301
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.16
    Marker Score: 47
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.15
    Marker Score: 260
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.14
    Marker Score: 59
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.13
    Marker Score: 71
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.13
    Marker Score: 48
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.13
    Marker Score: 99
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.12
    Marker Score: 199
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.11
    Marker Score: 73.5
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.1
    Marker Score: 87
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.1
    Marker Score: 109
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.08
    Marker Score: 31
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.08
    Marker Score: 189.5
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.08
    Marker Score: 96
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.08
    Marker Score: 68
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.07
    Marker Score: 107
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.07
    Marker Score: 106
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.07
    Marker Score: 300
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.07
    Marker Score: 29
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.07
    Marker Score: 17.5
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.07
    Marker Score: 28
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.07
    Marker Score: 34
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.07
    Marker Score: 68
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.07
    Marker Score: 153
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.07
    Marker Score: 44
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.06
    Marker Score: 558
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.06
    Marker Score: 78
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.06
    Marker Score: 182
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.06
    Marker Score: 65
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.06
    Marker Score: 52
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.05
    Marker Score: 1955
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.05
    Marker Score: 217
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.05
    Marker Score: 32
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.05
    Marker Score: 311
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.05
    Marker Score: 23.5
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.04
    Marker Score: 62
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.04
    Marker Score: 28
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.04
    Marker Score: 15

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Other Information

**Key characteristics** - KCNS1 is a transmembrane protein that is expressed in the plasma membrane of cells. - It is a member of the potassium voltage-gated channel subfamily S. - It is a key regulator of delayed rectifier potassium channel activity. - It is involved in neuronal system, perinuclear region of cytoplasm, and plasma membrane pathways. **Pathways and functions** - KCNS1 modulates the activity of the delayed rectifier potassium channel. - It is involved in the regulation of neuronal excitability. - It is involved in the regulation of synaptic plasticity. - It is involved in the regulation of muscle contraction. **Clinical significance** - Mutations in KCNS1 have been linked to a number of human diseases, including epilepsy, heart failure, and stroke. - KCNS1 is a potential therapeutic target for these diseases. - Targeting KCNS1 could be used to treat epilepsy by blocking the activity of the delayed rectifier potassium channel. - Targeting KCNS1 could also be used to treat heart failure by reducing the activity of the delayed rectifier potassium channel in the heart. - Targeting KCNS1 could also be used to treat stroke by blocking the activity of the delayed rectifier potassium channel in the brain.

Genular Protein ID: 4154302329

Symbol: KCNS1_HUMAN

Name: Potassium voltage-gated channel subfamily S member 1

UniProtKB Accession Codes:

Q96KK3 A2RUL9 B7ZM31 O43652 Q6DJU6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10484328

Title: Electrically silent potassium channel subunits from human lens epithelium.

PubMed ID: 10484328

DOI: 10.1152/ajpcell.1999.277.3.c412

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 526
  • Mass: 58372
  • Checksum: 00F0E415E3A68C91
  • Sequence:
    • MLMLLVRGTH YENLRSKVVL PTPLGGRSTE TFVSEFPGPD TGIRWRRSDE ALRVNVGGVR 
RQLSARALAR FPGTRLGRLQ AAASEEQARR LCDDYDEAAR EFYFDRHPGF FLSLLHFYRT 
GHLHVLDELC VFAFGQEADY WGLGENALAA CCRARYLERR LTQPHAWDED SDTPSSVDPC 
PDEISDVQRE LARYGAARCG RLRRRLWLTM ENPGYSLPSK LFSCVSISVV LASIAAMCIH 
SLPEYQAREA AAAVAAVAAG RSPEGVRDDP VLRRLEYFCI AWFSFEVSSR LLLAPSTRNF 
FCHPLNLIDI VSVLPFYLTL LAGVALGDQG GKEFGHLGKV VQVFRLMRIF RVLKLARHST 
GLRSLGATLK HSYREVGILL LYLAVGVSVF SGVAYTAEKE EDVGFNTIPA CWWWGTVSMT 
TVGYGDVVPV TVAGKLAASG CILGGILVVA LPITIIFNKF SHFYRRQKAL EAAVRNSNHQ 
EFEDLLSSID GVSEASLETS RETSQEGQSA DLESQAPSEP PHPQMY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.