Details for: KCNS1

Gene ID: 3787

Symbol: KCNS1

Ensembl ID: ENSG00000124134

Description: potassium voltage-gated channel modifier subfamily S member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 10.4675
    Cell Significance Index: -2.6600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.2796
    Cell Significance Index: 3.7300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2175
    Cell Significance Index: 3.1700
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.2065
    Cell Significance Index: 2.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1670
    Cell Significance Index: 33.5000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1475
    Cell Significance Index: 3.2300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0688
    Cell Significance Index: 0.9900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0215
    Cell Significance Index: 0.4600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0189
    Cell Significance Index: 0.9800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0063
    Cell Significance Index: 2.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0051
    Cell Significance Index: 0.2400
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.0042
    Cell Significance Index: 0.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0007
    Cell Significance Index: -0.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0013
    Cell Significance Index: -2.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0030
    Cell Significance Index: -1.6500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0031
    Cell Significance Index: -2.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0034
    Cell Significance Index: -2.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0036
    Cell Significance Index: -2.6100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0038
    Cell Significance Index: -2.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0043
    Cell Significance Index: -1.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0066
    Cell Significance Index: -3.7100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0082
    Cell Significance Index: -3.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0115
    Cell Significance Index: -1.4100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0143
    Cell Significance Index: -2.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0152
    Cell Significance Index: -2.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0191
    Cell Significance Index: -2.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0194
    Cell Significance Index: -3.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0195
    Cell Significance Index: -1.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0196
    Cell Significance Index: -4.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0198
    Cell Significance Index: -0.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0211
    Cell Significance Index: -2.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0229
    Cell Significance Index: -2.6700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0232
    Cell Significance Index: -3.1800
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0286
    Cell Significance Index: -0.4600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0306
    Cell Significance Index: -0.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0306
    Cell Significance Index: -3.6100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0324
    Cell Significance Index: -0.4400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0359
    Cell Significance Index: -0.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0381
    Cell Significance Index: -2.5600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0402
    Cell Significance Index: -1.2800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0403
    Cell Significance Index: -2.1000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0416
    Cell Significance Index: -2.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0424
    Cell Significance Index: -2.3800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0428
    Cell Significance Index: -0.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0429
    Cell Significance Index: -2.6300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0438
    Cell Significance Index: -2.3000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0460
    Cell Significance Index: -2.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0466
    Cell Significance Index: -2.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0478
    Cell Significance Index: -2.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0480
    Cell Significance Index: -3.5800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0482
    Cell Significance Index: -1.6900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0540
    Cell Significance Index: -0.6300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0549
    Cell Significance Index: -0.5200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0572
    Cell Significance Index: -0.7400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0592
    Cell Significance Index: -2.6200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0592
    Cell Significance Index: -2.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0593
    Cell Significance Index: -2.0600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0629
    Cell Significance Index: -2.0600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0660
    Cell Significance Index: -2.5000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0661
    Cell Significance Index: -0.7200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0662
    Cell Significance Index: -1.9500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0711
    Cell Significance Index: -2.0300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0768
    Cell Significance Index: -2.8200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0834
    Cell Significance Index: -2.0800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0841
    Cell Significance Index: -2.2500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0844
    Cell Significance Index: -2.4800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0878
    Cell Significance Index: -2.1900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0891
    Cell Significance Index: -1.8900
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0897
    Cell Significance Index: -0.9900
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0928
    Cell Significance Index: -1.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0937
    Cell Significance Index: -2.7000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0955
    Cell Significance Index: -2.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0974
    Cell Significance Index: -2.6000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0997
    Cell Significance Index: -2.4900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1007
    Cell Significance Index: -2.4400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1027
    Cell Significance Index: -2.0300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1033
    Cell Significance Index: -2.6400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1033
    Cell Significance Index: -1.5000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1044
    Cell Significance Index: -2.2600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1060
    Cell Significance Index: -2.7000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1099
    Cell Significance Index: -2.6400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1116
    Cell Significance Index: -2.2400
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: -0.1124
    Cell Significance Index: -0.9200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1151
    Cell Significance Index: -2.2500
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.1160
    Cell Significance Index: -1.4400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1174
    Cell Significance Index: -2.3100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1190
    Cell Significance Index: -1.6700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1207
    Cell Significance Index: -2.5200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1229
    Cell Significance Index: -2.5500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1255
    Cell Significance Index: -2.1700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1266
    Cell Significance Index: -3.6300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1277
    Cell Significance Index: -2.3600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1290
    Cell Significance Index: -2.6300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1302
    Cell Significance Index: -1.6500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1327
    Cell Significance Index: -1.8200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1408
    Cell Significance Index: -2.2800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1412
    Cell Significance Index: -1.9100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1414
    Cell Significance Index: -2.8200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1465
    Cell Significance Index: -2.2000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1492
    Cell Significance Index: -1.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Potassium Channel Regulation:** KCNS1 is a modifier of voltage-gated potassium channels, which are critical for regulating potassium ion flux across cell membranes. These channels play a key role in maintaining proper ion balance and cellular excitability. 2. **Cell Type-Specific Expression:** KCNS1 is significantly expressed in cells involved in immune responses, such as endothelial cells, dendritic cells, and intestinal crypt stem cells, as well as in the nervous system, including cerebral cortex GABAergic interneurons and forebrain radial glial cells. 3. **Voltage-Gated Potassium Channel Complex:** KCNS1 is part of the voltage-gated potassium channel complex, which is composed of multiple subunits. This complex is essential for regulating potassium channel activity and maintaining proper ion balance. **Pathways and Functions:** 1. **Delayed Rectifier Potassium Channel Activity:** KCNS1 regulates the activity of delayed rectifier potassium channels, which are essential for maintaining proper ion balance and regulating cellular excitability. 2. **Neuronal System:** KCNS1 is expressed in cerebral cortex GABAergic interneurons and forebrain radial glial cells, where it plays a crucial role in regulating neuronal excitability and synaptic transmission. 3. **Immune Response:** KCNS1 is expressed in immune cells, such as endothelial cells, dendritic cells, and intestinal crypt stem cells, where it regulates potassium channel activity and immune cell function. **Clinical Significance:** 1. **Immunological Disorders:** Alterations in KCNS1 expression have been implicated in various immunological disorders, including autoimmune diseases and inflammatory conditions. 2. **Neurological Disorders:** KCNS1 mutations have been associated with neurological disorders, such as epilepsy and anxiety disorders. 3. **Cancer:** KCNS1 expression has been altered in various types of cancer, including colorectal cancer and breast cancer. 4. **Cardiovascular Disease:** KCNS1 is expressed in cardiac endothelial cells, where it regulates potassium channel activity and cardiovascular function. In conclusion, the KCNS1 gene plays a crucial role in regulating potassium channels in immune cells and the nervous system. Alterations in KCNS1 expression have been implicated in various immunological and neurological disorders, highlighting the importance of this gene in maintaining proper ion balance and cellular excitability. Further research is needed to fully elucidate the functions of KCNS1 and its role in human disease.

Genular Protein ID: 4154302329

Symbol: KCNS1_HUMAN

Name: Potassium voltage-gated channel subfamily S member 1

UniProtKB Accession Codes:

Q96KK3 A2RUL9 B7ZM31 O43652 Q6DJU6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10484328

Title: Electrically silent potassium channel subunits from human lens epithelium.

PubMed ID: 10484328

DOI: 10.1152/ajpcell.1999.277.3.c412

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 526
  • Mass: 58372
  • Checksum: 00F0E415E3A68C91
  • Sequence:
    • MLMLLVRGTH YENLRSKVVL PTPLGGRSTE TFVSEFPGPD TGIRWRRSDE ALRVNVGGVR 
RQLSARALAR FPGTRLGRLQ AAASEEQARR LCDDYDEAAR EFYFDRHPGF FLSLLHFYRT 
GHLHVLDELC VFAFGQEADY WGLGENALAA CCRARYLERR LTQPHAWDED SDTPSSVDPC 
PDEISDVQRE LARYGAARCG RLRRRLWLTM ENPGYSLPSK LFSCVSISVV LASIAAMCIH 
SLPEYQAREA AAAVAAVAAG RSPEGVRDDP VLRRLEYFCI AWFSFEVSSR LLLAPSTRNF 
FCHPLNLIDI VSVLPFYLTL LAGVALGDQG GKEFGHLGKV VQVFRLMRIF RVLKLARHST 
GLRSLGATLK HSYREVGILL LYLAVGVSVF SGVAYTAEKE EDVGFNTIPA CWWWGTVSMT 
TVGYGDVVPV TVAGKLAASG CILGGILVVA LPITIIFNKF SHFYRRQKAL EAAVRNSNHQ 
EFEDLLSSID GVSEASLETS RETSQEGQSA DLESQAPSEP PHPQMY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.