Details for: KLRC2

Gene ID: 3822

Symbol: KLRC2

Ensembl ID: ENSG00000205809

Description: killer cell lectin like receptor C2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 4.4103
    Cell Significance Index: 270.3900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.0593
    Cell Significance Index: 31.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5959
    Cell Significance Index: 72.3400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.3225
    Cell Significance Index: 19.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2480
    Cell Significance Index: 123.4600
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 1.0346
    Cell Significance Index: 6.0000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6971
    Cell Significance Index: 629.4700
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.5968
    Cell Significance Index: 6.3500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5693
    Cell Significance Index: 12.1300
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.4927
    Cell Significance Index: 1.3200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4266
    Cell Significance Index: 69.3800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4163
    Cell Significance Index: 45.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2941
    Cell Significance Index: 55.9700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2579
    Cell Significance Index: 15.4800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2303
    Cell Significance Index: 15.9300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0336
    Cell Significance Index: 1.1800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0112
    Cell Significance Index: 0.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0066
    Cell Significance Index: 0.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0029
    Cell Significance Index: -5.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0030
    Cell Significance Index: -5.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0033
    Cell Significance Index: -5.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0039
    Cell Significance Index: -5.3100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0069
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0072
    Cell Significance Index: -5.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0076
    Cell Significance Index: -5.7200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0086
    Cell Significance Index: -6.3000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0093
    Cell Significance Index: -5.8100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0098
    Cell Significance Index: -6.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0098
    Cell Significance Index: -5.5400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0108
    Cell Significance Index: -0.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0133
    Cell Significance Index: -6.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0137
    Cell Significance Index: -2.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0145
    Cell Significance Index: -5.1900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0182
    Cell Significance Index: -0.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0192
    Cell Significance Index: -5.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0198
    Cell Significance Index: -2.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0200
    Cell Significance Index: -4.0100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0210
    Cell Significance Index: -1.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0258
    Cell Significance Index: -2.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0260
    Cell Significance Index: -5.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0269
    Cell Significance Index: -5.6700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0279
    Cell Significance Index: -1.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0299
    Cell Significance Index: -5.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0306
    Cell Significance Index: -3.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0366
    Cell Significance Index: -5.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0416
    Cell Significance Index: -6.0500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0490
    Cell Significance Index: -2.3100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0506
    Cell Significance Index: -1.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0508
    Cell Significance Index: -6.5600
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: -0.0550
    Cell Significance Index: -0.3500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0557
    Cell Significance Index: -6.5700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0570
    Cell Significance Index: -5.9400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0585
    Cell Significance Index: -5.9800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0638
    Cell Significance Index: -1.6400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0658
    Cell Significance Index: -1.8400
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0708
    Cell Significance Index: -0.6300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0782
    Cell Significance Index: -3.6500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0793
    Cell Significance Index: -1.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0849
    Cell Significance Index: -6.3300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0850
    Cell Significance Index: -6.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0857
    Cell Significance Index: -5.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0866
    Cell Significance Index: -5.8200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0894
    Cell Significance Index: -2.1700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0973
    Cell Significance Index: -6.2800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0979
    Cell Significance Index: -2.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1153
    Cell Significance Index: -5.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1168
    Cell Significance Index: -6.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1180
    Cell Significance Index: -6.1300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1185
    Cell Significance Index: -2.4800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1307
    Cell Significance Index: -2.2200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1315
    Cell Significance Index: -4.9800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1366
    Cell Significance Index: -4.7900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1374
    Cell Significance Index: -2.0100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1397
    Cell Significance Index: -1.9000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1479
    Cell Significance Index: -5.4300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1563
    Cell Significance Index: -4.2600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1565
    Cell Significance Index: -4.9500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1600
    Cell Significance Index: -5.2400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1623
    Cell Significance Index: -5.1700
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1683
    Cell Significance Index: -2.1800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1693
    Cell Significance Index: -2.2100
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.1867
    Cell Significance Index: -2.3900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1869
    Cell Significance Index: -4.9900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1938
    Cell Significance Index: -4.9500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.2036
    Cell Significance Index: -1.9300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2064
    Cell Significance Index: -5.8900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2065
    Cell Significance Index: -5.4300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2069
    Cell Significance Index: -5.1600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2105
    Cell Significance Index: -5.2500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2127
    Cell Significance Index: -5.7000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2142
    Cell Significance Index: -5.2300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2152
    Cell Significance Index: -6.3400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2185
    Cell Significance Index: -2.5800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2186
    Cell Significance Index: -5.0500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2241
    Cell Significance Index: -4.5600
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.2263
    Cell Significance Index: -2.3500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2263
    Cell Significance Index: -2.4600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2265
    Cell Significance Index: -5.7700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2271
    Cell Significance Index: -6.6700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.2296
    Cell Significance Index: -2.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** KLRC2 is a type II transmembrane protein that belongs to the C-type lectin superfamily. It is composed of two immunoglobulin-like domains and a C-type lectin-like domain. KLRC2 is characterized by its ability to bind to MHC class I molecules and other ligands, such as CD155 and CD155L, which are involved in the regulation of NK cell activation. KLRC2 also interacts with the adaptor protein DAP12, which is essential for the signaling pathways that lead to NK cell activation and cytotoxicity. **Pathways and Functions** KLRC2 plays a crucial role in the regulation of NK cell activation and cytotoxicity through the following pathways: 1. **DAP12 Signaling**: KLRC2 interacts with DAP12, which is a key adaptor protein involved in the signaling pathways that lead to NK cell activation and cytotoxicity. 2. **MHC Class I-Mediated Recognition**: KLRC2 binds to MHC class I molecules, which are expressed on the surface of tumor cells and virus-infected cells, allowing NK cells to recognize and target these cells for destruction. 3. **Stimulatory C-Type Lectin Receptor Signaling Pathway**: KLRC2 is involved in the stimulation of NK cell activation through the activation of the stimulatory c-type lectin receptor signaling pathway. 4. **Regulation of NK Cell Activation**: KLRC2 regulates NK cell activation by binding to MHC class I molecules and interacting with DAP12, which is essential for the signaling pathways that lead to NK cell activation and cytotoxicity. **Clinical Significance** KLRC2 has been implicated in various diseases, including: 1. **Cancer**: KLRC2 has been shown to play a role in the recognition and targeting of tumor cells by NK cells, suggesting its potential as a biomarker for cancer diagnosis and treatment. 2. **Viral Infections**: KLRC2 has been implicated in the regulation of NK cell activation and cytotoxicity in response to viral infections, suggesting its potential as a target for the development of antiviral therapies. 3. **Autoimmune Diseases**: KLRC2 has been shown to play a role in the regulation of immune responses in autoimmune diseases, such as multiple sclerosis and type 1 diabetes, suggesting its potential as a target for the development of immunotherapies. In conclusion, KLRC2 is a critical regulator of NK cell activation and cytotoxicity, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of KLRC2 in the immune system and its potential as a therapeutic target.

Genular Protein ID: 222987090

Symbol: NKG2C_HUMAN

Name: NKG2-C type II integral membrane protein

UniProtKB Accession Codes:

P26717 O43802 Q52M74 Q9NR42

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2007850

Title: DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells.

PubMed ID: 2007850

DOI: 10.1084/jem.173.4.1017

PubMed ID: 9683661

Title: The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex.

PubMed ID: 9683661

DOI: 10.1007/s002510050420

PubMed ID: 11751968

Title: Conservation and variation in human and common chimpanzee CD94 and NKG2 genes.

PubMed ID: 11751968

DOI: 10.4049/jimmunol.168.1.240

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9754572

Title: HLA-E-bound peptides influence recognition by inhibitory and triggering CD94/NKG2 receptors: preferential response to an HLA-G-derived nonamer.

PubMed ID: 9754572

DOI: 10.1002/(sici)1521-4141(199809)28:09<2854::aid-immu2854>3.0.co;2-w

PubMed ID: 9655483

Title: Association of DAP12 with activating CD94/NKG2C NK cell receptors.

PubMed ID: 9655483

DOI: 10.1016/s1074-7613(00)80574-9

PubMed ID: 9486650

Title: HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C.

PubMed ID: 9486650

DOI: 10.1038/35869

PubMed ID: 15940674

Title: The CD94/NKG2C killer lectin-like receptor constitutes an alternative activation pathway for a subset of CD8+ T cells.

PubMed ID: 15940674

DOI: 10.1002/eji.200425843

PubMed ID: 18083576

Title: The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition.

PubMed ID: 18083576

DOI: 10.1016/j.immuni.2007.10.013

PubMed ID: 20952657

Title: NKG2A inhibits NKG2C effector functions of gammadelta T cells: implications in health and disease.

PubMed ID: 20952657

DOI: 10.1189/jlb.0710413

PubMed ID: 21825173

Title: Expansion of a unique CD57-positive NKG2Chi natural killer cell subset during acute human cytomegalovirus infection.

PubMed ID: 21825173

DOI: 10.1073/pnas.1110900108

PubMed ID: 30134159

Title: Distinct HLA-E Peptide Complexes Modify Antibody-Driven Effector Functions of Adaptive NK Cells.

PubMed ID: 30134159

DOI: 10.1016/j.celrep.2018.07.069

PubMed ID: 37264229

Title: HLA class I signal peptide polymorphism determines the level of CD94/NKG2-HLA-E-mediated regulation of effector cell responses.

PubMed ID: 37264229

DOI: 10.1038/s41590-023-01523-z

PubMed ID: 20890284

Title: The structural basis for intramembrane assembly of an activating immunoreceptor complex.

PubMed ID: 20890284

DOI: 10.1038/ni.1943

Sequence Information:

  • Length: 231
  • Mass: 26159
  • Checksum: 0A6863C0645C7556
  • Sequence:
    • MNKQRGTFSE VSLAQDPKRQ QRKPKGNKSS ISGTEQEIFQ VELNLQNPSL NHQGIDKIYD 
CQGLLPPPEK LTAEVLGIIC IVLMATVLKT IVLIPFLEQN NFSPNTRTQK ARHCGHCPEE 
WITYSNSCYY IGKERRTWEE SLLACTSKNS SLLSIDNEEE MKFLASILPS SWIGVFRNSS 
HHPWVTINGL AFKHKIKDSD NAELNCAVLQ VNRLKSAQCG SSMIYHCKHK L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.