Details for: KLRC2

Gene ID: 3822

Symbol: KLRC2

Ensembl ID: ENSG00000205809

Description: killer cell lectin like receptor C2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 2.24
    Marker Score: 729
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.11
    Marker Score: 5816
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1171
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.35
    Marker Score: 417
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.33
    Marker Score: 1330.5
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.27
    Marker Score: 701
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 856
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 487
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4818
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7632
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.11
    Marker Score: 1237
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.04
    Marker Score: 660.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48056
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5348
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.89
    Marker Score: 1311
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.86
    Marker Score: 395
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.84
    Marker Score: 275
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 595
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.73
    Marker Score: 531
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 463
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.53
    Marker Score: 938
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.51
    Marker Score: 1482
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.51
    Marker Score: 415
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.49
    Marker Score: 124
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.48
    Marker Score: 592
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.47
    Marker Score: 203
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.42
    Marker Score: 180
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.41
    Marker Score: 186
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.4
    Marker Score: 205
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.39
    Marker Score: 380.5
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.38
    Marker Score: 219
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.37
    Marker Score: 483
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.37
    Marker Score: 132
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.35
    Marker Score: 234
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.32
    Marker Score: 160
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.31
    Marker Score: 177
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.31
    Marker Score: 313.5
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.31
    Marker Score: 748
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.3
    Marker Score: 68
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.27
    Marker Score: 197
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.26
    Marker Score: 738
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.25
    Marker Score: 214
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.25
    Marker Score: 115
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.23
    Marker Score: 96
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.21
    Marker Score: 180
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.21
    Marker Score: 89
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.21
    Marker Score: 72
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.21
    Marker Score: 337
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.2
    Marker Score: 125
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.2
    Marker Score: 107
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2
    Marker Score: 68
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.2
    Marker Score: 280
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.19
    Marker Score: 611
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.19
    Marker Score: 147
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.19
    Marker Score: 256
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.18
    Marker Score: 161
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.18
    Marker Score: 680
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.17
    Marker Score: 110
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.16
    Marker Score: 269
  • Cell Name: type II NK T cell (CL0000922)
    Fold Change: 0.15
    Marker Score: 45
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.13
    Marker Score: 127
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.13
    Marker Score: 86
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.13
    Marker Score: 124
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.13
    Marker Score: 95
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.12
    Marker Score: 56
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.12
    Marker Score: 293
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.12
    Marker Score: 73
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.12
    Marker Score: 95
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.11
    Marker Score: 65
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.11
    Marker Score: 62
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.1
    Marker Score: 93
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.1
    Marker Score: 52
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.09
    Marker Score: 46
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.09
    Marker Score: 98.5
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.09
    Marker Score: 21
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.09
    Marker Score: 98
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.08
    Marker Score: 151
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.08
    Marker Score: 170
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.08
    Marker Score: 152
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.08
    Marker Score: 136

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Other Information

**Key characteristics:** * It is a member of the killer cell lectin-like receptor family, which are a large family of cell surface receptors that are expressed on activated immune cells. * It is a type I transmembrane receptor, meaning that it is a protein that is anchored in the cell membrane and has transmembrane domains. * It is expressed on a variety of immune cells, including CD8+ T cells, NK cells, and dendritic cells. * It is a key receptor for activating the NKG2C-mediated signaling pathway, which is a major pathway for activating NK cells. **Pathways and functions:** * It is expressed on activated CD8+ T cells and NK cells, where it is found on the surface of activated T cells. * It is also expressed on dendritic cells, where it can be presented with antigens to NK cells. * It is a key receptor for activating the NKG2C-mediated signaling pathway, which is a major pathway for activating NK cells. * It is also involved in regulating the activation and cytotoxicity of NK cells. **Clinical significance:** * Mutations in KLRC2 have been linked to a number of human diseases, including cancer, autoimmune disorders, and infectious diseases. * Inhibition of KLRC2 has been shown to inhibit NK cell activity and can lead to the development of cancer. * Therefore, KLRC2 is a promising target for cancer immunotherapy.

Genular Protein ID: 222987090

Symbol: NKG2C_HUMAN

Name: NKG2-C type II integral membrane protein

UniProtKB Accession Codes:

P26717 O43802 Q52M74 Q9NR42

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2007850

Title: DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells.

PubMed ID: 2007850

DOI: 10.1084/jem.173.4.1017

PubMed ID: 9683661

Title: The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex.

PubMed ID: 9683661

DOI: 10.1007/s002510050420

PubMed ID: 11751968

Title: Conservation and variation in human and common chimpanzee CD94 and NKG2 genes.

PubMed ID: 11751968

DOI: 10.4049/jimmunol.168.1.240

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9754572

Title: HLA-E-bound peptides influence recognition by inhibitory and triggering CD94/NKG2 receptors: preferential response to an HLA-G-derived nonamer.

PubMed ID: 9754572

DOI: 10.1002/(sici)1521-4141(199809)28:09<2854::aid-immu2854>3.0.co;2-w

PubMed ID: 9655483

Title: Association of DAP12 with activating CD94/NKG2C NK cell receptors.

PubMed ID: 9655483

DOI: 10.1016/s1074-7613(00)80574-9

PubMed ID: 9486650

Title: HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C.

PubMed ID: 9486650

DOI: 10.1038/35869

PubMed ID: 15940674

Title: The CD94/NKG2C killer lectin-like receptor constitutes an alternative activation pathway for a subset of CD8+ T cells.

PubMed ID: 15940674

DOI: 10.1002/eji.200425843

PubMed ID: 18083576

Title: The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition.

PubMed ID: 18083576

DOI: 10.1016/j.immuni.2007.10.013

PubMed ID: 20952657

Title: NKG2A inhibits NKG2C effector functions of gammadelta T cells: implications in health and disease.

PubMed ID: 20952657

DOI: 10.1189/jlb.0710413

PubMed ID: 21825173

Title: Expansion of a unique CD57-positive NKG2Chi natural killer cell subset during acute human cytomegalovirus infection.

PubMed ID: 21825173

DOI: 10.1073/pnas.1110900108

PubMed ID: 30134159

Title: Distinct HLA-E Peptide Complexes Modify Antibody-Driven Effector Functions of Adaptive NK Cells.

PubMed ID: 30134159

DOI: 10.1016/j.celrep.2018.07.069

PubMed ID: 37264229

Title: HLA class I signal peptide polymorphism determines the level of CD94/NKG2-HLA-E-mediated regulation of effector cell responses.

PubMed ID: 37264229

DOI: 10.1038/s41590-023-01523-z

PubMed ID: 20890284

Title: The structural basis for intramembrane assembly of an activating immunoreceptor complex.

PubMed ID: 20890284

DOI: 10.1038/ni.1943

Sequence Information:

  • Length: 231
  • Mass: 26159
  • Checksum: 0A6863C0645C7556
  • Sequence:
    • MNKQRGTFSE VSLAQDPKRQ QRKPKGNKSS ISGTEQEIFQ VELNLQNPSL NHQGIDKIYD 
CQGLLPPPEK LTAEVLGIIC IVLMATVLKT IVLIPFLEQN NFSPNTRTQK ARHCGHCPEE 
WITYSNSCYY IGKERRTWEE SLLACTSKNS SLLSIDNEEE MKFLASILPS SWIGVFRNSS 
HHPWVTINGL AFKHKIKDSD NAELNCAVLQ VNRLKSAQCG SSMIYHCKHK L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.