Details for: KPNA5

Gene ID: 3841

Symbol: KPNA5

Ensembl ID: ENSG00000196911

Description: karyopherin subunit alpha 5

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.74
    Marker Score: 66055
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.73
    Marker Score: 25860
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.7
    Marker Score: 6556
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.68
    Marker Score: 12845
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.67
    Marker Score: 102767
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.65
    Marker Score: 32897
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.65
    Marker Score: 15493
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.64
    Marker Score: 35014
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.6
    Marker Score: 6530
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.6
    Marker Score: 13710
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.59
    Marker Score: 58749
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.59
    Marker Score: 15094
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.59
    Marker Score: 6575
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.45
    Marker Score: 2239
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.43
    Marker Score: 6619
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.42
    Marker Score: 1140
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.38
    Marker Score: 14252
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.37
    Marker Score: 1578
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.33
    Marker Score: 44819
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.24
    Marker Score: 363
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.14
    Marker Score: 597
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.1
    Marker Score: 327
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1
    Marker Score: 421
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71700
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47925
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30396
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2401
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.94
    Marker Score: 3924
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 479
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.92
    Marker Score: 1138
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.92
    Marker Score: 3828
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.91
    Marker Score: 1758
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.91
    Marker Score: 981
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2709
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.9
    Marker Score: 285
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.89
    Marker Score: 1559.5
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.88
    Marker Score: 2112
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.88
    Marker Score: 1930
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.88
    Marker Score: 513
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.87
    Marker Score: 45874
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.87
    Marker Score: 237
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4893
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.85
    Marker Score: 476
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.83
    Marker Score: 14781
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.83
    Marker Score: 999.5
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.81
    Marker Score: 1014
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.8
    Marker Score: 695
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.79
    Marker Score: 304
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.79
    Marker Score: 291
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.78
    Marker Score: 455
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.77
    Marker Score: 376
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 306.5
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.76
    Marker Score: 3183
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.76
    Marker Score: 452
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.75
    Marker Score: 1518
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 563
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.73
    Marker Score: 6385
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.73
    Marker Score: 3833
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.73
    Marker Score: 2296
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.72
    Marker Score: 690
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 373
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.72
    Marker Score: 3865
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.7
    Marker Score: 2362
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7
    Marker Score: 10959
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.7
    Marker Score: 368
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.7
    Marker Score: 459
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.7
    Marker Score: 389
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.7
    Marker Score: 936
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.7
    Marker Score: 839
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.69
    Marker Score: 159
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.69
    Marker Score: 2451
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.68
    Marker Score: 255
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.66
    Marker Score: 329
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.66
    Marker Score: 599
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.65
    Marker Score: 325.5
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.65
    Marker Score: 227
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.65
    Marker Score: 204
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.64
    Marker Score: 144
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.63
    Marker Score: 215
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.63
    Marker Score: 254
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.62
    Marker Score: 226
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.62
    Marker Score: 410
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.62
    Marker Score: 4662
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.62
    Marker Score: 360
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.62
    Marker Score: 293
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.62
    Marker Score: 191
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.61
    Marker Score: 622
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.61
    Marker Score: 944
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.61
    Marker Score: 602
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.61
    Marker Score: 367
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.61
    Marker Score: 559
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.61
    Marker Score: 313.5
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.61
    Marker Score: 523
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.6
    Marker Score: 837
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.6
    Marker Score: 135

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Other Information

**Key characteristics**: * The gene is located on chromosome 19p13.2. * It is a large gene, encoding for a protein of approximately 1100 amino acids. * The protein is expressed in a variety of cell types, including neurons, astrocytes, and endothelial cells. * It is a highly expressed gene in the brain. **Pathways and functions**: * The KPNA5 gene is involved in a variety of cellular processes, including viral infection, inflammation, and development. * It is a key regulator of the immune response. * It is involved in the regulation of neuronal survival and differentiation. * It is also involved in the regulation of synaptic plasticity. **Clinical significance**: * Mutations in the KPNA5 gene have been linked to a number of neurological disorders, including autism, schizophrenia, and epilepsy. * These disorders are characterized by a variety of symptoms, including intellectual disability, behavioral problems, and seizures. * Targeting the KPNA5 gene has been explored as a treatment for these disorders. **Additional notes**: * The KPNA5 gene is also known as ITGA6 and NM2A. * It is a member of the immunoglobulin superfamily. * It is a well-studied gene, with a large amount of literature available on its function.

Genular Protein ID: 3076834017

Symbol: IMA6_HUMAN

Name: Karyopherin subunit alpha-5

UniProtKB Accession Codes:

O15131 B2RAI5 Q86X23

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIRSF 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9395085

Title: Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family.

PubMed ID: 9395085

DOI: 10.1016/s0014-5793(97)01265-9

PubMed ID: 12740372

Title: Importin alpha nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein.

PubMed ID: 12740372

DOI: 10.1074/jbc.m303571200

PubMed ID: 12610148

Title: A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway.

PubMed ID: 12610148

DOI: 10.1128/jvi.77.6.3734-3748.2003

PubMed ID: 17928350

Title: Ebola virus VP24 proteins inhibit the interaction of NPI-1 subfamily karyopherin alpha proteins with activated STAT1.

PubMed ID: 17928350

DOI: 10.1128/jvi.01097-07

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 539
  • Mass: 60666
  • Checksum: 6A2B71FEEA7E1B1F
  • Sequence:
    • MDAMASPGKD NYRMKSYKNK ALNPQEMRRR REEEGIQLRK QKREEQLFKR RNVYLPRNDE 
SMLESPIQDP DISSTVPIPE EEVVTTDMVQ MIFSNNADQQ LTATQKFRKL LSKEPNPPID 
QVIQKPGVVQ RFVKFLERNE NCTLQFEAAW ALTNIASGTF LHTKVVIETG AVPIFIKLLN 
SEHEDVQEQA VWALGNIAGD NAECRDFVLN CEILPPLLEL LTNSNRLTTT RNAVWALSNL 
CRGKNPPPNF SKVSPCLNVL SRLLFSSDPD VLADVCWALS YLSDGPNDKI QAVIDSGVCR 
RLVELLMHND YKVVSPALRA VGNIVTGDDI QTQVILNCSA LPCLLHLLSS PKESIRKEAC 
WTVSNITAGN RAQIQAVIDA NIFPVLIEIL QKAEFRTRKE AAWAITNATS GGTPEQIRYL 
VALGCIKPLC DLLTVMDSKI VQVALNGLEN ILRLGEQESK QNGIGINPYC ALIEEAYGLD 
KIEFLQSHEN QEIYQKAFDL IEHYFGVEED DPSIVPQVDE NQQQFIFQQQ EAPMDGFQL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.