Details for: KPNA5

Gene ID: 3841

Symbol: KPNA5

Ensembl ID: ENSG00000196911

Description: karyopherin subunit alpha 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 231.1868
    Cell Significance Index: -35.9600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 136.7668
    Cell Significance Index: -34.6900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 76.1455
    Cell Significance Index: -35.9500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 68.9711
    Cell Significance Index: -28.0200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 65.1263
    Cell Significance Index: -33.5000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 29.3901
    Cell Significance Index: -28.0600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.2955
    Cell Significance Index: -36.1200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.7741
    Cell Significance Index: -34.2200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.9432
    Cell Significance Index: -30.5400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.2308
    Cell Significance Index: -36.4300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.3779
    Cell Significance Index: -11.7700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7358
    Cell Significance Index: 348.2000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.3441
    Cell Significance Index: 10.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.2706
    Cell Significance Index: 71.3000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.2420
    Cell Significance Index: 445.4800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.1804
    Cell Significance Index: 74.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.1756
    Cell Significance Index: 72.2600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.1392
    Cell Significance Index: 27.3200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0910
    Cell Significance Index: 216.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9601
    Cell Significance Index: 866.8900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.7581
    Cell Significance Index: 16.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6310
    Cell Significance Index: 120.0900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5507
    Cell Significance Index: 89.5700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5280
    Cell Significance Index: 57.4300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5238
    Cell Significance Index: 362.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5181
    Cell Significance Index: 19.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5037
    Cell Significance Index: 22.2800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.4480
    Cell Significance Index: 5.3400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4114
    Cell Significance Index: 74.1700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3550
    Cell Significance Index: 21.3100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2885
    Cell Significance Index: 5.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2852
    Cell Significance Index: 19.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2802
    Cell Significance Index: 21.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2505
    Cell Significance Index: 7.0000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2486
    Cell Significance Index: 31.8700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2360
    Cell Significance Index: 29.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2167
    Cell Significance Index: 11.3800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2138
    Cell Significance Index: 94.5100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1971
    Cell Significance Index: 19.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1431
    Cell Significance Index: 78.1400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1261
    Cell Significance Index: 2.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1162
    Cell Significance Index: 5.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1041
    Cell Significance Index: 14.2900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0937
    Cell Significance Index: 2.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0916
    Cell Significance Index: 58.1600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0704
    Cell Significance Index: 0.9600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0683
    Cell Significance Index: 128.6200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0508
    Cell Significance Index: 0.8700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0416
    Cell Significance Index: 1.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0409
    Cell Significance Index: 62.9300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0289
    Cell Significance Index: 53.2900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0200
    Cell Significance Index: 9.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0138
    Cell Significance Index: 18.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0136
    Cell Significance Index: -0.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0222
    Cell Significance Index: -16.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0286
    Cell Significance Index: -21.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0407
    Cell Significance Index: -2.8200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0427
    Cell Significance Index: -32.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0529
    Cell Significance Index: -29.8100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0638
    Cell Significance Index: -1.8200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0639
    Cell Significance Index: -3.3300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0649
    Cell Significance Index: -40.5000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0877
    Cell Significance Index: -1.9000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0911
    Cell Significance Index: -10.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0982
    Cell Significance Index: -5.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0984
    Cell Significance Index: -28.3000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1087
    Cell Significance Index: -12.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1095
    Cell Significance Index: -18.7000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1191
    Cell Significance Index: -17.3200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1193
    Cell Significance Index: -8.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1364
    Cell Significance Index: -8.8000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1645
    Cell Significance Index: -5.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1668
    Cell Significance Index: -17.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1713
    Cell Significance Index: -36.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1995
    Cell Significance Index: -9.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2121
    Cell Significance Index: -27.4000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2441
    Cell Significance Index: -27.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2876
    Cell Significance Index: -29.9500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2878
    Cell Significance Index: -13.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3298
    Cell Significance Index: -11.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3554
    Cell Significance Index: -21.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3616
    Cell Significance Index: -26.9500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3716
    Cell Significance Index: -29.4300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3950
    Cell Significance Index: -6.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4043
    Cell Significance Index: -12.9500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4428
    Cell Significance Index: -8.7600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4443
    Cell Significance Index: -8.9200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4801
    Cell Significance Index: -15.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4916
    Cell Significance Index: -13.3800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4982
    Cell Significance Index: -13.1000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5055
    Cell Significance Index: -16.1000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.5237
    Cell Significance Index: -7.5200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5352
    Cell Significance Index: -11.3600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.6125
    Cell Significance Index: -4.1500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6701
    Cell Significance Index: -19.2100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6716
    Cell Significance Index: -14.5100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7099
    Cell Significance Index: -24.8700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.7354
    Cell Significance Index: -9.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.7749
    Cell Significance Index: -20.6900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.7996
    Cell Significance Index: -12.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KPNA5 is a 44-kDa protein that belongs to the importin alpha family, which is characterized by its ability to bind to nuclear localization signals (NLS) and facilitate the nuclear import of proteins and RNAs. KPNA5 is specifically expressed in various cell types, including GABAergic cortical interneurons, astrocytes, and neurons, highlighting its critical role in neuronal function and immune regulation. The protein's NLS-binding capacity and nuclear import signal receptor activity enable it to interact with various nuclear import complexes, influencing the regulation of gene expression and cellular signaling pathways. **Pathways and Functions:** KPNA5 is involved in several key pathways, including: 1. **Antiviral mechanism by IFN-stimulated genes:** KPNA5 plays a crucial role in the regulation of IFN-stimulated genes, which are essential for the defense against viral infections. By facilitating the nuclear import of IFN-stimulated genes, KPNA5 contributes to the activation of antiviral signaling pathways. 2. **Cytokine signaling in the immune system:** KPNA5 is involved in the regulation of cytokine signaling, which is critical for the coordination of immune responses. By modulating the nuclear import of cytokine receptors and signaling molecules, KPNA5 influences the activation of immune cells and the regulation of immune responses. 3. **Nuclear import of proteins and RNAs:** KPNA5 is essential for the nuclear import of proteins and RNAs, which is necessary for the regulation of gene expression and cellular signaling pathways. By facilitating the nuclear import of proteins and RNAs, KPNA5 influences the regulation of various cellular processes, including cell growth, differentiation, and survival. 4. **NLS-dependent protein nuclear import complex:** KPNA5 interacts with NLS-binding proteins to form a nuclear import complex, which is responsible for the nuclear import of proteins and RNAs. This complex is essential for the regulation of gene expression and cellular signaling pathways. **Clinical Significance:** KPNA5 has been implicated in various immune system disorders and neurological diseases, including: 1. **Autoimmune disorders:** KPNA5 has been shown to play a role in the regulation of immune responses, and its dysregulation has been implicated in autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis. 2. **Neurological disorders:** KPNA5 has been implicated in the regulation of neuronal function and immune responses, and its dysregulation has been linked to neurological disorders, such as Parkinson's disease and Alzheimer's disease. 3. **Infectious diseases:** KPNA5 has been shown to play a role in the regulation of antiviral signaling pathways, and its dysregulation has been implicated in infectious diseases, such as HIV and influenza. In conclusion, KPNA5 is a multifunctional protein that plays a critical role in immune regulation, viral defense, and neuronal function. Its dysregulation has been implicated in various immune system disorders and neurological diseases, highlighting the importance of KPNA5 in maintaining cellular homeostasis and immune function. Further studies are necessary to elucidate the mechanisms by which KPNA5 regulates immune responses and neuronal function, and to explore its potential as a therapeutic target for the treatment of immune system disorders and neurological diseases.

Genular Protein ID: 3076834017

Symbol: IMA6_HUMAN

Name: Karyopherin subunit alpha-5

UniProtKB Accession Codes:

O15131 B2RAI5 Q86X23

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 6 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9395085

Title: Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family.

PubMed ID: 9395085

DOI: 10.1016/s0014-5793(97)01265-9

PubMed ID: 12740372

Title: Importin alpha nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein.

PubMed ID: 12740372

DOI: 10.1074/jbc.m303571200

PubMed ID: 12610148

Title: A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway.

PubMed ID: 12610148

DOI: 10.1128/jvi.77.6.3734-3748.2003

PubMed ID: 17928350

Title: Ebola virus VP24 proteins inhibit the interaction of NPI-1 subfamily karyopherin alpha proteins with activated STAT1.

PubMed ID: 17928350

DOI: 10.1128/jvi.01097-07

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 539
  • Mass: 60666
  • Checksum: 6A2B71FEEA7E1B1F
  • Sequence:
    • MDAMASPGKD NYRMKSYKNK ALNPQEMRRR REEEGIQLRK QKREEQLFKR RNVYLPRNDE 
SMLESPIQDP DISSTVPIPE EEVVTTDMVQ MIFSNNADQQ LTATQKFRKL LSKEPNPPID 
QVIQKPGVVQ RFVKFLERNE NCTLQFEAAW ALTNIASGTF LHTKVVIETG AVPIFIKLLN 
SEHEDVQEQA VWALGNIAGD NAECRDFVLN CEILPPLLEL LTNSNRLTTT RNAVWALSNL 
CRGKNPPPNF SKVSPCLNVL SRLLFSSDPD VLADVCWALS YLSDGPNDKI QAVIDSGVCR 
RLVELLMHND YKVVSPALRA VGNIVTGDDI QTQVILNCSA LPCLLHLLSS PKESIRKEAC 
WTVSNITAGN RAQIQAVIDA NIFPVLIEIL QKAEFRTRKE AAWAITNATS GGTPEQIRYL 
VALGCIKPLC DLLTVMDSKI VQVALNGLEN ILRLGEQESK QNGIGINPYC ALIEEAYGLD 
KIEFLQSHEN QEIYQKAFDL IEHYFGVEED DPSIVPQVDE NQQQFIFQQQ EAPMDGFQL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.