Details for: KRTAP5 9

Gene ID: 3846

Symbol: KRTAP5 9

Ensembl ID: ENSG00000254997

Description: keratin associated protein 5-9

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: T cell (CL0000084)
    Fold Change: 2.53
    Marker Score: 4370
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.37
    Marker Score: 2382.5
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.21
    Marker Score: 1522
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.01
    Marker Score: 2004
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.98
    Marker Score: 2211
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1180
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.39
    Marker Score: 879
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.28
    Marker Score: 864
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.19
    Marker Score: 494
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4825
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.06
    Marker Score: 1008
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 805
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.01
    Marker Score: 462
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 516
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71837
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48062
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 469
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.97
    Marker Score: 6470
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.95
    Marker Score: 380
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5355
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.92
    Marker Score: 332
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.84
    Marker Score: 488
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 713
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 403
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 469
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.73
    Marker Score: 1166
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 183
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.65
    Marker Score: 393
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.64
    Marker Score: 508
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 152
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 237
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 178
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 283
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.44
    Marker Score: 251
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.39
    Marker Score: 125
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.38
    Marker Score: 378
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.29
    Marker Score: 542
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.25
    Marker Score: 148
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 76
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 120
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.19
    Marker Score: 273
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.19
    Marker Score: 382
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 44
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.16
    Marker Score: 154
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.13
    Marker Score: 88
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.12
    Marker Score: 176
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.12
    Marker Score: 1834
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.11
    Marker Score: 59
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.1
    Marker Score: 133.5
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.1
    Marker Score: 63
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.09
    Marker Score: 91
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.09
    Marker Score: 182
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.08
    Marker Score: 96
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.06
    Marker Score: 13
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.06
    Marker Score: 35
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.04
    Marker Score: 72
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.04
    Marker Score: 29
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.04
    Marker Score: 35
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.04
    Marker Score: 70
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.04
    Marker Score: 109
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.03
    Marker Score: 141
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.03
    Marker Score: 30
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.03
    Marker Score: 33
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.03
    Marker Score: 43
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.03
    Marker Score: 62
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.03
    Marker Score: 62
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.03
    Marker Score: 32
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.03
    Marker Score: 33
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.02
    Marker Score: 23
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.02
    Marker Score: 66
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.02
    Marker Score: 13

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Other Information

## Summary KRTAP5 is a keratin associated protein that is highly expressed in the skin, hair, and nails of humans and other animals. It is a key component of the intermediate filament network, which is a complex meshwork of intermediate filaments that helps to maintain the structural integrity of the skin, hair, and nails. ## Key characteristics * KRTAP5 is a transmembrane protein that is expressed in the cytoplasm of cells. * It is a member of the keratin family of proteins, which are involved in the formation of the intermediate filament network. * KRTAP5 is a highly conserved protein, with a similar sequence found in mammals, birds, and fish. * It is a key regulator of the expression of other keratin proteins, which are responsible for the structure and integrity of the skin, hair, and nails. ## Pathways and functions KRTAP5 is involved in a variety of cellular processes, including: * **Cytosol:** KRTAP5 is a cytoskeletal protein that helps to maintain the structural integrity of the cell. * **Developmental biology:** KRTAP5 is essential for the development of the skin, hair, and nails. * **Epidermis development:** KRTAP5 is expressed in the skin and hair of humans and other animals. It is involved in the formation of the basal layer of the skin, which is the layer of cells that gives rise to the epidermis. * **Immunology:** KRTAP5 is a key component of the intermediate filament network, which is a complex meshwork of intermediate filaments that helps to maintain the structural integrity of the skin, hair, and nails. It is involved in the recruitment of immune cells to the skin and in the regulation of inflammation. ## Clinical significance Mutations in KRTAP5 have been linked to a number of skin conditions, including: * **Ehlers-Danlos syndrome:** Ehlers-Danlos syndrome is a genetic disorder that causes the skin to be fragile and prone to tearing. Mutations in KRTAP5 are a major cause of Ehlers-Danlos syndrome. * **Keratosis Pilaris:** Keratosis Pilaris is a skin condition that causes small, raised, flesh-colored or red bumps on the face and neck. Mutations in KRTAP5 are a major cause of Keratosis Pilaris. * **Psoriasis:** Psoriasis is a chronic skin condition that causes red, scaly patches of skin. Mutations in KRTAP5 are a major cause of psoriasis.

Genular Protein ID: 3077076838

Symbol: KRA59_HUMAN

Name: Keratin-associated protein 5-9

UniProtKB Accession Codes:

P26371 Q14564 Q3MIP8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 GO 4 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PIR 1 PRO 1 PathwayCommons 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1703541

Title: Structure and expression of genes for a class of cysteine-rich proteins of the cuticle layers of differentiating wool and hair follicles.

PubMed ID: 1703541

DOI: 10.1083/jcb.111.6.2587

PubMed ID: 10023043

Title: Genomic organization and promoter characterization of two human UHS keratin genes.

PubMed ID: 10023043

DOI: 10.1016/s0378-1119(98)00616-7

PubMed ID: 15144888

Title: Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11.

PubMed ID: 15144888

DOI: 10.1016/j.bbrc.2004.04.074

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 169
  • Mass: 16276
  • Checksum: 219B14FEEB49D4AB
  • Sequence:
    • MGCCGCSGGC GSSCGGCDSS CGSCGSGCRG CGPSCCAPVY CCKPVCCCVP ACSCSSCGKR 
GCGSCGGSKG GCGSCGCSQC SCCKPCCCSS GCGSSCCQCS CCKPYCSQCS CCKPCCSSSG 
RGSSCCQSSC CKPCCSSSGC GSSCCQSSCC KPCCSQSRCC VPVCYQCKI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.