Details for: KRTAP5 9

Gene ID: 3846

Symbol: KRTAP5 9

Ensembl ID: ENSG00000254997

Description: keratin associated protein 5-9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.4671
    Cell Significance Index: 89.9500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3527
    Cell Significance Index: 29.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0513
    Cell Significance Index: 54.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.6594
    Cell Significance Index: 21.1200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4803
    Cell Significance Index: 91.4100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3461
    Cell Significance Index: 7.3700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3241
    Cell Significance Index: 32.0700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2455
    Cell Significance Index: 221.6500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2093
    Cell Significance Index: 12.5600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2015
    Cell Significance Index: 21.9200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1992
    Cell Significance Index: 3.1600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1648
    Cell Significance Index: 26.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1014
    Cell Significance Index: 7.0100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0785
    Cell Significance Index: 1.3200
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.0756
    Cell Significance Index: 1.0500
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.0548
    Cell Significance Index: 0.6800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0253
    Cell Significance Index: 0.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0246
    Cell Significance Index: 4.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0121
    Cell Significance Index: 0.3500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0104
    Cell Significance Index: 0.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0040
    Cell Significance Index: 0.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0028
    Cell Significance Index: 0.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0024
    Cell Significance Index: 0.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0007
    Cell Significance Index: -0.4900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0010
    Cell Significance Index: -1.9100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0012
    Cell Significance Index: -2.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0015
    Cell Significance Index: -0.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0016
    Cell Significance Index: -2.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0018
    Cell Significance Index: -1.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0020
    Cell Significance Index: -0.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0024
    Cell Significance Index: -1.7800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0026
    Cell Significance Index: -1.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0027
    Cell Significance Index: -1.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0037
    Cell Significance Index: -1.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0042
    Cell Significance Index: -1.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0043
    Cell Significance Index: -0.2000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0055
    Cell Significance Index: -0.5600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0056
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0064
    Cell Significance Index: -1.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0067
    Cell Significance Index: -1.3200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0068
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0084
    Cell Significance Index: -0.9600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0084
    Cell Significance Index: -0.2300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0101
    Cell Significance Index: -0.2700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0106
    Cell Significance Index: -0.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0110
    Cell Significance Index: -1.2800
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0116
    Cell Significance Index: -0.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0122
    Cell Significance Index: -1.7700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0136
    Cell Significance Index: -0.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0139
    Cell Significance Index: -1.9100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0140
    Cell Significance Index: -0.2900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0175
    Cell Significance Index: -0.2500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0188
    Cell Significance Index: -0.2700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0199
    Cell Significance Index: -0.3000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0205
    Cell Significance Index: -0.4300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0217
    Cell Significance Index: -0.2000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0227
    Cell Significance Index: -0.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0231
    Cell Significance Index: -1.5500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0231
    Cell Significance Index: -0.3700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0233
    Cell Significance Index: -0.3100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0237
    Cell Significance Index: -0.8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0243
    Cell Significance Index: -1.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0266
    Cell Significance Index: -1.4900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0276
    Cell Significance Index: -0.6900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0282
    Cell Significance Index: -0.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0312
    Cell Significance Index: -1.9200
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0314
    Cell Significance Index: -0.4300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0323
    Cell Significance Index: -0.4900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0330
    Cell Significance Index: -0.4500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0337
    Cell Significance Index: -0.4100
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.0353
    Cell Significance Index: -0.4000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0359
    Cell Significance Index: -0.7000
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0369
    Cell Significance Index: -0.4000
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0379
    Cell Significance Index: -0.6100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0386
    Cell Significance Index: -1.2300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0394
    Cell Significance Index: -1.2900
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0394
    Cell Significance Index: -0.4300
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.0400
    Cell Significance Index: -0.4500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0400
    Cell Significance Index: -0.4400
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.0418
    Cell Significance Index: -0.4000
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0420
    Cell Significance Index: -0.5600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0428
    Cell Significance Index: -0.3300
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0435
    Cell Significance Index: -0.4500
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0436
    Cell Significance Index: -0.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0442
    Cell Significance Index: -2.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0449
    Cell Significance Index: -2.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0477
    Cell Significance Index: -2.1100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0497
    Cell Significance Index: -1.2400
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0506
    Cell Significance Index: -0.3300
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0515
    Cell Significance Index: -0.6600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0538
    Cell Significance Index: -1.4400
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0540
    Cell Significance Index: -0.5600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0545
    Cell Significance Index: -0.6900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0569
    Cell Significance Index: -0.8100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0571
    Cell Significance Index: -1.2500
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0571
    Cell Significance Index: -0.4100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0574
    Cell Significance Index: -1.6900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0584
    Cell Significance Index: -2.2100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0586
    Cell Significance Index: -0.6800
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0588
    Cell Significance Index: -0.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KRTAP5-9 is a small, acidic protein that belongs to the KAP family, which consists of six members. The protein is characterized by its ability to interact with intermediate filaments, particularly keratins, and its expression is tightly regulated during development and tissue differentiation. KRTAP5-9 is predominantly expressed in epithelial cells, including those of the skin, gut, and respiratory tract, where it plays a crucial role in maintaining epithelial barrier function and promoting keratinization. **Pathways and Functions:** KRTAP5-9 is involved in several key pathways that regulate epithelial homeostasis and immune function. These include: 1. **Keratinization:** KRTAP5-9 is essential for the process of keratinization, which involves the formation of intermediate filaments that provide mechanical strength and structural integrity to epithelial cells. 2. **Protein binding:** KRTAP5-9 interacts with various proteins, including keratins, and other KAPs, to regulate protein-protein interactions and maintain cytoskeletal organization. 3. **Cytoskeletal organization:** KRTAP5-9 plays a role in regulating the dynamics of the cytoskeleton, which is essential for maintaining epithelial barrier function and responding to environmental stimuli. 4. **Immune response:** KRTAP5-9 is expressed in immune cells, including T cells and dendritic cells, where it may play a role in regulating immune function and tissue homeostasis. **Clinical Significance:** Dysregulation of KRTAP5-9 expression has been implicated in various diseases, including: 1. **Epidermolysis bullosa:** Mutations in the KRTAP5-9 gene have been associated with epidermolysis bullosa, a genetic disorder characterized by blistering skin lesions. 2. **Cancer:** Alterations in KRTAP5-9 expression have been observed in various types of cancer, including colorectal and breast cancer. 3. **Autoimmune diseases:** KRTAP5-9 may play a role in regulating immune function and tissue homeostasis, and dysregulation of this gene may contribute to autoimmune diseases, such as psoriasis and rheumatoid arthritis. In conclusion, KRTAP5-9 is a critical regulator of epithelial homeostasis and immune function, and its dysregulation has been implicated in various diseases. Further studies are needed to fully elucidate the molecular mechanisms underlying KRTAP5-9's functions and to explore its potential as a therapeutic target for disease prevention and treatment.

Genular Protein ID: 3077076838

Symbol: KRA59_HUMAN

Name: Keratin-associated protein 5-9

UniProtKB Accession Codes:

P26371 Q14564 Q3MIP8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 EMBL 6 Ensembl 1 GO 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PIR 1 PRO 1 PathwayCommons 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1703541

Title: Structure and expression of genes for a class of cysteine-rich proteins of the cuticle layers of differentiating wool and hair follicles.

PubMed ID: 1703541

DOI: 10.1083/jcb.111.6.2587

PubMed ID: 10023043

Title: Genomic organization and promoter characterization of two human UHS keratin genes.

PubMed ID: 10023043

DOI: 10.1016/s0378-1119(98)00616-7

PubMed ID: 15144888

Title: Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11.

PubMed ID: 15144888

DOI: 10.1016/j.bbrc.2004.04.074

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 169
  • Mass: 16276
  • Checksum: 219B14FEEB49D4AB
  • Sequence:
    • MGCCGCSGGC GSSCGGCDSS CGSCGSGCRG CGPSCCAPVY CCKPVCCCVP ACSCSSCGKR 
GCGSCGGSKG GCGSCGCSQC SCCKPCCCSS GCGSSCCQCS CCKPYCSQCS CCKPCCSSSG 
RGSSCCQSSC CKPCCSSSGC GSSCCQSSCC KPCCSQSRCC VPVCYQCKI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.