Details for: LECT2

Gene ID: 3950

Symbol: LECT2

Ensembl ID: ENSG00000145826

Description: leukocyte cell derived chemotaxin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 7.7322
    Cell Significance Index: 130.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8472
    Cell Significance Index: 168.1300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.6376
    Cell Significance Index: 15.4500
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.4299
    Cell Significance Index: 3.9900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.2500
    Cell Significance Index: 3.6900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.2455
    Cell Significance Index: 4.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2084
    Cell Significance Index: 283.3300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1683
    Cell Significance Index: 4.5100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1208
    Cell Significance Index: 1.7300
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.0678
    Cell Significance Index: 0.7200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0648
    Cell Significance Index: 23.2400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.0615
    Cell Significance Index: 0.8500
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.0599
    Cell Significance Index: 0.6600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0579
    Cell Significance Index: 0.9900
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.0488
    Cell Significance Index: 0.4300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.0481
    Cell Significance Index: 0.6000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0470
    Cell Significance Index: 1.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0416
    Cell Significance Index: 6.0500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0310
    Cell Significance Index: 0.4400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0278
    Cell Significance Index: 0.8800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0129
    Cell Significance Index: 0.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0094
    Cell Significance Index: 17.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0048
    Cell Significance Index: 7.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0037
    Cell Significance Index: 0.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0036
    Cell Significance Index: 6.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0033
    Cell Significance Index: 0.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0015
    Cell Significance Index: 0.0700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0006
    Cell Significance Index: 0.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0007
    Cell Significance Index: -0.1000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0016
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0020
    Cell Significance Index: -1.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0024
    Cell Significance Index: -1.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0024
    Cell Significance Index: -0.7000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0031
    Cell Significance Index: -1.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0033
    Cell Significance Index: -1.5000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0049
    Cell Significance Index: -0.1900
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.0069
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0079
    Cell Significance Index: -1.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0081
    Cell Significance Index: -1.7100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0099
    Cell Significance Index: -0.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0116
    Cell Significance Index: -2.1000
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.0120
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0149
    Cell Significance Index: -1.7100
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: -0.0152
    Cell Significance Index: -0.0400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0162
    Cell Significance Index: -1.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0163
    Cell Significance Index: -2.0000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0182
    Cell Significance Index: -0.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0187
    Cell Significance Index: -0.5100
  • Cell Name: diffuse bipolar 3a cell (CL4033029)
    Fold Change: -0.0229
    Cell Significance Index: -0.2800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0231
    Cell Significance Index: -1.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0235
    Cell Significance Index: -0.6600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0242
    Cell Significance Index: -0.5800
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.0247
    Cell Significance Index: -0.1300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0248
    Cell Significance Index: -0.5200
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0267
    Cell Significance Index: -0.2200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0272
    Cell Significance Index: -0.5300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0277
    Cell Significance Index: -0.3800
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0289
    Cell Significance Index: -0.3000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0300
    Cell Significance Index: -0.4000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0331
    Cell Significance Index: -0.4000
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0344
    Cell Significance Index: -0.1800
  • Cell Name: unipolar brush cell (CL4023161)
    Fold Change: -0.0350
    Cell Significance Index: -0.3400
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0353
    Cell Significance Index: -0.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0356
    Cell Significance Index: -2.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0362
    Cell Significance Index: -1.7000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0376
    Cell Significance Index: -0.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0382
    Cell Significance Index: -1.6900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0390
    Cell Significance Index: -0.3700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0394
    Cell Significance Index: -1.3800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0394
    Cell Significance Index: -0.5100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0396
    Cell Significance Index: -0.4100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0398
    Cell Significance Index: -0.8600
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0406
    Cell Significance Index: -0.4700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0409
    Cell Significance Index: -1.3400
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0415
    Cell Significance Index: -0.5600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0418
    Cell Significance Index: -1.3300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0426
    Cell Significance Index: -0.4800
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.0429
    Cell Significance Index: -0.6100
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.0430
    Cell Significance Index: -0.5100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0439
    Cell Significance Index: -0.6400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0441
    Cell Significance Index: -1.1600
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0444
    Cell Significance Index: -0.4900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0451
    Cell Significance Index: -0.6300
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0493
    Cell Significance Index: -0.5300
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0504
    Cell Significance Index: -0.5500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0508
    Cell Significance Index: -1.4500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0514
    Cell Significance Index: -0.7800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0538
    Cell Significance Index: -1.0800
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0550
    Cell Significance Index: -0.5500
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0555
    Cell Significance Index: -0.4800
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0564
    Cell Significance Index: -0.5400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0564
    Cell Significance Index: -0.3800
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0577
    Cell Significance Index: -0.5600
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0580
    Cell Significance Index: -0.6000
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.0582
    Cell Significance Index: -0.6100
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0585
    Cell Significance Index: -0.4200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0589
    Cell Significance Index: -1.4700
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0593
    Cell Significance Index: -0.5300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0606
    Cell Significance Index: -1.7900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0606
    Cell Significance Index: -0.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LECT2 is a small chemokine, approximately 9 amino acids in length, which belongs to the CC chemokine family. It is predominantly expressed in the immune system, with notable expression in leukocytes, including T cells, B cells, and dendritic cells. LECT2 is also found in non-immune cells, such as retinal ganglion cells and cardiac endothelial cells, suggesting a broader role in tissue development and homeostasis. **Pathways and Functions:** LEC2 plays a crucial role in chemotaxis, the process by which immune cells migrate towards chemokines. It binds to its receptor, CXCR4, triggering a signaling cascade that regulates cell migration, adhesion, and proliferation. LECT2 has been implicated in various immune responses, including: 1. **T cell development**: LECT2 is essential for the migration and differentiation of T cells in the thymus, ensuring proper immune cell development and function. 2. **Innate immunity**: LECT2 is involved in the recruitment of innate immune cells, such as neutrophils and macrophages, to sites of infection or inflammation. 3. **Adaptive immunity**: LECT2 has been shown to modulate the activity of T cells and B cells, influencing the adaptive immune response. **Clinical Significance:** Dysregulation of LECT2 has been implicated in various diseases, including: 1. **Autoimmune disorders**: Altered expression of LECT2 has been linked to autoimmune diseases, such as multiple sclerosis and type 1 diabetes. 2. **Cancer**: LECT2 has been shown to promote tumor progression and metastasis in certain cancers, including breast and lung cancer. 3. **Neurological disorders**: LECT2 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where dysregulation of chemotaxis and immune responses contribute to disease progression. In conclusion, LECT2 is a crucial chemokine involved in the regulation of immune cell migration, development, and function. Its dysregulation has been implicated in various diseases, highlighting the importance of LECT2 in maintaining immune homeostasis and preventing disease. Further research is necessary to fully elucidate the mechanisms by which LECT2 influences immune responses and to explore its therapeutic potential in disease treatment.

Genular Protein ID: 2042319064

Symbol: LECT2_HUMAN

Name: Leukocyte cell-derived chemotaxin-2

UniProtKB Accession Codes:

O14960 B2RA90 O14565 Q52M49

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 3 DNASU 1 DisGeNET 1 EMBL 7 EMDB 1 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 9524238

Title: Molecular cloning of human and bovine LECT2 having a neutrophil chemotactic activity and its specific expression in the liver.

PubMed ID: 9524238

DOI: 10.1016/s0167-4781(97)00181-4

PubMed ID: 9545637

Title: Molecular cloning, structural characterization, and chromosomal mapping of the human LECT2 gene.

PubMed ID: 9545637

DOI: 10.1006/geno.1997.5198

PubMed ID: 9832057

Title: Systemic expression of a newly recognized protein, LECT2, in the human body.

PubMed ID: 9832057

DOI: 10.1111/j.1440-1827.1998.tb03855.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8877413

Title: Purification and primary amino acid sequence of a novel neutrophil chemotactic factor LECT2.

PubMed ID: 8877413

DOI: 10.1016/0165-2478(96)02572-2

PubMed ID: 20103838

Title: Identification and assignment of three disulfide bonds in mammalian leukocyte cell-derived chemotaxin 2 by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

PubMed ID: 20103838

PubMed ID: 27334921

Title: Crystal structure of human leukocyte cell-derived chemotaxin 2 (LECT2) reveals a mechanistic basis of functional evolution in a mammalian protein with an M23 metalloendopeptidase fold.

PubMed ID: 27334921

DOI: 10.1074/jbc.m116.720375

Sequence Information:

  • Length: 151
  • Mass: 16390
  • Checksum: 3C1DFCA1B4F8792F
  • Sequence:
    • MFSTKALLLA GLISTALAGP WANICAGKSS NEIRTCDRHG CGQYSAQRSQ RPHQGVDILC 
SAGSTVYAPF TGMIVGQEKP YQNKNAINNG VRISGRGFCV KMFYIKPIKY KGPIKKGEKL 
GTLLPLQKVY PGIQSHVHIE NCDSSDPTAY L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.