Details for: LGALS9
Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.56
Marker Score: 143370 - Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 2.54
Marker Score: 4942 - Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.2
Marker Score: 56315 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 2.14
Marker Score: 13660 - Cell Name: pro-T cell (CL0000827)
Fold Change: 2
Marker Score: 8198 - Cell Name: non-classical monocyte (CL0000875)
Fold Change: 1.99
Marker Score: 4810 - Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 1.98
Marker Score: 1435 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.95
Marker Score: 1073 - Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 1.91
Marker Score: 2297 - Cell Name: colon epithelial cell (CL0011108)
Fold Change: 1.9
Marker Score: 5973 - Cell Name: intestine goblet cell (CL0019031)
Fold Change: 1.89
Marker Score: 1813 - Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 1.82
Marker Score: 585 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.76
Marker Score: 17797.5 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.75
Marker Score: 1762 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.73
Marker Score: 1730 - Cell Name: late pro-B cell (CL0002048)
Fold Change: 1.67
Marker Score: 1972.5 - Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 1.67
Marker Score: 695 - Cell Name: lung macrophage (CL1001603)
Fold Change: 1.59
Marker Score: 1820 - Cell Name: blood cell (CL0000081)
Fold Change: 1.57
Marker Score: 18215.5 - Cell Name: B-1 B cell (CL0000819)
Fold Change: 1.52
Marker Score: 2643 - Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.48
Marker Score: 3826 - Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 1.47
Marker Score: 4053 - Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.4
Marker Score: 3813 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.4
Marker Score: 3492 - Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 1.4
Marker Score: 489 - Cell Name: elicited macrophage (CL0000861)
Fold Change: 1.35
Marker Score: 8202 - Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 1.28
Marker Score: 881 - Cell Name: dendritic cell, human (CL0001056)
Fold Change: 1.24
Marker Score: 1264 - Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.23
Marker Score: 2802 - Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 1.23
Marker Score: 462 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.19
Marker Score: 1181.5 - Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 1.16
Marker Score: 567.5 - Cell Name: dendritic cell (CL0000451)
Fold Change: 1.13
Marker Score: 776 - Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 1.13
Marker Score: 770 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.11
Marker Score: 2265 - Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 1.11
Marker Score: 8227 - Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 1.1
Marker Score: 831 - Cell Name: enterocyte (CL0000584)
Fold Change: 1.1
Marker Score: 5267 - Cell Name: mucus secreting cell (CL0000319)
Fold Change: 1.1
Marker Score: 279 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.06
Marker Score: 306 - Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 1.04
Marker Score: 515 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: 1.03
Marker Score: 482.5 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.02
Marker Score: 1941.5 - Cell Name: naive B cell (CL0000788)
Fold Change: 1.02
Marker Score: 910 - Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 1.02
Marker Score: 352 - Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 1.01
Marker Score: 996 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71706 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47931 - Cell Name: immature B cell (CL0000816)
Fold Change: 0.98
Marker Score: 650 - Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.98
Marker Score: 246 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30395 - Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.98
Marker Score: 225 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2399 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.94
Marker Score: 486 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.93
Marker Score: 441 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.92
Marker Score: 586 - Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.92
Marker Score: 617 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5231 - Cell Name: decidual cell (CL2000002)
Fold Change: 0.91
Marker Score: 3938 - Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.91
Marker Score: 263 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.91
Marker Score: 450 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2709 - Cell Name: Leydig cell (CL0000178)
Fold Change: 0.9
Marker Score: 970 - Cell Name: classical monocyte (CL0000860)
Fold Change: 0.9
Marker Score: 3722 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.89
Marker Score: 221 - Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 0.88
Marker Score: 760 - Cell Name: stem cell (CL0000034)
Fold Change: 0.88
Marker Score: 2094 - Cell Name: Unknown (CL0000548)
Fold Change: 0.88
Marker Score: 642 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.87
Marker Score: 314 - Cell Name: osteoclast (CL0000092)
Fold Change: 0.87
Marker Score: 433 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.86
Marker Score: 5239 - Cell Name: centrocyte (CL0009111)
Fold Change: 0.86
Marker Score: 205 - Cell Name: mature T cell (CL0002419)
Fold Change: 0.86
Marker Score: 8534 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.86
Marker Score: 585 - Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.86
Marker Score: 806 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.85
Marker Score: 1251 - Cell Name: pro-B cell (CL0000826)
Fold Change: 0.84
Marker Score: 812 - Cell Name: macrophage (CL0000235)
Fold Change: 0.84
Marker Score: 935 - Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.83
Marker Score: 488 - Cell Name: secretory cell (CL0000151)
Fold Change: 0.83
Marker Score: 1515 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.82
Marker Score: 433 - Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.82
Marker Score: 283 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.81
Marker Score: 12666.5 - Cell Name: microglial cell (CL0000129)
Fold Change: 0.79
Marker Score: 1440 - Cell Name: club cell (CL0000158)
Fold Change: 0.78
Marker Score: 916 - Cell Name: eurydendroid cell (CL0000253)
Fold Change: 0.78
Marker Score: 320 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.78
Marker Score: 596 - Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.78
Marker Score: 381.5 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1261 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.78
Marker Score: 311 - Cell Name: Langerhans cell (CL0000453)
Fold Change: 0.77
Marker Score: 230 - Cell Name: monocyte (CL0000576)
Fold Change: 0.76
Marker Score: 984 - Cell Name: paneth cell (CL0000510)
Fold Change: 0.75
Marker Score: 523 - Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.75
Marker Score: 197 - Cell Name: endothelial cell (CL0000115)
Fold Change: 0.74
Marker Score: 662 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.74
Marker Score: 381 - Cell Name: germinal center B cell (CL0000844)
Fold Change: 0.73
Marker Score: 444 - Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 0.73
Marker Score: 177 - Cell Name: myeloid cell (CL0000763)
Fold Change: 0.72
Marker Score: 1160 - Cell Name: lung secretory cell (CL1000272)
Fold Change: 0.72
Marker Score: 643
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Other Information
Genular Protein ID: 3522390391
Symbol: LEG9_HUMAN
Name: Galectin-9
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9045665
Title: Molecular definition of a novel human galectin which is immunogenic in patients with Hodgkin's disease.
PubMed ID: 9045665
PubMed ID: 9642261
Title: Human ecalectin, a variant of human galectin-9, is a novel eosinophil chemoattractant produced by T lymphocytes.
PubMed ID: 9642261
PubMed ID: 16625196
Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
PubMed ID: 16625196
DOI: 10.1038/nature04689
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 16116184
Title: Galectin-9 induces maturation of human monocyte-derived dendritic cells.
PubMed ID: 16116184
PubMed ID: 16286920
Title: The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity.
PubMed ID: 16286920
DOI: 10.1038/ni1271
PubMed ID: 20209097
Title: A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection.
PubMed ID: 20209097
PubMed ID: 21670307
Title: Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry.
PubMed ID: 21670307
PubMed ID: 23242525
Title: Profiling Lgals9 splice variant expression at the fetal-maternal interface: implications in normal and pathological human pregnancy.
PubMed ID: 23242525
PubMed ID: 23817958
Title: Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation.
PubMed ID: 23817958
PubMed ID: 23408620
Title: Galectin-9 functionally impairs natural killer cells in humans and mice.
PubMed ID: 23408620
DOI: 10.1128/jvi.01085-12
PubMed ID: 24786365
Title: Galectin-9 is rapidly released during acute HIV-1 infection and remains sustained at high levels despite viral suppression even in elite controllers.
PubMed ID: 24786365
PubMed ID: 24333696
Title: Endothelial LGALS9 splice variant expression in endothelial cell biology and angiogenesis.
PubMed ID: 24333696
PubMed ID: 24465902
Title: Galectin-9 enhances cytokine secretion, but suppresses survival and degranulation, in human mast cell line.
PubMed ID: 24465902
PubMed ID: 25578313
Title: The Galectin-9/Tim-3 pathway is involved in the regulation of NK cell function at the maternal-fetal interface in early pregnancy.
PubMed ID: 25578313
DOI: 10.1038/cmi.2014.126
PubMed ID: 25754930
Title: Up-regulation of galectin-9 induces cell migration in human dendritic cells infected with dengue virus.
PubMed ID: 25754930
DOI: 10.1111/jcmm.12500
PubMed ID: 18005988
Title: Structural analysis of the human galectin-9 N-terminal carbohydrate recognition domain reveals unexpected properties that differ from the mouse orthologue.
PubMed ID: 18005988
PubMed ID: 18977853
Title: Structural analysis of the recognition mechanism of poly-N-acetyllactosamine by the human galectin-9 N-terminal carbohydrate recognition domain.
PubMed ID: 18977853
PubMed ID: 20861009
Title: X-ray structures of human galectin-9 C-terminal domain in complexes with a biantennary oligosaccharide and sialyllactose.
PubMed ID: 20861009
Sequence Information:
- Length: 355
- Mass: 39518
- Checksum: 4748C22FCAFA536A
- Sequence:
MAFSGSQAPY LSPAVPFSGT IQGGLQDGLQ ITVNGTVLSS SGTRFAVNFQ TGFSGNDIAF HFNPRFEDGG YVVCNTRQNG SWGPEERKTH MPFQKGMPFD LCFLVQSSDF KVMVNGILFV QYFHRVPFHR VDTISVNGSV QLSYISFQNP RTVPVQPAFS TVPFSQPVCF PPRPRGRRQK PPGVWPANPA PITQTVIHTV QSAPGQMFST PAIPPMMYPH PAYPMPFITT ILGGLYPSKS ILLSGTVLPS AQRFHINLCS GNHIAFHLNP RFDENAVVRN TQIDNSWGSE ERSLPRKMPF VRGQSFSVWI LCEAHCLKVA VDGQHLFEYY HRLRNLPTIN RLEVGGDIQL THVQT
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.