Details for: LIMK1

Gene ID: 3984

Symbol: LIMK1

Ensembl ID: ENSG00000106683

Description: LIM domain kinase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 98.1065
    Cell Significance Index: -15.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 57.8371
    Cell Significance Index: -14.6700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 34.4732
    Cell Significance Index: -14.0100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.3849
    Cell Significance Index: -15.2700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.9573
    Cell Significance Index: -13.2800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.8874
    Cell Significance Index: -15.3400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8461
    Cell Significance Index: 161.0200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7798
    Cell Significance Index: 10.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7149
    Cell Significance Index: 143.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5674
    Cell Significance Index: 56.1300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4389
    Cell Significance Index: 12.5800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4002
    Cell Significance Index: 276.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3991
    Cell Significance Index: 360.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3491
    Cell Significance Index: 41.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3350
    Cell Significance Index: 120.1600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3012
    Cell Significance Index: 49.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3003
    Cell Significance Index: 35.0000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3002
    Cell Significance Index: 19.3700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2969
    Cell Significance Index: 32.2900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2677
    Cell Significance Index: 16.0700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2580
    Cell Significance Index: 5.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1952
    Cell Significance Index: 38.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1769
    Cell Significance Index: 25.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1769
    Cell Significance Index: 24.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1349
    Cell Significance Index: 6.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1094
    Cell Significance Index: 7.5700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1031
    Cell Significance Index: 56.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0952
    Cell Significance Index: 17.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0674
    Cell Significance Index: 5.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0626
    Cell Significance Index: 7.7000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0605
    Cell Significance Index: 1.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0488
    Cell Significance Index: 2.3000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0452
    Cell Significance Index: 1.2900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0437
    Cell Significance Index: 1.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0364
    Cell Significance Index: 0.9100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0327
    Cell Significance Index: 2.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0264
    Cell Significance Index: 11.6900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0199
    Cell Significance Index: 0.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0169
    Cell Significance Index: 0.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0129
    Cell Significance Index: 24.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0072
    Cell Significance Index: 13.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0066
    Cell Significance Index: 10.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0049
    Cell Significance Index: 0.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0021
    Cell Significance Index: 0.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0017
    Cell Significance Index: 2.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0008
    Cell Significance Index: -0.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0040
    Cell Significance Index: -0.4600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0064
    Cell Significance Index: -0.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0164
    Cell Significance Index: -12.4300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0174
    Cell Significance Index: -12.7500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0198
    Cell Significance Index: -14.6300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0217
    Cell Significance Index: -1.2200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0243
    Cell Significance Index: -0.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0247
    Cell Significance Index: -11.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0254
    Cell Significance Index: -14.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0271
    Cell Significance Index: -1.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0274
    Cell Significance Index: -17.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0329
    Cell Significance Index: -5.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0359
    Cell Significance Index: -3.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0359
    Cell Significance Index: -4.6400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0438
    Cell Significance Index: -1.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0443
    Cell Significance Index: -2.3000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0468
    Cell Significance Index: -2.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0473
    Cell Significance Index: -2.0900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0536
    Cell Significance Index: -15.4200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0776
    Cell Significance Index: -2.9400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0790
    Cell Significance Index: -5.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0818
    Cell Significance Index: -17.2400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0858
    Cell Significance Index: -1.8200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0942
    Cell Significance Index: -2.2600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0966
    Cell Significance Index: -5.9200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1005
    Cell Significance Index: -2.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1029
    Cell Significance Index: -7.6700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1084
    Cell Significance Index: -2.8500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1225
    Cell Significance Index: -2.0500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1236
    Cell Significance Index: -8.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1419
    Cell Significance Index: -14.7700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1589
    Cell Significance Index: -2.2300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1595
    Cell Significance Index: -4.1000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1609
    Cell Significance Index: -4.3800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1668
    Cell Significance Index: -8.7600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1704
    Cell Significance Index: -2.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1739
    Cell Significance Index: -10.9600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1760
    Cell Significance Index: -3.6500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1866
    Cell Significance Index: -5.9800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1867
    Cell Significance Index: -14.7900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2019
    Cell Significance Index: -5.4000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2220
    Cell Significance Index: -7.0700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2473
    Cell Significance Index: -4.8900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2514
    Cell Significance Index: -8.2300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2692
    Cell Significance Index: -5.4100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2693
    Cell Significance Index: -6.5700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2912
    Cell Significance Index: -10.2000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2934
    Cell Significance Index: -6.3400
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2962
    Cell Significance Index: -2.4500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3112
    Cell Significance Index: -3.8600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3260
    Cell Significance Index: -11.3300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.3319
    Cell Significance Index: -5.4700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3336
    Cell Significance Index: -4.2100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3360
    Cell Significance Index: -4.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** LIMK1 is a serine/threonine kinase enzyme that belongs to the LIM kinase family. It is characterized by its ability to phosphorylate and regulate the activity of actin-binding proteins, such as cofilin and LIM-domain containing proteins. This phosphorylation event leads to the depolymerization of actin filaments, thereby modulating cell migration, adhesion, and axon guidance. LIMK1 is also involved in the regulation of Rho GTPases, which are essential for cell migration, cytoskeleton organization, and axon guidance. **Pathways and Functions** LIMK1 is involved in various signaling pathways, including: 1. **Actin Cytoskeleton Organization**: LIMK1 regulates the formation of actin filaments, stress fibers, and lamellipodia, which are essential for cell migration, adhesion, and axon guidance. 2. **Eph-Ephrin Signaling**: LIMK1 modulates the activity of Eph receptors and ephrin ligands, which are involved in axon guidance and neuronal development. 3. **Fc-gamma Receptor Signaling**: LIMK1 regulates the activity of Fc-gamma receptors, which are involved in phagocytosis and immune response. 4. **Rho GTPase Signaling**: LIMK1 modulates the activity of Rho GTPases, which are essential for cell migration, cytoskeleton organization, and axon guidance. 5. **Stress Fiber Assembly**: LIMK1 regulates the assembly of stress fibers, which are essential for cell migration and adhesion. **Clinical Significance** Dysregulation of LIMK1 has been implicated in various diseases, including: 1. **Neurological Disorders**: LIMK1 has been shown to play a role in the development of neurological disorders, such as autism, schizophrenia, and Parkinson's disease. 2. **Cancer**: LIMK1 has been implicated in the progression of various cancers, including breast, lung, and colon cancer. 3. **Immune System Disorders**: LIMK1 has been shown to play a role in the regulation of the immune response, and dysregulation of LIMK1 has been implicated in autoimmune disorders, such as multiple sclerosis. 4. **Neurodegenerative Diseases**: LIMK1 has been shown to play a role in the development of neurodegenerative diseases, such as Alzheimer's disease and amyotrophic lateral sclerosis (ALS). In conclusion, LIMK1 is a critical regulator of actin dynamics, cell migration, and axon guidance, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of LIMK1 in human disease and to develop therapeutic strategies for the treatment of LIMK1-related disorders.

Genular Protein ID: 2233805992

Symbol: LIMK1_HUMAN

Name: LIM domain kinase 1

UniProtKB Accession Codes:

P53667 B7Z6I8 D3DXF4 D3DXF5 O15283 Q15820 Q15821 Q75MU3 Q9Y5Q1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CPTAC 2 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EC 2 EMBL 13 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 30 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIR 1 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 6 RefSeq 2 Rhea 8 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8183554

Title: Identification of a human cDNA encoding a novel protein kinase with two repeats of the LIM/double zinc finger motif.

PubMed ID: 8183554

PubMed ID: 8689688

Title: LIM-kinase1 hemizygosity implicated in impaired visuospatial constructive cognition.

PubMed ID: 8689688

DOI: 10.1016/s0092-8674(00)80077-x

PubMed ID: 8812460

Title: Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients.

PubMed ID: 8812460

DOI: 10.1006/geno.1996.0469

PubMed ID: 10196227

Title: Structural features of LIM kinase that control effects on the actin cytoskeleton.

PubMed ID: 10196227

DOI: 10.1074/jbc.274.16.11352

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 10559936

Title: Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics.

PubMed ID: 10559936

DOI: 10.1038/12963

PubMed ID: 10436159

Title: Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase.

PubMed ID: 10436159

DOI: 10.1126/science.285.5429.895

PubMed ID: 10652353

Title: Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop.

PubMed ID: 10652353

DOI: 10.1074/jbc.275.5.3577

PubMed ID: 11340065

Title: Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha.

PubMed ID: 11340065

DOI: 10.1074/jbc.c100196200

PubMed ID: 11413130

Title: Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin.

PubMed ID: 11413130

DOI: 10.1074/jbc.m100871200

PubMed ID: 11832213

Title: Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin.

PubMed ID: 11832213

DOI: 10.1016/s0092-8674(01)00638-9

PubMed ID: 12807904

Title: Cell cycle-associated changes in Slingshot phosphatase activity and roles in cytokinesis in animal cells.

PubMed ID: 12807904

DOI: 10.1074/jbc.m305802200

PubMed ID: 14530263

Title: p57Kip2 regulates actin dynamics by binding and translocating LIM-kinase 1 to the nucleus.

PubMed ID: 14530263

DOI: 10.1074/jbc.m309334200

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 15660133

Title: Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin.

PubMed ID: 15660133

DOI: 10.1038/sj.emboj.7600543

PubMed ID: 16230460

Title: Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration.

PubMed ID: 16230460

DOI: 10.1083/jcb.200504029

PubMed ID: 16456544

Title: MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migration.

PubMed ID: 16456544

DOI: 10.1038/sj.emboj.7600973

PubMed ID: 16641196

Title: Hsp90 increases LIM kinase activity by promoting its homo-dimerization.

PubMed ID: 16641196

DOI: 10.1096/fj.05-5258fje

PubMed ID: 18028908

Title: The phosphorylation of p25/TPPP by LIM kinase 1 inhibits its ability to assemble microtubules.

PubMed ID: 18028908

DOI: 10.1016/j.yexcr.2007.08.012

PubMed ID: 17188549

Title: Lim kinases, regulators of actin dynamics.

PubMed ID: 17188549

DOI: 10.1016/j.biocel.2006.11.011

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 22886629

Title: LIM kinases are attractive targets with many macromolecular partners and only a few small molecule regulators.

PubMed ID: 22886629

DOI: 10.1002/med.20230

PubMed ID: 21682918

Title: Nuclear and cytoplasmic LIMK1 enhances human breast cancer progression.

PubMed ID: 21682918

DOI: 10.1186/1476-4598-10-75

PubMed ID: 22328514

Title: TPPP acts downstream of RhoA-ROCK-LIMK2 to regulate astral microtubule organization and spindle orientation.

PubMed ID: 22328514

DOI: 10.1242/jcs.096818

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23633677

Title: Beta-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6.

PubMed ID: 23633677

DOI: 10.1126/scisignal.2003627

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 647
  • Mass: 72585
  • Checksum: 9838BEFBE7006447
  • Sequence:
    • MRLTLLCCTW REERMGEEGS ELPVCASCGQ RIYDGQYLQA LNADWHADCF RCCDCSASLS 
HQYYEKDGQL FCKKDYWARY GESCHGCSEQ ITKGLVMVAG ELKYHPECFI CLTCGTFIGD 
GDTYTLVEHS KLYCGHCYYQ TVVTPVIEQI LPDSPGSHLP HTVTLVSIPA SSHGKRGLSV 
SIDPPHGPPG CGTEHSHTVR VQGVDPGCMS PDVKNSIHVG DRILEINGTP IRNVPLDEID 
LLIQETSRLL QLTLEHDPHD TLGHGLGPET SPLSSPAYTP SGEAGSSARQ KPVLRSCSID 
RSPGAGSLGS PASQRKDLGR SESLRVVCRP HRIFRPSDLI HGEVLGKGCF GQAIKVTHRE 
TGEVMVMKEL IRFDEETQRT FLKEVKVMRC LEHPNVLKFI GVLYKDKRLN FITEYIKGGT 
LRGIIKSMDS QYPWSQRVSF AKDIASGMAY LHSMNIIHRD LNSHNCLVRE NKNVVVADFG 
LARLMVDEKT QPEGLRSLKK PDRKKRYTVV GNPYWMAPEM INGRSYDEKV DVFSFGIVLC 
EIIGRVNADP DYLPRTMDFG LNVRGFLDRY CPPNCPPSFF PITVRCCDLD PEKRPSFVKL 
EHWLETLRMH LAGHLPLGPQ LEQLDRGFWE TYRRGESGLP AHPEVPD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.