Details for: LIMK1

Gene ID: 3984

Symbol: LIMK1

Ensembl ID: ENSG00000106683

Description: LIM domain kinase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169071
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.24
    Marker Score: 45902
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.18
    Marker Score: 1829
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.15
    Marker Score: 70731
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.08
    Marker Score: 10114
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.06
    Marker Score: 2162
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.05
    Marker Score: 9970
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.03
    Marker Score: 8848
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71772
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47997
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.98
    Marker Score: 4518
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.96
    Marker Score: 1004
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.96
    Marker Score: 3967
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.94
    Marker Score: 1645
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 485
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 439
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2726
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.9
    Marker Score: 549
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5103
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.88
    Marker Score: 13737
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.87
    Marker Score: 591
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5264
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.81
    Marker Score: 30625
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.8
    Marker Score: 334
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.78
    Marker Score: 444
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.78
    Marker Score: 15436
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1257
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.77
    Marker Score: 2122
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.76
    Marker Score: 25754
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.76
    Marker Score: 3172.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.76
    Marker Score: 454
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.73
    Marker Score: 2810
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 551
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.71
    Marker Score: 284.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 646
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.71
    Marker Score: 10550
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.7
    Marker Score: 5379
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.68
    Marker Score: 187
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.67
    Marker Score: 216
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.63
    Marker Score: 559
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.62
    Marker Score: 568
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.61
    Marker Score: 1812
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.59
    Marker Score: 415
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.56
    Marker Score: 267
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 439
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.54
    Marker Score: 226
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.54
    Marker Score: 13729
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.52
    Marker Score: 3180
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.52
    Marker Score: 3135
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.52
    Marker Score: 326
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.51
    Marker Score: 328
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.51
    Marker Score: 28245
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.49
    Marker Score: 172
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.49
    Marker Score: 4934
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.49
    Marker Score: 587
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.49
    Marker Score: 1106
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.48
    Marker Score: 2007
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.48
    Marker Score: 513
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.47
    Marker Score: 148
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.47
    Marker Score: 6279
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.47
    Marker Score: 566.5
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.47
    Marker Score: 647
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.47
    Marker Score: 116
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.46
    Marker Score: 743
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.46
    Marker Score: 308
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.46
    Marker Score: 116
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.46
    Marker Score: 388
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.45
    Marker Score: 6019
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.45
    Marker Score: 186
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.44
    Marker Score: 183
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.44
    Marker Score: 445
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.43
    Marker Score: 124
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.42
    Marker Score: 361
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.42
    Marker Score: 287
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.41
    Marker Score: 131
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.41
    Marker Score: 147
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.4
    Marker Score: 133
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.4
    Marker Score: 142
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.4
    Marker Score: 265
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.39
    Marker Score: 8430
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.39
    Marker Score: 237
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.39
    Marker Score: 174
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.39
    Marker Score: 88
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.39
    Marker Score: 437
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.39
    Marker Score: 430
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.38
    Marker Score: 166
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.38
    Marker Score: 416
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.38
    Marker Score: 543
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.38
    Marker Score: 542
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.38
    Marker Score: 181
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.37
    Marker Score: 1373
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.37
    Marker Score: 414
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.37
    Marker Score: 128
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.37
    Marker Score: 367
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.37
    Marker Score: 88

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Other Information

**Key characteristics:** * LIMK1 is a serine/threonine kinase that is involved in the regulation of actin dynamics. * It is a key regulator of axon guidance, as it is required for the migration of neurons along the developing optic nerve. * It is also involved in the development of the immune system, as it is expressed in cells that are responsible for the development and maintenance of the immune system. **Pathways and functions:** * LIMK1 is involved in a variety of cellular processes, including axon guidance, developmental biology, and the immune system. * In axon guidance, LIMK1 is required for the migration of neurons along the developing optic nerve. * In developmental biology, LIMK1 is involved in the formation of the neural tube and the specification of the developing brain and spinal cord. * In the immune system, LIMK1 is involved in the regulation of immune cell migration and activation. **Clinical significance:** * Mutations in the LIMK1 gene have been linked to a number of human diseases, including autism, schizophrenia, and developmental disorders. * These mutations can lead to a variety of neurological symptoms, including autism, intellectual disability, and behavioral problems. * Therefore, LIMK1 is a promising target for the treatment of neurological diseases.

Genular Protein ID: 2233805992

Symbol: LIMK1_HUMAN

Name: LIM domain kinase 1

UniProtKB Accession Codes:

P53667 B7Z6I8 D3DXF4 D3DXF5 O15283 Q15820 Q15821 Q75MU3 Q9Y5Q1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CPTAC 2 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 2 EMBL 13 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 28 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 10 PIR 1 PRINTS 1 PRO 1 PROSITE 5 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 6 RefSeq 2 Rhea 8 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8183554

Title: Identification of a human cDNA encoding a novel protein kinase with two repeats of the LIM/double zinc finger motif.

PubMed ID: 8183554

PubMed ID: 8689688

Title: LIM-kinase1 hemizygosity implicated in impaired visuospatial constructive cognition.

PubMed ID: 8689688

DOI: 10.1016/s0092-8674(00)80077-x

PubMed ID: 8812460

Title: Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients.

PubMed ID: 8812460

DOI: 10.1006/geno.1996.0469

PubMed ID: 10196227

Title: Structural features of LIM kinase that control effects on the actin cytoskeleton.

PubMed ID: 10196227

DOI: 10.1074/jbc.274.16.11352

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 10559936

Title: Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics.

PubMed ID: 10559936

DOI: 10.1038/12963

PubMed ID: 10436159

Title: Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase.

PubMed ID: 10436159

DOI: 10.1126/science.285.5429.895

PubMed ID: 10652353

Title: Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop.

PubMed ID: 10652353

DOI: 10.1074/jbc.275.5.3577

PubMed ID: 11340065

Title: Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha.

PubMed ID: 11340065

DOI: 10.1074/jbc.c100196200

PubMed ID: 11413130

Title: Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin.

PubMed ID: 11413130

DOI: 10.1074/jbc.m100871200

PubMed ID: 11832213

Title: Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin.

PubMed ID: 11832213

DOI: 10.1016/s0092-8674(01)00638-9

PubMed ID: 12807904

Title: Cell cycle-associated changes in Slingshot phosphatase activity and roles in cytokinesis in animal cells.

PubMed ID: 12807904

DOI: 10.1074/jbc.m305802200

PubMed ID: 14530263

Title: p57Kip2 regulates actin dynamics by binding and translocating LIM-kinase 1 to the nucleus.

PubMed ID: 14530263

DOI: 10.1074/jbc.m309334200

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 15660133

Title: Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin.

PubMed ID: 15660133

DOI: 10.1038/sj.emboj.7600543

PubMed ID: 16230460

Title: Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration.

PubMed ID: 16230460

DOI: 10.1083/jcb.200504029

PubMed ID: 16456544

Title: MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migration.

PubMed ID: 16456544

DOI: 10.1038/sj.emboj.7600973

PubMed ID: 16641196

Title: Hsp90 increases LIM kinase activity by promoting its homo-dimerization.

PubMed ID: 16641196

DOI: 10.1096/fj.05-5258fje

PubMed ID: 18028908

Title: The phosphorylation of p25/TPPP by LIM kinase 1 inhibits its ability to assemble microtubules.

PubMed ID: 18028908

DOI: 10.1016/j.yexcr.2007.08.012

PubMed ID: 17188549

Title: Lim kinases, regulators of actin dynamics.

PubMed ID: 17188549

DOI: 10.1016/j.biocel.2006.11.011

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 22886629

Title: LIM kinases are attractive targets with many macromolecular partners and only a few small molecule regulators.

PubMed ID: 22886629

DOI: 10.1002/med.20230

PubMed ID: 21682918

Title: Nuclear and cytoplasmic LIMK1 enhances human breast cancer progression.

PubMed ID: 21682918

DOI: 10.1186/1476-4598-10-75

PubMed ID: 22328514

Title: TPPP acts downstream of RhoA-ROCK-LIMK2 to regulate astral microtubule organization and spindle orientation.

PubMed ID: 22328514

DOI: 10.1242/jcs.096818

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23633677

Title: Beta-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6.

PubMed ID: 23633677

DOI: 10.1126/scisignal.2003627

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 647
  • Mass: 72585
  • Checksum: 9838BEFBE7006447
  • Sequence:
    • MRLTLLCCTW REERMGEEGS ELPVCASCGQ RIYDGQYLQA LNADWHADCF RCCDCSASLS 
HQYYEKDGQL FCKKDYWARY GESCHGCSEQ ITKGLVMVAG ELKYHPECFI CLTCGTFIGD 
GDTYTLVEHS KLYCGHCYYQ TVVTPVIEQI LPDSPGSHLP HTVTLVSIPA SSHGKRGLSV 
SIDPPHGPPG CGTEHSHTVR VQGVDPGCMS PDVKNSIHVG DRILEINGTP IRNVPLDEID 
LLIQETSRLL QLTLEHDPHD TLGHGLGPET SPLSSPAYTP SGEAGSSARQ KPVLRSCSID 
RSPGAGSLGS PASQRKDLGR SESLRVVCRP HRIFRPSDLI HGEVLGKGCF GQAIKVTHRE 
TGEVMVMKEL IRFDEETQRT FLKEVKVMRC LEHPNVLKFI GVLYKDKRLN FITEYIKGGT 
LRGIIKSMDS QYPWSQRVSF AKDIASGMAY LHSMNIIHRD LNSHNCLVRE NKNVVVADFG 
LARLMVDEKT QPEGLRSLKK PDRKKRYTVV GNPYWMAPEM INGRSYDEKV DVFSFGIVLC 
EIIGRVNADP DYLPRTMDFG LNVRGFLDRY CPPNCPPSFF PITVRCCDLD PEKRPSFVKL 
EHWLETLRMH LAGHLPLGPQ LEQLDRGFWE TYRRGESGLP AHPEVPD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.