Details for: LMO1

Gene ID: 4004

Symbol: LMO1

Ensembl ID: ENSG00000166407

Description: LIM domain only 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 33.9059
    Cell Significance Index: -8.6000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.1801
    Cell Significance Index: 25.8400
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.1207
    Cell Significance Index: 15.7400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.8530
    Cell Significance Index: 22.4300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.4558
    Cell Significance Index: 11.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3013
    Cell Significance Index: 38.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2486
    Cell Significance Index: 109.9100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2469
    Cell Significance Index: 15.5600
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.1951
    Cell Significance Index: 2.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0709
    Cell Significance Index: 32.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0601
    Cell Significance Index: 3.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0547
    Cell Significance Index: 10.9700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0475
    Cell Significance Index: 89.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0401
    Cell Significance Index: 7.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0209
    Cell Significance Index: 7.4800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0198
    Cell Significance Index: 0.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0190
    Cell Significance Index: 12.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0081
    Cell Significance Index: 1.1800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0076
    Cell Significance Index: 5.2500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0073
    Cell Significance Index: 0.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0067
    Cell Significance Index: 4.9400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.0044
    Cell Significance Index: 0.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0035
    Cell Significance Index: 1.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0034
    Cell Significance Index: 0.5800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0014
    Cell Significance Index: 1.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0006
    Cell Significance Index: -0.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0007
    Cell Significance Index: -0.4000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0020
    Cell Significance Index: -3.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0026
    Cell Significance Index: -4.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0039
    Cell Significance Index: -5.3000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0076
    Cell Significance Index: -5.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0132
    Cell Significance Index: -3.8000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0182
    Cell Significance Index: -2.0800
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0221
    Cell Significance Index: -0.2900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0235
    Cell Significance Index: -1.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0242
    Cell Significance Index: -1.8600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0288
    Cell Significance Index: -1.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0291
    Cell Significance Index: -5.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0291
    Cell Significance Index: -2.9700
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0316
    Cell Significance Index: -0.3400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0326
    Cell Significance Index: -0.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0329
    Cell Significance Index: -3.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0343
    Cell Significance Index: -4.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0350
    Cell Significance Index: -2.1500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0352
    Cell Significance Index: -0.4200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0406
    Cell Significance Index: -3.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0418
    Cell Significance Index: -5.1500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0424
    Cell Significance Index: -1.2100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0425
    Cell Significance Index: -5.4900
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0476
    Cell Significance Index: -0.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0500
    Cell Significance Index: -3.3600
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0506
    Cell Significance Index: -0.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0521
    Cell Significance Index: -6.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0534
    Cell Significance Index: -6.1200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0640
    Cell Significance Index: -0.3800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0687
    Cell Significance Index: -1.7100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0699
    Cell Significance Index: -1.9500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0707
    Cell Significance Index: -8.3400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0737
    Cell Significance Index: -5.4900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0803
    Cell Significance Index: -1.1500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0816
    Cell Significance Index: -1.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0889
    Cell Significance Index: -2.9100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0891
    Cell Significance Index: -2.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0942
    Cell Significance Index: -4.2700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0973
    Cell Significance Index: -6.2800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1012
    Cell Significance Index: -5.2700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1024
    Cell Significance Index: -4.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1029
    Cell Significance Index: -6.3100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1042
    Cell Significance Index: -3.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1112
    Cell Significance Index: -4.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1119
    Cell Significance Index: -5.2600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1130
    Cell Significance Index: -3.9600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1161
    Cell Significance Index: -1.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1341
    Cell Significance Index: -3.6500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1407
    Cell Significance Index: -2.3700
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.1411
    Cell Significance Index: -1.7100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1450
    Cell Significance Index: -5.0400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1487
    Cell Significance Index: -2.2000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1493
    Cell Significance Index: -3.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1525
    Cell Significance Index: -7.1100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1768
    Cell Significance Index: -3.7800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1782
    Cell Significance Index: -5.2500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1783
    Cell Significance Index: -1.6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1807
    Cell Significance Index: -6.3500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1840
    Cell Significance Index: -4.9300
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.1869
    Cell Significance Index: -1.6900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1897
    Cell Significance Index: -3.9700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1912
    Cell Significance Index: -5.4800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1916
    Cell Significance Index: -4.7800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2030
    Cell Significance Index: -3.5100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2048
    Cell Significance Index: -3.5100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2053
    Cell Significance Index: -5.0100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2079
    Cell Significance Index: -4.9900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2131
    Cell Significance Index: -6.7400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2157
    Cell Significance Index: -5.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2161
    Cell Significance Index: -5.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2214
    Cell Significance Index: -6.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2243
    Cell Significance Index: -6.0000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2246
    Cell Significance Index: -4.5100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2257
    Cell Significance Index: -8.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LMO1 is a transcriptional regulator that belongs to the LIM domain family, characterized by the presence of a LIM domain and a coiled-coil domain. This gene has been identified as a key player in the regulation of gene expression, particularly in the context of transcriptional coactivation and negative regulation by RNA polymerase II. LMO1's expression is restricted to specific cell types, including immune cells, and its protein interactions, such as with Rhombotin-1 (RBTN1), suggest a complex network of molecular interactions. **Pathways and Functions:** LMO1's involvement in transcriptional regulation is mediated through its interaction with RNA polymerase II and Runx1, a transcription factor essential for the differentiation of hematopoietic stem cells. The LMO1-Runx1 complex regulates the transcription of genes involved in the differentiation of hematopoietic stem cells, highlighting the importance of this interaction in the development and homeostasis of the immune system. Additionally, LMO1's involvement in the regulation of T-cell homeostatic proliferation suggests its role in maintaining the balance between cell growth and differentiation in the immune system. **Clinical Significance:** The dysregulation of LMO1 has been implicated in various immunological disorders, including autoimmune diseases and lymphomas. Mutations in the LMO1 gene have been associated with an increased risk of developing certain types of cancer, highlighting the importance of this gene in maintaining immune homeostasis and preventing cancer development. Furthermore, the study of LMO1's molecular mechanisms may provide insights into the development of novel therapeutic strategies for the treatment of immunological disorders. In conclusion, LMO1 is a critical transcriptional regulator that plays a pivotal role in the development, homeostasis, and function of various immune cells. Its involvement in the regulation of transcriptional coactivation and negative regulation by RNA polymerase II highlights its importance in the immune system. Further studies on LMO1's molecular mechanisms and functional significance are essential for understanding the underlying mechanisms of immunological disorders and developing novel therapeutic strategies.

Genular Protein ID: 1660324068

Symbol: RBTN1_HUMAN

Name: Rhombotin-1

UniProtKB Accession Codes:

P25800 E9PSF5 Q4VBC5 Q8IXR0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2501659

Title: The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein.

PubMed ID: 2501659

DOI: 10.1128/mcb.9.5.2124-2132.1989

PubMed ID: 2311586

Title: An unusual structure of a putative T cell oncogene which allows production of similar proteins from distinct mRNAs.

PubMed ID: 2311586

DOI: 10.1002/j.1460-2075.1990.tb08183.x

PubMed ID: 1703797

Title: T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells.

PubMed ID: 1703797

PubMed ID: 11528126

Title: Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1).

PubMed ID: 11528126

DOI: 10.1159/000056998

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2052354

Title: Developmentally regulated and tissue specific expression of mRNAs encoding the two alternative forms of the LIM domain oncogene rhombotin: evidence for thymus expression.

PubMed ID: 2052354

Sequence Information:

  • Length: 156
  • Mass: 17828
  • Checksum: 6BAFBE1F870CCAAC
  • Sequence:
    • MMVLDKEDGV PMLSVQPKGK QKGCAGCNRK IKDRYLLKAL DKYWHEDCLK CACCDCRLGE 
VGSTLYTKAN LILCRRDYLR LFGTTGNCAA CSKLIPAFEM VMRARDNVYH LDCFACQLCN 
QRFCVGDKFF LKNNMILCQM DYEEGQLNGT FESQVQ

Genular Protein ID: 968239365

Symbol: E9PK83_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PK83

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 2 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 2 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 145
  • Mass: 16612
  • Checksum: 16A5B7D33A42C612
  • Sequence:
    • MLSVQPKGKQ KGCAGCNRKI KDRYLLKALD KYWHEDCLKC ACCDCRLGEV GSTLYTKANL 
ILCRRDYLRL FGTTGNCAAC SKLIPAFEMV MRARDNVYHL DCFACQLCNQ RFCVGDKFFL 
KNNMILCQMD YEEGQLNGTF ESQVQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.