Gene LMO1 - ENSG00000166407 | NCBI Gene ID: 4004

Details for: LMO1

Gene ID: 4004

Symbol: LMO1

Ensembl ID: ENSG00000166407

Description: LIM domain only 1

Associated with

Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Rna polymerase ii transcription
(R-HSA-73857)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-HSA-8939236)
Transcriptional regulation by runx1
(R-HSA-8878171)
Dna-binding transcription factor binding
(GO:0140297)
Metal ion binding
(GO:0046872)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of t cell homeostatic proliferation
(GO:0046013)
Transcription coactivator activity
(GO:0003713)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 2.19
Marker Score: 1511
Cell Name: plasma cell (CL0000786)
Fold Change: 1.74
Marker Score: 1940
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.62
Marker Score: 3073
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.49
Marker Score: 3034
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.37
Marker Score: 869
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.18
Marker Score: 18527
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 1.16
Marker Score: 2405
Cell Name: goblet cell (CL0000160)
Fold Change: 1.13
Marker Score: 7494
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 1.09
Marker Score: 1559
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.04
Marker Score: 796
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.03
Marker Score: 2257
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71822
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48046
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2426
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5350
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2739
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5285
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.86
Marker Score: 273.5
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1262
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 708
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 395
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.72
Marker Score: 291
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.68
Marker Score: 410
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.64
Marker Score: 2672
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.62
Marker Score: 6432.5
Cell Name: mast cell (CL0000097)
Fold Change: 0.62
Marker Score: 358
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.61
Marker Score: 401
Cell Name: chromaffin cell (CL0000166)
Fold Change: 0.59
Marker Score: 832
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.59
Marker Score: 282
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.56
Marker Score: 5661
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.56
Marker Score: 148
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.56
Marker Score: 232
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.43
Marker Score: 246
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.43
Marker Score: 188
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.43
Marker Score: 145.5
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.42
Marker Score: 3644
Cell Name: neural cell (CL0002319)
Fold Change: 0.42
Marker Score: 204
Cell Name: PP cell (CL0000696)
Fold Change: 0.42
Marker Score: 94
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.41
Marker Score: 181
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.41
Marker Score: 402.5
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.4
Marker Score: 24466.5
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.39
Marker Score: 379
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 0.38
Marker Score: 285
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 370.5
Cell Name: retina horizontal cell (CL0000745)
Fold Change: 0.37
Marker Score: 352
Cell Name: neuron (CL0000540)
Fold Change: 0.36
Marker Score: 1464
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.35
Marker Score: 113
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.34
Marker Score: 100
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.32
Marker Score: 882
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.31
Marker Score: 107.5
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.31
Marker Score: 193
Cell Name: neural crest cell (CL0011012)
Fold Change: 0.29
Marker Score: 311
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.29
Marker Score: 9639
Cell Name: rod bipolar cell (CL0000751)
Fold Change: 0.28
Marker Score: 145
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.28
Marker Score: 441
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.27
Marker Score: 70
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.27
Marker Score: 627
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 0.26
Marker Score: 88
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.26
Marker Score: 685
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.25
Marker Score: 79
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.25
Marker Score: 78
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.24
Marker Score: 82
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.24
Marker Score: 141
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.24
Marker Score: 69
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.23
Marker Score: 237
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.23
Marker Score: 113
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 0.23
Marker Score: 213
Cell Name: enteric neuron (CL0007011)
Fold Change: 0.22
Marker Score: 117
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.22
Marker Score: 740
Cell Name: endocrine cell (CL0000163)
Fold Change: 0.21
Marker Score: 107
Cell Name: Unknown (CL0002371)
Fold Change: 0.21
Marker Score: 219
Cell Name: retinal cone cell (CL0000573)
Fold Change: 0.2
Marker Score: 575
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.19
Marker Score: 172.5
Cell Name: sympathetic neuron (CL0011103)
Fold Change: 0.19
Marker Score: 63
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.19
Marker Score: 779
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.18
Marker Score: 226
Cell Name: microglial cell (CL0000129)
Fold Change: 0.18
Marker Score: 330
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.18
Marker Score: 171
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.17
Marker Score: 63
Cell Name: Schwann cell (CL0002573)
Fold Change: 0.17
Marker Score: 60
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.16
Marker Score: 335
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.16
Marker Score: 1500
Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.16
Marker Score: 57
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 0.16
Marker Score: 439
Cell Name: podocyte (CL0000653)
Fold Change: 0.15
Marker Score: 55
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 0.15
Marker Score: 139
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.15
Marker Score: 122
Cell Name: astrocyte (CL0000127)
Fold Change: 0.15
Marker Score: 126
Cell Name: Schwann cell precursor (CL0002375)
Fold Change: 0.14
Marker Score: 36
Cell Name: interneuron (CL0000099)
Fold Change: 0.14
Marker Score: 66
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.14
Marker Score: 62
Cell Name: oocyte (CL0000023)
Fold Change: 0.13
Marker Score: 32
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.13
Marker Score: 367
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.13
Marker Score: 586
Cell Name: melanocyte (CL0000148)
Fold Change: 0.13
Marker Score: 51
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.12
Marker Score: 154.5
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.12
Marker Score: 186

Hover over a box to see details here...

**Key characteristics:** * LMO1 is a transcription factor that belongs to the Krüppel-like transcription factor family. * It is expressed in high levels in embryonic and adult immune cells. * LMO1 is a key regulator of T cell development and function. * It is required for the differentiation of naive CD4+ T cells into effector T cells. * It is also required for the maintenance of effector T cells and the regulation of immune responses. **Pathways and functions:** * LMO1 binds to DNA sequences in the promoters of target genes and regulates their expression. * It is a key regulator of the development and differentiation of immune cells. * It is involved in the regulation of T cell survival, proliferation, and differentiation. * It is also involved in the regulation of inflammation and autoimmune diseases. **Clinical significance:** * Mutations in the LMO1 gene have been linked to a number of human diseases, including autoimmune diseases, cancer, and inflammatory diseases. * LMO1 inhibitors are being investigated as potential treatments for these diseases. **Additional notes:** * LMO1 is a highly conserved protein that is found in vertebrates. * It is a multi-functional protein that can bind to both DNA and RNA molecules. * It is a key regulator of the immune system and is essential for the development and maintenance of immune cells.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Rhombotin-1
E9PK83_HUMAN

Genular Protein ID: 1660324068

Symbol: RBTN1_HUMAN

Name: Rhombotin-1

UniProtKB Accession Codes:

P25800 E9PSF5 Q4VBC5 Q8IXR0

Database IDs:

Citations:

PubMed ID: 2501659

Title: The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein.

PubMed ID: 2501659

DOI: 10.1128/mcb.9.5.2124-2132.1989

PubMed ID: 2311586

Title: An unusual structure of a putative T cell oncogene which allows production of similar proteins from distinct mRNAs.

PubMed ID: 2311586

DOI: 10.1002/j.1460-2075.1990.tb08183.x

PubMed ID: 1703797

Title: T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells.

PubMed ID: 1703797

PubMed ID: 11528126

Title: Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1).

PubMed ID: 11528126

DOI: 10.1159/000056998

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2052354

Title: Developmentally regulated and tissue specific expression of mRNAs encoding the two alternative forms of the LIM domain oncogene rhombotin: evidence for thymus expression.

PubMed ID: 2052354

Sequence Information:

Length: 156
Mass: 17828
Checksum: 6BAFBE1F870CCAAC
Sequence:

MMVLDKEDGV PMLSVQPKGK QKGCAGCNRK IKDRYLLKAL DKYWHEDCLK CACCDCRLGE 
VGSTLYTKAN LILCRRDYLR LFGTTGNCAA CSKLIPAFEM VMRARDNVYH LDCFACQLCN 
QRFCVGDKFF LKNNMILCQM DYEEGQLNGT FESQVQ

Genular Protein ID: 968239365

Symbol: E9PK83_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PK83

Database IDs:

Citations:

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

Length: 145
Mass: 16612
Checksum: 16A5B7D33A42C612
Sequence:

MLSVQPKGKQ KGCAGCNRKI KDRYLLKALD KYWHEDCLKC ACCDCRLGEV GSTLYTKANL 
ILCRRDYLRL FGTTGNCAAC SKLIPAFEMV MRARDNVYHL DCFACQLCNQ RFCVGDKFFL 
KNNMILCQMD YEEGQLNGTF ESQVQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: LMO1

Associated with

Cells (max top 100)

Other Information

The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein. PubMed ID: 2501659

An unusual structure of a putative T cell oncogene which allows production of similar proteins from distinct mRNAs. PubMed ID: 2311586

T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells. PubMed ID: 1703797

Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1). PubMed ID: 11528126

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Developmentally regulated and tissue specific expression of mRNAs encoding the two alternative forms of the LIM domain oncogene rhombotin: evidence for thymus expression. PubMed ID: 2052354

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

Database document:

PubMed ID: 2501659

PubMed ID: 2311586

PubMed ID: 1703797

PubMed ID: 11528126

PubMed ID: 16554811

PubMed ID: 15489334

PubMed ID: 2052354

PubMed ID: 16554811