Gene LTA - ENSG00000226979 | NCBI Gene ID: 4049

Details for: LTA

Gene ID: 4049

Symbol: LTA

Ensembl ID: ENSG00000226979

Description: lymphotoxin alpha

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Immune system
(R-HSA-168256)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Tnf receptor superfamily (tnfsf) members mediating non-canonical nf-kb pathway
(R-HSA-5676594)
Tnfs bind their physiological receptors
(R-HSA-5669034)
Apoptotic process
(GO:0006915)
Cell-cell signaling
(GO:0007267)
Cytokine activity
(GO:0005125)
Defense response to gram-positive bacterium
(GO:0050830)
Extracellular space
(GO:0005615)
Humoral immune response
(GO:0006959)
Lymph node development
(GO:0048535)
Negative regulation of fibroblast proliferation
(GO:0048147)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of chronic inflammatory response to antigenic stimulus
(GO:0002876)
Positive regulation of glial cell proliferation
(GO:0060252)
Positive regulation of humoral immune response mediated by circulating immunoglobulin
(GO:0002925)
Positive regulation of type ii interferon production
(GO:0032729)
Protein binding
(GO:0005515)
Response to hypoxia
(GO:0001666)
Response to lipopolysaccharide
(GO:0032496)
Response to nutrient
(GO:0007584)
Response to xenobiotic stimulus
(GO:0009410)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Tumor necrosis factor receptor binding
(GO:0005164)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.24
Marker Score: 7953
Cell Name: goblet cell (CL0000160)
Fold Change: 1.15
Marker Score: 7675
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251806
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5318
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2741
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5284
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.81
Marker Score: 617.5
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1267
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 707
Cell Name: B-1 B cell (CL0000819)
Fold Change: 0.73
Marker Score: 1274
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 176.5
Cell Name: centrocyte (CL0009111)
Fold Change: 0.66
Marker Score: 157
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.64
Marker Score: 647
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 0.64
Marker Score: 907
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.61
Marker Score: 665
Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
Fold Change: 0.61
Marker Score: 138
Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 0.59
Marker Score: 130
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.59
Marker Score: 1739
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.57
Marker Score: 280
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.53
Marker Score: 27816
Cell Name: germinal center B cell (CL0000844)
Fold Change: 0.51
Marker Score: 313
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 0.5
Marker Score: 902
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 0.5
Marker Score: 2159
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.48
Marker Score: 127
Cell Name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human (CL0001074)
Fold Change: 0.46
Marker Score: 128
Cell Name: regulatory T cell (CL0000815)
Fold Change: 0.45
Marker Score: 502
Cell Name: T-helper 1 cell (CL0000545)
Fold Change: 0.44
Marker Score: 170
Cell Name: B-1a B cell (CL0000820)
Fold Change: 0.42
Marker Score: 101
Cell Name: Unknown (CL0000548)
Fold Change: 0.41
Marker Score: 299
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.4
Marker Score: 230
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.39
Marker Score: 764
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.38
Marker Score: 319
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.38
Marker Score: 275
Cell Name: thymocyte (CL0000893)
Fold Change: 0.37
Marker Score: 387
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 0.37
Marker Score: 634
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 0.37
Marker Score: 265
Cell Name: naive B cell (CL0000788)
Fold Change: 0.36
Marker Score: 324
Cell Name: centroblast (CL0009112)
Fold Change: 0.35
Marker Score: 172
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.35
Marker Score: 209
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.34
Marker Score: 262
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.33
Marker Score: 194
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 0.33
Marker Score: 293
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 0.32
Marker Score: 310.5
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 0.3
Marker Score: 950
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 0.29
Marker Score: 714
Cell Name: blood cell (CL0000081)
Fold Change: 0.29
Marker Score: 3333
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 0.28
Marker Score: 155
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.27
Marker Score: 254
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 0.26
Marker Score: 243
Cell Name: mature B cell (CL0000785)
Fold Change: 0.26
Marker Score: 187
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 0.25
Marker Score: 107
Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.25
Marker Score: 58
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 0.25
Marker Score: 704
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.25
Marker Score: 558
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.24
Marker Score: 152
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 0.24
Marker Score: 130
Cell Name: memory B cell (CL0000787)
Fold Change: 0.23
Marker Score: 175
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.23
Marker Score: 245
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 0.22
Marker Score: 135
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.21
Marker Score: 132
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.21
Marker Score: 181
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 0.21
Marker Score: 437
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.21
Marker Score: 104
Cell Name: leukocyte (CL0000738)
Fold Change: 0.2
Marker Score: 117
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.2
Marker Score: 137
Cell Name: B cell (CL0000236)
Fold Change: 0.2
Marker Score: 192
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.2
Marker Score: 165
Cell Name: immature B cell (CL0000816)
Fold Change: 0.19
Marker Score: 129
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.19
Marker Score: 210
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.19
Marker Score: 126
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.19
Marker Score: 109
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 0.18
Marker Score: 49
Cell Name: T follicular regulatory cell (CL0009113)
Fold Change: 0.18
Marker Score: 50
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.18
Marker Score: 107
Cell Name: group 2 innate lymphoid cell (CL0001069)
Fold Change: 0.18
Marker Score: 62
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.18
Marker Score: 149
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 0.18
Marker Score: 159
Cell Name: naive T cell (CL0000898)
Fold Change: 0.18
Marker Score: 113
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.17
Marker Score: 167
Cell Name: mast cell (CL0000097)
Fold Change: 0.17
Marker Score: 100
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.17
Marker Score: 235.5
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.17
Marker Score: 129
Cell Name: gut endothelial cell (CL0000131)
Fold Change: 0.17
Marker Score: 61
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 0.17
Marker Score: 1415
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 0.16
Marker Score: 49
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.16
Marker Score: 42
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 0.16
Marker Score: 80
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 0.15
Marker Score: 228
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.15
Marker Score: 121
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.15
Marker Score: 64
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 0.15
Marker Score: 99
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.15
Marker Score: 54
Cell Name: ILC1, human (CL0001077)
Fold Change: 0.15
Marker Score: 37
Cell Name: platelet (CL0000233)
Fold Change: 0.14
Marker Score: 65
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.14
Marker Score: 50
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.14
Marker Score: 49
Cell Name: B-2 B cell (CL0000822)
Fold Change: 0.13
Marker Score: 164

Hover over a box to see details here...

**Key characteristics:** * LTA is a type I transmembrane protein belonging to the TNF superfamily. * It is a key cytokine that plays a role in regulating inflammation and immune responses. * LTA is produced by a variety of cell types, including immune cells, epithelial cells, and tumor cells. * It is a key regulator of the inflammatory response, promoting inflammation and tumor growth. * It is involved in the regulation of type II interferon production and the activation of the canonical NF-κB pathway. **Pathways and functions:** * LTA signaling is initiated by the binding of its ligand, tumor necrosis factor-alpha (TNF-alpha), to its receptor, TNFR. * This binding triggers the activation of the canonical NF-κB pathway, leading to the production of inflammatory cytokines and chemokines. * LTA also plays a role in the regulation of the humoral immune response, promoting the production of antibodies and activating immune cells. * It is involved in the regulation of chronic inflammatory responses to antigenic stimuli and the development of cancer. **Clinical significance:** * LTA gene mutations have been linked to the development of various diseases, including cancer, autoimmune disorders, and inflammatory diseases. * Targeting LTA signaling has emerged as a potential therapeutic strategy for these diseases. * LTA is a promising target for the development of novel immunotherapies for cancer and inflammatory diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Lymphotoxin-alpha

Genular Protein ID: 3171799262

Symbol: TNFB_HUMAN

Name: Lymphotoxin-alpha

UniProtKB Accession Codes:

P01374 Q8N4C3 Q9UKS8

Database IDs:

Citations:

PubMed ID: 3555974

Title: Tandem arrangement of genes coding for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) in the human genome.

PubMed ID: 3555974

DOI: 10.1101/sqb.1986.051.01.073

PubMed ID: 3001109

Title: Structure and chromosomal localization of the human lymphotoxin gene.

PubMed ID: 3001109

DOI: 10.1002/jcb.240290302

PubMed ID: 3536896

Title: Cloning and expression of human lymphotoxin mRNA derived from a human T cell hybridoma.

PubMed ID: 3536896

DOI: 10.1093/oxfordjournals.jbchem.a121765

PubMed ID: 6334807

Title: Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity.

PubMed ID: 6334807

DOI: 10.1038/312721a0

PubMed ID: 1353024

Title: Nucleotide sequence of a cDNA encoding human tumor necrosis factor beta from B lymphoblastoid cell RPMI 1788.

PubMed ID: 1353024

DOI: 10.1016/0014-5793(92)80425-g

PubMed ID: 8499947

Title: Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment.

PubMed ID: 8499947

DOI: 10.1038/ng0293-137

PubMed ID: 10202016

Title: A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC.

PubMed ID: 10202016

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1451807

Title: Natural human tumor necrosis factor beta (lymphotoxin). Variable O-glycosylation at Thr7, proteolytic processing, and allelic variation.

PubMed ID: 1451807

DOI: 10.1016/0014-5793(92)81467-z

PubMed ID: 9462508

Title: LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator.

PubMed ID: 9462508

DOI: 10.1016/s1074-7613(00)80455-0

PubMed ID: 1733919

Title: The structure of human lymphotoxin (tumor necrosis factor-beta) at 1.9-A resolution.

PubMed ID: 1733919

DOI: 10.1016/s0021-9258(18)45849-8

PubMed ID: 8387891

Title: Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.

PubMed ID: 8387891

DOI: 10.1016/0092-8674(93)90132-a

PubMed ID: 1670638

Title: Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production.

PubMed ID: 1670638

DOI: 10.1084/jem.173.1.209

PubMed ID: 1671667

Title: Haplotypic polymorphisms of the TNFB gene.

PubMed ID: 1671667

DOI: 10.1007/bf00211695

PubMed ID: 12746914

Title: Cytokine gene polymorphisms: association with psoriatic arthritis susceptibility and severity.

PubMed ID: 12746914

DOI: 10.1002/art.10935

PubMed ID: 17353895

Title: Stepwise replication identifies a low-producing lymphotoxin-alpha allele as a major risk factor for early-onset leprosy.

PubMed ID: 17353895

DOI: 10.1038/ng2000

Sequence Information:

Length: 205
Mass: 22297
Checksum: 1BBD5E7D496A3A82
Sequence:

MTPPERLFLP RVCGTTLHLL LLGLLLVLLP GAQGLPGVGL TPSAAQTARQ HPKMHLAHST 
LKPAAHLIGD PSKQNSLLWR ANTDRAFLQD GFSLSNNSLL VPTSGIYFVY SQVVFSGKAY 
SPKATSSPLY LAHEVQLFSS QYPFHVPLLS SQKMVYPGLQ EPWLHSMYHG AAFQLTQGDQ 
LSTHTDGIPH LVLSPSTVFF GAFAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: LTA

Associated with

Cells (max top 100)

Other Information

Tandem arrangement of genes coding for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) in the human genome. PubMed ID: 3555974

Structure and chromosomal localization of the human lymphotoxin gene. PubMed ID: 3001109

Cloning and expression of human lymphotoxin mRNA derived from a human T cell hybridoma. PubMed ID: 3536896

Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity. PubMed ID: 6334807

Nucleotide sequence of a cDNA encoding human tumor necrosis factor beta from B lymphoblastoid cell RPMI 1788. PubMed ID: 1353024

Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment. PubMed ID: 8499947

A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC. PubMed ID: 10202016

Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. PubMed ID: 14656967

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Natural human tumor necrosis factor beta (lymphotoxin). Variable O-glycosylation at Thr7, proteolytic processing, and allelic variation. PubMed ID: 1451807

LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator. PubMed ID: 9462508

The structure of human lymphotoxin (tumor necrosis factor-beta) at 1.9-A resolution. PubMed ID: 1733919

Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation. PubMed ID: 8387891

Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production. PubMed ID: 1670638

Haplotypic polymorphisms of the TNFB gene. PubMed ID: 1671667

Cytokine gene polymorphisms: association with psoriatic arthritis susceptibility and severity. PubMed ID: 12746914

Stepwise replication identifies a low-producing lymphotoxin-alpha allele as a major risk factor for early-onset leprosy. PubMed ID: 17353895