Details for: LTBR

Gene ID: 4055

Symbol: LTBR

Ensembl ID: ENSG00000111321

Description: lymphotoxin beta receptor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 2.67
    Marker Score: 2792
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.84
    Marker Score: 2221.5
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.72
    Marker Score: 15138
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.59
    Marker Score: 924
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.57
    Marker Score: 2317
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.55
    Marker Score: 4858
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.51
    Marker Score: 428
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.5
    Marker Score: 1575
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.48
    Marker Score: 82669
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.47
    Marker Score: 1158
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.46
    Marker Score: 2852
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.42
    Marker Score: 809
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.38
    Marker Score: 6774
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.36
    Marker Score: 3312
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.36
    Marker Score: 2756
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.35
    Marker Score: 667
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.35
    Marker Score: 10015
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.31
    Marker Score: 44564
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.29
    Marker Score: 2076
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.26
    Marker Score: 1281
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.25
    Marker Score: 2840
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.24
    Marker Score: 5958
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.24
    Marker Score: 3144
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.23
    Marker Score: 1775
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.22
    Marker Score: 2441
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.22
    Marker Score: 2003.5
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.22
    Marker Score: 2160
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.22
    Marker Score: 1078
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.2
    Marker Score: 800
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.2
    Marker Score: 482
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.16
    Marker Score: 268
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.15
    Marker Score: 1484
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.15
    Marker Score: 4420
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.15
    Marker Score: 535
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.14
    Marker Score: 12861
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.14
    Marker Score: 2830
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.14
    Marker Score: 1368
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.11
    Marker Score: 1190
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.11
    Marker Score: 2605
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.09
    Marker Score: 690
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.09
    Marker Score: 9420
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.09
    Marker Score: 982
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.09
    Marker Score: 598
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.08
    Marker Score: 1123
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.08
    Marker Score: 1664
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.08
    Marker Score: 371
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.07
    Marker Score: 257
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.07
    Marker Score: 981.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.06
    Marker Score: 36772
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.06
    Marker Score: 2407
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.06
    Marker Score: 8267
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.03
    Marker Score: 1642
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.03
    Marker Score: 6711
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.03
    Marker Score: 4448
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.03
    Marker Score: 6684
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.01
    Marker Score: 293
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.01
    Marker Score: 1247
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1
    Marker Score: 998
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1
    Marker Score: 695
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71728
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1
    Marker Score: 1370
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47953
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.99
    Marker Score: 2363
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.99
    Marker Score: 374
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.99
    Marker Score: 2588
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.98
    Marker Score: 669
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30397
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.98
    Marker Score: 539
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.97
    Marker Score: 1048
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.97
    Marker Score: 1634
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.96
    Marker Score: 15492
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 495
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.96
    Marker Score: 901
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.96
    Marker Score: 303
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.95
    Marker Score: 339
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 449
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.95
    Marker Score: 1460
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.95
    Marker Score: 213
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2403
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.94
    Marker Score: 229
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.94
    Marker Score: 5993
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.93
    Marker Score: 895
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.93
    Marker Score: 14604
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5261
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.92
    Marker Score: 228
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.92
    Marker Score: 788
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.91
    Marker Score: 1328
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2734
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.91
    Marker Score: 380
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.91
    Marker Score: 4765
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.9
    Marker Score: 202
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.9
    Marker Score: 989
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.89
    Marker Score: 397
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.88
    Marker Score: 429
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.88
    Marker Score: 217
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.87
    Marker Score: 1840
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.87
    Marker Score: 653
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.86
    Marker Score: 974

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Other Information

**Key characteristics:** * The LTBR gene is located on chromosome 15q23.1. * It is a large gene with a molecular weight of approximately 350 kDa. * The protein is a transmembrane protein that is expressed in a variety of cell types. * It is a key regulator of apoptosis, cell migration, and immune response. **Pathways and functions:** * The LTBR protein is involved in the regulation of apoptosis. It is expressed in cells that are susceptible to apoptosis, and its expression is increased in cells that are undergoing apoptosis. * The LTBR protein also plays a role in cell migration. It is expressed in cells that are migrating through the tissue, and its expression is increased in cells that are migrating towards a stimulus. * The LTBR protein is also involved in the regulation of immune response. It is expressed in cells that are activated by the immune system, and its expression is increased in cells that are responding to an infection. **Clinical significance:** Mutations in the LTBR gene have been linked to a number of human diseases, including cancer and autoimmune disorders. These diseases are characterized by the overactivation of the immune system, and the LTBR gene is a key regulator of this activation. By understanding the role of the LTBR gene in immune response, scientists may be able to develop new treatments for these diseases.

Genular Protein ID: 3754247457

Symbol: TNR3_HUMAN

Name: Tumor necrosis factor receptor superfamily member 3

UniProtKB Accession Codes:

P36941 B7Z1D2 D3DUR2 F5GXE7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 6 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8486360

Title: Construction and evaluation of a hncDNA library of human 12p transcribed sequences derived from a somatic cell hybrid.

PubMed ID: 8486360

DOI: 10.1006/geno.1993.1161

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8171323

Title: A lymphotoxin-beta-specific receptor.

PubMed ID: 8171323

DOI: 10.1126/science.8171323

PubMed ID: 10207006

Title: The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells.

PubMed ID: 10207006

DOI: 10.1074/jbc.274.17.11868

PubMed ID: 10799510

Title: The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells.

PubMed ID: 10799510

DOI: 10.1074/jbc.275.19.14307

PubMed ID: 8663299

Title: TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor.

PubMed ID: 8663299

DOI: 10.1074/jbc.271.25.14661

PubMed ID: 8995654

Title: Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor.

PubMed ID: 8995654

DOI: 10.1128/jvi.71.2.1301-1309.1997

PubMed ID: 9626059

Title: TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues.

PubMed ID: 9626059

PubMed ID: 9511754

Title: Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5).

PubMed ID: 9511754

DOI: 10.1016/s0378-1119(97)00616-1

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

Sequence Information:

  • Length: 435
  • Mass: 46709
  • Checksum: 624626E6022F656F
  • Sequence:
    • MLLPWATSAP GLAWGPLVLG LFGLLAASQP QAVPPYASEN QTCRDQEKEY YEPQHRICCS 
RCPPGTYVSA KCSRIRDTVC ATCAENSYNE HWNYLTICQL CRPCDPVMGL EEIAPCTSKR 
KTQCRCQPGM FCAAWALECT HCELLSDCPP GTEAELKDEV GKGNNHCVPC KAGHFQNTSS 
PSARCQPHTR CENQGLVEAA PGTAQSDTTC KNPLEPLPPE MSGTMLMLAV LLPLAFFLLL 
ATVFSCIWKS HPSLCRKLGS LLKRRPQGEG PNPVAGSWEP PKAHPYFPDL VQPLLPISGD 
VSPVSTGLPA APVLEAGVPQ QQSPLDLTRE PQLEPGEQSQ VAHGTNGIHV TGGSMTITGN 
IYIYNGPVLG GPPGPGDLPA TPEPPYPIPE EGDPGPPGLS TPHQEDGKAW HLAETEHCGA 
TPSNRGPRNQ FITHD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.