Details for: LTBR

Gene ID: 4055

Symbol: LTBR

Ensembl ID: ENSG00000111321

Description: lymphotoxin beta receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 162.1393
    Cell Significance Index: -25.2200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 88.8255
    Cell Significance Index: -22.5300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 57.1805
    Cell Significance Index: -23.2300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 54.6680
    Cell Significance Index: -25.8100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 51.1922
    Cell Significance Index: -26.3300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 24.2788
    Cell Significance Index: -23.1800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.5279
    Cell Significance Index: -25.3100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.8475
    Cell Significance Index: -26.3800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.4127
    Cell Significance Index: -25.3100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.0404
    Cell Significance Index: -13.2200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.7908
    Cell Significance Index: 51.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.0573
    Cell Significance Index: 83.2200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.4276
    Cell Significance Index: 394.8300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.1162
    Cell Significance Index: 110.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.8936
    Cell Significance Index: 220.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.7708
    Cell Significance Index: 51.0200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.6110
    Cell Significance Index: 24.1400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6051
    Cell Significance Index: 174.5900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5755
    Cell Significance Index: 71.4100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4301
    Cell Significance Index: 74.2900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.2082
    Cell Significance Index: 22.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0867
    Cell Significance Index: 195.8900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9910
    Cell Significance Index: 26.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9507
    Cell Significance Index: 130.5600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.9404
    Cell Significance Index: 8.6600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9171
    Cell Significance Index: 112.7600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9101
    Cell Significance Index: 62.9400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.8941
    Cell Significance Index: 15.8000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8739
    Cell Significance Index: 25.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8658
    Cell Significance Index: 171.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8581
    Cell Significance Index: 23.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7539
    Cell Significance Index: 56.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7093
    Cell Significance Index: 33.3400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.7007
    Cell Significance Index: 7.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6803
    Cell Significance Index: 31.7200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6371
    Cell Significance Index: 347.9100
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.5633
    Cell Significance Index: 3.4900
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.5081
    Cell Significance Index: 4.5100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.5058
    Cell Significance Index: 8.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4553
    Cell Significance Index: 58.8300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4029
    Cell Significance Index: 8.5800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.3662
    Cell Significance Index: 4.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3237
    Cell Significance Index: 143.1000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3140
    Cell Significance Index: 22.2100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.2991
    Cell Significance Index: 3.1000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.2886
    Cell Significance Index: 4.8300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2869
    Cell Significance Index: 36.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2616
    Cell Significance Index: 44.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2458
    Cell Significance Index: 46.7700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2251
    Cell Significance Index: 22.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1762
    Cell Significance Index: 6.1900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1717
    Cell Significance Index: 8.6800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1322
    Cell Significance Index: 119.4000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0464
    Cell Significance Index: 1.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0409
    Cell Significance Index: 30.9300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0407
    Cell Significance Index: 0.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0245
    Cell Significance Index: 45.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0193
    Cell Significance Index: 36.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0185
    Cell Significance Index: 11.7600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0133
    Cell Significance Index: 1.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0124
    Cell Significance Index: 19.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0082
    Cell Significance Index: 0.8400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0038
    Cell Significance Index: 0.0600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0048
    Cell Significance Index: -3.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0073
    Cell Significance Index: -5.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0098
    Cell Significance Index: -4.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0115
    Cell Significance Index: -15.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0146
    Cell Significance Index: -8.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0220
    Cell Significance Index: -16.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0310
    Cell Significance Index: -4.5000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0353
    Cell Significance Index: -2.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0395
    Cell Significance Index: -8.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0505
    Cell Significance Index: -18.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0591
    Cell Significance Index: -1.2800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0714
    Cell Significance Index: -1.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0720
    Cell Significance Index: -14.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0858
    Cell Significance Index: -24.7000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1140
    Cell Significance Index: -2.8500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1257
    Cell Significance Index: -2.4500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1357
    Cell Significance Index: -0.8200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1546
    Cell Significance Index: -17.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1589
    Cell Significance Index: -10.2500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.1698
    Cell Significance Index: -1.0500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1830
    Cell Significance Index: -1.2400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2236
    Cell Significance Index: -3.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2239
    Cell Significance Index: -26.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2244
    Cell Significance Index: -23.3700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2273
    Cell Significance Index: -7.2800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2737
    Cell Significance Index: -5.7300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3104
    Cell Significance Index: -24.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3549
    Cell Significance Index: -21.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3644
    Cell Significance Index: -22.9700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3691
    Cell Significance Index: -9.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3752
    Cell Significance Index: -25.2300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4482
    Cell Significance Index: -27.5500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4571
    Cell Significance Index: -25.6500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4590
    Cell Significance Index: -13.5200
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.4613
    Cell Significance Index: -2.8600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4714
    Cell Significance Index: -12.4000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4844
    Cell Significance Index: -5.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Receptor structure:** LTBR is a type I transmembrane receptor, consisting of an extracellular domain, a transmembrane domain, and an intracellular domain. 2. **Ligand binding:** LTBR binds to LT-alpha and LT-beta, which are members of the TNF family of cytokines. 3. **Signaling pathways:** LTBR activates various signaling pathways, including the NF-κB, JNK, and apoptosis pathways. 4. **Cellular expression:** LTBR is expressed on various cell types, including thymocytes, myeloid leukocytes, lung endothelial cells, and epithelial cells. **Pathways and Functions:** 1. **Apoptotic process:** LTBR plays a crucial role in regulating apoptosis, particularly in the context of immune responses. 2. **Cytokine signaling:** LTBR mediates the signaling of LT-alpha and LT-beta, leading to the activation of downstream pathways. 3. **Immune response:** LTBR is involved in the regulation of immune responses, including the activation of immune cells and the production of cytokines. 4. **Cellular differentiation:** LTBR is required for the differentiation of myeloid dendritic cells and the development of hematopoietic or lymphoid organs. **Clinical Significance:** 1. **Autoimmune diseases:** LTBR has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus. 2. **Cancer:** LTBR is overexpressed in various types of cancer, including lung, colon, and prostate cancer, suggesting its potential role in tumorigenesis. 3. **Infectious diseases:** LTBR plays a critical role in the regulation of immune responses to infections, particularly those caused by bacteria and viruses. 4. **Immunodeficiency disorders:** LTBR mutations have been associated with immunodeficiency disorders, highlighting its importance in immune function. In conclusion, LTBR is a complex receptor that plays a multifaceted role in regulating immune responses, apoptosis, and cellular differentiation. Its dysregulation has been implicated in various diseases, emphasizing the need for further research into its mechanisms and clinical applications.

Genular Protein ID: 3754247457

Symbol: TNR3_HUMAN

Name: Tumor necrosis factor receptor superfamily member 3

UniProtKB Accession Codes:

P36941 B7Z1D2 D3DUR2 F5GXE7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 6 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8486360

Title: Construction and evaluation of a hncDNA library of human 12p transcribed sequences derived from a somatic cell hybrid.

PubMed ID: 8486360

DOI: 10.1006/geno.1993.1161

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8171323

Title: A lymphotoxin-beta-specific receptor.

PubMed ID: 8171323

DOI: 10.1126/science.8171323

PubMed ID: 10207006

Title: The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells.

PubMed ID: 10207006

DOI: 10.1074/jbc.274.17.11868

PubMed ID: 10799510

Title: The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells.

PubMed ID: 10799510

DOI: 10.1074/jbc.275.19.14307

PubMed ID: 8663299

Title: TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor.

PubMed ID: 8663299

DOI: 10.1074/jbc.271.25.14661

PubMed ID: 8995654

Title: Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor.

PubMed ID: 8995654

DOI: 10.1128/jvi.71.2.1301-1309.1997

PubMed ID: 9626059

Title: TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues.

PubMed ID: 9626059

PubMed ID: 9511754

Title: Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5).

PubMed ID: 9511754

DOI: 10.1016/s0378-1119(97)00616-1

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 29507355

Title: Salivary factor LTRIN from Aedes aegypti facilitates the transmission of Zika virus by interfering with the lymphotoxin-beta receptor.

PubMed ID: 29507355

DOI: 10.1038/s41590-018-0063-9

PubMed ID: 38248473

Title: Recognition of Aedes aegypti Mosquito Saliva Protein LTRIN by the Human Receptor LTbetaR for Controlling the Immune Response.

PubMed ID: 38248473

DOI: 10.3390/biology13010042

PubMed ID: 24248355

Title: Dimerization of LTbetaR by LTalpha1beta2 is necessary and sufficient for signal transduction.

PubMed ID: 24248355

DOI: 10.1073/pnas.1310838110

Sequence Information:

  • Length: 435
  • Mass: 46709
  • Checksum: 624626E6022F656F
  • Sequence:
    • MLLPWATSAP GLAWGPLVLG LFGLLAASQP QAVPPYASEN QTCRDQEKEY YEPQHRICCS 
RCPPGTYVSA KCSRIRDTVC ATCAENSYNE HWNYLTICQL CRPCDPVMGL EEIAPCTSKR 
KTQCRCQPGM FCAAWALECT HCELLSDCPP GTEAELKDEV GKGNNHCVPC KAGHFQNTSS 
PSARCQPHTR CENQGLVEAA PGTAQSDTTC KNPLEPLPPE MSGTMLMLAV LLPLAFFLLL 
ATVFSCIWKS HPSLCRKLGS LLKRRPQGEG PNPVAGSWEP PKAHPYFPDL VQPLLPISGD 
VSPVSTGLPA APVLEAGVPQ QQSPLDLTRE PQLEPGEQSQ VAHGTNGIHV TGGSMTITGN 
IYIYNGPVLG GPPGPGDLPA TPEPPYPIPE EGDPGPPGLS TPHQEDGKAW HLAETEHCGA 
TPSNRGPRNQ FITHD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.