Details for: MAN1A1

Gene ID: 4121

Symbol: MAN1A1

Ensembl ID: ENSG00000111885

Description: mannosidase alpha class 1A member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 273.6182
    Cell Significance Index: -42.5600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 159.1605
    Cell Significance Index: -40.3700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 100.2917
    Cell Significance Index: -47.3500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 96.1952
    Cell Significance Index: -39.0800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 87.2303
    Cell Significance Index: -44.8700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 41.4143
    Cell Significance Index: -39.5400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.9323
    Cell Significance Index: -43.0700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 17.5181
    Cell Significance Index: -38.3400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.5891
    Cell Significance Index: -44.4400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 12.9732
    Cell Significance Index: 87.9000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.6525
    Cell Significance Index: -35.7900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.2568
    Cell Significance Index: -44.4200
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 7.2831
    Cell Significance Index: 91.7100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 5.9341
    Cell Significance Index: 99.9600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 5.5808
    Cell Significance Index: 149.5400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 5.0556
    Cell Significance Index: 98.6700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.8110
    Cell Significance Index: 168.5700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.6659
    Cell Significance Index: 138.8200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.4823
    Cell Significance Index: 76.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.1857
    Cell Significance Index: 1142.6500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 3.0385
    Cell Significance Index: 86.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.9289
    Cell Significance Index: 581.2500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.7490
    Cell Significance Index: 154.2600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.0294
    Cell Significance Index: 220.7400
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.7169
    Cell Significance Index: 17.3200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6847
    Cell Significance Index: 337.9500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.6214
    Cell Significance Index: 23.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.1397
    Cell Significance Index: 28.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8808
    Cell Significance Index: 25.2500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8521
    Cell Significance Index: 589.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7990
    Cell Significance Index: 144.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7724
    Cell Significance Index: 59.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7565
    Cell Significance Index: 123.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7328
    Cell Significance Index: 72.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4628
    Cell Significance Index: 56.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4044
    Cell Significance Index: 55.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3994
    Cell Significance Index: 752.0600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3947
    Cell Significance Index: 3.6400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.3043
    Cell Significance Index: 4.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3028
    Cell Significance Index: 57.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2732
    Cell Significance Index: 46.6500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2594
    Cell Significance Index: 6.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2257
    Cell Significance Index: 143.3300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2150
    Cell Significance Index: 6.2000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1975
    Cell Significance Index: 10.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1320
    Cell Significance Index: 243.4000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1159
    Cell Significance Index: 178.4200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0894
    Cell Significance Index: 80.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0823
    Cell Significance Index: 3.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0655
    Cell Significance Index: 48.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0605
    Cell Significance Index: 26.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0192
    Cell Significance Index: 8.7300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0012
    Cell Significance Index: -1.6600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0016
    Cell Significance Index: -1.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0182
    Cell Significance Index: -1.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0218
    Cell Significance Index: -13.6000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0224
    Cell Significance Index: -0.3300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0267
    Cell Significance Index: -1.6000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0273
    Cell Significance Index: -20.6800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0404
    Cell Significance Index: -1.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0447
    Cell Significance Index: -25.2300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0480
    Cell Significance Index: -0.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0624
    Cell Significance Index: -2.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0694
    Cell Significance Index: -14.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0720
    Cell Significance Index: -39.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0763
    Cell Significance Index: -2.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1036
    Cell Significance Index: -10.5900
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.1066
    Cell Significance Index: -0.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1101
    Cell Significance Index: -16.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1267
    Cell Significance Index: -2.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1307
    Cell Significance Index: -37.6000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1564
    Cell Significance Index: -3.3300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1612
    Cell Significance Index: -3.4400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1625
    Cell Significance Index: -11.2400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1697
    Cell Significance Index: -19.3700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1777
    Cell Significance Index: -11.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1900
    Cell Significance Index: -9.8700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2073
    Cell Significance Index: -24.4500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2201
    Cell Significance Index: -28.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2419
    Cell Significance Index: -27.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2488
    Cell Significance Index: -32.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2649
    Cell Significance Index: -27.5800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2661
    Cell Significance Index: -12.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2681
    Cell Significance Index: -31.2500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3053
    Cell Significance Index: -22.7600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3252
    Cell Significance Index: -6.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3521
    Cell Significance Index: -22.7200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4617
    Cell Significance Index: -32.6500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4621
    Cell Significance Index: -14.8000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4924
    Cell Significance Index: -39.0000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4932
    Cell Significance Index: -10.2300
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.5025
    Cell Significance Index: -7.6500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.5547
    Cell Significance Index: -9.3300
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.6019
    Cell Significance Index: -2.6200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6494
    Cell Significance Index: -9.3000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6774
    Cell Significance Index: -18.9300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6991
    Cell Significance Index: -22.8900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7322
    Cell Significance Index: -23.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7505
    Cell Significance Index: -46.0100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7556
    Cell Significance Index: -47.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzyme Function:** MAN1A1 is a type of alpha-mannosidase, specifically responsible for the progressive trimming of alpha-1,2-linked mannose residues from glycoproteins, leading to the production of mature glycoproteins. 2. **Golgi Apparatus Localization:** The MAN1A1 protein is localized to the Golgi apparatus, where it participates in the processing and modification of glycoproteins. 3. **Cellular Expression:** MAN1A1 is significantly expressed in various cell types, including skeletal muscle fibroblasts, cortical cells of the adrenal gland, Purkinje cells, endocrine cells, hepatoblasts, IgG plasmablasts, alveolar type 2 fibroblast cells, kidney collecting duct principal cells, skin fibroblasts, and IgA plasmablasts. 4. **Protein Interactions:** MAN1A1 interacts with other proteins involved in the glycosylation process, including enzymes and chaperones, to regulate the proper functioning of glycoproteins. **Pathways and Functions:** 1. **Asparagine N-Linked Glycosylation:** MAN1A1 plays a crucial role in the processing and modification of asparagine N-linked glycoproteins, which are essential for the proper functioning of proteins in various cellular contexts. 2. **Endoplasmic Reticulum-Golgi Intermediate Compartment (ER-GIC) Trafficking:** MAN1A1 is involved in the transport of glycoproteins from the ER-GIC to the Golgi apparatus, where they undergo further modification and processing. 3. **Protein Glycosylation:** MAN1A1 regulates the glycosylation process, which is essential for the proper functioning of proteins in immune cells and other cell types. 4. **Immune Cell Function:** MAN1A1 is significantly expressed in immune cells, including IgG plasmablasts and IgA plasmablasts, where it plays a crucial role in the regulation of protein glycosylation and immune cell function. **Clinical Significance:** Dysregulation of MAN1A1 has been implicated in various diseases, including autoimmune disorders and cancer. For example, alterations in MAN1A1 expression have been observed in patients with rheumatoid arthritis and lupus. Additionally, MAN1A1 has been identified as a potential target for cancer therapy, as its dysregulation can contribute to the development of cancer. Further research is necessary to fully understand the role of MAN1A1 in human disease and to explore its potential as a therapeutic target. In conclusion, the MAN1A1 gene plays a crucial role in the processing and modification of glycoproteins in the Golgi apparatus, which is essential for the proper functioning of proteins in various cellular contexts, including immune cells. Further research is necessary to fully understand the role of MAN1A1 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 599060959

Symbol: MA1A1_HUMAN

Name: Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA

UniProtKB Accession Codes:

P33908 E7EU32 Q6P052 Q9NU44 Q9UJI3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 6 Ensembl 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 6 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8223597

Title: Molecular cloning and primary structure of Man9-mannosidase from human kidney.

PubMed ID: 8223597

DOI: 10.1111/j.1432-1033.1993.tb18274.x

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 653
  • Mass: 72969
  • Checksum: 9B164926636D8554
  • Sequence:
    • MPVGGLLPLF SSPAGGVLGG GLGGGGGRKG SGPAALRLTE KFVLLLVFSA FITLCFGAIF 
FLPDSSKLLS GVLFHSSPAL QPAADHKPGP GARAEDAAEG RARRREEGAP GDPEAALEDN 
LARIRENHER ALREAKETLQ KLPEEIQRDI LLEKKKVAQD QLRDKAPFRG LPPVDFVPPI 
GVESREPADA AIREKRAKIK EMMKHAWNNY KGYAWGLNEL KPISKGGHSS SLFGNIKGAT 
IVDALDTLFI MEMKHEFEEA KSWVEENLDF NVNAEISVFE VNIRFVGGLL SAYYLSGEEI 
FRKKAVELGV KLLPAFHTPS GIPWALLNMK SGIGRNWPWA SGGSSILAEF GTLHLEFMHL 
SHLSGNPIFA EKVMNIRTVL NKLEKPQGLY PNYLNPSSGQ WGQHHVSVGG LGDSFYEYLL 
KAWLMSDKTD LEAKKMYFDA VQAIETHLIR KSSSGLTYIA EWKGGLLEHK MGHLTCFAGG 
MFALGADAAP EGMAQHYLEL GAEIARTCHE SYNRTFMKLG PEAFRFDGGV EAIATRQNEK 
YYILRPEVME TYMYMWRLTH DPKYRKWAWE AVEALENHCR VNGGYSGLRD VYLLHESYDD 
VQQSFFLAET LKYLYLIFSD DDLLPLEHWI FNSEAHLLPI LPKDKKEVEI REE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.