Details for: MATK

Gene ID: 4145

Symbol: MATK

Ensembl ID: ENSG00000007264

Description: megakaryocyte-associated tyrosine kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 89.7488
    Cell Significance Index: -13.9600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 36.4547
    Cell Significance Index: -14.8100
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 13.5430
    Cell Significance Index: 36.2800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 11.5122
    Cell Significance Index: -2.9200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.4197
    Cell Significance Index: -14.0800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.6847
    Cell Significance Index: -14.5400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.8084
    Cell Significance Index: 43.4500
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.1091
    Cell Significance Index: 22.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.0795
    Cell Significance Index: 205.7100
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.5851
    Cell Significance Index: 15.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1614
    Cell Significance Index: 221.0200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0798
    Cell Significance Index: 175.6200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9513
    Cell Significance Index: 103.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6709
    Cell Significance Index: 134.5800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.5800
    Cell Significance Index: 16.5500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5420
    Cell Significance Index: 37.4900
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 0.5234
    Cell Significance Index: 1.3400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4183
    Cell Significance Index: 26.9900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3828
    Cell Significance Index: 264.7400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3743
    Cell Significance Index: 22.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2976
    Cell Significance Index: 20.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1852
    Cell Significance Index: 66.4200
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.1292
    Cell Significance Index: 1.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1008
    Cell Significance Index: 5.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0236
    Cell Significance Index: 0.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0190
    Cell Significance Index: 2.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0094
    Cell Significance Index: 0.3300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0031
    Cell Significance Index: -0.0800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0046
    Cell Significance Index: -0.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0052
    Cell Significance Index: -9.8900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0058
    Cell Significance Index: -10.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0066
    Cell Significance Index: -0.2900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0078
    Cell Significance Index: -0.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0081
    Cell Significance Index: -12.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0091
    Cell Significance Index: -12.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0175
    Cell Significance Index: -13.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0205
    Cell Significance Index: -9.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0207
    Cell Significance Index: -0.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0214
    Cell Significance Index: -15.8900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0253
    Cell Significance Index: -16.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0257
    Cell Significance Index: -14.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0257
    Cell Significance Index: -16.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0280
    Cell Significance Index: -15.7900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0317
    Cell Significance Index: -14.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0439
    Cell Significance Index: -12.6200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0470
    Cell Significance Index: -1.7800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0479
    Cell Significance Index: -0.4800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0589
    Cell Significance Index: -1.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0589
    Cell Significance Index: -11.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0706
    Cell Significance Index: -12.7400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0758
    Cell Significance Index: -15.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0777
    Cell Significance Index: -9.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0785
    Cell Significance Index: -3.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0794
    Cell Significance Index: -13.5500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0817
    Cell Significance Index: -5.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0887
    Cell Significance Index: -2.4800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0898
    Cell Significance Index: -3.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0958
    Cell Significance Index: -13.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0979
    Cell Significance Index: -13.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0993
    Cell Significance Index: -2.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1111
    Cell Significance Index: -13.6600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1155
    Cell Significance Index: -2.5300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1281
    Cell Significance Index: -9.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1298
    Cell Significance Index: -13.2600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1311
    Cell Significance Index: -15.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1326
    Cell Significance Index: -8.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1382
    Cell Significance Index: -14.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1384
    Cell Significance Index: -15.8600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1469
    Cell Significance Index: -4.6800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1755
    Cell Significance Index: -9.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1847
    Cell Significance Index: -14.1700
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1979
    Cell Significance Index: -2.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2153
    Cell Significance Index: -16.0500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2169
    Cell Significance Index: -7.1000
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.2225
    Cell Significance Index: -3.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2359
    Cell Significance Index: -14.4600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2436
    Cell Significance Index: -4.8900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2440
    Cell Significance Index: -1.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2512
    Cell Significance Index: -14.1000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2539
    Cell Significance Index: -8.9000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2553
    Cell Significance Index: -6.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2572
    Cell Significance Index: -13.3600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2720
    Cell Significance Index: -3.9000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2882
    Cell Significance Index: -3.1400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2940
    Cell Significance Index: -6.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2971
    Cell Significance Index: -13.8500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3009
    Cell Significance Index: -6.5000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3126
    Cell Significance Index: -4.7100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3195
    Cell Significance Index: -7.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3288
    Cell Significance Index: -10.5300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3520
    Cell Significance Index: -6.9600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3520
    Cell Significance Index: -12.9200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3557
    Cell Significance Index: -8.5300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3768
    Cell Significance Index: -5.4000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3898
    Cell Significance Index: -6.6800
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.3975
    Cell Significance Index: -2.8600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4226
    Cell Significance Index: -8.8200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.4235
    Cell Significance Index: -5.6500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.4370
    Cell Significance Index: -13.8200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4377
    Cell Significance Index: -12.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Expression:** MATK is significantly expressed in various immune cell subsets, including neural progenitor cells, CD56-positive natural killer cells, human NKp46-positive innate lymphoid cells, decidual natural killer cells, mature gamma-delta T cells, and alpha-beta cytokine-secreting effector T cells. 2. **Tyrosine Kinase Activity:** MATK is a non-receptor tyrosine kinase that phosphorylates tyrosine residues on target proteins, leading to the activation of downstream signaling pathways. 3. **Signaling Pathways:** MATK is involved in multiple signaling pathways, including the regulation of cell population proliferation, positive regulation of ERBB2 signaling, and downregulation of ERBB2 signaling. 4. **Protein Binding:** MATK interacts with various proteins, including other kinases, phosphatases, and transcription factors, to modulate its activity and influence downstream signaling. **Pathways and Functions:** MATK's involvement in multiple signaling pathways underscores its importance in regulating immune cell function. Some of the key pathways and functions associated with MATK include: 1. **Cell Proliferation:** MATK regulates cell proliferation by phosphorylating and activating downstream targets that control cell cycle progression and apoptosis. 2. **ERBB2 Signaling:** MATK is involved in the regulation of ERBB2 signaling, which is critical for the development and function of various immune cell types. 3. **Natural Killer Cell Function:** MATK is expressed in natural killer cells and is required for their development, activation, and function. 4. **T Cell Function:** MATK is also expressed in T cells and is involved in regulating their development, activation, and function. **Clinical Significance:** The multifunctional nature of MATK and its involvement in various immune cell types make it an attractive target for the development of novel therapeutic strategies for immune-related disorders. Some potential applications of MATK include: 1. **Cancer Immunotherapy:** MATK's role in regulating natural killer cell function makes it a potential target for cancer immunotherapy. 2. **Autoimmune Diseases:** MATK's involvement in T cell function and regulation of ERBB2 signaling may make it a potential target for the treatment of autoimmune diseases. 3. **Infectious Diseases:** MATK's expression in innate lymphoid cells and its role in regulating ERBB2 signaling may make it a potential target for the treatment of infectious diseases. In conclusion, the megakaryocyte-associated tyrosine kinase (MATK) is a multifunctional gene that plays a critical role in regulating immune cell function. Its involvement in multiple signaling pathways and its expression in various immune cell subsets make it an attractive target for further investigation into the mechanisms underlying immune homeostasis and disease.

Genular Protein ID: 2096259430

Symbol: MATK_HUMAN

Name: Megakaryocyte-associated tyrosine-protein kinase

UniProtKB Accession Codes:

P42679 B3KNZ9 Q9NST8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 3 CPTAC 1 CTD 1 ChEBI 7 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 EMBL 20 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 2 PRINTS 2 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8134117

Title: Molecular cloning of a novel non-receptor tyrosine kinase, HYL (hematopoietic consensus tyrosine-lacking kinase).

PubMed ID: 8134117

PubMed ID: 8288563

Title: Identification and characterization of a novel tyrosine kinase from megakaryocytes.

PubMed ID: 8288563

DOI: 10.1016/s0021-9258(17)42222-8

PubMed ID: 7530249

Title: Structural and functional studies of the intracellular tyrosine kinase MATK gene and its translated product.

PubMed ID: 7530249

DOI: 10.1074/jbc.270.4.1833

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7936664

Title: Characterization of mouse non-receptor tyrosine kinase gene, HYL.

PubMed ID: 7936664

PubMed ID: 9171348

Title: Translocation of the Csk homologous kinase (Chk/Hyl) controls activity of CD36-anchored Lyn tyrosine kinase in thrombin-stimulated platelets.

PubMed ID: 9171348

DOI: 10.1093/emboj/16.9.2342

PubMed ID: 9038210

Title: Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes.

PubMed ID: 9038210

DOI: 10.1074/jbc.272.9.5915

PubMed ID: 16129412

Title: Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor.

PubMed ID: 16129412

DOI: 10.1016/j.bbrc.2005.08.055

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 507
  • Mass: 56469
  • Checksum: 85721C6E024575EF
  • Sequence:
    • MAGRGSLVSW RAFHGCDSAE ELPRVSPRFL RAWHPPPVSA RMPTRRWAPG TQCITKCEHT 
RPKPGELAFR KGDVVTILEA CENKSWYRVK HHTSGQEGLL AAGALREREA LSADPKLSLM 
PWFHGKISGQ EAVQQLQPPE DGLFLVRESA RHPGDYVLCV SFGRDVIHYR VLHRDGHLTI 
DEAVFFCNLM DMVEHYSKDK GAICTKLVRP KRKHGTKSAE EELARAGWLL NLQHLTLGAQ 
IGEGEFGAVL QGEYLGQKVA VKNIKCDVTA QAFLDETAVM TKMQHENLVR LLGVILHQGL 
YIVMEHVSKG NLVNFLRTRG RALVNTAQLL QFSLHVAEGM EYLESKKLVH RDLAARNILV 
SEDLVAKVSD FGLAKAERKG LDSSRLPVKW TAPEALKHGK FTSKSDVWSF GVLLWEVFSY 
GRAPYPKMSL KEVSEAVEKG YRMEPPEGCP GPVHVLMSSC WEAEPARRPP FRKLAEKLAR 
ELRSAGAPAS VSGQDADGST SPRSQEP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.