Details for: MEIS2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 412.8237
Cell Significance Index: -104.7100 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 205.0426
Cell Significance Index: -83.3000 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 87.5419
Cell Significance Index: -83.5800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 34.1844
Cell Significance Index: 4969.1100 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 26.4619
Cell Significance Index: -104.4200 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 13.4622
Cell Significance Index: 119.5000 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 7.4089
Cell Significance Index: 45.7100 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 5.5373
Cell Significance Index: 244.9300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 5.2193
Cell Significance Index: 400.5300 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 5.1427
Cell Significance Index: 194.7400 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 4.6952
Cell Significance Index: 64.0600 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 3.9408
Cell Significance Index: 205.2700 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 3.5424
Cell Significance Index: 36.6900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 2.9362
Cell Significance Index: 5528.4900 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.8613
Cell Significance Index: 64.6800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.5267
Cell Significance Index: 71.1800 - Cell Name: preadipocyte (CL0002334)
Fold Change: 1.3967
Cell Significance Index: 27.2600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.3662
Cell Significance Index: 271.1200 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 1.2721
Cell Significance Index: 18.7800 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 1.2290
Cell Significance Index: 14.6500 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.1334
Cell Significance Index: 1744.7600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.0877
Cell Significance Index: 218.2000 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.0728
Cell Significance Index: 29.9800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.0687
Cell Significance Index: 1453.1300 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.0094
Cell Significance Index: 56.6400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.9222
Cell Significance Index: 585.7200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.8762
Cell Significance Index: 1615.8500 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.7232
Cell Significance Index: 20.7300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.5964
Cell Significance Index: 113.5100 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.4921
Cell Significance Index: 340.3600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.4463
Cell Significance Index: 46.4700 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.3127
Cell Significance Index: 4.4900 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2002
Cell Significance Index: 88.5200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0867
Cell Significance Index: 10.6600 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0435
Cell Significance Index: 2.7400 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0354
Cell Significance Index: 31.9500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0391
Cell Significance Index: -28.9700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0445
Cell Significance Index: -15.9700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0486
Cell Significance Index: -8.7700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0683
Cell Significance Index: -9.3800 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0686
Cell Significance Index: -42.8300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0863
Cell Significance Index: -39.1500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1060
Cell Significance Index: -59.7800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.1291
Cell Significance Index: -94.6500 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1437
Cell Significance Index: -16.4000 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.1491
Cell Significance Index: -112.8400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1772
Cell Significance Index: -37.3200 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.1890
Cell Significance Index: -103.2000 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.1949
Cell Significance Index: -4.0800 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2450
Cell Significance Index: -4.1000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.3407
Cell Significance Index: -98.0400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.3958
Cell Significance Index: -67.5900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.5171
Cell Significance Index: -60.2600 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.5250
Cell Significance Index: -85.3900 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.5328
Cell Significance Index: -9.1300 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.5372
Cell Significance Index: -58.4400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.5538
Cell Significance Index: -15.9600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.6429
Cell Significance Index: -73.6600 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.6460
Cell Significance Index: -83.4600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.6466
Cell Significance Index: -22.7200 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.7166
Cell Significance Index: -91.8700 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.7909
Cell Significance Index: -47.4800 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: -0.8377
Cell Significance Index: -6.0900 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.8378
Cell Significance Index: -39.3800 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.8418
Cell Significance Index: -58.2200 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.8442
Cell Significance Index: -99.5600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.8617
Cell Significance Index: -88.0200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.9250
Cell Significance Index: -29.6300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.9271
Cell Significance Index: -91.7100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.9415
Cell Significance Index: -49.4300 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.9688
Cell Significance Index: -25.9600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.9780
Cell Significance Index: -69.1700 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.9917
Cell Significance Index: -12.3000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -1.0293
Cell Significance Index: -53.4700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.1944
Cell Significance Index: -94.6000 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.2532
Cell Significance Index: -27.1500 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -1.3002
Cell Significance Index: -96.9100 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -1.3090
Cell Significance Index: -16.7900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -1.3193
Cell Significance Index: -59.8000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.3550
Cell Significance Index: -83.0800 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.4196
Cell Significance Index: -35.4900 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.4774
Cell Significance Index: -47.0600 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -1.4812
Cell Significance Index: -25.6100 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -1.5564
Cell Significance Index: -100.4100 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -1.6222
Cell Significance Index: -24.4500 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.6399
Cell Significance Index: -110.2700 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -1.6951
Cell Significance Index: -104.1900 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -1.8180
Cell Significance Index: -22.6700 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.8708
Cell Significance Index: -61.2500 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -2.0093
Cell Significance Index: -70.3900 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -2.2887
Cell Significance Index: -57.0900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -2.3407
Cell Significance Index: -62.5000 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -2.3681
Cell Significance Index: -74.9000 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -2.7078
Cell Significance Index: -99.4000 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -2.7249
Cell Significance Index: -77.7600 - Cell Name: granulosa cell (CL0000501)
Fold Change: -2.7384
Cell Significance Index: -72.0100 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -2.7580
Cell Significance Index: -42.6700 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -2.8071
Cell Significance Index: -82.6800 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: -2.9071
Cell Significance Index: -33.7600 - Cell Name: astrocyte (CL0000127)
Fold Change: -3.1214
Cell Significance Index: -35.7300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3890267073
Symbol: MEIS2_HUMAN
Name: Homeobox protein Meis2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10764806
Title: Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription.
PubMed ID: 10764806
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16572171
Title: Analysis of the DNA sequence and duplication history of human chromosome 15.
PubMed ID: 16572171
DOI: 10.1038/nature04601
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9383298
Title: Chromosomal mapping to 15q14 and expression analysis of the human MEIS2 homeobox gene.
PubMed ID: 9383298
PubMed ID: 11279116
Title: DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex.
PubMed ID: 11279116
PubMed ID: 20523026
Title: Spatiotemporal distribution of PAX6 and MEIS2 expression and total cell numbers in the ganglionic eminence in the early developing human forebrain.
PubMed ID: 20523026
DOI: 10.1159/000297602
PubMed ID: 20553494
Title: An autoinhibitory effect of the homothorax domain of Meis2.
PubMed ID: 20553494
PubMed ID: 19559479
Title: MEIS proteins as partners of the TLX1/HOX11 oncoprotein.
PubMed ID: 19559479
PubMed ID: 21746878
Title: Cooperative transcriptional activation by Klf4, Meis2, and Pbx1.
PubMed ID: 21746878
DOI: 10.1128/mcb.01456-10
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24678003
Title: Haploinsufficiency of MEIS2 is associated with orofacial clefting and learning disability.
PubMed ID: 24678003
DOI: 10.1002/ajmg.a.36498
PubMed ID: 26550823
Title: DNA-dependent formation of transcription factor pairs alters their binding specificity.
PubMed ID: 26550823
DOI: 10.1038/nature15518
PubMed ID: 25712757
Title: MEIS2 involvement in cardiac development, cleft palate, and intellectual disability.
PubMed ID: 25712757
DOI: 10.1002/ajmg.a.36989
PubMed ID: 27225850
Title: De novo MEIS2 mutation causes syndromic developmental delay with persistent gastro-esophageal reflux.
PubMed ID: 27225850
DOI: 10.1038/jhg.2016.54
Sequence Information:
- Length: 477
- Mass: 51790
- Checksum: 94EBD0801A312B24
- Sequence:
MAQRYDELPH YGGMDGVGVP ASMYGDPHAP RPIPPVHHLN HGPPLHATQH YGAHAPHPNV MPASMGSAVN DALKRDKDAI YGHPLFPLLA LVFEKCELAT CTPREPGVAG GDVCSSDSFN EDIAVFAKQV RAEKPLFSSN PELDNLMIQA IQVLRFHLLE LEKVHELCDN FCHRYISCLK GKMPIDLVID ERDGSSKSDH EELSGSSTNL ADHNPSSWRD HDDATSTHSA GTPGPSSGGH ASQSGDNSSE QGDGLDNSVA SPGTGDDDDP DKDKKRQKKR GIFPKVATNI MRAWLFQHLT HPYPSEEQKK QLAQDTGLTI LQVNNWFINA RRRIVQPMID QSNRAGFLLD PSVSQGAAYS PEGQPMGSFV LDGQQHMGIR PAGLQSMPGD YVSQGGPMGM SMAQPSYTPP QMTPHPTQLR HGPPMHSYLP SHPHHPAMMM HGGPPTHPGM TMSAQSPTML NSVDPNVGGQ VMDIHAQ
Genular Protein ID: 1860660238
Symbol: B7Z6F6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 457
- Mass: 49541
- Checksum: 465000408DFF504B
- Sequence:
MDGVGVPASM YGDPHAPRPI PPVHHLNHGP PLHATQHYGA HAPHPNVMPA SMGSAVNDAL KRDKDAIYGH PLFPLLALVF EKCKLATCTP REPGVAGGDV CSSDSFNEDI AVFAKQVRAE KPLFSSNPEL DNLMIQAIQV LRFHLLELEK VHELCDNFCH RYISCLKGKM PIDLVIDERD GSSKSDHEEL SGSSTNLADH NPSSWRDHDD ATSTHSAGTP GPSSGGHASQ SGDNSSEQGD GLDNSVASPG TGDDDDPDKD KKRQKKRGIF PKVATNIMRA WLFQHLTHPY PSEEQKKQLA QDTGLTILQV NNWFINARRR IVQPMIDQSN RAVSQGAAYS PEGQPMGSFV LDGQQHMGIR PAGLQSMPGD YVSQGGPMGM SMAQPSYTPP QMTPHPTQLR HGPPMHSYLP SHPHHPAMMM HGGPPTHPGM TMSAQSPTML NSVDPNVGGQ VMDIHAQ
Genular Protein ID: 2351306299
Symbol: B3KPD8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
Sequence Information:
- Length: 388
- Mass: 42256
- Checksum: 59B5404A0DC5B533
- Sequence:
MDGVGVPASM YGDPHAPRPI PPVHHLNHGP PLHATQHYGA HAPHPNVMPA SMGSAVNDAL KRDKDAIYGH PLFPLLALVF EKCEPATCTP REPGVAGGDV CSSDSFNEDI AVFAKQVRAE KPLFSSNPEL DNLMIQAIQV LRFHLLELEK VHELCDNFCH RYISCLKGKM PIDLVIDERD GSSKSDHEEL SGSSTNLADH NPSSWRDHDD ATSTHSAGTP GPSSGGHASQ SGDNSSEQGD GLDNSVASPG TGDDDDPDKD KKRQKKRGIF PKVATNIMRA WLFQHLTHPY PSEEQKKQLA QDTGLTILQV NNWFINARRR IVQPMIDQSN RAGFLLDPSV SQGAAYSPEG QPMGSFVLDG QQHMGIRPAG PMSGMGMNMG MDGQWHYM
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.