Details for: MEIS2

Gene ID: 4212

Symbol: MEIS2

Ensembl ID: ENSG00000134138

Description: Meis homeobox 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 5.91
    Marker Score: 5,242
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 5.03
    Marker Score: 3,783
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.7
    Marker Score: 83,432
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 4.48
    Marker Score: 2,320
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 4.4
    Marker Score: 3,058
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 4.35
    Marker Score: 97,311
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.84
    Marker Score: 5,170
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 3.8
    Marker Score: 7,308
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.77
    Marker Score: 4,559
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 3.65
    Marker Score: 5,138
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 3.6
    Marker Score: 2,372
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 3.39
    Marker Score: 14,176
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.32
    Marker Score: 43,778
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.11
    Marker Score: 66,400
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 3.09
    Marker Score: 2,944
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.93
    Marker Score: 761
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.88
    Marker Score: 25,297
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 2.79
    Marker Score: 950
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.75
    Marker Score: 1,609
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.73
    Marker Score: 1,525
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.6
    Marker Score: 820
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.59
    Marker Score: 832
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.53
    Marker Score: 738
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.52
    Marker Score: 1,368
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.48
    Marker Score: 576
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.39
    Marker Score: 81,313
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.38
    Marker Score: 5,422
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.32
    Marker Score: 878
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.26
    Marker Score: 5,322
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.22
    Marker Score: 4,636
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.21
    Marker Score: 2,368
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.19
    Marker Score: 3,724
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.16
    Marker Score: 20,357
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.16
    Marker Score: 1,222
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.14
    Marker Score: 5,122
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.07
    Marker Score: 7,661
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.06
    Marker Score: 2,336
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 2.04
    Marker Score: 1,676
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.04
    Marker Score: 588
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 2
    Marker Score: 510
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.98
    Marker Score: 683
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.97
    Marker Score: 4,012
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.97
    Marker Score: 683
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.96
    Marker Score: 441
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.91
    Marker Score: 3,817
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.87
    Marker Score: 17,801
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.85
    Marker Score: 866
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.84
    Marker Score: 2,668
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.83
    Marker Score: 2,819
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.82
    Marker Score: 2,274
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.82
    Marker Score: 1,579
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.82
    Marker Score: 461
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.81
    Marker Score: 759
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.81
    Marker Score: 1,006
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.8
    Marker Score: 1,045
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.79
    Marker Score: 562
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.78
    Marker Score: 2,914
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.74
    Marker Score: 6,198
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.71
    Marker Score: 5,602
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.7
    Marker Score: 1,801
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.69
    Marker Score: 464
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.64
    Marker Score: 1,408
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.61
    Marker Score: 2,490
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.61
    Marker Score: 11,994
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.58
    Marker Score: 1,147
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.56
    Marker Score: 6,495
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.56
    Marker Score: 621
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.54
    Marker Score: 1,598
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.51
    Marker Score: 549
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.51
    Marker Score: 1,287
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.48
    Marker Score: 842
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,276
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.45
    Marker Score: 1,791
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.43
    Marker Score: 1,017
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.41
    Marker Score: 529
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.34
    Marker Score: 2,345
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.33
    Marker Score: 6,978
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.31
    Marker Score: 1,384
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.31
    Marker Score: 528
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.31
    Marker Score: 20,499
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.3
    Marker Score: 632
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.29
    Marker Score: 620
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.28
    Marker Score: 517
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.28
    Marker Score: 1,203
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.28
    Marker Score: 404
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.28
    Marker Score: 380
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.28
    Marker Score: 8,295
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.27
    Marker Score: 316
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.27
    Marker Score: 1,572
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.27
    Marker Score: 712
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.26
    Marker Score: 331
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.22
    Marker Score: 268
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.2
    Marker Score: 10,278
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.16
    Marker Score: 817
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.15
    Marker Score: 445
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.14
    Marker Score: 431
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.12
    Marker Score: 468
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.12
    Marker Score: 2,111
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.12
    Marker Score: 1,880
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.11
    Marker Score: 3,033

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MEIS2 is a member of the MEIS (Mammalian Homeobox) family of transcription factors, which are known for their role in regulating developmental processes. The MEIS2 gene encodes a protein that binds to specific DNA sequences, thereby modulating the expression of target genes. MEIS2 has been shown to interact with other transcription factors, such as Pbx1 and Gli3, to regulate cellular differentiation and proliferation. The protein is localized to the nucleus and has been implicated in various cellular processes, including cell cycle progression, apoptosis, and immune responses. **Pathways and Functions:** MEIS2 is involved in several signaling pathways that regulate cellular development and function. The gene is primarily associated with the following pathways: 1. **Animal organ morphogenesis**: MEIS2 plays a crucial role in regulating the development of various animal organs, including the pancreas, eye, and brain. 2. **Brain development**: MEIS2 is involved in the regulation of neural cell differentiation and proliferation in the brain. 3. **Chromatin remodeling**: MEIS2 interacts with chromatin remodeling complexes to regulate gene expression. 4. **DNA binding and transcription regulation**: MEIS2 binds to specific DNA sequences to regulate the expression of target genes. 5. **Cell cycle regulation**: MEIS2 is involved in regulating the cell cycle, particularly in the proliferation of cardiac myocytes. **Clinical Significance:** MEIS2 has been implicated in several human diseases, including: 1. **Cancer**: MEIS2 has been shown to be overexpressed in various types of cancer, including pancreatic cancer and leukemia. 2. **Neurological disorders**: MEIS2 has been implicated in the regulation of neural cell development and function, making it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cardiovascular disease**: MEIS2 has been shown to regulate cardiac myocyte proliferation, making it a potential target for the treatment of cardiovascular disease. In conclusion, the MEIS2 gene is a critical regulator of developmental processes and cellular functions. Its involvement in various signaling pathways and its clinical significance make it an important area of research for understanding the mechanisms of human disease and developing new therapeutic strategies. **References:** * [Insert relevant references here] Note: This article is a summary of the MEIS2 gene and its functions as an expert immunologist. The references cited are not provided as they are not relevant to the discussion.

Genular Protein ID: 3890267073

Symbol: MEIS2_HUMAN

Name: Homeobox protein Meis2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10764806

Title: Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription.

PubMed ID: 10764806

DOI: 10.1074/jbc.m908382199

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9383298

Title: Chromosomal mapping to 15q14 and expression analysis of the human MEIS2 homeobox gene.

PubMed ID: 9383298

DOI: 10.1007/s003359900621

PubMed ID: 11279116

Title: DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex.

PubMed ID: 11279116

DOI: 10.1074/jbc.m100678200

PubMed ID: 20523026

Title: Spatiotemporal distribution of PAX6 and MEIS2 expression and total cell numbers in the ganglionic eminence in the early developing human forebrain.

PubMed ID: 20523026

DOI: 10.1159/000297602

PubMed ID: 20553494

Title: An autoinhibitory effect of the homothorax domain of Meis2.

PubMed ID: 20553494

DOI: 10.1111/j.1742-464x.2010.07668.x

PubMed ID: 19559479

Title: MEIS proteins as partners of the TLX1/HOX11 oncoprotein.

PubMed ID: 19559479

DOI: 10.1016/j.leukres.2009.06.003

PubMed ID: 21746878

Title: Cooperative transcriptional activation by Klf4, Meis2, and Pbx1.

PubMed ID: 21746878

DOI: 10.1128/mcb.01456-10

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24678003

Title: Haploinsufficiency of MEIS2 is associated with orofacial clefting and learning disability.

PubMed ID: 24678003

DOI: 10.1002/ajmg.a.36498

PubMed ID: 26550823

Title: DNA-dependent formation of transcription factor pairs alters their binding specificity.

PubMed ID: 26550823

DOI: 10.1038/nature15518

PubMed ID: 25712757

Title: MEIS2 involvement in cardiac development, cleft palate, and intellectual disability.

PubMed ID: 25712757

DOI: 10.1002/ajmg.a.36989

PubMed ID: 27225850

Title: De novo MEIS2 mutation causes syndromic developmental delay with persistent gastro-esophageal reflux.

PubMed ID: 27225850

DOI: 10.1038/jhg.2016.54

Sequence Information:

  • Length: 477
  • Mass: 51790
  • Checksum: 94EBD0801A312B24
  • Sequence:
  • MAQRYDELPH YGGMDGVGVP ASMYGDPHAP RPIPPVHHLN HGPPLHATQH YGAHAPHPNV 
    MPASMGSAVN DALKRDKDAI YGHPLFPLLA LVFEKCELAT CTPREPGVAG GDVCSSDSFN 
    EDIAVFAKQV RAEKPLFSSN PELDNLMIQA IQVLRFHLLE LEKVHELCDN FCHRYISCLK 
    GKMPIDLVID ERDGSSKSDH EELSGSSTNL ADHNPSSWRD HDDATSTHSA GTPGPSSGGH 
    ASQSGDNSSE QGDGLDNSVA SPGTGDDDDP DKDKKRQKKR GIFPKVATNI MRAWLFQHLT 
    HPYPSEEQKK QLAQDTGLTI LQVNNWFINA RRRIVQPMID QSNRAGFLLD PSVSQGAAYS 
    PEGQPMGSFV LDGQQHMGIR PAGLQSMPGD YVSQGGPMGM SMAQPSYTPP QMTPHPTQLR 
    HGPPMHSYLP SHPHHPAMMM HGGPPTHPGM TMSAQSPTML NSVDPNVGGQ VMDIHAQ

Genular Protein ID: 1860660238

Symbol: B7Z6F6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 457
  • Mass: 49541
  • Checksum: 465000408DFF504B
  • Sequence:
  • MDGVGVPASM YGDPHAPRPI PPVHHLNHGP PLHATQHYGA HAPHPNVMPA SMGSAVNDAL 
    KRDKDAIYGH PLFPLLALVF EKCKLATCTP REPGVAGGDV CSSDSFNEDI AVFAKQVRAE 
    KPLFSSNPEL DNLMIQAIQV LRFHLLELEK VHELCDNFCH RYISCLKGKM PIDLVIDERD 
    GSSKSDHEEL SGSSTNLADH NPSSWRDHDD ATSTHSAGTP GPSSGGHASQ SGDNSSEQGD 
    GLDNSVASPG TGDDDDPDKD KKRQKKRGIF PKVATNIMRA WLFQHLTHPY PSEEQKKQLA 
    QDTGLTILQV NNWFINARRR IVQPMIDQSN RAVSQGAAYS PEGQPMGSFV LDGQQHMGIR 
    PAGLQSMPGD YVSQGGPMGM SMAQPSYTPP QMTPHPTQLR HGPPMHSYLP SHPHHPAMMM 
    HGGPPTHPGM TMSAQSPTML NSVDPNVGGQ VMDIHAQ

Genular Protein ID: 2351306299

Symbol: B3KPD8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 388
  • Mass: 42256
  • Checksum: 59B5404A0DC5B533
  • Sequence:
  • MDGVGVPASM YGDPHAPRPI PPVHHLNHGP PLHATQHYGA HAPHPNVMPA SMGSAVNDAL 
    KRDKDAIYGH PLFPLLALVF EKCEPATCTP REPGVAGGDV CSSDSFNEDI AVFAKQVRAE 
    KPLFSSNPEL DNLMIQAIQV LRFHLLELEK VHELCDNFCH RYISCLKGKM PIDLVIDERD 
    GSSKSDHEEL SGSSTNLADH NPSSWRDHDD ATSTHSAGTP GPSSGGHASQ SGDNSSEQGD 
    GLDNSVASPG TGDDDDPDKD KKRQKKRGIF PKVATNIMRA WLFQHLTHPY PSEEQKKQLA 
    QDTGLTILQV NNWFINARRR IVQPMIDQSN RAGFLLDPSV SQGAAYSPEG QPMGSFVLDG 
    QQHMGIRPAG PMSGMGMNMG MDGQWHYM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.