Details for: MMP11

Gene ID: 4320

Symbol: MMP11

Ensembl ID: ENSG00000099953

Description: matrix metallopeptidase 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 37.6739
    Cell Significance Index: -5.8600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 22.2359
    Cell Significance Index: -5.6400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 12.2638
    Cell Significance Index: -5.7900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 5.9231
    Cell Significance Index: -5.6600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.7528
    Cell Significance Index: -5.8600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 4.1838
    Cell Significance Index: 53.5800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.7418
    Cell Significance Index: 57.3900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.6100
    Cell Significance Index: 40.3800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.3368
    Cell Significance Index: -6.2600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.7091
    Cell Significance Index: 27.4200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.5981
    Cell Significance Index: 9.9300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.4863
    Cell Significance Index: -5.8700
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.2726
    Cell Significance Index: 11.5500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2397
    Cell Significance Index: 235.9300
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.9115
    Cell Significance Index: 4.2100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6613
    Cell Significance Index: 17.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6201
    Cell Significance Index: 61.3400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.5670
    Cell Significance Index: 8.1200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.5417
    Cell Significance Index: 13.5100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.4535
    Cell Significance Index: 4.9300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4382
    Cell Significance Index: 395.6300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4289
    Cell Significance Index: 25.7500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3758
    Cell Significance Index: 13.0600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3294
    Cell Significance Index: 53.5700
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.3186
    Cell Significance Index: 1.8700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2958
    Cell Significance Index: 40.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2919
    Cell Significance Index: 57.9200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2352
    Cell Significance Index: 5.1500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.2042
    Cell Significance Index: 1.7200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1956
    Cell Significance Index: 13.5300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1821
    Cell Significance Index: 11.7500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0929
    Cell Significance Index: 2.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0716
    Cell Significance Index: 9.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0653
    Cell Significance Index: 2.9600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.0627
    Cell Significance Index: 0.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0440
    Cell Significance Index: 5.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0366
    Cell Significance Index: 0.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0365
    Cell Significance Index: 19.9600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0364
    Cell Significance Index: 0.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0257
    Cell Significance Index: 0.7400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0248
    Cell Significance Index: 0.6200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0220
    Cell Significance Index: 2.5100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0166
    Cell Significance Index: 1.2800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0128
    Cell Significance Index: 1.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0101
    Cell Significance Index: 4.4800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0087
    Cell Significance Index: 0.4400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0071
    Cell Significance Index: 0.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0023
    Cell Significance Index: 1.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0009
    Cell Significance Index: 1.7100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0011
    Cell Significance Index: -0.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0030
    Cell Significance Index: -5.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0031
    Cell Significance Index: -2.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0036
    Cell Significance Index: -5.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0041
    Cell Significance Index: -5.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0043
    Cell Significance Index: -1.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0051
    Cell Significance Index: -1.8500
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: -0.0069
    Cell Significance Index: -0.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0075
    Cell Significance Index: -5.6600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0078
    Cell Significance Index: -4.9600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0079
    Cell Significance Index: -5.7600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0079
    Cell Significance Index: -0.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0084
    Cell Significance Index: -4.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0087
    Cell Significance Index: -1.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0088
    Cell Significance Index: -0.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0099
    Cell Significance Index: -1.9900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0105
    Cell Significance Index: -4.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0111
    Cell Significance Index: -0.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0128
    Cell Significance Index: -2.7000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0150
    Cell Significance Index: -0.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0185
    Cell Significance Index: -0.9700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0208
    Cell Significance Index: -3.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0211
    Cell Significance Index: -3.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0217
    Cell Significance Index: -2.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0228
    Cell Significance Index: -2.3300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0251
    Cell Significance Index: -0.2600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0293
    Cell Significance Index: -1.2000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0328
    Cell Significance Index: -1.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0342
    Cell Significance Index: -4.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0444
    Cell Significance Index: -5.7300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0468
    Cell Significance Index: -0.9700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0515
    Cell Significance Index: -3.6400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0546
    Cell Significance Index: -5.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0568
    Cell Significance Index: -3.4800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0600
    Cell Significance Index: -0.5100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0619
    Cell Significance Index: -1.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0631
    Cell Significance Index: -2.9400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0669
    Cell Significance Index: -0.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0749
    Cell Significance Index: -5.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0750
    Cell Significance Index: -4.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0753
    Cell Significance Index: -2.0100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0792
    Cell Significance Index: -1.1700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0868
    Cell Significance Index: -2.2300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0871
    Cell Significance Index: -0.5900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0895
    Cell Significance Index: -5.6400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0902
    Cell Significance Index: -0.7200
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0939
    Cell Significance Index: -1.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1059
    Cell Significance Index: -4.9800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1114
    Cell Significance Index: -5.8500
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1126
    Cell Significance Index: -0.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1138
    Cell Significance Index: -5.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MMP11 is a 44-kDa protein that belongs to the matrix metalloproteinase family, which is characterized by the presence of a zinc-binding site and a catalytic domain. The enzyme is a type II transmembrane protein, with a short intracellular tail and a long extracellular tail that contains multiple proteolytic sites. MMP11 is expressed in various tissues, including the kidney, lung, ovary, and bone, where it is involved in the degradation and remodeling of the ECM. One of the key characteristics of MMP11 is its ability to degrade a wide range of ECM components, including collagens, elastin, and laminin. The enzyme also exhibits a high degree of substrate specificity, with a preference for degrading type II collagen. In addition, MMP11 has been shown to be involved in the regulation of various cellular processes, including cell migration, adhesion, and differentiation. **Pathways and Functions** MMP11 plays a crucial role in various physiological and pathological processes, including: 1. **Tissue development and remodeling**: MMP11 is involved in the degradation and remodeling of the ECM during tissue development and remodeling. The enzyme is expressed in various tissues, including the kidney, lung, and bone, where it is involved in the formation of new tissue and the repair of damaged tissue. 2. **Inflammation and immune response**: MMP11 is involved in the regulation of the inflammatory response and the immune response. The enzyme is expressed in various immune cells, including macrophages and neutrophils, where it is involved in the degradation of ECM components and the release of pro-inflammatory cytokines. 3. **Cancer progression**: MMP11 is involved in the degradation and remodeling of the ECM during cancer progression. The enzyme is expressed in various types of cancer, including breast, lung, and colon cancer, where it is involved in the invasion and metastasis of cancer cells. 4. **Bone remodeling**: MMP11 is involved in the regulation of bone remodeling, where it is expressed in osteoblasts and osteoclasts. The enzyme is involved in the degradation of ECM components and the release of growth factors that regulate bone formation. **Clinical Significance** MMP11 has been implicated in various diseases, including: 1. **Osteoarthritis**: MMP11 has been shown to be involved in the degradation and remodeling of the ECM in osteoarthritis, where it contributes to the progression of the disease. 2. **Cancer**: MMP11 has been shown to be involved in the degradation and remodeling of the ECM in various types of cancer, where it contributes to the invasion and metastasis of cancer cells. 3. **Rheumatoid arthritis**: MMP11 has been shown to be involved in the degradation and remodeling of the ECM in rheumatoid arthritis, where it contributes to the progression of the disease. 4. **Cardiovascular disease**: MMP11 has been shown to be involved in the degradation and remodeling of the ECM in cardiovascular disease, where it contributes to the progression of atherosclerosis. In conclusion, MMP11 is a multifunctional enzyme that plays a crucial role in various physiological and pathological processes, including tissue development, inflammation, cancer progression, and bone remodeling. Its dysregulation has been implicated in various diseases, including osteoarthritis, cancer, rheumatoid arthritis, and cardiovascular disease.

Genular Protein ID: 2745722639

Symbol: MMP11_HUMAN

Name: Stromelysin-3

UniProtKB Accession Codes:

P24347 Q5FX24 Q6PEZ6 Q9UC26

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 10 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1701851

Title: A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas.

PubMed ID: 1701851

DOI: 10.1038/348699a0

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7657606

Title: Structure and promoter characterization of the human stromelysin-3 gene.

PubMed ID: 7657606

DOI: 10.1074/jbc.270.35.20337

PubMed ID: 7746327

Title: Furin-dependent intracellular activation of the human stromelysin-3 zymogen.

PubMed ID: 7746327

DOI: 10.1038/375244a0

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 488
  • Mass: 54590
  • Checksum: F03C537EE76706A9
  • Sequence:
    • MAPAAWLRSA AARALLPPML LLLLQPPPLL ARALPPDAHH LHAERRGPQP WHAALPSSPA 
PAPATQEAPR PASSLRPPRC GVPDPSDGLS ARNRQKRFVL SGGRWEKTDL TYRILRFPWQ 
LVQEQVRQTM AEALKVWSDV TPLTFTEVHE GRADIMIDFA RYWHGDDLPF DGPGGILAHA 
FFPKTHREGD VHFDYDETWT IGDDQGTDLL QVAAHEFGHV LGLQHTTAAK ALMSAFYTFR 
YPLSLSPDDC RGVQHLYGQP WPTVTSRTPA LGPQAGIDTN EIAPLEPDAP PDACEASFDA 
VSTIRGELFF FKAGFVWRLR GGQLQPGYPA LASRHWQGLP SPVDAAFEDA QGHIWFFQGA 
QYWVYDGEKP VLGPAPLTEL GLVRFPVHAA LVWGPEKNKI YFFRGRDYWR FHPSTRRVDS 
PVPRRATDWR GVPSEIDAAF QDADGYAYFL RGRLYWKFDP VKVKALEGFP RLVGPDFFGC 
AEPANTFL

Genular Protein ID: 1035160422

Symbol: B3KQS8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KQS8

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 21 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 GO 4 Gene3D 2 InterPro 9 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 2 SMART 3 SUPFAM 2

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

Sequence Information:

  • Length: 354
  • Mass: 38811
  • Checksum: 5CAE5F858382D7AD
  • Sequence:
    • MAPAAWLRSA AARALLPPML LLLLQPPPLL ARALPPDVHH LHAERRGPQP WHAALPSSPA 
PAPATQEAPR PASSLRPPRC GVPDPSDGLS ARNRQKRILR FPWQLVQEQV RQTMAEALKV 
WSDVTPLTFT EVHEGRADIM IDFARYWHGD DLPFDGPGGI LAHAFFPKTH REGDVHFDYD 
ETWTIGDDQG TDLLQVAAHE FGHVLGLQHT TAAKALMSAF YTFRYPLSLS PDDCRGVQHL 
YGQPWPTVTS RTPALGPQAG IDTNEIAPLE PDAPPDACEA SFDAVSTIRG ELFFFKAGFV 
WRLRGGQLQP GYPALASRHW QGLPSPVDAA FEDAQGHIWF FQGTTGVSTP APGV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.