Details for: MRE11

Gene ID: 4361

Symbol: MRE11

Ensembl ID: ENSG00000020922

Description: MRE11 homolog, double strand break repair nuclease

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 59.6032
    Cell Significance Index: -28.1400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 55.9990
    Cell Significance Index: -22.7500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 42.0403
    Cell Significance Index: -28.2100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 23.9541
    Cell Significance Index: -22.8700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.4070
    Cell Significance Index: -25.2000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.2604
    Cell Significance Index: -22.3000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.4367
    Cell Significance Index: -9.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.2699
    Cell Significance Index: 224.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.2813
    Cell Significance Index: 71.9000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2008
    Cell Significance Index: 130.6200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1617
    Cell Significance Index: 15.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1210
    Cell Significance Index: 224.8700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0154
    Cell Significance Index: 60.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8609
    Cell Significance Index: 170.8500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8055
    Cell Significance Index: 22.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5674
    Cell Significance Index: 102.2900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5497
    Cell Significance Index: 380.2200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5335
    Cell Significance Index: 36.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4621
    Cell Significance Index: 17.5000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.4589
    Cell Significance Index: 9.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4582
    Cell Significance Index: 164.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4436
    Cell Significance Index: 54.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4221
    Cell Significance Index: 18.6700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3981
    Cell Significance Index: 7.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3896
    Cell Significance Index: 8.4400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3838
    Cell Significance Index: 19.3900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3677
    Cell Significance Index: 23.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3574
    Cell Significance Index: 158.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3544
    Cell Significance Index: 48.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3082
    Cell Significance Index: 8.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3035
    Cell Significance Index: 18.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2903
    Cell Significance Index: 158.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2553
    Cell Significance Index: 13.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2435
    Cell Significance Index: 16.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2108
    Cell Significance Index: 24.8600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1842
    Cell Significance Index: 5.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1827
    Cell Significance Index: 8.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1693
    Cell Significance Index: 7.9600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1345
    Cell Significance Index: 9.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0945
    Cell Significance Index: 12.1200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0768
    Cell Significance Index: 14.6200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0765
    Cell Significance Index: 12.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0736
    Cell Significance Index: 3.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0654
    Cell Significance Index: 5.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0408
    Cell Significance Index: 76.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0408
    Cell Significance Index: 4.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0398
    Cell Significance Index: 73.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0388
    Cell Significance Index: 59.6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0364
    Cell Significance Index: 1.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0192
    Cell Significance Index: 8.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0189
    Cell Significance Index: 12.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0186
    Cell Significance Index: 16.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0059
    Cell Significance Index: 8.0800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0047
    Cell Significance Index: 0.0800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0004
    Cell Significance Index: 0.0100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0136
    Cell Significance Index: -0.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0193
    Cell Significance Index: -14.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0270
    Cell Significance Index: -3.9200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0285
    Cell Significance Index: -21.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0302
    Cell Significance Index: -22.8600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0347
    Cell Significance Index: -5.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0414
    Cell Significance Index: -23.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0451
    Cell Significance Index: -2.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0470
    Cell Significance Index: -6.0800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0482
    Cell Significance Index: -3.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0529
    Cell Significance Index: -33.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0784
    Cell Significance Index: -22.5700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0809
    Cell Significance Index: -1.9400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0921
    Cell Significance Index: -9.4100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1129
    Cell Significance Index: -13.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1406
    Cell Significance Index: -29.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1480
    Cell Significance Index: -4.7400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1512
    Cell Significance Index: -3.7800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1545
    Cell Significance Index: -3.2800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1741
    Cell Significance Index: -6.0500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1970
    Cell Significance Index: -14.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2065
    Cell Significance Index: -21.5000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2202
    Cell Significance Index: -5.6600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2279
    Cell Significance Index: -5.2700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2850
    Cell Significance Index: -4.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3033
    Cell Significance Index: -24.0200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3042
    Cell Significance Index: -8.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3183
    Cell Significance Index: -16.7100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3241
    Cell Significance Index: -8.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3271
    Cell Significance Index: -8.6000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3431
    Cell Significance Index: -4.2600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3608
    Cell Significance Index: -7.9000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4310
    Cell Significance Index: -14.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4386
    Cell Significance Index: -26.8900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4389
    Cell Significance Index: -13.9800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4413
    Cell Significance Index: -12.6500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4560
    Cell Significance Index: -6.5300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4622
    Cell Significance Index: -5.5100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4789
    Cell Significance Index: -7.0700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.5110
    Cell Significance Index: -7.3500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5166
    Cell Significance Index: -13.8200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5300
    Cell Significance Index: -10.4800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5486
    Cell Significance Index: -19.2200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.5696
    Cell Significance Index: -8.1800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5976
    Cell Significance Index: -17.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MRE11 is a 3' to 5' exonuclease that is involved in the processing of DNA DSBs, which are caused by various forms of cellular stress, including radiation, chemical mutagens, and viral infections. The gene encodes a large protein that forms a complex with other proteins, including ATM and ATR, to facilitate the repair of DSBs. MRE11 is also involved in the regulation of cell cycle checkpoints and apoptosis, and its dysregulation has been linked to cancer and other diseases. **Pathways and Functions** MRE11 is involved in the following pathways and functions: 1. **Homologous Recombination Repair (HRR)**: MRE11 plays a central role in the HRR pathway, which is responsible for repairing DSBs by using a template to synthesize new DNA strands. 2. **Non-Homologous End Joining (NHEJ)**: MRE11 also participates in the NHEJ pathway, which is an alternative mechanism for repairing DSBs. 3. **DNA Damage Response**: MRE11 is involved in the DNA damage response, which is a complex network of signaling pathways that respond to DNA damage and activate repair mechanisms. 4. **Cell Cycle Checkpoints**: MRE11 regulates cell cycle checkpoints, which are mechanisms that prevent cells from entering the S phase of the cell cycle until DNA damage has been repaired. 5. **Apoptosis**: MRE11 is involved in the regulation of apoptosis, which is a process of programmed cell death that occurs in response to DNA damage or other forms of cellular stress. **Clinical Significance** Dysregulation of MRE11 has been linked to various diseases, including: 1. **Cancer**: Mutations or deficiencies in MRE11 have been associated with various types of cancer, including breast, ovarian, and prostate cancer. 2. **Neurodegenerative Disorders**: MRE11 has been implicated in neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. 3. **Premature Aging**: MRE11 has been linked to premature aging, which is characterized by accelerated aging and increased risk of age-related diseases. 4. **Immune System Disorders**: MRE11 is involved in the regulation of the immune system, and dysregulation of MRE11 has been associated with immune system disorders, including autoimmune diseases and immunodeficiency. In conclusion, MRE11 is a crucial gene that plays a central role in maintaining genome stability and regulating cell cycle checkpoints and apoptosis. Dysregulation of MRE11 has been linked to various diseases, including cancer, neurodegenerative disorders, and premature aging. Further research is needed to fully understand the functions of MRE11 and its role in human disease.

Genular Protein ID: 884606402

Symbol: MRE11_HUMAN

Name: Meiotic recombination 11 homolog A

UniProtKB Accession Codes:

P49959 B3KTC7 O43475

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 1 CPTC 1 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 26 EMDB 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 49 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 22 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8530104

Title: Isolation and characterization of the human MRE11 homologue.

PubMed ID: 8530104

DOI: 10.1006/geno.1995.1217

PubMed ID: 9651580

Title: The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks.

PubMed ID: 9651580

DOI: 10.1016/s1097-2765(00)80097-0

PubMed ID: 11371508

Title: hMRE11: genomic structure and a null mutation identified in a transcript protected from nonsense-mediated mRNA decay.

PubMed ID: 11371508

DOI: 10.1093/hmg/10.11.1155

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9590181

Title: The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response.

PubMed ID: 9590181

DOI: 10.1016/s0092-8674(00)81175-7

PubMed ID: 9705271

Title: Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95.

PubMed ID: 9705271

DOI: 10.1074/jbc.273.34.21447

PubMed ID: 10783165

Title: BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

PubMed ID: 10783165

PubMed ID: 10839544

Title: Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products.

PubMed ID: 10839544

DOI: 10.1038/35013083

PubMed ID: 10888888

Title: Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres.

PubMed ID: 10888888

DOI: 10.1038/77139

PubMed ID: 11741547

Title: Human Rad50/Mre11 is a flexible complex that can tether DNA ends.

PubMed ID: 11741547

DOI: 10.1016/s1097-2765(01)00381-1

PubMed ID: 12124628

Title: Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex.

PubMed ID: 12124628

DOI: 10.1038/nature00863

PubMed ID: 14657032

Title: The Mre11 complex is required for ATM activation and the G2/M checkpoint.

PubMed ID: 14657032

DOI: 10.1093/emboj/cdg630

PubMed ID: 15456891

Title: Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response.

PubMed ID: 15456891

DOI: 10.1128/mcb.24.20.9207-9220.2004

PubMed ID: 15064416

Title: Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex.

PubMed ID: 15064416

DOI: 10.1126/science.1091496

PubMed ID: 15723659

Title: Ataxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage.

PubMed ID: 15723659

DOI: 10.1111/j.1349-7006.2005.00019.x

PubMed ID: 15741314

Title: Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control.

PubMed ID: 15741314

DOI: 10.1101/gad.1279805

PubMed ID: 15916964

Title: ATM-dependent phosphorylation of ATF2 is required for the DNA damage response.

PubMed ID: 15916964

DOI: 10.1016/j.molcel.2005.04.015

PubMed ID: 15790808

Title: ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex.

PubMed ID: 15790808

DOI: 10.1126/science.1108297

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16601701

Title: ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks.

PubMed ID: 16601701

DOI: 10.1038/sj.emboj.7601045

PubMed ID: 16622404

Title: Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex.

PubMed ID: 16622404

DOI: 10.1038/nsmb1090

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18469862

Title: Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links.

PubMed ID: 18469862

DOI: 10.1038/onc.2008.139

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20943970

Title: Physical interaction between the herpes simplex virus type 1 exonuclease, UL12, and the DNA double-strand break-sensing MRN complex.

PubMed ID: 20943970

DOI: 10.1128/jvi.01506-10

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22863007

Title: Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling.

PubMed ID: 22863007

DOI: 10.1016/j.cell.2012.06.028

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24316220

Title: DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities.

PubMed ID: 24316220

DOI: 10.1016/j.molcel.2013.11.003

PubMed ID: 26215093

Title: MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex.

PubMed ID: 26215093

DOI: 10.1038/ncomms8744

PubMed ID: 26240375

Title: ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1.

PubMed ID: 26240375

DOI: 10.1093/nar/gkv754

PubMed ID: 27568553

Title: MRNIP/C5orf45 interacts with the MRN complex and contributes to the DNA damage response.

PubMed ID: 27568553

DOI: 10.1016/j.celrep.2016.07.087

PubMed ID: 27814491

Title: Nbs1 converts the human Mre11/Rad50 nuclease complex into an endo/exonuclease machine specific for protein-DNA adducts.

PubMed ID: 27814491

DOI: 10.1016/j.molcel.2016.10.010

PubMed ID: 27889449

Title: Phosphorylated CtIP functions as a co-factor of the MRE11-RAD50-NBS1 endonuclease in DNA end resection.

PubMed ID: 27889449

DOI: 10.1016/j.molcel.2016.10.017

PubMed ID: 26807646

Title: EXD2 promotes homologous recombination by facilitating DNA end resection.

PubMed ID: 26807646

DOI: 10.1038/ncb3303

PubMed ID: 28512243

Title: Plk1 Phosphorylation of Mre11 Antagonizes the DNA Damage Response.

PubMed ID: 28512243

DOI: 10.1158/0008-5472.can-16-2787

PubMed ID: 28834754

Title: SAMHD1 promotes DNA end resection to facilitate DNA repair by homologous recombination.

PubMed ID: 28834754

DOI: 10.1016/j.celrep.2017.08.008

PubMed ID: 28867292

Title: Single-molecule imaging reveals how Mre11-Rad50-Nbs1 initiates DNA break repair.

PubMed ID: 28867292

DOI: 10.1016/j.molcel.2017.08.002

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29670289

Title: SAMHD1 acts at stalled replication forks to prevent interferon induction.

PubMed ID: 29670289

DOI: 10.1038/s41586-018-0050-1

PubMed ID: 30464262

Title: DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells.

PubMed ID: 30464262

DOI: 10.1038/s41586-018-0670-5

PubMed ID: 29651020

Title: GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1.

PubMed ID: 29651020

DOI: 10.1038/s41467-018-03817-5

PubMed ID: 30612738

Title: UBQLN4 represses homologous recombination and is overexpressed in aggressive tumors.

PubMed ID: 30612738

DOI: 10.1016/j.cell.2018.11.024

PubMed ID: 30787182

Title: NBS1 promotes the endonuclease activity of the MRE11-RAD50 complex by sensing CtIP phosphorylation.

PubMed ID: 30787182

DOI: 10.15252/embj.2018101005

PubMed ID: 31353207

Title: C1QBP promotes homologous recombination by stabilizing MRE11 and controlling the assembly and activation of MRE11/RAD50/NBS1 complex.

PubMed ID: 31353207

DOI: 10.1016/j.molcel.2019.06.023

PubMed ID: 31537797

Title: MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription-replication conflicts.

PubMed ID: 31537797

DOI: 10.1038/s41467-019-12271-w

PubMed ID: 30783677

Title: MRE11 UFMylation promotes ATM activation.

PubMed ID: 30783677

DOI: 10.1093/nar/gkz110

PubMed ID: 36050397

Title: Crosstalk between SUMOylation and ubiquitylation controls DNA end resection by maintaining MRE11 homeostasis on chromatin.

PubMed ID: 36050397

DOI: 10.1038/s41467-022-32920-x

PubMed ID: 36563124

Title: RNF126-mediated MRE11 ubiquitination activates the DNA damage response and confers resistance of triple-negative breast cancer to radiotherapy.

PubMed ID: 36563124

DOI: 10.1002/advs.202203884

PubMed ID: 37696958

Title: Dynamics of the DYNLL1-MRE11 complex regulate DNA end resection and recruitment of Shieldin to DSBs.

PubMed ID: 37696958

DOI: 10.1038/s41594-023-01074-9

PubMed ID: 38128537

Title: Metabolic regulation of homologous recombination repair by MRE11 lactylation.

PubMed ID: 38128537

DOI: 10.1016/j.cell.2023.11.022

PubMed ID: 22078559

Title: Crystal structure of human Mre11: understanding tumorigenic mutations.

PubMed ID: 22078559

DOI: 10.1016/j.str.2011.09.010

PubMed ID: 36577401

Title: Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions.

PubMed ID: 36577401

DOI: 10.1016/j.molcel.2022.12.003

PubMed ID: 10612394

Title: The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder.

PubMed ID: 10612394

DOI: 10.1016/s0092-8674(00)81547-0

PubMed ID: 11196167

Title: Alterations of the double-strand break repair gene MRE11 in cancer.

PubMed ID: 11196167

PubMed ID: 15269180

Title: MRE11 mutations and impaired ATM-dependent responses in an Italian family with ataxia-telangiectasia-like disorder.

PubMed ID: 15269180

DOI: 10.1093/hmg/ddh221

PubMed ID: 14684699

Title: Mutation screening of Mre11 complex genes: indication of RAD50 involvement in breast and ovarian cancer susceptibility.

PubMed ID: 14684699

DOI: 10.1136/jmg.40.12.e131

PubMed ID: 15574463

Title: Identification and functional consequences of a novel MRE11 mutation affecting 10 Saudi Arabian patients with the ataxia telangiectasia-like disorder.

PubMed ID: 15574463

DOI: 10.1093/hmg/ddi027

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 19732584

Title: Two brothers with ataxia-telangiectasia-like disorder with lung adenocarcinoma.

PubMed ID: 19732584

DOI: 10.1016/j.jpeds.2009.02.037

PubMed ID: 23080121

Title: Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair.

PubMed ID: 23080121

DOI: 10.1093/nar/gks954

PubMed ID: 24332946

Title: Exome sequencing reveals a novel MRE11 mutation in a patient with progressive myoclonic ataxia.

PubMed ID: 24332946

DOI: 10.1016/j.jns.2013.11.032

Sequence Information:

  • Length: 708
  • Mass: 80593
  • Checksum: D94ABFBDDF6106AD
  • Sequence:
    • MSTADALDDE NTFKILVATD IHLGFMEKDA VRGNDTFVTL DEILRLAQEN EVDFILLGGD 
LFHENKPSRK TLHTCLELLR KYCMGDRPVQ FEILSDQSVN FGFSKFPWVN YQDGNLNISI 
PVFSIHGNHD DPTGADALCA LDILSCAGFV NHFGRSMSVE KIDISPVLLQ KGSTKIALYG 
LGSIPDERLY RMFVNKKVTM LRPKEDENSW FNLFVIHQNR SKHGSTNFIP EQFLDDFIDL 
VIWGHEHECK IAPTKNEQQL FYISQPGSSV VTSLSPGEAV KKHVGLLRIK GRKMNMHKIP 
LHTVRQFFME DIVLANHPDI FNPDNPKVTQ AIQSFCLEKI EEMLENAERE RLGNSHQPEK 
PLVRLRVDYS GGFEPFSVLR FSQKFVDRVA NPKDIIHFFR HREQKEKTGE EINFGKLITK 
PSEGTTLRVE DLVKQYFQTA EKNVQLSLLT ERGMGEAVQE FVDKEEKDAI EELVKYQLEK 
TQRFLKERHI DALEDKIDEE VRRFRETRQK NTNEEDDEVR EAMTRARALR SQSEESASAF 
SADDLMSIDL AEQMANDSDD SISAATNKGR GRGRGRRGGR GQNSASRGGS QRGRADTGLE 
TSTRSRNSKT AVSASRNMSI IDAFKSTRQQ PSRNVTTKNY SEVIEVDESD VEEDIFPTTS 
KTDQRWSSTS SSKIMSQSQV SKGVDFESSE DDDDDPFMNT SSLRRNRR

Genular Protein ID: 2689336242

Symbol: F8W7U8_HUMAN

Name: N/A

UniProtKB Accession Codes:

F8W7U8

Database IDs:

ARBA 16 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 2 GeneTree 1 HGNC 1 IntAct 1 InterPro 6 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 1 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 2 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.M111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 707
  • Mass: 80522
  • Checksum: C4A14D1836549935
  • Sequence:
    • MSTADALDDE NTFKILVATD IHLGFMEKDA VRGNDTFVTL DEILRLAQEN EVDFILLGGD 
LFHENKPSRK TLHTCLELLR KYCMGDRPVQ FEILSDQSVN FGFSKFPWVN YQDGNLNISI 
PVFSIHGNHD DPTGADALCA LDILSCAGFV NHFGRSMSVE KIDISPVLLQ KGSTKIALYG 
LGSIPDERLY RMFVNKKVTM LRPKEDENSW FNLFVIHQNR SKHGSTNFIP EQFLDDFIDL 
VIWGHEHECK IAPTKNEQQL FYISQPGSSV VTSLSPGEAV KKHVGLLRIK GRKMNMHKIP 
LHTVRQFFME DIVLANHPDI FNPDNPKVTQ AIQSFCLEKI EEMLENAERE RLGNSHQPEK 
PLVRLRVDYS GGFEPFSVLR FSQKFVDRVA NPKDIIHFFR HREQKEKTGE EINFGKLITK 
PSEGTTLRVE DLVKQYFQTA EKNVQLSLLT ERGMGEAVQE FVDKEEKDAI EELVKYQLEK 
TQRFLKERHI DALEDKIDEE VRRFRETRQK NTNEEDDEVR EAMTRARALR SQSEESASAF 
SADDLMSIDL AEQMANDSDD SISAATNKGR GRGRGRRGGR GQNSASRGGS QRGRDTGLET 
STRSRNSKTA VSASRNMSII DAFKSTRQQP SRNVTTKNYS EVIEVDESDV EEDIFPTTSK 
TDQRWSSTSS SKIMSQSQVS KGVDFESSED DDDDPFMNTS SLRRNRR

Genular Protein ID: 3811432848

Symbol: Q05D78_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q05D78

Database IDs:

ARBA 16 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 13 Gene3D 2 InterPro 6 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 RuleBase 1 SMART 2 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 517
  • Mass: 59724
  • Checksum: C9D454197D1B334B
  • Sequence:
    • MSTADALDDE NTFKILVATD IHLGFMEKDA VRGNDTFVTL DEILRLAQEN EVDFILLGGD 
LFHENKPSRK TLHTCLELLR KYCMGDRPVQ FEILSDQSVN FGFSKFPWVN YQDGNLNISI 
PVFSIHGNHD DPTGADALCA LDILSCAGFV NHFGRSMSVE KIDISPVLLQ KGSTKIALYG 
LGSIPDERLY RMFVNKKVTM LRPKEDENSW FNLFVIHQNR SKHGSTNFIP EQFLDDFIDL 
VIWGHEHECK IAPTKNEQQL FYISQPGSSV VTSLSPGEAV KKHVGLLRIK GRKMNMHKIP 
LHTVRQFFME DIVLANHPDI FNPDNPKVTQ AIQSFCLEKI EEMLENAERE RLGNSHQPEK 
PLVRLRVDYS GGFEPFSVLR FSQKFVDRVA NPKDIIHFFR HREQKEKTGE EINFGKLITK 
PSEGTTLRVE DLVKQYFQTA EKNVQLSLLT ERGMGEAVQE FVDKEEKDAI EELVKYQLEK 
TQRFLKERHI DALEDKIDEE VRRFRETRKK KKKKKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.